{"id":91011,"date":"2025-10-31T00:21:57","date_gmt":"2025-10-30T23:21:57","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=91011"},"modified":"2025-10-30T10:40:40","modified_gmt":"2025-10-30T09:40:40","slug":"107-studii-spojuje-vakciny-s-autismem-a-dalsimi-poruchami-mozku-metaanalyza-nadace-mccullough","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/10\/31\/107-studii-spojuje-vakciny-s-autismem-a-dalsimi-poruchami-mozku-metaanalyza-nadace-mccullough\/","title":{"rendered":"107 studi\u00ed spojuje vakc\u00edny s autismem a dal\u0161\u00edmi poruchami mozku: metaanal\u00fdza Nadace McCullough"},"content":{"rendered":"
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\u201eO\u010dkov\u00e1n\u00ed v d\u011btstv\u00ed p\u0159edstavuje nejv\u00fdznamn\u011bj\u0161\u00ed modifikovateln\u00fd rizikov\u00fd faktor\u201c pro autismus, p\u00ed\u0161\u00ed Hulscher, McCullough, Wakefield a sedm dal\u0161\u00edch v\u00fdzkumn\u00edk\u016f.<\/span><\/p>\n

Jon Fleetwood<\/span><\/p>\n

Komplexn\u00ed nov\u00e1 anal\u00fdza proveden\u00e1 Nadac\u00ed McCullough potvrdila, \u017ee \u201enejv\u00fdznamn\u011bj\u0161\u00edm modifikovateln\u00fdm rizikov\u00fdm faktorem\u201c autismu je o\u010dkov\u00e1n\u00ed v d\u011btstv\u00ed.<\/span><\/p>\n

Dokument\u00a0<\/span>Nadace McCullough<\/span><\/a>\u00a0s n\u00e1zvem \u201eDeterminanty poruchy autistick\u00e9ho spektra\u201c shrnuje ohromuj\u00edc\u00edch 136 v\u011bdeck\u00fdch studi\u00ed.<\/span><\/p>\n

V\u011bt\u0161ina z nich uv\u00e1d\u00ed, \u017ee sou\u010dasn\u00fd o\u010dkovac\u00ed pl\u00e1n je v souvislosti s autismem \u201enal\u00e9havou prioritou ve\u0159ejn\u00e9ho zdrav\u00ed\u201c.<\/span><\/p>\n

To znamen\u00e1, \u017ee vakc\u00edny \u2013 jejich\u017e tr\u017en\u00ed hodnota se v roce 2025 odhadovala na 82 miliard dolar\u016f a do roku 2032 by m\u011bla celosv\u011btov\u011b dos\u00e1hnout 125 miliard dolar\u016f \u2013 pravd\u011bpodobn\u011b zp\u016fsob\u00ed jeden z nejni\u010div\u011bj\u0161\u00edch a nejtragi\u010dt\u011bj\u0161\u00edch naru\u0161en\u00ed lidsk\u00fdch d\u011bjin.<\/span><\/p>\n

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Auto\u0159i p\u00ed\u0161\u00ed:<\/span><\/strong><\/p>\n

\u201eKombinovan\u00e9 a v\u010dasn\u00e9 rutinn\u00ed o\u010dkov\u00e1n\u00ed d\u011bt\u00ed p\u0159edstavuje nejv\u00fdznamn\u011bj\u0161\u00ed modifikovateln\u00fd rizikov\u00fd faktor pro poruchu autistick\u00e9ho spektra (PAS), co\u017e podporuj\u00ed shodn\u00e9 mechanistick\u00e9, klinick\u00e9 a epidemiologick\u00e9 d\u016fkazy a je charakterizov\u00e1no intenzivn\u011bj\u0161\u00edm pou\u017e\u00edv\u00e1n\u00edm, shlukov\u00e1n\u00edm v\u00edce d\u00e1vek b\u011bhem kritick\u00fdch neurov\u00fdvojov\u00fdch \u010dasov\u00fdch oken a nedostatkem v\u00fdzkumu kumulativn\u00ed bezpe\u010dnosti cel\u00e9ho pediatrick\u00e9ho pl\u00e1nu. Vzhledem k tomu, \u017ee prevalence PAS nad\u00e1le neb\u00fdvale roste, z\u016fst\u00e1v\u00e1 objasn\u011bn\u00ed rizik spojen\u00fdch s kumulativn\u00edmi d\u00e1vkami vakc\u00edny a na\u010dasov\u00e1n\u00edm nal\u00e9havou prioritou ve\u0159ejn\u00e9ho zdrav\u00ed.\u201c<\/span><\/em><\/p>\n

\u010cl\u00e1nek uv\u00e1d\u00ed n\u00e1sleduj\u00edc\u00ed autory: Nicolas Hulscher, MPH; John S. Leake, MA; Simon Troupe, MPH; Claire Rogers, MSPAS, PA-C; Kirstin Cosgrove, BM, CCRA; M. Nathaniel Mead, MSc, PhD; Breanne Craven, PA-C; Mila Radetich; Andrew Wakefield, MBBS; a Peter A. McCullough, MD, MPH.<\/span><\/p>\n

V\u011bt\u0161ina studi\u00ed poukazuje na souvislost mezi o\u010dkov\u00e1n\u00edm a o\u010dkov\u00e1n\u00edm.<\/span><\/strong><\/p>\n

Nadace McCullough Foundation prozkoumala v\u00edce ne\u017e sto publikac\u00ed, kter\u00e9 hodnotily souvislosti mezi o\u010dkov\u00e1n\u00edm a neurov\u00fdvojov\u00fdmi v\u00fdsledky.<\/span><\/p>\n

V\u011bt\u0161ina z nich pouk\u00e1zala na to, \u017ee probl\u00e9mem jsou o\u010dkov\u00e1n\u00ed.<\/span><\/p>\n

Auto\u0159i p\u00ed\u0161\u00ed:<\/span><\/p>\n

\u201eZe 136 studi\u00ed, kter\u00e9 zkoumaly d\u011btsk\u00e9 vakc\u00edny nebo jejich adjuvans, 29 zjistilo neutr\u00e1ln\u00ed rizika nebo \u017e\u00e1dnou souvislost, zat\u00edmco 107 nazna\u010dilo mo\u017enou souvislost mezi imunizac\u00ed nebo slo\u017ekami vakc\u00edny a poruchami autistick\u00e9ho spektra (PAS) nebo jin\u00fdmi neurov\u00fdvojov\u00fdmi poruchami (NDD).\u201c<\/span><\/em><\/p>\n

Jin\u00fdmi slovy, t\u00e9m\u011b\u0159 \u010dty\u0159i z p\u011bti recenzovan\u00fdch studi\u00ed prok\u00e1zaly ur\u010dit\u00fd stupe\u0148 korelace mezi vystaven\u00edm vakc\u00edn\u011b a neurov\u00fdvojov\u00fdmi zm\u011bnami.<\/span><\/p>\n

Neexistuje \u017e\u00e1dn\u00e1 dlouhodob\u00e1 studie o kompletn\u00edm o\u010dkovac\u00edm sch\u00e9matu.<\/span><\/strong><\/p>\n

Zpr\u00e1va ukazuje, \u017ee bezpe\u010dnostn\u00ed testy nikdy nehodnotily kumulativn\u00ed o\u010dkovac\u00ed program, kter\u00fd d\u011bti skute\u010dn\u011b dost\u00e1vaj\u00ed.<\/span><\/p>\n

\u201eDosud \u017e\u00e1dn\u00e1 studie nehodnotila bezpe\u010dnost cel\u00e9ho kumulativn\u00edho o\u010dkovac\u00edho sch\u00e9matu d\u011bt\u00ed z hlediska neurov\u00fdvojov\u00fdch v\u00fdsledk\u016f do v\u011bku 9 nebo 18 let. T\u00e9m\u011b\u0159 ve\u0161ker\u00fd existuj\u00edc\u00ed v\u00fdzkum se zam\u011b\u0159il na \u00fazkou podskupinu jednotliv\u00fdch vakc\u00edn nebo jejich slo\u017eek \u2013 zejm\u00e9na MMR vakc\u00edny, vakc\u00edny obsahuj\u00edc\u00ed thimerosal nebo vakc\u00edny s hlin\u00edkov\u00fdmi adjuvans \u2013 co\u017e znamen\u00e1, \u017ee pouze mal\u00e1 \u010d\u00e1st celkov\u00e9 expozice d\u011btstv\u00ed vakc\u00edn\u011b byla kdy hodnocena z hlediska souvislosti s poruchami autistick\u00e9ho spektra (PAS) nebo jin\u00fdmi neurodestruktivn\u00edmi poruchami (NDD).\u201c<\/span><\/em><\/p>\n

Ka\u017ed\u00e1 vakc\u00edna je schv\u00e1lena jednotliv\u011b, ale d\u011bti jsou vystaveny des\u00edtk\u00e1m v kombinaci.<\/span><\/p>\n

Toto je z\u00e1sadn\u00ed regula\u010dn\u00ed mezera, kter\u00e1 podkop\u00e1v\u00e1 jak\u00e9koli tvrzen\u00ed o \u201ebezpe\u010dnosti a \u00fa\u010dinnosti\u201c pl\u00e1nu jako celku.<\/span><\/p>\n

Neo\u010dkovan\u00e9 d\u011bti jsou prokazateln\u011b celkov\u011b v lep\u0161\u00edm zdravotn\u00edm stavu.<\/span><\/strong><\/p>\n

Auto\u0159i zd\u016fraz\u0148uj\u00ed \u010d\u00e1ste\u010dn\u00e9 srovn\u00e1n\u00ed mezi o\u010dkovanou a zcela neo\u010dkovanou populac\u00ed.<\/span><\/p>\n

\u201eDvan\u00e1ct studi\u00ed porovn\u00e1vaj\u00edc\u00edch rutinn\u011b o\u010dkovan\u00e9 a zcela neo\u010dkovan\u00e9 d\u011bti nebo mlad\u00e9 dosp\u011bl\u00e9 konzistentn\u011b prok\u00e1zalo lep\u0161\u00ed celkov\u00e9 zdravotn\u00ed v\u00fdsledky v neo\u010dkovan\u00e9 skupin\u011b, v\u010detn\u011b v\u00fdrazn\u011b ni\u017e\u0161\u00edho rizika chronick\u00fdch zdravotn\u00edch probl\u00e9m\u016f a neuropsychiatrick\u00fdch poruch, jako je porucha autistick\u00e9ho spektra.\u201c<\/span><\/em><\/p>\n

Tyto v\u00fdsledky ukazuj\u00ed reprodukovateln\u00fd vzorec nap\u0159\u00ed\u010d nez\u00e1visl\u00fdmi datov\u00fdmi soubory.<\/span><\/p>\n

To nazna\u010duje, \u017ee vystaven\u00ed o\u010dkov\u00e1n\u00ed koreluje s hor\u0161\u00edmi dlouhodob\u00fdmi zdravotn\u00edmi v\u00fdsledky.<\/span><\/p>\n

Auto\u0159i tvrd\u00ed, \u017ee slo\u017eky vakc\u00edny mohou po\u0161kodit mozek.<\/span><\/strong><\/p>\n

Zpr\u00e1va analyzuje biologickou pravd\u011bpodobnost neuroz\u00e1n\u011btu vyvolan\u00e9ho vakc\u00ednou.<\/span><\/p>\n

\u201eMitochondri\u00e1ln\u00ed a neuroimunitn\u00ed dysfunkce, po\u0161kozen\u00ed centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu a n\u00e1sledn\u00e1 po\u010d\u00ednaj\u00edc\u00ed fenotypov\u00e1 exprese ASD vyvolan\u00e1 antigenem, konzerva\u010dn\u00edmi l\u00e1tkami a adjuvans (ethylrtu\u0165 a hlin\u00edk).\u201c<\/span><\/em><\/p>\n

Popisuj\u00ed kask\u00e1du, v n\u00ed\u017e hlin\u00edk a rtu\u0165 spou\u0161t\u011bj\u00ed oxida\u010dn\u00ed stres a po\u0161kozen\u00ed mitochondri\u00ed u citliv\u00fdch d\u011bt\u00ed.<\/span><\/p>\n

Toto je nab\u00edzeno jako mechanistick\u00fd z\u00e1klad pro jejich \u0161ir\u0161\u00ed argumentaci.<\/span><\/p>\n

\u0158\u00edk\u00e1 se, \u017ee na\u010dasov\u00e1n\u00ed a \u010detnost o\u010dkov\u00e1n\u00ed toto riziko zvy\u0161uj\u00ed.<\/span><\/strong><\/p>\n

Auto\u0159i tak\u00e9 ukazuj\u00ed, \u017ee na\u010dasov\u00e1n\u00ed je z\u00e1sadn\u00ed \u2013 \u017ee v\u00edce o\u010dkov\u00e1n\u00ed sou\u010dasn\u011b zvy\u0161uje riziko.<\/span><\/p>\n

\u201eD\u00e1vkov\u00e1n\u00ed koncentrovan\u00e9 vakc\u00edny a d\u0159\u00edv\u011bj\u0161\u00ed expozice b\u011bhem kritick\u00fdch neurov\u00fdvojov\u00fdch \u010dasov\u00fdch oken z\u0159ejm\u011b zvy\u0161uj\u00ed riziko poruch autistick\u00e9ho spektra.\u201c<\/span><\/em><\/p>\n

Tvrd\u00ed, \u017ee imunitn\u00ed stimulace vyvolan\u00e1 vakc\u00ednou b\u011bhem rychl\u00e9ho r\u016fstu mozku v d\u011btstv\u00ed m\u016f\u017ee v\u00e9st k chronick\u00e9mu z\u00e1n\u011btu.<\/span><\/p>\n

V\u00fdskyt autismu roste soub\u011b\u017en\u011b s roz\u0161\u00ed\u0159en\u00edm povinn\u00e9ho o\u010dkov\u00e1n\u00ed<\/span><\/strong><\/p>\n

\u010cl\u00e1nek upozor\u0148uje na obdob\u00ed mezi zaveden\u00edm z\u00e1konn\u00e9 ochrany odpov\u011bdnosti v\u00fdrobc\u016f a rostouc\u00ed m\u00edrou autismu.<\/span><\/p>\n

\u201eNejv\u00fdrazn\u011bj\u0161\u00edm rysem tohoto strm\u011b rostouc\u00edho trendu ve v\u00fdskytu a prevalenci autismu je, \u017ee za\u010dal kr\u00e1tce po schv\u00e1len\u00ed N\u00e1rodn\u00edho z\u00e1kona o \u00farazech zp\u016fsoben\u00fdch o\u010dkov\u00e1n\u00edm v d\u011btstv\u00ed (NCVIA) v roce 1986\u2026 Od t\u00e9 doby se po\u010det nov\u00fdch vakc\u00edn v o\u010dkovac\u00edm kalend\u00e1\u0159i d\u011bt\u00ed prudce zv\u00fd\u0161il, z 12 vakc\u00edn v roce 1986 na 54 vakc\u00edn v roce 2019.\u201c<\/span><\/em><\/p>\n

Auto\u0159i spojuj\u00ed pr\u00e1vn\u00ed imunitu v\u00fdrobc\u016f s rychl\u00fdm r\u016fstem o\u010dkovac\u00edho pl\u00e1nu.<\/span><\/p>\n

To je d\u016fkazem toho, \u017ee finan\u010dn\u00ed a regula\u010dn\u00ed pob\u00eddky zv\u00fd\u0161ily expozici a z\u00e1rove\u0148 potla\u010dily odpov\u011bdnost za bezpe\u010dnost.<\/span><\/p>\n

Se\u010dteno a podtr\u017eeno<\/span><\/strong><\/p>\n

Zpr\u00e1va McCulloughovy nadace p\u0159edkl\u00e1d\u00e1 n\u011bkolik siln\u00fdch argument\u016f, kter\u00e9 zpochyb\u0148uj\u00ed desetilet\u00ed z\u00e1ruk ve\u0159ejn\u00e9ho zdrav\u00ed:<\/span><\/p>\n