{"id":85480,"date":"2025-08-14T00:12:45","date_gmt":"2025-08-13T22:12:45","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=85480"},"modified":"2025-08-13T15:48:07","modified_gmt":"2025-08-13T13:48:07","slug":"globalni-datova-bomba-vakciny-s-mrna-proti-covidu-jsou-na-vrcholu-seznamu-leku-nejcasteji-spojovanych-se-zanetem-srdce","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/08\/14\/globalni-datova-bomba-vakciny-s-mrna-proti-covidu-jsou-na-vrcholu-seznamu-leku-nejcasteji-spojovanych-se-zanetem-srdce\/","title":{"rendered":"Glob\u00e1ln\u00ed datov\u00e1 bomba: Vakc\u00edny s mRNA proti COVIDu jsou na vrcholu seznamu l\u00e9k\u016f nej\u010dast\u011bji spojovan\u00fdch se z\u00e1n\u011btem srdce"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p>Komplexn\u00ed nov\u00fd v\u00fdzkum veden\u00fd Dr. Jaehyeong Choem, Dong Keon Yonem a kolegy z Kyung Hee University a dal\u0161\u00edch p\u0159edn\u00edch korejsk\u00fdch v\u00fdzkumn\u00fdch instituc\u00ed, publikovan\u00fd 7. srpna 2025 v\u00a0<em>\u010dasopise Scientific Reports<\/em>\u00a0, zmapoval glob\u00e1ln\u00ed farmakovigilan\u010dn\u00ed profil dvou potenci\u00e1ln\u011b \u017eivot ohro\u017euj\u00edc\u00edch z\u00e1n\u011btliv\u00fdch onemocn\u011bn\u00ed srdce \u2013 myokarditidy a perikarditidy \u2013 nap\u0159\u00ed\u010d v\u00edce ne\u017e p\u011bti desetilet\u00edmi zpr\u00e1v o bezpe\u010dnosti. Hypot\u00e9za: N\u011bkter\u00e9 b\u011b\u017en\u011b pou\u017e\u00edvan\u00e9 l\u00e9ky, v\u010detn\u011b vakc\u00edn, jsou v souvislosti s t\u011bmito stavy ne\u00fam\u011brn\u011b \u010dast\u011bji hl\u00e1\u0161eny. Zji\u0161t\u011bn\u00ed je pozoruhodn\u00e9 i znepokojiv\u00e9: mRNA vakc\u00edny proti COVID-19 p\u0159edstavovaly v\u011bt\u0161inu hl\u00e1\u0161en\u00fdch p\u0159\u00edpad\u016f v obou kategori\u00edch \u2013 co\u017e vyvol\u00e1v\u00e1 slo\u017eit\u00e9, n\u011bkdy alarmuj\u00edc\u00ed ot\u00e1zky pro l\u00e9ka\u0159e, regula\u010dn\u00ed org\u00e1ny i ve\u0159ejnost.<\/p>\n<h3 class=\"wp-block-heading\">Design a metoda studie<\/h3>\n<p>V\u00fdzkumn\u00edci pou\u017eili nejv\u011bt\u0161\u00ed sv\u011btov\u00fd archiv hl\u00e1\u0161en\u00ed o ne\u017e\u00e1douc\u00edch \u00fa\u010dinc\u00edch l\u00e9k\u016f \u2013 v\u00edce ne\u017e 35 milion\u016f hl\u00e1\u0161en\u00ed z v\u00edce ne\u017e 140 zem\u00ed, shrom\u00e1\u017ed\u011bn\u00fdch mezi lety 1968 a 2024. Aby se p\u0159ede\u0161lo zkreslen\u00ed, byly vylou\u010deny l\u00e9ky pou\u017e\u00edvan\u00e9 k l\u00e9\u010db\u011b z\u00e1n\u011btu srdce. V\u011bdci pot\u00e9 identifikovali deset nej\u010dast\u011bji hl\u00e1\u0161en\u00fdch l\u00e9k\u016f pro ka\u017ed\u00e9 onemocn\u011bn\u00ed. Statistick\u00e1 detekce sign\u00e1l\u016f byla provedena pomoc\u00ed pom\u011br\u016f \u0161anc\u00ed (ROR) a Bayesovsk\u00fdch informa\u010dn\u00edch komponent (IC) \u2013 metod, kter\u00e9 identifikuj\u00ed obzvl\u00e1\u0161t\u011b n\u00e1padn\u00e9 shluky.<\/p>\n<h3 class=\"wp-block-heading\">V\u00fdsledky<\/h3>\n<p>\u010c\u00edsla jsou zar\u00e1\u017eej\u00edc\u00ed:<\/p>\n<ul>\n<li><strong>Myokarditida:<\/strong>\u00a035 017 hl\u00e1\u0161en\u00fdch p\u0159\u00edpad\u016f; 76,16 % (26 670) bylo spojeno s vakc\u00ednami proti COVID-19 s mRNA, n\u00e1sledovan\u00fdmi klozapinem (15,29 %).<\/li>\n<li><strong>Perikarditida:<\/strong>\u00a024 959 hl\u00e1\u0161en\u00fdch p\u0159\u00edpad\u016f; 88,15 % (22 001) u vakc\u00edn s mRNA proti COVID-19; \u017e\u00e1dn\u00e1 jin\u00e1 vakc\u00edna nep\u0159ekro\u010dila hranici 10 %.<\/li>\n<\/ul>\n<p>Dal\u0161\u00ed v\u00fdznamn\u00e9 sign\u00e1ly se t\u00fdkaly vakc\u00edn proti ne\u0161tovic\u00edm a ch\u0159ipce, klozapinu a mesalazinu. Inhibitory imunitn\u00edch kontroln\u00edch bod\u016f (nivolumab, pembrolizumab, ipilimumab) vykazovaly obzvl\u00e1\u0161t\u011b vysokou \u00famrtnost (p\u0159ibli\u017en\u011b 20 %) v p\u0159\u00edpadech myokarditidy. Obzvl\u00e1\u0161t\u011b alarmuj\u00edc\u00ed: Nejsiln\u011bj\u0161\u00ed statistick\u00e9 sign\u00e1ly se objevily ve v\u011bkov\u00e9 skupin\u011b 0\u201317 let.<\/p>\n<p>V roce 2021 byl pozorov\u00e1n v\u00fdznamn\u00fd n\u00e1r\u016fst hl\u00e1\u0161en\u00fdch p\u0159\u00edpad\u016f, soub\u011b\u017en\u011b s glob\u00e1ln\u00edmi kampan\u011bmi hromadn\u00e9ho o\u010dkov\u00e1n\u00ed proti COVID-19 a akutn\u00ed f\u00e1z\u00ed pandemie. A\u010dkoli studie neprokazuje kauzalitu, pod\u00edl hl\u00e1\u0161en\u00ed souvisej\u00edc\u00edch s o\u010dkov\u00e1n\u00edm je tak vysok\u00fd, \u017ee si zaslou\u017e\u00ed hloubkov\u00e9 vy\u0161et\u0159en\u00ed.<\/p>\n<p><strong>Procentu\u00e1ln\u00ed rozlo\u017een\u00ed hl\u00e1\u0161en\u00ed ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f myokarditidy (A) a perikarditidy (B) u r\u016fzn\u00fdch l\u00e9k\u016f.<\/strong><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/imagedelivery.net\/WEWiZyGwyq-Q4qn_WluYYg\/088301f8-428c-455e-f322-edc02fd8e400\/public\" alt=\"\" width=\"592\" height=\"717\" \/><\/figure>\n<h3 class=\"wp-block-heading\">Pohled TrialSite<\/h3>\n<p>Obzvl\u00e1\u0161t\u011b znepokojiv\u00fd je velmi vysok\u00fd sign\u00e1l myokarditidy a perikarditidy u d\u011bt\u00ed ve v\u011bku 0\u201317 let \u2013 populace, u kter\u00e9 byl COVID-19 m\u00edrn\u00fd a\u017e st\u0159edn\u011b z\u00e1va\u017en\u00fd ve v\u00edce ne\u017e 95 % p\u0159\u00edpad\u016f, zejm\u00e9na od objeven\u00ed se varianty Omicron. Z\u00e1va\u017en\u00e9 komplikace, jako je MIS-C, byly vz\u00e1cn\u00e9 a byly pozorov\u00e1ny p\u0159edev\u0161\u00edm b\u011bhem vlny Delta. Vzhledem k n\u00edzk\u00e9mu z\u00e1kladn\u00edmu riziku a \u0161irok\u00e9 imunit\u011b vyvol\u00e1v\u00e1 v\u00fdskyt t\u011bchto srde\u010dn\u00edch rizik u dosp\u00edvaj\u00edc\u00edch v\u00e1\u017en\u00e9 ot\u00e1zky ohledn\u011b posouzen\u00ed p\u0159\u00ednos\u016f a rizik.<\/p>\n<p>V t\u00e9to souvislosti nab\u00fdv\u00e1 rozhodnut\u00ed ministra zdravotnictv\u00ed a soci\u00e1ln\u00edch slu\u017eeb USA Roberta F. Kennedyho Jr. zru\u0161it ofici\u00e1ln\u00ed doporu\u010den\u00ed o\u010dkov\u00e1n\u00ed mal\u00fdch d\u011bt\u00ed. Data podtrhuj\u00ed etickou nezbytnost zdravotn\u00edch strategi\u00ed odpov\u00eddaj\u00edc\u00edch v\u011bku a riziku \u2013 zejm\u00e9na pokud l\u00e9ka\u0159sk\u00fd z\u00e1krok u skupiny s n\u00edzk\u00fdm rizikem vyvol\u00e1v\u00e1 zv\u00fd\u0161en\u00fd po\u010det hl\u00e1\u0161en\u00ed ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/p>\n<h3 class=\"wp-block-heading\">Omezen\u00ed<\/h3>\n<p>Anal\u00fdza je zalo\u017eena na spont\u00e1nn\u00edch hl\u00e1\u0161en\u00edch, kter\u00e1 mohou zahrnovat jak nedostate\u010dn\u00e9, tak i nadm\u011brn\u00e9 hl\u00e1\u0161en\u00ed, a tak\u00e9 diagnostickou nejistotu. Pozornost m\u00e9di\u00ed mohla v\u00e9st ke zv\u00fd\u0161en\u00e9 citlivosti na tyto diagn\u00f3zy a masov\u00e9 o\u010dkovac\u00ed kampan\u011b mohly v\u00e9st k v\u011bt\u0161\u00edmu po\u010dtu hl\u00e1\u0161en\u00ed (stimulovan\u00e9 hl\u00e1\u0161en\u00ed). M\u00edru incidence nelze z dat odvodit a nelze potvrdit kauz\u00e1ln\u00ed vztah.<\/p>\n<h3 class=\"wp-block-heading\">Financov\u00e1n\u00ed a st\u0159ety z\u00e1jm\u016f<\/h3>\n<p>Studie byla financov\u00e1na z n\u011bkolika vl\u00e1dn\u00edch v\u00fdzkumn\u00fdch grant\u016f v Ji\u017en\u00ed Koreji. Auto\u0159i neuvedli \u017e\u00e1dn\u00fd st\u0159et z\u00e1jm\u016f.<\/p>\n<h3 class=\"wp-block-heading\">Z\u00e1v\u011br a v\u00fdznam<\/h3>\n<p>Glob\u00e1ln\u00ed anal\u00fdza ukazuje pot\u0159ebu c\u00edlen\u00e9ho monitorov\u00e1n\u00ed srde\u010dn\u00ed bezpe\u010dnosti, zejm\u00e9na u mlad\u0161\u00edch lid\u00ed a mu\u017esk\u00fdch pacient\u016f, u kter\u00fdch se zd\u00e1 b\u00fdt zv\u00fd\u0161en\u00e9 riziko myokarditidy. L\u00e9ka\u0159i by m\u011bli b\u00fdt obzvl\u00e1\u0161t\u011b ostra\u017eit\u00ed ohledn\u011b p\u0159\u00edznak\u016f, jako je bolest na hrudi, du\u0161nost nebo bu\u0161en\u00ed srdce, v dnech po pod\u00e1n\u00ed n\u011bkter\u00fdch o\u010dkov\u00e1n\u00ed nebo rizikov\u00fdch l\u00e9k\u016f. Pro tv\u016frce politik to p\u0159edstavuje vyva\u017eov\u00e1n\u00ed: V\u00fdsledky nesni\u017euj\u00ed z\u00e1kladn\u00ed p\u0159\u00ednosy vakc\u00edn, ale zd\u016fraz\u0148uj\u00ed pot\u0159ebu transparentnosti, vzd\u011bl\u00e1v\u00e1n\u00ed pacient\u016f a c\u00edlen\u00e9ho sni\u017eov\u00e1n\u00ed rizik.<\/p>\n<p>Kardiolog, kter\u00fd data zkontroloval, je shrnul takto:<\/p>\n<p><em>\u201eToto nen\u00ed studie proti o\u010dkov\u00e1n\u00ed \u2013 je to v\u00fdzva k bli\u017e\u0161\u00edmu prozkoum\u00e1n\u00ed toho, kdy, jak a komu jsou ur\u010dit\u00e9 l\u00e9ky pod\u00e1v\u00e1ny.\u201c<\/em><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.trialsitenews.com\/a\/global-data-bombshell-covid-19-mrna-vaccines-top-list-of-drugs-most-often-reported-with-heart-inflammation-ebaad01c\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-85002 aligncenter\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/Plakat1-212x300.jpg\" alt=\"\" width=\"634\" height=\"897\" srcset=\"https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/Plakat1-212x300.jpg 212w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/Plakat1-724x1024.jpg 724w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/Plakat1-768x1086.jpg 768w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/Plakat1-1086x1536.jpg 1086w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/Plakat1-1024x1449.jpg 1024w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/08\/Plakat1.jpg 1131w\" sizes=\"(max-width: 634px) 100vw, 634px\" \/><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Komplexn\u00ed nov\u00fd v\u00fdzkum veden\u00fd Dr. Jaehyeong Choem, Dong Keon Yonem a kolegy z Kyung Hee&#8230;<\/p>\n","protected":false},"author":2,"featured_media":85481,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,694,1556,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/85480"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=85480"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/85480\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/85481"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=85480"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=85480"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=85480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}