{"id":96828,"date":"2026-01-14T00:20:02","date_gmt":"2026-01-13T23:20:02","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=96828"},"modified":"2026-01-13T10:52:23","modified_gmt":"2026-01-13T09:52:23","slug":"studie-ukazuje-polovina-pacientu-s-rakovinou-brzliku-vykazuje-zanetlive-zmeny-lipidu-po-ockovani-mrna-proti-covid-19","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/01\/14\/studie-ukazuje-polovina-pacientu-s-rakovinou-brzliku-vykazuje-zanetlive-zmeny-lipidu-po-ockovani-mrna-proti-covid-19\/","title":{"rendered":"Studie ukazuje: Polovina pacient\u016f s rakovinou brzl\u00edku vykazuje z\u00e1n\u011btliv\u00e9 zm\u011bny lipid\u016f po o\u010dkov\u00e1n\u00ed mRNA proti COVID-19"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><span dir=\"auto\">Nov\u00e1 prospektivn\u00ed studie z It\u00e1lie nastoluje ot\u00e1zky ohledn\u011b imunologick\u00fdch \u00fa\u010dink\u016f mRNA vakc\u00edn proti COVID-19 u obzvl\u00e1\u0161t\u011b zraniteln\u00fdch skupin pacient\u016f. V\u00fdzkumn\u00edci pod veden\u00edm Gustava Cernery z Univerzity\u00a0<\/span><strong><span dir=\"auto\">Federica II v Neapoli<\/span><\/strong><span dir=\"auto\">\u00a0uv\u00e1d\u011bj\u00ed, \u017ee u p\u0159ibli\u017en\u011b poloviny pacient\u016f s n\u00e1dory brzl\u00edkov\u00e9ho epitelu (TET) se po dvou d\u00e1vk\u00e1ch vakc\u00edny Pfizer-BioNTech objevily m\u011b\u0159iteln\u00e9 zm\u011bny v ur\u010dit\u00fdch subfrakc\u00edch HDL lipid\u016f spojen\u00fdch se z\u00e1n\u011btliv\u00fdmi procesy.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Co bylo vy\u0161et\u0159ov\u00e1no?<\/span><\/h3>\n<p><span dir=\"auto\">Studie publikovan\u00e1 v\u00a0<\/span><em><span dir=\"auto\">\u010dasopise Scientific Reports<\/span><\/em><span dir=\"auto\">\u00a0prospektivn\u011b sledovala 45 dosp\u011bl\u00fdch pacient\u016f s TET p\u0159ed a po o\u010dkov\u00e1n\u00ed mRNA. Byly zkoum\u00e1ny klasick\u00e9 hladiny lipid\u016f v krvi, stejn\u011b jako detailn\u00ed subfrakce HDL, zejm\u00e9na tzv. \u201emal\u00e9 \u010d\u00e1stice HDL\u201c, kter\u00fdm se b\u011b\u017en\u011b p\u0159ipisuj\u00ed protiz\u00e1n\u011btliv\u00e9 a c\u00e9vn\u011b ochrann\u00e9 vlastnosti.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Kl\u00ed\u010dov\u00e1 zji\u0161t\u011bn\u00ed<\/span><\/h3>\n<p><span dir=\"auto\">Zat\u00edmco celkov\u00e9 hladiny HDL z\u016fstaly v pr\u016fm\u011bru do zna\u010dn\u00e9 m\u00edry nezm\u011bn\u011bny, byl pozorov\u00e1n statisticky v\u00fdznamn\u00fd pokles mal\u00fdch \u010d\u00e1stic HDL. Obzvl\u00e1\u0161t\u011b pozoruhodn\u00fd byl v\u00fdrazn\u00fd pokles v jasn\u011b definovan\u00e9 podskupin\u011b p\u0159ibli\u017en\u011b 53 procent \u00fa\u010dastn\u00edk\u016f studie. Sou\u010dasn\u011b v\u011bdci zjistili inverzn\u00ed korelaci mezi sn\u00ed\u017een\u00fdmi hladinami HDL a z\u00e1n\u011btliv\u00fdm markerem interleukinem-6 (IL-6) \u2013 co\u017e je indik\u00e1tor imunologick\u00e9 aktivace.<\/span><\/p>\n<p><span dir=\"auto\">Stru\u010dn\u011b \u0159e\u010deno: \u010c\u00edm ni\u017e\u0161\u00ed byly ur\u010dit\u00e9 subfrakce HDL, t\u00edm vy\u0161\u0161\u00ed byly centr\u00e1ln\u00ed z\u00e1n\u011btliv\u00e9 markery.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Co to znamen\u00e1 pro pacienty?<\/span><\/h3>\n<p><span dir=\"auto\">Je d\u016fle\u017eit\u00e9 uv\u00e9st tuto skute\u010dnost do perspektivy: Studie dokumentuje\u00a0<\/span><strong><span dir=\"auto\">zm\u011bny biomarker\u016f<\/span><\/strong><span dir=\"auto\">\u00a0, nikoli klinick\u00e9 po\u0161kozen\u00ed. B\u011bhem kr\u00e1tk\u00e9ho obdob\u00ed pozorov\u00e1n\u00ed se nevyskytly ani autoimunitn\u00ed reakce, ani kardiovaskul\u00e1rn\u00ed \u010di trombotick\u00e9 p\u0159\u00edhody. Zda jsou pozorovan\u00e9 zm\u011bny do\u010dasn\u00e9, nebo by mohly m\u00edt dlouhodob\u00e9 zdravotn\u00ed n\u00e1sledky, z\u016fst\u00e1v\u00e1 nejasn\u00e9.<\/span><\/p>\n<p><span dir=\"auto\">Sami auto\u0159i zd\u016fraz\u0148uj\u00ed, \u017ee se jedn\u00e1 o\u00a0<\/span><strong><span dir=\"auto\">v\u00fdsledky generuj\u00edc\u00ed hypot\u00e9zy<\/span><\/strong><span dir=\"auto\">\u00a0\u2013 zejm\u00e9na pro skupinu pacient\u016f s ji\u017e existuj\u00edc\u00edm onkologick\u00fdm a imunologick\u00fdm onemocn\u011bn\u00edm.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Omezen\u00ed studie<\/span><\/h3>\n<p><span dir=\"auto\">Zji\u0161t\u011bn\u00ed jsou omezen\u00e1: neexistuje \u017e\u00e1dn\u00e1 zdrav\u00e1 kontroln\u00ed skupina, velikost vzorku je mal\u00e1, doba sledov\u00e1n\u00ed je kr\u00e1tk\u00e1 a vn\u011bj\u0161\u00ed faktory, jako je strava nebo fyzick\u00e1 aktivita, bylo mo\u017en\u00e9 zohlednit pouze \u010d\u00e1ste\u010dn\u011b. Anal\u00fdza v\u00edcen\u00e1sobn\u00fdch korelac\u00ed nav\u00edc zvy\u0161uje riziko statisticky v\u00fdznamn\u00fdch souvislost\u00ed v d\u016fsledku n\u00e1hody.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Z\u00e1v\u011br<\/span><\/h3>\n<p><span dir=\"auto\">Studie poskytuje m\u00edrn\u00e9 d\u016fkazy o tom, \u017ee mRNA vakcinace mohou b\u00fdt u n\u011bkter\u00fdch vysoce rizikov\u00fdch pacient\u016f spojeny s m\u011b\u0159iteln\u00fdmi zm\u011bnami v metabolismu lipid\u016f souvisej\u00edc\u00edmi se z\u00e1n\u011btem. Zda jsou tyto posuny biomarker\u016f klinicky relevantn\u00ed, z\u016fst\u00e1v\u00e1 nejasn\u00e9. V\u00fdsledky v\u0161ak zd\u016fraz\u0148uj\u00ed pot\u0159ebu podrobn\u011bj\u0161\u00edch dlouhodob\u00fdch studi\u00ed \u2013 p\u0159edev\u0161\u00edm u onkologicky a imunologicky citliv\u00fdch populac\u00ed.<\/span><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.trialsitenews.com\/a\/half-of-thymic-cancer-patients-show-inflammatory-lipid-shifts-after-mrna-covid-19-vaccination-study-finds-6df3facf\" target=\"_blank\" rel=\"nofollow noopener\"><span dir=\"auto\">Zdroj<\/span><\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nov\u00e1 prospektivn\u00ed studie z It\u00e1lie nastoluje ot\u00e1zky ohledn\u011b imunologick\u00fdch \u00fa\u010dink\u016f mRNA vakc\u00edn proti COVID-19 u&#8230;<\/p>\n","protected":false},"author":2,"featured_media":96829,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[213,1366,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/96828"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=96828"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/96828\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/96829"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=96828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=96828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=96828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}