{"id":86452,"date":"2025-08-27T00:15:59","date_gmt":"2025-08-26T22:15:59","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=86452"},"modified":"2025-08-26T13:03:06","modified_gmt":"2025-08-26T11:03:06","slug":"technologie-mrna-spousti-retezovou-reakci-biologicke-destrukce","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/08\/27\/technologie-mrna-spousti-retezovou-reakci-biologicke-destrukce\/","title":{"rendered":"Technologie mRNA spou\u0161t\u00ed \u0159et\u011bzovou reakci biologick\u00e9 destrukce"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><strong><span dir=\"auto\">Dv\u011b pr\u016flomov\u00e9 studie odhaluj\u00ed \u201ekask\u00e1du po\u0161kozen\u00ed\u201c \u2013 od molekul\u00e1rn\u00edho chaosu a\u017e po klinick\u00e9 katastrofy<\/span><\/strong><\/p>\n<p><em><span dir=\"auto\">Nicolas Hulscher, MPH<\/span><\/em><\/p>\n<p><span dir=\"auto\">Dv\u011b nov\u00e9 pr\u016flomov\u00e9 studie odhaluj\u00ed komplexn\u00ed\u00a0<\/span><strong><span dir=\"auto\">kask\u00e1du po\u0161kozen\u00ed<\/span><\/strong><span dir=\"auto\">\u00a0vyvolan\u00e9ho injekcemi mRNA COVID-19. Poprv\u00e9 p\u0159edstavuj\u00ed ucelen\u00fd obraz: od\u00a0<\/span><strong><span dir=\"auto\">molekul\u00e1rn\u00ed nestability<\/span><\/strong><span dir=\"auto\">\u00a0p\u0159es\u00a0<\/span><strong><span dir=\"auto\">syst\u00e9mov\u00fd stres<\/span><\/strong><span dir=\"auto\">\u00a0a\u017e po\u00a0<\/span><strong><span dir=\"auto\">katastrofick\u00e9 klinick\u00e9 v\u00fdsledky<\/span><\/strong><span dir=\"auto\">\u00a0.<\/span><\/p>\n<p><span dir=\"auto\">Anal\u00fdzy jsou zalo\u017eeny na n\u00e1sleduj\u00edc\u00ed pr\u00e1ci:<\/span><\/p>\n<ol>\n<li><strong><span dir=\"auto\">\u201eSyntetick\u00e9 mRNA vakc\u00edny a transkriptomick\u00e1 dysregulace: D\u016fkazy o vznikaj\u00edc\u00edch\u00a0<\/span><a href=\"https:\/\/www.preprints.org\/manuscript\/202507.2155\/v1\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.preprints.org\/manuscript\/202507.2155\/v1\"><span dir=\"auto\">ne\u017e\u00e1douc\u00edch<\/span><\/a><span dir=\"auto\">\u00a0\u00fa\u010dinc\u00edch a rakovin\u011b po o\u010dkov\u00e1n\u00ed\u201c<\/span><\/strong><\/li>\n<li><strong><a href=\"https:\/\/www.mdpi.com\/1422-0067\/26\/16\/8007\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.mdpi.com\/1422-0067\/26\/16\/8007\"><span dir=\"auto\">\u201eKlinick\u00e9 a proteomick\u00e9 souvislosti mezi infekc\u00ed SARS-CoV-2 a o\u010dkov\u00e1n\u00edm proti COVID-19 u multimorbidn\u00edch pacient\u016f: Pr\u016f\u0159ezov\u00e1 observa\u010dn\u00ed studie\u201c<\/span><\/a><\/strong><\/li>\n<\/ol>\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/substackcdn.com\/image\/fetch\/$s_!REVB!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep\/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa6cb9ed0-211f-4bc8-91f8-07a35a2d87c3_1712x1076.png\" alt=\"\" width=\"736\" height=\"462\" \/><\/figure>\n<h2 class=\"wp-block-heading\"><span dir=\"auto\">F\u00e1ze 1 \u2013 Transkriptomick\u00e1 dysregulace: Molekul\u00e1rn\u00ed chaos<\/span><\/h2>\n<p><span dir=\"auto\">Prvn\u00ed f\u00e1ze popisuje\u00a0<\/span><strong><span dir=\"auto\">masivn\u00ed naru\u0161en\u00ed genov\u00e9 exprese<\/span><\/strong><span dir=\"auto\">\u00a0po injekc\u00edch mRNA:<\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\">Tis\u00edce dysregulovan\u00fdch gen\u016f<\/span><\/strong><span dir=\"auto\">\u00a0po o\u010dkov\u00e1n\u00ed<\/span><\/li>\n<li><strong><span dir=\"auto\">Ribozom\u00e1ln\u00ed dysfunkce<\/span><\/strong><span dir=\"auto\">\u00a0, kter\u00e1 spou\u0161t\u00ed nesmysln\u011b zprost\u0159edkovan\u00fd rozpad<\/span><\/li>\n<li><strong><span dir=\"auto\">D\u016fkazy o mitochondri\u00e1ln\u00edm kolapsu<\/span><\/strong><span dir=\"auto\">\u00a0\u2192 ohro\u017een\u00ed produkce bun\u011b\u010dn\u00e9 energie<\/span><\/li>\n<\/ul>\n<p><strong><span dir=\"auto\">Z\u00e1v\u011br:<\/span><\/strong><span dir=\"auto\">\u00a0Na \u00farovni genov\u00e9 exprese se ot\u0159\u00e1s\u00e1 z\u00e1klad biologick\u00e9 stability.<\/span><\/p>\n<h2 class=\"wp-block-heading\"><span dir=\"auto\">F\u00e1ze 2 \u2013 Proteomick\u00e9 anom\u00e1lie: vadn\u00e1 tvorba protein\u016f<\/span><\/h2>\n<p><span dir=\"auto\">Transkriptomick\u00e9 poruchy maj\u00ed p\u0159\u00edm\u00fd vliv na\u00a0<\/span><strong><span dir=\"auto\">produkci protein\u016f<\/span><\/strong><span dir=\"auto\">\u00a0:<\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\">Abnorm\u00e1ln\u00ed skl\u00e1d\u00e1n\u00ed a tvorba protein\u016f<\/span><\/strong><\/li>\n<li><strong><span dir=\"auto\">Zm\u011bny fibrinogenu, aktinu a amyloidn\u00edch protein\u016f<\/span><\/strong><\/li>\n<li><span dir=\"auto\">Tvorba\u00a0<\/span><strong><span dir=\"auto\">\u0161patn\u011b slo\u017een\u00fdch agreg\u00e1t\u016f<\/span><\/strong><span dir=\"auto\">\u00a0spojen\u00e1\u00a0s\u00a0<\/span><strong><span dir=\"auto\">koagulac\u00ed<\/span><\/strong><span dir=\"auto\">\u00a0a\u00a0<\/span><strong><span dir=\"auto\">po\u0161kozen\u00edm tk\u00e1n\u011b<\/span><\/strong><\/li>\n<\/ul>\n<p><span dir=\"auto\">Tyto zm\u011bny funguj\u00ed jako\u00a0<\/span><strong><span dir=\"auto\">z\u00e1rode\u010dn\u00e9 bu\u0148ky chronick\u00fdch patologi\u00ed<\/span><\/strong><span dir=\"auto\">\u00a0.<\/span><\/p>\n<h2 class=\"wp-block-heading\"><span dir=\"auto\">F\u00e1ze 3 \u2013 Syst\u00e9mov\u00fd biochemick\u00fd stres<\/span><\/h2>\n<p><span dir=\"auto\">M\u011b\u0159iteln\u00e9 sign\u00e1ly t\u00edsn\u011b se objevuj\u00ed na \u00farovni krve a org\u00e1n\u016f:<\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\">\u2191 proBNP<\/span><\/strong><span dir=\"auto\">\u00a0\u2192 z\u00e1t\u011b\u017e srdce, riziko srde\u010dn\u00edho selh\u00e1n\u00ed<\/span><\/li>\n<li><strong><span dir=\"auto\">\u2191 Mo\u010dovina<\/span><\/strong><span dir=\"auto\">\u00a0\u2192 Indikace ren\u00e1ln\u00ed dysfunkce<\/span><\/li>\n<li><strong><span dir=\"auto\">\u2191 CRP a feritin<\/span><\/strong><span dir=\"auto\">\u00a0\u2192 markery syst\u00e9mov\u00e9ho z\u00e1n\u011btu a nadm\u011brn\u00e9 imunitn\u00ed reakce<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">T\u011blo bije na poplach \u2013 biochemick\u00e9 sign\u00e1ly SOS varuj\u00ed p\u0159ed masivn\u00edm po\u0161kozen\u00edm org\u00e1n\u016f.<\/span><\/p>\n<h2 class=\"wp-block-heading\"><span dir=\"auto\">F\u00e1ze 4 \u2013 Klinick\u00e9 katastrofy<\/span><\/h2>\n<p><span dir=\"auto\">Molekul\u00e1rn\u00ed nestabilita se projevuje z\u00e1va\u017en\u00fdmi klinick\u00fdmi obrazy:<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">Myokarditida a perikarditida<\/span><\/li>\n<li><span dir=\"auto\">Hyperkoagulace a poruchy koagulace<\/span><\/li>\n<li><span dir=\"auto\">Dysregulace imunitn\u00edho syst\u00e9mu a extr\u00e9mn\u00ed vy\u010derp\u00e1n\u00ed<\/span><\/li>\n<li><strong><span dir=\"auto\">Turbo rakovina<\/span><\/strong><\/li>\n<li><strong><span dir=\"auto\">N\u00e1hl\u00e1 smrt<\/span><\/strong><\/li>\n<li><span dir=\"auto\">Dal\u0161\u00ed z\u00e1va\u017en\u00e9 komplikace<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">Co za\u010d\u00edn\u00e1 na molekul\u00e1rn\u00ed \u00farovni, kon\u010d\u00ed\u00a0<\/span><strong><span dir=\"auto\">viditelnou nemoc\u00ed<\/span><\/strong><span dir=\"auto\">\u00a0a\u00a0<\/span><strong><span dir=\"auto\">ztr\u00e1tou \u017eivota<\/span><\/strong><span dir=\"auto\">\u00a0.<\/span><\/p>\n<h2 class=\"wp-block-heading\"><span dir=\"auto\">Souvisl\u00fd obraz \u0161kody<\/span><\/h2>\n<p><span dir=\"auto\">Tyto dv\u011b studie poprv\u00e9 poskytuj\u00ed\u00a0<\/span><strong><span dir=\"auto\">celkov\u00fd mechanistick\u00fd obraz<\/span><\/strong><span dir=\"auto\">\u00a0:<\/span><\/p>\n<p><em><span dir=\"auto\">Od dysregulace transkriptomu \u2192 k po\u0161kozen\u00ed proteomu \u2192 k biochemick\u00e9mu stresu \u2192 a nakonec\u00a0<\/span><strong><span dir=\"auto\">ke katastrofick\u00fdm klinick\u00fdm d\u016fsledk\u016fm<\/span><\/strong><span dir=\"auto\">\u00a0.<\/span><\/em><\/p>\n<p><span dir=\"auto\">Zji\u0161t\u011bn\u00ed p\u0159edstavuj\u00ed z\u00e1sadn\u00ed zm\u011bnu:\u00a0<\/span><strong><span dir=\"auto\">biologick\u00e9 d\u016fkazy jsou nezpochybniteln\u00e9<\/span><\/strong><span dir=\"auto\">\u00a0a vy\u017eaduj\u00ed\u00a0<\/span><strong><span dir=\"auto\">nal\u00e9hav\u00e9 kroky<\/span><\/strong><span dir=\"auto\">\u00a0, jasn\u00e9\u00a0<\/span><strong><span dir=\"auto\">uzn\u00e1n\u00ed rizik<\/span><\/strong><span dir=\"auto\">\u00a0a skute\u010dnou\u00a0<\/span><strong><span dir=\"auto\">odpov\u011bdnost<\/span><\/strong><span dir=\"auto\">\u00a0.<\/span><\/p>\n<p><strong><span dir=\"auto\">Autor:<\/span><\/strong><br \/>\n<em><span dir=\"auto\">Nicolas Hulscher, MPH<\/span><\/em><br \/>\n<span dir=\"auto\">epidemiolog a spr\u00e1vce\u00a0<\/span><strong><span dir=\"auto\">Nadace McCullough<\/span><\/strong><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.thefocalpoints.com\/p\/breaking-mrna-technology-triggers?utm_source=post-email-title&amp;publication_id=1119676&amp;post_id=171575803&amp;utm_campaign=email-post-title&amp;isFreemail=true&amp;r=3uby4s&amp;triedRedirect=true&amp;utm_medium=email\" target=\"_blank\" rel=\"nofollow noopener\"><span dir=\"auto\">Zdroj<\/span><\/a><\/span><\/h3>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-86134 aligncenter\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/volby10-212x300.png\" alt=\"\" width=\"728\" height=\"1030\" srcset=\"https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/volby10-212x300.png 212w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/volby10-724x1024.png 724w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/volby10-768x1086.png 768w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/volby10-1087x1536.png 1087w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/volby10-1449x2048.png 1449w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/volby10-1024x1447.png 1024w\" sizes=\"(max-width: 728px) 100vw, 728px\" \/><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dv\u011b pr\u016flomov\u00e9 studie odhaluj\u00ed \u201ekask\u00e1du po\u0161kozen\u00ed\u201c \u2013 od molekul\u00e1rn\u00edho chaosu a\u017e po klinick\u00e9 katastrofy Nicolas&#8230;<\/p>\n","protected":false},"author":2,"featured_media":78316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1042,694,1301,651,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/86452"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=86452"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/86452\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/78316"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=86452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=86452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=86452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}