{"id":84949,"date":"2025-08-05T00:21:20","date_gmt":"2025-08-04T22:21:20","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=84949"},"modified":"2025-08-04T12:30:22","modified_gmt":"2025-08-04T10:30:22","slug":"bude-geneticka-slepota-lecitelna-zablesk-nadeje-z-jizni-koreje","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/08\/05\/bude-geneticka-slepota-lecitelna-zablesk-nadeje-z-jizni-koreje\/","title":{"rendered":"Bude genetick\u00e1 slepota l\u00e9\u010diteln\u00e1? Z\u00e1blesk nad\u011bje z Ji\u017en\u00ed Koreje"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<p><strong><span>P\u0159ibli\u017en\u011b jeden a p\u016fl milionu lid\u00ed na cel\u00e9m sv\u011bt\u011b trp\u00ed retinitis pigmentosa, d\u011bdi\u010dn\u00fdm onemocn\u011bn\u00edm s\u00edtnice. Toto onemocn\u011bn\u00ed nevyhnuteln\u011b vede k slepot\u011b. Skupina jihokorejsk\u00fdch v\u011bdc\u016f v\u0161ak nyn\u00ed dos\u00e1hla p\u016fsobiv\u00e9ho \u00fasp\u011bchu. Op\u011bt m\u016f\u017ee pomoci hled\u00e1n\u00ed pomoci v p\u0159\u00edrod\u011b.<\/span><\/strong><\/p>\n<p><span>Lid\u00e9, kte\u0159\u00ed trp\u00ed retinitis pigmentosa, v\u011bd\u00ed, \u017ee d\u0159\u00edve \u010di pozd\u011bji \u00fapln\u011b oslepnou. Vin\u00edkem je protein zvan\u00fd PROX1. Tento protein v podstat\u011b br\u00e1n\u00ed tzv. M\u00fcllerov\u00fdm gliov\u00fdm bu\u0148k\u00e1m v prov\u00e1d\u011bn\u00ed opravn\u00fdch prac\u00ed na sv\u011btlocitliv\u00fdch bu\u0148k\u00e1ch v s\u00edtnici. T\u00fdm v\u00fdzkumn\u00edk\u016f z Ji\u017en\u00ed Koreje to p\u0159im\u011blo obr\u00e1tit se k p\u0159\u00edrod\u011b. Existuje zv\u00ed\u0159e se schopnost\u00ed opravit s\u00edtnici? A na\u0161li ho \u2013 zeb\u0159i\u010dku. Pokud je jejich s\u00edtnice po\u0161kozen\u00e1, mohou ji jednodu\u0161e regenerovat. S pomoc\u00ed t\u011bchto pomocn\u00fdch bun\u011bk, kter\u00e9 se v p\u0159\u00edpad\u011b pot\u0159eby jednodu\u0161e transformuj\u00ed na nov\u00e9 nervov\u00e9 bu\u0148ky.<\/span><\/p>\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\">\n<div class=\"wp-block-embed__wrapper\">\n<div class=\"twitter-tweet twitter-tweet-rendered\"><iframe id=\"twitter-widget-0\" class=\"\" title=\"X P\u0159\u00edsp\u011bvek\" src=\"https:\/\/platform.twitter.com\/embed\/Tweet.html?dnt=true&amp;embedId=twitter-widget-0&amp;features=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%3D%3D&amp;frame=false&amp;hideCard=false&amp;hideThread=false&amp;id=1951693997598028281&amp;lang=de&amp;origin=https%3A%2F%2Freport24.news%2Fwird-genetisch-bedingte-blindheit-heilbar-ein-hoffnungsschimmer-aus-suedkorea%2F&amp;sessionId=59a1bf003c107d4ad1ae5bb2dbe61e09a4b8bf00&amp;theme=light&amp;widgetsVersion=2615f7e52b7e0%3A1702314776716&amp;width=550px\" frameborder=\"0\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\" data-tweet-id=\"1951693997598028281\" data-mce-fragment=\"1\"><\/iframe><\/div>\n<\/div>\n<\/figure>\n<p><span>A p\u0159esn\u011b tyto bu\u0148ky maj\u00ed i lid\u00e9. Jen v na\u0161em p\u0159\u00edpad\u011b ned\u011blaj\u00ed&#8230; nic. Sed\u00ed tam, ti\u0161e a neaktivn\u011b. D\u016fvod? Pr\u00e1v\u011b tento protein PROX1. Jihokorejsk\u00fd v\u00fdzkumn\u00fd t\u00fdm z renomovan\u00e9ho Korejsk\u00e9ho institutu pokro\u010dil\u00fdch v\u011bd a technologi\u00ed (KAIST) si polo\u017eil ot\u00e1zku: Co by se stalo, kdyby se tento z\u00e1kaz jednodu\u0161e zru\u0161il? Odpov\u011b\u010f: Vyvinuli protil\u00e1tku, kter\u00e1 neutralizovala PROX1. T\u00edm se M\u00fcllerovy bu\u0148ky op\u011bt aktivovaly a mohly plnit svou funkci \u2013 stejn\u011b jako jejich zv\u00ed\u0159ec\u00ed prot\u011bj\u0161ky. A skute\u010dn\u011b, pot\u00e9, co tuto protil\u00e1tku vst\u0159\u00edkli do o\u010d\u00ed geneticky slep\u00fdch my\u0161\u00ed, gliov\u00e9 bu\u0148ky za\u010daly fungovat. Transformovaly se na funk\u010dn\u00ed nervov\u00e9 bu\u0148ky, v\u010detn\u011b sv\u011btlocitliv\u00fdch fotoreceptor\u016f. V\u00fdsledek: Zv\u00ed\u0159ata mohla znovu vid\u011bt \u2013 a to i po v\u00edce ne\u017e \u0161esti m\u011bs\u00edc\u00edch.<\/span><\/p>\n<p><span>Studie s n\u00e1zvem \u201e\u00a0<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40133314\/\"><span>Obnova regenera\u010dn\u00edho potenci\u00e1lu s\u00edtnice M\u00fcllerov\u00fdch gli\u00ed naru\u0161en\u00edm mezibun\u011b\u010dn\u00e9ho p\u0159enosu Prox1<\/span><\/a><span>\u00a0\u201c, publikovan\u00e1 v renomovan\u00e9m \u010dasopise PLOS Biology, nyn\u00ed slou\u017e\u00ed jako podnikatelsk\u00fd z\u00e1klad pro\u00a0<\/span><a href=\"https:\/\/scitechdaily.com\/breakthrough-drug-restores-vision-researchers-successfully-reverse-retinal-damage\/\"><span>nov\u00fd startup<\/span><\/a><span> s n\u00e1zvem Cellia Inc., v n\u011bm\u017e si t\u00fdm KAIST klade za c\u00edl p\u0159en\u00e9st tuto novou terapii z laborato\u0159e do re\u00e1ln\u00fdch aplikac\u00ed na lidech. Protil\u00e1tka PROX1 by m\u011bla b\u00fdt testov\u00e1na v klinick\u00fdch studi\u00edch na lidech nejpozd\u011bji do roku 2028. C\u00edlem je regenerativn\u00ed l\u00e9k, kter\u00fd by mohl dlouhodob\u011b l\u00e9\u010dit nejen retinitis pigmentosa, ale i dal\u0161\u00ed degenerace s\u00edtnice \u2013 to v\u0161e bez genov\u00e9 terapie, implant\u00e1t\u016f nebo transplantac\u00ed kmenov\u00fdch bun\u011bk.<\/span><\/p>\n<p><span>I kdy\u017e bude jist\u011b trvat je\u0161t\u011b n\u011bkolik let, ne\u017e tato l\u00e9\u010debn\u00e1 metoda z\u00edsk\u00e1 schv\u00e1len\u00ed na trhu a bude moci b\u00fdt pou\u017eita v hum\u00e1nn\u00ed medic\u00edn\u011b, nyn\u00ed se pro posti\u017een\u00e9 objevuje velk\u00e1 jisk\u0159i\u010dka nad\u011bje. Tato v\u011bdeck\u00e1 pr\u00e1ce d\u00e1le dokazuje, \u017ee n\u011bkdy sta\u010d\u00ed obr\u00e1tit se na p\u0159\u00edrodu, aby na\u0161la l\u00e9ka\u0159sk\u00e1 \u0159e\u0161en\u00ed \u2013 zcela bez genetick\u00e9 manipulace. Je p\u0159ed n\u00e1mi je\u0161t\u011b dlouh\u00e1 cesta, ale pokud budou klinick\u00e9 studie na lidech stejn\u011b \u00fasp\u011b\u0161n\u00e9, mohlo by to otev\u0159\u00edt novou \u00e9ru regenerativn\u00ed o\u010dn\u00ed medic\u00edny.<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-1185\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2021\/04\/kuryr-podpis.png\" alt=\"\" width=\"84\" height=\"24\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>P\u0159ibli\u017en\u011b jeden a p\u016fl milionu lid\u00ed na cel\u00e9m sv\u011bt\u011b trp\u00ed retinitis pigmentosa, d\u011bdi\u010dn\u00fdm onemocn\u011bn\u00edm s\u00edtnice&#8230;.<\/p>\n","protected":false},"author":2,"featured_media":84950,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[677,1155,2382,1631],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/84949"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=84949"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/84949\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/84950"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=84949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=84949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=84949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}