{"id":92270,"date":"2025-11-15T00:22:17","date_gmt":"2025-11-14T23:22:17","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=92270"},"modified":"2025-11-14T09:02:22","modified_gmt":"2025-11-14T08:02:22","slug":"32-hrotoveho-proteinu-covidu-odpovida-lidskym-genum-coz-naznacuje-bud-kontaminaci-nebo-umyslny-chimericky-design-analyza-blastp","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/11\/15\/32-hrotoveho-proteinu-covidu-odpovida-lidskym-genum-coz-naznacuje-bud-kontaminaci-nebo-umyslny-chimericky-design-analyza-blastp\/","title":{"rendered":"32 % \u201ehrotov\u00e9ho proteinu\u201c COVIDu odpov\u00edd\u00e1 lidsk\u00fdm gen\u016fm \u2013 co\u017e nazna\u010duje bu\u010f kontaminaci, nebo \u00famysln\u00fd chim\u00e9rick\u00fd design: anal\u00fdza BLASTp"},"content":{"rendered":"
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Jedna t\u0159etina tzv. spike proteinu SARS-CoV-2 byla sestavena z\u00a0<\/span>lidsk\u00e9ho genetick\u00e9ho materi\u00e1lu,<\/span><\/strong>\u00a0nikoli z virov\u00e9 RNA, co\u017e vyvol\u00e1v\u00e1 nal\u00e9hav\u00e9 ot\u00e1zky ohledn\u011b p\u016fvodu sekvence pou\u017eit\u00e9 v mRNA vakc\u00edn\u00e1ch.<\/span><\/p>\n

Nejd\u016fle\u017eit\u011bj\u0161\u00ed genetick\u00fd konstrukt v historii modern\u00ed medic\u00edny \u2013 \u201ehrotov\u00fd protein\u201c viru SARS-CoV-2 \u2013\u00a0<\/span>v p\u0159\u00edrod\u011b mo\u017en\u00e1 nikdy neexistoval<\/span><\/strong>\u00a0.<\/span><\/p>\n

Jak vysv\u011btluji ve sv\u00e9m nov\u00e9m v\u00fdzkumn\u00e9m \u010dl\u00e1nku s n\u00e1zvem \u201e\u00a0<\/span>Mozaika z 32 % lidsk\u00e9ho p\u016fvodu v proteinu spike viru SARS-CoV-2 sestaven\u00e9m in silico: N\u00e1hodn\u00e9 vnesen\u00ed kontaminantu nebo \u00famysln\u00fd funk\u010dn\u00ed chim\u00e9rick\u00fd design?\u201c,<\/span><\/a><\/em>\u00a0wuchansk\u00fd \u201espike\u201c vir nebyl nikdy izolov\u00e1n z viru.<\/span><\/p>\n

Byl\u00a0<\/span>digit\u00e1ln\u011b sestaven \u2013 in silico (v po\u010d\u00edta\u010di)<\/span><\/strong>\u00a0\u2013 z fragment\u016f RNA nalezen\u00fdch v plicn\u00ed tekutin\u011b pacienta v \u010c\u00edn\u011b \u010d\u00ednsk\u00fdmi v\u011bdci za\u010d\u00e1tkem ledna 2020.<\/span><\/p>\n

Tato genetick\u00e1 informace byla rychle \u0161\u00ed\u0159ena prost\u0159ednictv\u00edm datab\u00e1z\u00ed, jako jsou\u00a0<\/span>GenBank<\/span><\/strong>\u00a0a\u00a0<\/span>GISAID<\/span><\/strong>\u00a0.<\/span><\/p>\n

Kl\u00ed\u010dov\u00e1 publikace\u00a0<\/span>Wu a kol.<\/span><\/strong>\u00a0v\u00a0<\/span>\u010dasopise Nature<\/span><\/em>\u00a0v \u00fanoru 2020 byla prvn\u00edm recenzovan\u00fdm \u010dl\u00e1nkem, kter\u00fd p\u0159edstavil kompletn\u00ed genomovou sekvenci nov\u00e9ho koronaviru (SARS-CoV-2) \u2013 v\u010detn\u011b sekvence jeho spike proteinu.<\/span><\/p>\n

Tento\u00a0<\/span>syntetick\u00fd model<\/span><\/strong>\u00a0se pot\u00e9 stal\u00a0<\/span>pl\u00e1nem pro mRNA vakc\u00edny od spole\u010dnost\u00ed Pfizer a Moderna<\/span><\/strong>\u00a0, kter\u00e9 byly injek\u010dn\u011b aplikov\u00e1ny v\u00edce ne\u017e p\u011bti miliard\u00e1m lid\u00ed po cel\u00e9m sv\u011bt\u011b.<\/span><\/p>\n

To vyvol\u00e1v\u00e1 z\u00e1sadn\u00ed ot\u00e1zku:<\/span>
\nPokud byl \u201evirus\u201c wuchansk\u00e9ho t\u00fdmu sestaven z plicn\u00ed tekutiny nemocn\u00e9ho mu\u017ee, pro\u010d jeho charakteristick\u00fd spike protein obsahuje rozs\u00e1hl\u00fd\u00a0<\/span>lidsk\u00fd genetick\u00fd materi\u00e1l<\/span><\/strong>\u00a0? Je tato\u00a0<\/span>kontaminace<\/span><\/strong>\u00a0pacientovou RNA, nebo je to\u00a0<\/span>d\u016fkaz um\u011bl\u00e9 konstrukce<\/span><\/strong>\u00a0s vyu\u017eit\u00edm lidsk\u00fdch gen\u016f?<\/span><\/p>\n

Pro identifikaci lidsk\u00fdch slo\u017eek tohoto digit\u00e1ln\u00edho konstruktu jsem pou\u017eil n\u00e1stroj NCBI\u00a0<\/span>BLASTp<\/span><\/strong>\u00a0\u2013 bioinformatick\u00fd vyhled\u00e1va\u010d provozovan\u00fd americkou vl\u00e1dou, kter\u00fd porovn\u00e1v\u00e1 proteinov\u00e9 sekvence s glob\u00e1ln\u00ed datab\u00e1z\u00ed zn\u00e1m\u00fdch organism\u016f \u2013 a systematicky jsem zkoumal wuchansk\u00fd spike protein na shody s lidsk\u00fdmi proteiny. To odhalilo rozs\u00e1hl\u00e9\u00a0<\/span>shody s lidsk\u00fdmi endogenn\u00edmi retroviry<\/span><\/strong>\u00a0a\u00a0<\/span>bun\u011b\u010dn\u00fdmi geny,<\/span><\/strong>\u00a0kter\u00e9 se nenach\u00e1zej\u00ed v \u017e\u00e1dn\u00e9m koronaviru netop\u00fdra ani luskouna.<\/span><\/p>\n

Cel\u00fd v\u00fdzkumn\u00fd \u010dl\u00e1nek \u2013 v\u010detn\u011b v\u0161ech \u0161esti soubor\u016f nezpracovan\u00fdch dat z b\u011bh\u016f NCBI-BLASTp a jejich reprodukovateln\u00fdch ID po\u017eadavk\u016f \u2013 byl ve\u0159ejn\u011b archivov\u00e1n na\u00a0<\/span>Zenodo<\/span><\/strong>\u00a0(DOI\u00a0<\/span>https:\/\/zenodo.org\/records\/17584539<\/span><\/a>\u00a0), aby byla zaji\u0161t\u011bna pln\u00e1 transparentnost a nez\u00e1visl\u00e9 ov\u011b\u0159en\u00ed ka\u017ed\u00e9 hl\u00e1\u0161en\u00e9 shody.<\/span><\/p>\n

Kl\u00ed\u010dov\u00e1 zji\u0161t\u011bn\u00ed<\/span><\/strong><\/h3>\n