{"id":91148,"date":"2025-11-02T00:15:18","date_gmt":"2025-11-01T23:15:18","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=91148"},"modified":"2025-11-01T09:45:38","modified_gmt":"2025-11-01T08:45:38","slug":"mohou-mrna-vakciny-podporovat-rakovinu-nova-studie-vyvolava-obavy","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/11\/02\/mohou-mrna-vakciny-podporovat-rakovinu-nova-studie-vyvolava-obavy\/","title":{"rendered":"Mohou mRNA vakc\u00edny podporovat rakovinu? Nov\u00e1 studie vyvol\u00e1v\u00e1 obavy"},"content":{"rendered":"
<\/div>\n

V nov\u00e9, dosud nerecenzovan\u00e9\u00a0studii<\/a>\u00a0si italsk\u00fd patolog\u00a0<\/span>Ciro Isidoro<\/span><\/strong>\u00a0klade nep\u0159\u00edjemnou ot\u00e1zku: Mohly by\u00a0infekce SARS-CoV-2<\/strong>\u00a0a\u00a0mRNA vakc\u00edny<\/strong>\u00a0za ur\u010dit\u00fdch okolnost\u00ed\u00a0podporovat\u00a0r\u016fst nebo recidivu n\u00e1dor\u016f ?<\/strong><\/span><\/p>\n

Ve sv\u00e9m preprintu\u00a0zve\u0159ejn\u011bn\u00e9m\u00a0na\u00a0<\/a>Preprints.org<\/em><\/a><\/span>\u00a028. \u0159\u00edjna 2025<\/span><\/strong>\u00a0Isidoro popisuje \u0159adu biologick\u00fdch mechanism\u016f, kter\u00fdmi by virus a vakc\u00edna\u00a0mohly nep\u0159\u00edmo podporovat rakovinu<\/strong>\u00a0. Zmi\u0148uje z\u00e1n\u011bt, potla\u010den\u00ed interferonov\u00e9 odpov\u011bdi, zhor\u0161en\u00fd imunitn\u00ed dohled a dysregulaci bun\u011b\u010dn\u00e9 autofagie \u2013 v\u0161echny procesy zn\u00e1m\u00e9 v onkologii.<\/span><\/p>\n

Podle Isidora jsou \u00fa\u010dinky\u00a0<\/span>obzvl\u00e1\u0161t\u011b v\u00fdrazn\u00e9 u jedinc\u016f, kte\u0159\u00ed byli opakovan\u011b o\u010dkov\u00e1ni a byli opakovan\u011b infikov\u00e1ni<\/span><\/strong>\u00a0. Virov\u00fd spike protein a spike protein produkovan\u00fd mRNA vakc\u00edny jsou \u201estruktur\u00e1ln\u011b velmi podobn\u00e9\u201c, a proto mohou vyvolat srovnateln\u00e9 reakce. V t\u00e9to kombinaci, uvedl, m\u016f\u017ee vzniknout\u00a0<\/span>\u201esynergie mezi virem a vakc\u00ednou\u201c<\/span><\/strong>\u00a0, kter\u00e1 podporuje \u201e\u0161kodliv\u00fd v\u00fdsledek\u201c.<\/span><\/p>\n

Autor cituje\u00a0<\/span>35 kazuistik<\/span><\/strong>\u00a0z literatury \u2013 v\u010detn\u011b 25 nov\u00fdch p\u0159\u00edpad\u016f a 10 relaps\u016f \u2013 u kter\u00fdch se rakovina objevila po o\u010dkov\u00e1n\u00ed nebo infekc\u00edch. Zd\u016fraz\u0148uje, \u017ee tato pozorov\u00e1n\u00ed nejsou\u00a0<\/span>d\u016fkazem<\/span><\/strong>\u00a0, ale\u00a0<\/span>sp\u00ed\u0161e n\u00e1znakem mo\u017en\u00e9ho vzorce<\/span><\/strong>\u00a0, kter\u00fd je t\u0159eba v\u011bdecky prozkoumat. Isidoro nicm\u00e9n\u011b doslovn\u011b p\u00ed\u0161e: \u201eVakc\u00edny s mRNA proti COVID-19 mohly p\u0159isp\u011bt k recidiv\u011b onemocn\u011bn\u00ed a hor\u0161\u00edmu klinick\u00e9mu pr\u016fb\u011bhu u pacient\u016f s rakovinou.\u201c<\/span><\/p>\n

Jeho hypot\u00e9za je, \u017ee\u00a0<\/span>chronick\u00fd z\u00e1n\u011bt<\/span><\/strong>\u00a0a\u00a0<\/span>zm\u011bny v imunitn\u00ed odpov\u011bdi<\/span><\/strong>\u00a0by mohly \u201eprobudit\u201c sp\u00edc\u00ed rakovinn\u00e9 bu\u0148ky nebo urychlit r\u016fst n\u00e1doru. Isidoro pova\u017euje modulaci vrozen\u00e9ho imunitn\u00edho syst\u00e9mu \u2013 nap\u0159\u00edklad sn\u00ed\u017een\u00ed antivirov\u00e9ho sign\u00e1lu\u00a0<\/span>IFN-\u03b1<\/span><\/strong>\u00a0a sou\u010dasn\u00e9 zv\u00fd\u0161en\u00ed z\u00e1n\u011btliv\u00fdch cytokin\u016f\u00a0<\/span>IL-1\u03b2<\/span><\/strong>\u00a0a\u00a0<\/span>IL-6<\/span><\/strong>\u00a0\u2013 za obzvl\u00e1\u0161t\u011b rizikovou.<\/span><\/p>\n

Kritick\u00e1 recenze<\/span><\/strong><\/h3>\n

Navzdory alarmuj\u00edc\u00edmu zn\u011bn\u00ed pr\u00e1ce neposkytuje\u00a0<\/span>\u017e\u00e1dn\u00e1 klinick\u00e1 data<\/span><\/strong>\u00a0. Jedn\u00e1 se o\u00a0<\/span>teoretick\u00e9 pojedn\u00e1n\u00ed<\/span><\/strong>\u00a0zalo\u017een\u00e9 na zn\u00e1m\u00fdch molekul\u00e1rn\u011b biologick\u00fdch drah\u00e1ch, nikoli na nov\u00fdch experimentech. 35 p\u0159\u00edpad\u016f jsou\u00a0<\/span>neofici\u00e1ln\u00ed zpr\u00e1vy<\/span><\/strong>\u00a0z jednotliv\u00fdch kazuistik bez statistick\u00e9 anal\u00fdzy.<\/span><\/p>\n

Probl\u00e9m je v tom, \u017ee preprint na n\u011bkolika m\u00edstech zmi\u0148uje, \u017ee existuje\u00a0<\/span>v\u00e1\u017en\u00e9 riziko<\/span><\/em>\u00a0, p\u0159esto\u017ee nejsou k dispozici \u017e\u00e1dn\u00e9 epidemiologick\u00e9 ani experiment\u00e1ln\u00ed d\u016fkazy. To snadno vytv\u00e1\u0159\u00ed dojem, \u017ee ji\u017e existuj\u00ed d\u016fkazy o kauzalit\u011b \u2013 a\u010dkoli s\u00e1m autor p\u00ed\u0161e, \u017ee \u201ekauz\u00e1ln\u00ed vztah v sou\u010dasn\u00e9 dob\u011b nelze prok\u00e1zat\u201c.<\/span><\/p>\n

Z\u00e1v\u011br<\/span><\/strong><\/h3>\n

Isidor\u016fv preprint je\u00a0<\/span>provokativn\u00edm p\u0159\u00edsp\u011bvkem k prob\u00edhaj\u00edc\u00ed debat\u011b<\/span><\/strong>\u00a0o mo\u017en\u00fdch dlouhodob\u00fdch \u00fa\u010dinc\u00edch mRNA vakc\u00edn. Neposkytuje sice\u00a0<\/span>\u017e\u00e1dn\u00e9 d\u016fkazy<\/span><\/strong>\u00a0, ale \u0159adu hypot\u00e9z, kter\u00e9 je t\u0159eba v\u011bdecky ov\u011b\u0159it.<\/span><\/p>\n

Studie\u00a0<\/span>nen\u00ed recenzovan\u00e1<\/span><\/strong>\u00a0, neobsahuje\u00a0<\/span>\u017e\u00e1dn\u00e1 nov\u00e1 data<\/span><\/strong>\u00a0a\u00a0<\/span>postr\u00e1d\u00e1 statistick\u00e9 d\u016fkazy<\/span><\/strong>\u00a0. Jej\u00ed v\u00fdznam spo\u010d\u00edv\u00e1 m\u00e9n\u011b ve v\u00fdsledc\u00edch samotn\u00fdch ne\u017e ve varov\u00e1n\u00ed, \u017ee by m\u011bl b\u00fdt pokra\u010dov\u00e1n v\u00fdzkum dlouhodob\u00fdch molekul\u00e1rn\u00edch \u00fa\u010dink\u016f modern\u00edch vakc\u00edn.<\/span><\/p>\n

\"\"<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

V nov\u00e9, dosud nerecenzovan\u00e9\u00a0studii\u00a0si italsk\u00fd patolog\u00a0Ciro Isidoro\u00a0klade nep\u0159\u00edjemnou ot\u00e1zku: Mohly by\u00a0infekce SARS-CoV-2\u00a0a\u00a0mRNA vakc\u00edny\u00a0za ur\u010dit\u00fdch okolnost\u00ed\u00a0podporovat\u00a0r\u016fst…<\/p>\n","protected":false},"author":2,"featured_media":53558,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[694,1366,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/91148"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=91148"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/91148\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/53558"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=91148"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=91148"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=91148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}