{"id":95617,"date":"2025-12-30T00:17:26","date_gmt":"2025-12-29T23:17:26","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=95617"},"modified":"2025-12-29T17:53:01","modified_gmt":"2025-12-29T16:53:01","slug":"chlapec-7-zemrel-hruznou-smrti-po-ockovani-mrna-od-pfizeru","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/12\/30\/chlapec-7-zemrel-hruznou-smrti-po-ockovani-mrna-od-pfizeru\/","title":{"rendered":"Chlapec (7) zem\u0159el hr\u016fznou smrt\u00ed po o\u010dkov\u00e1n\u00ed mRNA od Pfizeru"},"content":{"rendered":"
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L\u00e9ka\u0159sk\u00fd \u010dasopis\u00a0<\/span>Vaccines<\/span><\/em>\u00a0ned\u00e1vno publikoval kazuistiku\u00a0sedmilet\u00e9ho chlapce, kter\u00fd zem\u0159el na t\u011b\u017ekou myokarditidu kr\u00e1tce po pod\u00e1n\u00ed prvn\u00ed d\u00e1vky mRNA vakc\u00edny proti COVID-19. Auto\u0159i popisuj\u00ed slo\u017eit\u00fd klinick\u00fd pr\u016fb\u011bh s mnoha mo\u017en\u00fdmi p\u0159\u00ed\u010dinami a zd\u016fraz\u0148uj\u00ed obt\u00ed\u017enost stanoven\u00ed definitivn\u00ed diagn\u00f3zy v takov\u00fdch p\u0159\u00edpadech\u00a0<\/span>.<\/span><\/a><\/p>\n

Z\u00e1n\u011bty srdce, jako je myokarditida a perikarditida, jsou u d\u011bt\u00ed vz\u00e1cn\u00e9 a mohou m\u00edt r\u016fzn\u00e9 p\u0159\u00ed\u010diny. Mohou b\u00fdt d\u016fsledkem infekc\u00ed, autoimunitn\u00edch reakc\u00ed nebo syst\u00e9mov\u00fdch z\u00e1n\u011btliv\u00fdch proces\u016f. Proto\u017ee p\u0159\u00edznaky \u010dasto za\u010d\u00ednaj\u00ed nespecificky, onemocn\u011bn\u00ed nen\u00ed v\u017edy rozpozn\u00e1no okam\u017eit\u011b, i kdy\u017e n\u00e1sledky mohou b\u00fdt v n\u011bkter\u00fdch p\u0159\u00edpadech z\u00e1va\u017en\u00e9 nebo dokonce fat\u00e1ln\u00ed.<\/span><\/p>\n

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Pr\u016fb\u011bh onemocn\u011bn\u00ed po o\u010dkov\u00e1n\u00ed<\/span><\/h3>\n

Chlapec byl d\u0159\u00edve zdrav\u00fd a t\u0159i dny po prvn\u00edm o\u010dkov\u00e1n\u00ed proti COVID-19 se u n\u011bj objevily bolesti sval\u016f a hore\u010dka. Jeho rodi\u010de nehl\u00e1sili \u017e\u00e1dn\u00e9 p\u0159edchoz\u00ed infekce ani kontakt s nemoc\u00ed. O t\u00fdden pozd\u011bji se u n\u011bj n\u00e1hle objevila bolest a otok v prav\u00e9m kotn\u00edku. Testy odhalily zv\u00fd\u0161en\u00fd po\u010det b\u00edl\u00fdch krvinek, co\u017e nazna\u010dovalo z\u00e1n\u011btlivou reakci. Zobrazovac\u00ed vy\u0161et\u0159en\u00ed nebyla pozoruhodn\u00e1, ale l\u00e9ka\u0159i m\u011bli podez\u0159en\u00ed na infekci kloubu a zah\u00e1jili antibiotickou l\u00e9\u010dbu.<\/span><\/p>\n

Navzdory t\u00e9to l\u00e9\u010db\u011b p\u0159\u00edznaky p\u0159etrv\u00e1valy. Dal\u0161\u00ed testy uk\u00e1zaly zlep\u0161en\u00ed n\u011bkter\u00fdch krevn\u00edch hodnot, ale p\u0159\u00edznaky zcela nezmizely. O n\u011bkolik t\u00fddn\u016f pozd\u011bji se bolest kloub\u016f zhor\u0161ila a chlapec m\u011bl pot\u00ed\u017ee s ch\u016fz\u00ed. Nov\u00e9 krevn\u00ed testy odhalily zv\u00fd\u0161en\u00e9 hladiny antistreptolysinu, co\u017e nazna\u010duje ned\u00e1vno prod\u011blanou streptokokovou infekci. To vedlo k hospitalizaci a intenzivn\u011bj\u0161\u00ed antibiotick\u00e9 l\u00e9\u010db\u011b.<\/span><\/p>\n

P\u0159esto\u017ee bolest kloub\u016f zpo\u010d\u00e1tku ustoupila, stav d\u00edt\u011bte se n\u00e1hle zhor\u0161il. Rozvinuly se u n\u011bj gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee, v\u010detn\u011b zvracen\u00ed krve a bolest\u00ed b\u0159icha. Kr\u00e1tce nato do\u0161lo k siln\u00e9mu krv\u00e1cen\u00ed a vy\u017eadovalo neodkladnou intubaci. Zobrazen\u00ed plic odhalilo z\u00e1n\u011btliv\u00e9 l\u00e9ze, zat\u00edmco test na COVID-19 byl negativn\u00ed. Navzdory l\u00e9ka\u0159sk\u00e9mu z\u00e1sahu chlapec kr\u00e1tce pot\u00e9 zem\u0159el.<\/span><\/p>\n

Pitevn\u00ed n\u00e1lezy<\/span><\/h3>\n

Pitva odhalila, \u017ee t\u011blo bylo siln\u011b nafoukl\u00e9 v d\u016fsledku zadr\u017eov\u00e1n\u00ed tekutin. Kolem srdce byla p\u0159\u00edtomna tekutina a perikard vykazoval zn\u00e1mky z\u00e1n\u011btu s usazeninami fibrinu. Samotn\u00fd srde\u010dn\u00ed sval byl po\u0161kozen a vykazoval bled\u00e9 i krvav\u00e9 oblasti. Mikroskopick\u00e9 vy\u0161et\u0159en\u00ed odhalilo v\u00fdraznou z\u00e1n\u011btlivou reakci v srde\u010dn\u00ed tk\u00e1ni zp\u016fsobenou imunitn\u00edmi bu\u0148kami. Srde\u010dn\u00ed chlopn\u011b byly neporu\u0161en\u00e9.<\/span><\/p>\n

Kone\u010dnou p\u0159\u00ed\u010dinou smrti bylo akutn\u00ed srde\u010dn\u00ed selh\u00e1n\u00ed v d\u016fsledku kombinace myokarditidy a perikarditidy s n\u00e1sledn\u00fdm plicn\u00edm ed\u00e9mem a z\u00e1va\u017en\u00fdm po\u0161kozen\u00edm dal\u0161\u00edch org\u00e1n\u016f, v\u010detn\u011b ledvin a jater.<\/span><\/p>\n

Potenci\u00e1ln\u00ed p\u0159isp\u00edvaj\u00edc\u00ed role mRNA vakc\u00edny<\/span><\/h3>\n

L\u00e9ka\u0159i zkoumali n\u011bkolik mo\u017en\u00fdch vysv\u011btlen\u00ed z\u00e1n\u011btu srdce. Kombinace z\u00e1n\u011btu kloub\u016f, zv\u00fd\u0161en\u00fdch hladin antistreptolysinu a z\u00e1n\u011btu srdce \u010d\u00e1ste\u010dn\u011b odpov\u00edd\u00e1 akutn\u00ed revmatick\u00e9 hore\u010dce, vz\u00e1cn\u00e9 komplikaci po streptokokov\u00e9 infekci. Typick\u00e9 znaky tohoto onemocn\u011bn\u00ed, jako je po\u0161kozen\u00ed srde\u010dn\u00edch chlopn\u00ed, v\u0161ak chyb\u011bly, tak\u017ee tuto diagn\u00f3zu nebylo mo\u017en\u00e9 definitivn\u011b stanovit.<\/span><\/p>\n

Vzhledem k tomu, \u017ee se prvn\u00ed p\u0159\u00edznaky objevily kr\u00e1tce po o\u010dkov\u00e1n\u00ed, byla do anal\u00fdzy zahrnuta i mRNA vakc\u00edna proti COVID-19. Auto\u0159i poukazuj\u00ed na to, \u017ee mRNA vakc\u00edny mohou vyvolat silnou imunitn\u00ed odpov\u011b\u010f, kter\u00e1 m\u016f\u017ee p\u0159isp\u00edvat k z\u00e1va\u017en\u00fdm z\u00e1n\u011btliv\u00fdm proces\u016fm. P\u0159\u00edznaky tohoto pacienta vykazovaly podobnosti s multisyst\u00e9mov\u00fdm z\u00e1n\u011btliv\u00fdm syndromem, kter\u00fd ji\u017e byl pops\u00e1n po o\u010dkov\u00e1n\u00ed proti COVID-19.<\/span><\/p>\n

V\u00fdzkumn\u00edci dosp\u011bli k z\u00e1v\u011bru, \u017ee prim\u00e1rn\u00ed p\u0159\u00ed\u010dinu z\u00e1n\u011btu srdce nelze s jistotou ur\u010dit. Pova\u017euj\u00ed v\u0161ak za mo\u017en\u00e9, \u017ee o\u010dkov\u00e1n\u00ed zhor\u0161ilo ji\u017e existuj\u00edc\u00ed nebo po\u010d\u00ednaj\u00edc\u00ed z\u00e1n\u011btlivou reakci. Podle autor\u016f tento p\u0159\u00edpad zd\u016fraz\u0148uje d\u016fle\u017eitost pe\u010dliv\u00e9 diagnostiky a dlouhodob\u00e9ho sledov\u00e1n\u00ed d\u011bt\u00ed s nevysv\u011btliteln\u00fdmi z\u00e1n\u011btliv\u00fdmi p\u0159\u00edznaky po o\u010dkov\u00e1n\u00ed.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

L\u00e9ka\u0159sk\u00fd \u010dasopis\u00a0Vaccines\u00a0ned\u00e1vno publikoval kazuistiku\u00a0sedmilet\u00e9ho chlapce, kter\u00fd zem\u0159el na t\u011b\u017ekou myokarditidu kr\u00e1tce po pod\u00e1n\u00ed prvn\u00ed d\u00e1vky…<\/p>\n","protected":false},"author":2,"featured_media":68367,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1027,315,523,46],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/95617"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=95617"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/95617\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/68367"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=95617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=95617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=95617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}