{"id":93784,"date":"2025-12-04T00:21:42","date_gmt":"2025-12-03T23:21:42","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=93784"},"modified":"2025-12-03T09:33:39","modified_gmt":"2025-12-03T08:33:39","slug":"cdc-a-pfizer-vyvijeji-geneticky-modifikovane-konstrukty-viru-ptaci-chripky-h5-s-vyuzitim-stejne-mrna-platformy-jako-covid-19","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/12\/04\/cdc-a-pfizer-vyvijeji-geneticky-modifikovane-konstrukty-viru-ptaci-chripky-h5-s-vyuzitim-stejne-mrna-platformy-jako-covid-19\/","title":{"rendered":"CDC a Pfizer vyv\u00edjej\u00ed geneticky modifikovan\u00e9 konstrukty viru pta\u010d\u00ed ch\u0159ipky H5 s vyu\u017eit\u00edm stejn\u00e9 mRNA platformy jako COVID-19"},"content":{"rendered":"
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CDC a Pfizer vyv\u00edjej\u00ed konstrukty proti pta\u010d\u00ed ch\u0159ipce s optimalizovan\u00fdm \u0161t\u011bpn\u00fdm m\u00edstem pro novou mRNA vakc\u00ednu: \u201enpj Vaccines\u201c<\/span><\/strong><\/p>\n

Pou\u017eit\u00edm \u201estejn\u00fdch metod platformy, jak\u00e9 se pou\u017e\u00edvaj\u00ed pro mRNA vakc\u00edny spole\u010dnosti Pfizer proti COVID-19 a sez\u00f3nn\u00ed ch\u0159ipce\u201c.<\/span><\/strong><\/p>\n

V\u00fdzkumn\u00edci z americk\u00fdch Center pro kontrolu a prevenci nemoc\u00ed (CDC) a spole\u010dnosti Pfizer Inc. vyvinuli nov\u00e9, geneticky modifikovan\u00e9 konstrukty genu pro pta\u010d\u00ed ch\u0159ipku H5, v\u010detn\u011b genu pro hemaglutinin (HA) s optimalizovan\u00fdmi kodony a synteticky modifikovan\u00fdm m\u00edstem \u0161t\u011bpen\u00ed, jak je pops\u00e1no v publikaci publikovan\u00e9 v sobotu v \u010dasopise\u00a0<\/span>npj Vaccines<\/span><\/em><\/a>\u00a0.<\/span><\/p>\n

Podle autor\u016f bylo deklarovan\u00fdm c\u00edlem studie vyhodnotit vakc\u00ednu H5 na b\u00e1zi mRNA, kterou popisuj\u00ed jako \u201enukleosidov\u011b modifikovan\u00fd mRNA konstrukt k\u00f3duj\u00edc\u00ed kodonem optimalizovan\u00fd HA protein v pln\u00e9 d\u00e9lce s polybazick\u00fdm \u0161t\u011bpn\u00fdm m\u00edstem odstran\u011bn\u00fdm z A\/Astrakhan\/3212\/2020 A(H5N8)\u201c.<\/span><\/p>\n

Publikace potvrzuje, \u017ee um\u011ble vyroben\u00e1 HA pou\u017eit\u00e1 ve studii byla geneticky modifikov\u00e1na nad r\u00e1mec sv\u00e9 \u00fadajn\u00e9 p\u0159irozen\u00e9 formy.<\/span><\/p>\n

Optimalizovan\u00fd bod \u0161t\u011bpen\u00ed<\/span><\/strong><\/h3>\n

Auto\u0159i uv\u00e1d\u011bj\u00ed, \u017ee m\u00edsto \u0161t\u011bpen\u00ed bylo synteticky modifikov\u00e1no, a p\u00ed\u0161\u00ed, \u017ee polybazick\u00e9 aminokyseliny byly mutov\u00e1ny \u201ez \u201aREKRRKR\u2018 na \u201aRETR\u2018\u201c.<\/span><\/p>\n

M\u00edsto \u0161t\u011bpen\u00ed je jako sp\u00edna\u010d, kter\u00fd je t\u0159eba p\u0159epnout, aby se virus ch\u0159ipky \u201ezapnul\u201c, aby mohl infikovat bu\u0148ky. Pokud toto m\u00edsto dok\u00e1\u017ee roz\u0161t\u011bpit mnoho typ\u016f enzym\u016f v t\u011ble, virus se m\u016f\u017ee \u0161\u00ed\u0159it ve v\u011bt\u0161\u00edm m\u011b\u0159\u00edtku a zp\u016fsobit z\u00e1va\u017en\u011bj\u0161\u00ed onemocn\u011bn\u00ed.<\/span><\/p>\n

LNP pro mRNA terapii<\/span><\/strong><\/h3>\n

Konstruovan\u00e9 konstrukty byly pot\u00e9 formulov\u00e1ny do lipidov\u00fdch nano\u010d\u00e1stic za pou\u017eit\u00ed \u201estejn\u00fdch platformn\u00edch metod, jak\u00e9 se pou\u017e\u00edvaj\u00ed pro vakc\u00edny Pfizer mRNA proti COVID-19 a sez\u00f3nn\u00ed ch\u0159ipce\u201c.<\/span><\/p>\n

Pr\u00e1ci provedlo n\u011bkolik odd\u011blen\u00ed CDC, v\u010detn\u011b divize ch\u0159ipky, divize vysoce nebezpe\u010dn\u00fdch patogen\u016f a patologie a \u00da\u0159adu pro pokro\u010dilou molekul\u00e1rn\u00ed detekci.<\/span><\/p>\n

V\u011bdci ze spole\u010dnosti Pfizer v laborato\u0159i BSL-3<\/span><\/strong><\/h3>\n

Studie byla provedena v\u011bdci ze spole\u010dnosti Pfizer v jej\u00edm z\u00e1vod\u011b v Pearl River ve st\u00e1t\u011b New York za \u00fa\u010dasti dal\u0161\u00edch instituc\u00ed z ORISE.<\/span><\/p>\n

Auto\u0159i uv\u00e1d\u011bj\u00ed, \u017ee \u201eve\u0161ker\u00fd v\u00fdzkum s viry HPAI-A(H5N1) byl proveden v za\u0159\u00edzen\u00edch CDC Biosafety Level 3 Enhanced (BSL-3E) nebo ABSL-3\u201c.<\/span><\/p>\n

100% p\u0159enosov\u00e1 rychlost<\/span><\/strong><\/h3>\n

Pro testov\u00e1n\u00ed v\u00fdkonnosti um\u011ble vyroben\u00fdch konstrukt\u016f provedl t\u00fdm CDC-Pfizer experimenty s \u017eiv\u00fdmi viry s pou\u017eit\u00edm izol\u00e1t\u016f H5N1 odvozen\u00fdch od lid\u00ed.<\/span><\/p>\n

Fretky byly naka\u017eeny virov\u00fdmi formacemi \u201eA\/Chile\/25945\/2023\u201c a \u201eA\/Michigan\/90\/2024\u2026\u201c zem\u011bd\u011blsk\u00fdm pracovn\u00edkem, kter\u00fd p\u0159i\u0161el do kontaktu s naka\u017een\u00fdmi hospod\u00e1\u0159sk\u00fdmi zv\u00ed\u0159aty.<\/span><\/p>\n

Pomoc\u00ed t\u011bchto lidsk\u00fdch izol\u00e1t\u016f v\u011bdci zdokumentovali efektivn\u00ed p\u0159enos ze savce na savce a u neo\u010dkovan\u00fdch fretek zaznamenali \u201e100% m\u00edru p\u0159enosu\u201c.<\/span><\/p>\n

Financov\u00e1n\u00ed a st\u0159ety z\u00e1jm\u016f<\/span><\/strong><\/h3>\n

Informace t\u00fdkaj\u00edc\u00ed se financov\u00e1n\u00ed nazna\u010duj\u00ed p\u0159\u00edm\u00e9 financov\u00e1n\u00ed od feder\u00e1ln\u00ed vl\u00e1dy a spole\u010dnost\u00ed.<\/span><\/p>\n

Auto\u0159i vysv\u011btluj\u00ed: \u201eTuto pr\u00e1ci financovala centra pro kontrolu a prevenci nemoc\u00ed (CDC) v USA a spole\u010dnost Pfizer Inc.\u201c<\/span><\/p>\n

Auto\u0159i rovn\u011b\u017e uv\u00e1d\u011bj\u00ed pln\u00e9 zapojen\u00ed spole\u010dnosti do v\u011bdeck\u00e9ho procesu a p\u00ed\u0161\u00ed: \u201eSpole\u010dnost Pfizer se pod\u00edlela na koncepci, anal\u00fdze a interpretaci dat v t\u011bchto v\u00fdzkumn\u00fdch studi\u00edch, na p\u0159\u00edprav\u011b t\u00e9to zpr\u00e1vy a na rozhodnut\u00ed o jej\u00edm zve\u0159ejn\u011bn\u00ed.\u201c<\/span><\/p>\n

\u010cl\u00e1nek d\u00e1le zd\u016fraz\u0148uje, \u017ee v\u00fdzkumn\u00edci spole\u010dnosti Pfizer zapojen\u00ed do projektu jsou \u201evyn\u00e1lezci patentov\u00fdch p\u0159ihl\u00e1\u0161ek t\u00fdkaj\u00edc\u00edch se slo\u017een\u00ed mRNA viru ch\u0159ipky\u201c.<\/span><\/p>\n

Z\u00e1v\u011br<\/span><\/strong><\/h3>\n

Nov\u00e1 studie dokumentuje, \u017ee CDC a Pfizer spole\u010dn\u011b vyvinuly nov\u00e9 konstrukty H5 pomoc\u00ed optimalizace kodon\u016f a mutace \u0161t\u011bpn\u00e9ho m\u00edsta, formulovaly je s vyu\u017eit\u00edm platformy mRNA-LNP spole\u010dnosti Pfizer a pot\u00e9 je testovaly v laborato\u0159\u00edch BSL-3E CDC na sou\u010dasn\u00fdch lidsk\u00fdch izol\u00e1tech H5N1.<\/span><\/p>\n

V\u00fdsledkem je feder\u00e1ln\u011b podporovan\u00fd a korpor\u00e1tn\u011b \u0159\u00edzen\u00fd program, v n\u011bm\u017e americk\u00e9 \u00fa\u0159ady a spole\u010dnost Pfizer potichu vyvinuly geny viru ch\u0159ipky H5 a testovaly je s virem H5N1, kter\u00fd je naka\u017eliv\u00fd pro \u010dlov\u011bka \u2013 \u010d\u00edm\u017e se st\u00edr\u00e1 hranice mezi v\u00fdvojem vakc\u00edn a manipulac\u00ed s vysoce rizikov\u00fdmi patogeny.<\/span><\/p>\n

Tyto nebezpe\u010dn\u00e9 experimenty vyvol\u00e1vaj\u00ed obavy o n\u00e1rodn\u00ed bezpe\u010dnost.<\/span><\/p>\n

Od Jona Fleetwooda<\/span><\/em><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

CDC a Pfizer vyv\u00edjej\u00ed konstrukty proti pta\u010d\u00ed ch\u0159ipce s optimalizovan\u00fdm \u0161t\u011bpn\u00fdm m\u00edstem pro novou mRNA…<\/p>\n","protected":false},"author":2,"featured_media":73672,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1037,23,694,315,2206,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/93784"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=93784"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/93784\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/73672"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=93784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=93784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=93784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}