{"id":91651,"date":"2025-11-07T00:39:10","date_gmt":"2025-11-06T23:39:10","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=91651"},"modified":"2025-11-06T18:11:01","modified_gmt":"2025-11-06T17:11:01","slug":"usa-a-jizni-korea-vyvinuly-chimericky-virus-ptaci-chripky-100-smrtelny-pro-savce-infikuje-lidske-krvinky-a-napada-mozek","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/11\/07\/usa-a-jizni-korea-vyvinuly-chimericky-virus-ptaci-chripky-100-smrtelny-pro-savce-infikuje-lidske-krvinky-a-napada-mozek\/","title":{"rendered":"USA a Ji\u017en\u00ed Korea vyvinuly chim\u00e9rick\u00fd virus pta\u010d\u00ed ch\u0159ipky \u2013 100% smrteln\u00fd pro savce, infikuje lidsk\u00e9 krvinky a napad\u00e1 mozek"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><strong><span dir=\"auto\">Studie potvrzuje:<\/span><\/strong><span dir=\"auto\">\u00a0Laboratorn\u011b vytvo\u0159en\u00fd hybridn\u00ed virus H5N1 pronik\u00e1 imunitn\u00edmi bu\u0148kami, replikuje se v lidsk\u00e9 krvi, \u0161\u00ed\u0159\u00ed se po cel\u00e9m t\u011ble \u2013 dokonce i do mozku \u2013 a zabil v\u0161echny testovan\u00e9 savce.<\/span><\/p>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12466913\/\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12466913\/\"><span dir=\"auto\">Studie<\/span><\/a><span dir=\"auto\">\u00a0publikovan\u00e1 v z\u00e1\u0159\u00ed\u00a0v\u00a0<\/span><em><span dir=\"auto\">\u010dasopise Science Advances<\/span><\/em><span dir=\"auto\">\u00a0potvrzuje, \u017ee ameri\u010dt\u00ed a jihokorej\u0161t\u00ed v\u011bdci vyvinuli chim\u00e9rick\u00fd virus pta\u010d\u00ed ch\u0159ipky podobn\u00fd \u201eFrankensteinovi\u201c, kter\u00fd je pro savce 100% smrteln\u00fd, infikuje lidsk\u00e9 imunitn\u00ed bu\u0148ky a \u0161\u00ed\u0159\u00ed se po cel\u00e9m t\u011ble \u2013 v\u010detn\u011b mozku.<\/span><\/p>\n<p><span dir=\"auto\">Mezin\u00e1rodn\u00ed t\u00fdm veden\u00fd\u00a0<\/span><strong><span dir=\"auto\">Young Ki Choiem<\/span><\/strong><span dir=\"auto\">\u00a0(Korejsk\u00fd institut pro v\u00fdzkum vir\u016f) a\u00a0<\/span><strong><span dir=\"auto\">Richardem J. Webbym<\/span><\/strong><span dir=\"auto\">\u00a0(D\u011btsk\u00e1 v\u00fdzkumn\u00e1 nemocnice St. Jude, Memphis, Tennessee) rekonstruoval a geneticky modifikoval severoamerick\u00fd kmen viru H5N1\u00a0<\/span><em><span dir=\"auto\">A\/Lesser Scaup\/Georgia\/W22-145E\/2022 (GA\/W22-145E\/22)<\/span><\/em><span dir=\"auto\">\u00a0.<\/span><\/p>\n<p><span dir=\"auto\">Experimenty financovan\u00e9 jihokorejskou vl\u00e1dou vyvol\u00e1vaj\u00ed bezpe\u010dnostn\u00ed obavy \u2013 zejm\u00e9na pot\u00e9, co americk\u00fd Kongres, B\u00edl\u00fd d\u016fm, ministerstvo energetiky, FBI a CIA potvrdily, \u017ee pandemie COVID-19 je pravd\u011bpodobn\u011b zp\u016fsobena laboratorn\u00ed manipulac\u00ed s patogeny.<\/span><\/p>\n<p><strong><span dir=\"auto\">Kl\u00ed\u010dov\u00e1 ot\u00e1zka:<\/span><\/strong><span dir=\"auto\">\u00a0Vytv\u00e1\u0159ej\u00ed vl\u00e1dy dal\u0161\u00ed pandemii \u00famysln\u011b, nebo ne\u00famysln\u011b?<\/span><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/substackcdn.com\/image\/fetch\/$s_!ip9b!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep\/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc5374c01-2117-48cf-b5c9-e613f86f1672_809x921.png\" alt=\"\" width=\"707\" height=\"805\" \/><\/figure>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">laboratorn\u011b vytvo\u0159en\u00e1 chim\u00e9ra<\/span><\/h3>\n<p><span dir=\"auto\">Nov\u00fd virus nevznikl v p\u0159\u00edrod\u011b.<\/span><br \/>\n<span dir=\"auto\">T\u00fdm pou\u017eil\u00a0<\/span><strong><span dir=\"auto\">syst\u00e9m reverzn\u00ed genetiky s osmi plazmidy<\/span><\/strong><span dir=\"auto\">\u00a0, techniku\u00a0<\/span><em><span dir=\"auto\">\u200b\u200b\u200b\u200bz\u00edsk\u00e1n\u00ed funkce<\/span><\/em><span dir=\"auto\">\u00a0, kter\u00e1 umo\u017e\u0148uje syntetizovat kompletn\u00ed virov\u00fd genom z DNA plazmid\u016f, vn\u00e9st ho do lidsk\u00fdch nebo zv\u00ed\u0159ec\u00edch bun\u011bk a tak vytvo\u0159it infek\u010dn\u00ed patogen.<\/span><\/p>\n<p><span dir=\"auto\">V\u011bdci zkombinovali geny ze severoamerick\u00e9ho kmene GA\/W22-145E\/22 se segmenty z euroasijsk\u00e9ho kmene\u00a0<\/span><em><span dir=\"auto\">A\/Common Teal\/Korea\/W811\/2021 (KR\/W811\/21)<\/span><\/em><span dir=\"auto\">\u00a0. P\u016fvodn\u00ed kmen byl ji\u017e\u00a0<\/span><strong><span dir=\"auto\">hybridem<\/span><\/strong><span dir=\"auto\">\u00a0obou ch\u0159ipkov\u00fdch rodin, na jeho\u017e z\u00e1klad\u011b byly zavedeny nov\u00e9 syntetick\u00e9 mutace \u2013 skute\u010dn\u00e1\u00a0<\/span><em><span dir=\"auto\">chim\u00e9ra<\/span><\/em><span dir=\"auto\">\u00a0, slo\u017een\u00e1 z r\u016fzn\u00fdch genetick\u00fdch zdroj\u016f a amplifikovan\u00e1 v laborato\u0159i.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">C\u00edlen\u00e9 mutace<\/span><\/h3>\n<p><span dir=\"auto\">Zam\u011b\u0159en\u00ed bylo zam\u011b\u0159eno na dv\u011b mutace \u2013\u00a0<\/span><strong><span dir=\"auto\">PB2-478I<\/span><\/strong><span dir=\"auto\">\u00a0a\u00a0<\/span><strong><span dir=\"auto\">NP-450N<\/span><\/strong><span dir=\"auto\">\u00a0.<\/span><br \/>\n<span dir=\"auto\">Ty v\u00fdrazn\u011b zv\u00fd\u0161ily agresivitu viru, roz\u0161\u00ed\u0159ily po\u010det infikovateln\u00fdch typ\u016f bun\u011bk a umo\u017enily mu \u0161\u00ed\u0159it se i mimo pl\u00edce.<\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\">PB2-478I<\/span><\/strong><span dir=\"auto\">\u00a0se nach\u00e1z\u00ed v genu polymer\u00e1zy \u2013 zlep\u0161uje schopnost viru ovl\u00e1dat \u201ep\u0159ep\u00ednac\u00ed mechanismy\u201c lidsk\u00fdch bun\u011bk a rychle se mno\u017eit.<\/span><\/li>\n<li><strong><span dir=\"auto\">NP-450N<\/span><\/strong><span dir=\"auto\">\u00a0ovliv\u0148uje nukleoprotein, kter\u00fd chr\u00e1n\u00ed a transportuje virov\u00fd genom \u2013 tato zm\u011bna zp\u016fsobila, \u017ee ka\u017ed\u00e1 infikovan\u00e1 bu\u0148ka uvol\u0148ovala v\u00edce virov\u00fdch \u010d\u00e1stic.<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">V kombinaci ob\u011b mutace vedly k viru, kter\u00fd infikoval imunitn\u00ed bu\u0148ky (T, B, makrof\u00e1gy, monocyty), vstupoval do org\u00e1n\u016f krevn\u00edm \u0159e\u010di\u0161t\u011bm a dosahoval mozku.<\/span><\/p>\n<p><span dir=\"auto\">Auto\u0159i p\u00ed\u0161\u00ed:<\/span><\/p>\n<p><em><span dir=\"auto\">\u201ePB2-478I a NP-450N p\u016fsob\u00ed synergicky a zvy\u0161uj\u00ed aktivitu polymer\u00e1zy, synt\u00e9zu vRNA a \u00fa\u010dinnost replikace u v\u00edce druh\u016f hostitel\u016f.\u201c<\/span><\/em><\/p>\n<p><span dir=\"auto\">Kdy\u017e byly mutace reverzibiln\u00ed (PB2-478V a NP-450S), virus z\u016fstal omezen na pl\u00edce \u2013 \u017e\u00e1dn\u00e9 zv\u00ed\u0159e nezem\u0159elo.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">100% smrt\u00edc\u00ed u savc\u016f<\/span><\/h3>\n<p><span dir=\"auto\">V\u0161ech 24 fretek infikovan\u00fdch geneticky modifikovan\u00fdm kmenem GA\/W22-145E\/22 uhynulo do sedmi dn\u016f. Kontroln\u00ed skupina infikovan\u00e1 eurasijsk\u00fdm virem p\u0159e\u017eila.<\/span><\/p>\n<p><span dir=\"auto\">Pitvy prok\u00e1zaly replikaci viru t\u00e9m\u011b\u0159 ve v\u0161ech org\u00e1nech \u2013 plic\u00edch, j\u00e1trech, slezin\u011b, ledvin\u00e1ch, st\u0159evech, lymfatick\u00fdch uzlin\u00e1ch a mozku \u2013 p\u0159i\u010dem\u017e detekce RNA se roz\u0161\u00ed\u0159ila do hlubok\u00fdch oblast\u00ed mozku \u010dty\u0159i dny po infekci.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Infekce lidsk\u00fdch krevn\u00edch bun\u011bk<\/span><\/h3>\n<p><span dir=\"auto\">V dal\u0161\u00edch testech se chim\u00e9rick\u00e1 varianta efektivn\u011b replikovala v lidsk\u00fdch perifern\u00edch krevn\u00edch bu\u0148k\u00e1ch (PBMC) a monocytech THP-1 \u2013 co\u017e dokazuje, \u017ee p\u0159\u00edmo napad\u00e1 lidsk\u00e9 imunitn\u00ed bu\u0148ky:<\/span><\/p>\n<p><em><span dir=\"auto\">\u201eLidsk\u00e9 PBMC infikovan\u00e9 virem GA\/W22-145E\/22 vykazovaly v\u00fdznamn\u011b vy\u0161\u0161\u00ed replikaci (\u2026 hladiny cRNA, mRNA a vRNA \u2026) ne\u017e bu\u0148ky infikovan\u00e9 virem KR\/W811\/21.\u201c<\/span><\/em><\/p>\n<p><span dir=\"auto\">To umo\u017e\u0148uje viru vyu\u017e\u00edvat k \u0161\u00ed\u0159en\u00ed samotn\u00fd imunitn\u00ed syst\u00e9m \u2013 co\u017e je pro ch\u0159ipku neobvykle nebezpe\u010dn\u00e1 vlastnost.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Neuroinvaze \u2013 infekce mozku<\/span><\/h3>\n<p><span dir=\"auto\">Mikroskopick\u00e9 sn\u00edmky uk\u00e1zaly, \u017ee virov\u00e1 RNA sah\u00e1 za \u010dichov\u00fd bulb do mozkov\u00e9 k\u016fry \u2013 jasn\u00fd d\u016fkaz mozkov\u00e9 infekce.<\/span><br \/>\n<span dir=\"auto\">Imunitn\u00ed bu\u0148ky v mozkov\u00e9 tk\u00e1ni z\u0159ejm\u011b slou\u017eily jako transportn\u00ed prost\u0159edky pro virus p\u0159es hematoencefalickou bari\u00e9ru.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Virus Frankenstein z laborato\u0159e<\/span><\/h3>\n<p><span dir=\"auto\">Stru\u010dn\u011b \u0159e\u010deno:<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">Genom ch\u0159ipky rekonstruovan\u00fd z plazmid\u016f,<\/span><\/li>\n<li><span dir=\"auto\">Sm\u00edchan\u00e9 euroasijsk\u00e9 a severoamerick\u00e9 geny,<\/span><\/li>\n<li><span dir=\"auto\">Byly vlo\u017eeny nov\u00e9 mutace pro zv\u00fd\u0161en\u00ed aktivity polymer\u00e1zy a virulence.<\/span><\/li>\n<li><span dir=\"auto\">Byla prok\u00e1z\u00e1na infekce lidsk\u00fdch bun\u011bk, syst\u00e9mov\u00e9 \u0161\u00ed\u0159en\u00ed a neuroinvaze.<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">To znamen\u00e1, \u017ee projekt spl\u0148uje definici chim\u00e9rick\u00e9ho viru\u00a0<\/span><em><span dir=\"auto\">s vylep\u0161enou funkc\u00ed<\/span><\/em><span dir=\"auto\">\u00a0\u2013 z\u00e1m\u011brn\u011b vytvo\u0159en\u00e9ho hybridu s nov\u00fdmi, nebezpe\u010dn\u011bj\u0161\u00edmi vlastnostmi.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span dir=\"auto\">Z\u00e1v\u011br<\/span><\/h3>\n<p><span dir=\"auto\">Studie zve\u0159ejn\u011bn\u00e1 v\u00a0<\/span><em><span dir=\"auto\">\u010dasopise Science Advances<\/span><\/em><span dir=\"auto\">\u00a0dokumentuje z\u00e1m\u011brn\u00e9 vytvo\u0159en\u00ed laboratorn\u011b vyroben\u00e9ho chim\u00e9rick\u00e9ho viru H5N1 \u201eFrankenstein\u201c, kter\u00fd&#8230;<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">zabil v\u0161echny testovan\u00e9 savce,<\/span><\/li>\n<li><span dir=\"auto\">mno\u017e\u00ed se v lidsk\u00fdch krevn\u00edch bu\u0148k\u00e1ch<\/span><\/li>\n<li><span dir=\"auto\">\u0161\u00ed\u0159\u00ed se syst\u00e9mov\u011b prost\u0159ednictv\u00edm imunitn\u00edch bun\u011bk a<\/span><\/li>\n<li><span dir=\"auto\">za\u00fato\u010dil na mozek.<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">Sami auto\u0159i k tomu doch\u00e1zej\u00ed:<\/span><\/p>\n<p><em><span dir=\"auto\">&#8222;Tyto mutace zp\u016fsobuj\u00ed syst\u00e9mov\u00e9 \u0161\u00ed\u0159en\u00ed zprost\u0159edkovan\u00e9 imunitn\u00edmi bu\u0148kami, neuroinvazi a potenci\u00e1ln\u00ed vertik\u00e1ln\u00ed p\u0159enos.&#8220;<\/span><\/em><\/p>\n<p><span dir=\"auto\">Jednodu\u0161e \u0159e\u010deno: Nejednalo se o p\u0159irozenou evoluci \u2013 ale o \u00famysln\u00e9 vytvo\u0159en\u00ed hybridn\u00edho viru v laborato\u0159i, kter\u00fd infikuje lidsk\u00e9 bu\u0148ky a je smrteln\u00fd pro savce nap\u0159\u00ed\u010d druhy, pod rou\u0161kou \u201ep\u0159\u00edpravy na pandemii\u201c.<\/span><\/p>\n<p><em><strong><span dir=\"auto\">Od Jona Fleetwooda\u00a0<\/span><\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/jonfleetwood.substack.com\/p\/us-south-korea-lab-engineer-chimeric?utm_source=post-email-title&amp;publication_id=520511&amp;post_id=176643911&amp;utm_campaign=email-post-title&amp;isFreemail=true&amp;r=pf6gr&amp;triedRedirect=true&amp;utm_medium=email\" target=\"_blank\" rel=\"nofollow noopener\"><span dir=\"auto\">Zdroj<\/span><\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Studie potvrzuje:\u00a0Laboratorn\u011b vytvo\u0159en\u00fd hybridn\u00ed virus H5N1 pronik\u00e1 imunitn\u00edmi bu\u0148kami, replikuje se v lidsk\u00e9 krvi, \u0161\u00ed\u0159\u00ed&#8230;<\/p>\n","protected":false},"author":2,"featured_media":91652,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1963,1189,2206,37,1337],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/91651"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=91651"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/91651\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/91652"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=91651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=91651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=91651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}