{"id":84307,"date":"2025-07-26T00:21:44","date_gmt":"2025-07-25T22:21:44","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=84307"},"modified":"2025-07-25T12:26:24","modified_gmt":"2025-07-25T10:26:24","slug":"nova-prulomova-studie-chemoterapie-reaktivuje-spici-rakovinne-bunky-spousti-metastazy","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/07\/26\/nova-prulomova-studie-chemoterapie-reaktivuje-spici-rakovinne-bunky-spousti-metastazy\/","title":{"rendered":"Nov\u00e1 pr\u016flomov\u00e1 studie: Chemoterapie reaktivuje sp\u00edc\u00ed rakovinn\u00e9 bu\u0148ky \u2013 spou\u0161t\u00ed metast\u00e1zy"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><span>Nov\u00e1 pr\u016flomov\u00e1 studie ukazuje, \u017ee standardn\u00ed l\u00e9\u010dba rakoviny se m\u016f\u017ee obr\u00e1tit proti nim \u2013 s ni\u010div\u00fdmi n\u00e1sledky.<\/span><\/p>\n<p><span>Chemoterapie m\u00e1 rakovinu zab\u00edt, ne ji vr\u00e1tit zp\u011bt. Pr\u016flomov\u00e1\u00a0<\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1535610825002570\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1535610825002570\"><span>studie rakovinn\u00fdch bun\u011bk od\u00a0<\/span><em><span>Hea a kol.<\/span><\/em><\/a><span>\u00a0v\u0161ak uk\u00e1zala, \u017ee b\u011b\u017en\u00e9 l\u00e9ky proti rakovin\u011b, jako je doxorubicin a cisplatina, probouzej\u00ed sp\u00edc\u00ed n\u00e1dorov\u00e9 bu\u0148ky a spou\u0161t\u00ed smrteln\u00e9 metastatick\u00e9 relapsy, zejm\u00e9na v plic\u00edch.<\/span><\/p>\n<p><span>Tyto \u201esp\u00edc\u00ed\u201c rakovinn\u00e9 bu\u0148ky, naz\u00fdvan\u00e9 diseminovan\u00e9 n\u00e1dorov\u00e9 bu\u0148ky (DTC), mohou z\u016fstat skryt\u00e9 po cel\u00e9 roky, ne\u017e se znovu aktivuj\u00ed. Tato studie je prvn\u00ed, kter\u00e1 p\u0159\u00edmo prokazuje, \u017ee samotn\u00e1 chemoterapie je m\u016f\u017ee probudit.<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/i0.wp.com\/substackcdn.com\/image\/fetch\/%24s_%21PzU4%21%2Cw_1456%2Cc_limit%2Cf_webp%2Cq_auto%3Agood%2Cfl_progressive%3Asteep\/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F78f1e23b-d04d-4fbc-8d70-e0b65481d582_5390x3200.png?fit=800%2C475&amp;ssl=1\" width=\"760\" height=\"451\" \/><\/p>\n<p><strong><span>METODY<\/span><\/strong><\/p>\n<p><span>V\u011bdci pou\u017eili my\u0161i s rakovinou prsu k modelov\u00e1n\u00ed toho, jak chemoterapie ovliv\u0148uje dormantn\u00ed rakovinn\u00e9 bu\u0148ky. Vyvinuli n\u00e1stroj pro genetick\u00e9 sledov\u00e1n\u00ed s n\u00e1zvem\u00a0<\/span><strong><span>DormTracer<\/span><\/strong><span>\u00a0, kter\u00fd ozna\u010duje bu\u0148ky, kter\u00e9 vstupuj\u00ed do dormance, a indikuje, zda se pozd\u011bji za\u010dnou znovu d\u011blit.<\/span><\/p>\n<p><strong><span>D\u016fle\u017eit\u00e9 kroky:<\/span><\/strong><\/p>\n<ul>\n<li><span>My\u0161i dost\u00e1valy chemoterapii (doxorubicin nebo cisplatinu) a pot\u00e9 byly v pr\u016fb\u011bhu \u010dasu sledov\u00e1ny dormantn\u00ed n\u00e1dorov\u00e9 bu\u0148ky.<\/span><\/li>\n<li><span>Pokro\u010dil\u00e9 zobrazovac\u00ed techniky a genetick\u00e9 markery rozli\u0161ovaly mezi bu\u0148kami, kter\u00e9 z\u016fstaly neaktivn\u00ed, a t\u011bmi, kter\u00e9 se \u201eprobudily\u201c.<\/span><\/li>\n<li><span>N\u011bkter\u00e9 my\u0161i dost\u00e1valy\u00a0<\/span><strong><span>senolytick\u00e9 l\u00e9ky<\/span><\/strong><span>\u00a0(k eliminaci po\u0161kozen\u00fdch strom\u00e1ln\u00edch bun\u011bk) nebo\u00a0<\/span><strong><span>inhibitory NET<\/span><\/strong><span>\u00a0(k blokov\u00e1n\u00ed past\u00ed imunitn\u00edho syst\u00e9mu).<\/span><\/li>\n<li><span>Tak\u00e9 zkoumali\u00a0<\/span><strong><span>n\u00e1dorovou tk\u00e1\u0148 a krev pacientek s rakovinou prsu p\u0159ed a po chemoterapii<\/span><\/strong><span>\u00a0\u2013 na z\u00e1n\u011bt, imunitn\u00ed aktivitu a sign\u00e1ly relapsu.<\/span><\/li>\n<\/ul>\n<p><strong><span>KL\u00cd\u010cOV\u00c1 ZJI\u0160T\u011aN\u00cd<\/span><\/strong><\/p>\n<p><strong><span>1. Chemoterapie reaktivuje sp\u00edc\u00ed rakovinn\u00e9 bu\u0148ky<\/span><\/strong><\/p>\n<ul>\n<li><span>Pomoc\u00ed DormTraceru byl t\u00fdm schopen prok\u00e1zat, \u017ee u my\u0161\u00ed l\u00e9\u010den\u00fdch chemoterapi\u00ed do\u0161lo k n\u00e1r\u016fstu d\u0159\u00edve dormantn\u00edch rakovinn\u00fdch bun\u011bk, kter\u00e9 se znovu vstupovaly do bun\u011b\u010dn\u00e9ho cyklu.<\/span><\/li>\n<li><span>Tyto znovu probuzen\u00e9 bu\u0148ky vytvo\u0159ily agresivn\u00ed plicn\u00ed metast\u00e1zy t\u00fddny po chemoterapii \u2013 a to i v p\u0159\u00edpadech, kdy prim\u00e1rn\u00ed n\u00e1dor zmizel.<\/span><\/li>\n<li><span>Tento \u00fa\u010dinek byl specifick\u00fd pro\u00a0<\/span><strong><span>dormantn\u00ed<\/span><\/strong><span>\u00a0bu\u0148ky; chemoterapie potla\u010dovala aktivn\u00ed n\u00e1dory, ale ne\u00famysln\u011b aktivovala dormantn\u00ed bu\u0148ky.<\/span><\/li>\n<\/ul>\n<p><strong><span>2. Neutrofiln\u00ed extracelul\u00e1rn\u00ed pasti (NET) jsou spou\u0161t\u011b\u010dem<\/span><\/strong><\/p>\n<ul>\n<li><span>Chemoterapie nejen ovlivnila rakovinn\u00e9 bu\u0148ky, ale tak\u00e9 zp\u016fsobila, \u017ee\u00a0<\/span><strong><span>fibroblasty v plic\u00edch<\/span><\/strong><span>\u00a0vstoupily do stavu zvan\u00e9ho\u00a0<\/span><strong><span>senescence<\/span><\/strong><span>\u00a0(biologick\u00e9 st\u00e1rnut\u00ed).<\/span><\/li>\n<li><span>Tyto senescentn\u00ed bu\u0148ky uvol\u0148ovaly proz\u00e1n\u011btliv\u00e9 sign\u00e1ly, kter\u00e9 aktivovaly\u00a0<\/span><strong><span>neutrofily<\/span><\/strong><span>\u00a0, typ b\u00edl\u00fdch krvinek.<\/span><\/li>\n<li><span>Neutrofily tvo\u0159\u00ed\u00a0<\/span><strong><span>NET<\/span><\/strong><span>\u00a0\u2013 lepkav\u00e9 s\u00edt\u011b DNA a enzym\u016f, jako je MMP9 a neutrofiln\u00ed elast\u00e1za \u2013 kter\u00e9\u00a0<\/span><strong><span>remodeluj\u00ed plicn\u00ed mikroprost\u0159ed\u00ed<\/span><\/strong><span>\u00a0a p\u0159\u00edmo spou\u0161t\u011bj\u00ed probuzen\u00ed dormantn\u00edch DTC.<\/span><\/li>\n<\/ul>\n<p><strong><span>3. Proteiny SASP (C3, MIF, CXCL1) \u0159\u00edd\u00ed tuto \u0159et\u011bzovou reakci<\/span><\/strong><\/p>\n<ul>\n<li><span>St\u00e1rnouc\u00ed fibroblasty uvol\u0148uj\u00ed toxick\u00fd koktejl\u00a0zn\u00e1m\u00fd jako\u00a0<\/span><strong><span>SASP<\/span><\/strong><span>\u00a0(\u00a0<\/span><em><span>sekre\u010dn\u00ed fenotyp asociovan\u00fd se senescenc\u00ed ).<\/span><\/em><\/li>\n<li><span>T\u0159i kl\u00ed\u010dov\u00e9 faktory \u2013\u00a0<\/span><strong><span>komplement C3, inhibi\u010dn\u00ed faktor migrace makrof\u00e1g\u016f (MIF)<\/span><\/strong><span>\u00a0a\u00a0<\/span><strong><span>CXCL1<\/span><\/strong><span>\u00a0\u2013 byly identifikov\u00e1ny jako hlavn\u00ed faktory p\u0159isp\u00edvaj\u00edc\u00ed k tvorb\u011b NET.<\/span><\/li>\n<li><span>U my\u0161\u00ed bez C3 byla aktivita NET v\u00fdznamn\u011b ni\u017e\u0161\u00ed a m\u00edra metast\u00e1z byla po chemoterapii ni\u017e\u0161\u00ed.<\/span><\/li>\n<\/ul>\n<p><strong><span>4. Blokov\u00e1n\u00ed neuroendokrinn\u00edch bun\u011bk (NET) nebo eliminace st\u00e1rnouc\u00edch bun\u011bk zabra\u0148uje relapsu<\/span><\/strong><\/p>\n<ul>\n<li><span>Pod\u00e1v\u00e1n\u00ed\u00a0<\/span><strong><span>DN\u00e1zy I<\/span><\/strong><span>\u00a0(kter\u00e1 naru\u0161uje tvorbu neuroendokrinn\u00edch bun\u011bk) nebo\u00a0<\/span><strong><span>GSK484<\/span><\/strong><span>\u00a0(inhibitor PAD4, kter\u00fd blokuje tvorbu neuroendokrinn\u00edch bun\u011bk)\u00a0<\/span><strong><span>u my\u0161\u00ed zcela zabr\u00e1nilo metast\u00e1z\u00e1m vyvolan\u00fdm chemoterapi\u00ed<\/span><\/strong><span>\u00a0.<\/span><\/li>\n<li><span>Pod\u00e1v\u00e1n\u00ed\u00a0<\/span><strong><span>dasatinibu + kvercetinu<\/span><\/strong><span>\u00a0(senolytick\u00e1 kombinace)\u00a0<\/span><strong><span>eliminovalo senescentn\u00ed fibroblasty<\/span><\/strong><span>\u00a0a vypnulo celou kask\u00e1du, co\u017e vedlo ke kontrole prim\u00e1rn\u00edho n\u00e1doru a\u00a0<\/span><strong><span>k \u017e\u00e1dn\u00e9 relapsu<\/span><\/strong><span>\u00a0.<\/span><\/li>\n<li><span>D\u016fle\u017eit\u00e9 je, \u017ee tato kombinace\u00a0<\/span><strong><span>neohrozila \u00fa\u010dinnost chemoterapie p\u0159i zmen\u0161ov\u00e1n\u00ed prim\u00e1rn\u00edho n\u00e1doru.<\/span><\/strong><\/li>\n<\/ul>\n<p><strong><span>5. Mechanismus byl potvrzen u lid\u00ed<\/span><\/strong><\/p>\n<ul>\n<li><span>U pacientek s rakovinou prsu vykazovaly plicn\u00ed metast\u00e1zy\u00a0<\/span><strong><span>po chemoterapii<\/span><\/strong><span>\u00a0vy\u0161\u0161\u00ed hustotu NET a zv\u00fd\u0161en\u00e9\u00a0<\/span><strong><span>hladiny C3, MIF a CXCL1<\/span><\/strong><span>\u00a0.<\/span><\/li>\n<li><strong><span>Vzorky krve uk\u00e1zaly<\/span><\/strong><span>\u00a0, \u017ee hladiny C3 a MIF byly po l\u00e9\u010db\u011b zv\u00fd\u0161en\u00e9, zejm\u00e9na u pacient\u016f, u kter\u00fdch se pozd\u011bji rozvinula plicn\u00ed relaps.<\/span><\/li>\n<li><span>Tyto markery by se v budouc\u00edch studi\u00edch mohly st\u00e1t\u00a0<\/span><strong><span>prediktivn\u00edmi biomarkery<\/span><\/strong><span>\u00a0rizika relapsu.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-size: 14pt;\"><strong>Z\u00e1v\u011br:<\/strong><\/span><br \/>\n<span>Tato studie obrac\u00ed sc\u00e9n\u00e1\u0159 konven\u010dn\u00ed terapie rakoviny vzh\u016fru nohama. Chemoterapie m\u016f\u017ee bojovat proti prim\u00e1rn\u00edmu n\u00e1doru, ale m\u016f\u017ee tak\u00e9 podpo\u0159it budouc\u00ed metast\u00e1zy probuzen\u00edm skryt\u00fdch rakovinn\u00fdch bun\u011bk prost\u0159ednictv\u00edm z\u00e1n\u011btu a aktivace imunitn\u00edho syst\u00e9mu. Kombinace chemoterapie se\u00a0<\/span><strong><span>senolytiky nebo blok\u00e1tory NET<\/span><\/strong><span>\u00a0by mohla drasticky sn\u00ed\u017eit relapsy \u2013 a prvn\u00ed klinick\u00e9 studie ji\u017e prob\u00edhaj\u00ed.<\/span><\/p>\n<p><strong><span>Je v\u0161ak na\u010dase<\/span><\/strong><span>\u00a0prozkoumat l\u00e9\u010dbu rakoviny, kter\u00e1 nepo\u0161kozuje cel\u00e9 t\u011blo a probouz\u00ed sp\u00edc\u00ed rakovinn\u00e9 bu\u0148ky, jako nap\u0159\u00edklad:<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span>IVERMEKTIN<\/span><\/h3>\n<p><strong><a href=\"https:\/\/www.thefocalpoints.com\/p\/new-study-ivermectin-shows-striking\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.thefocalpoints.com\/p\/new-study-ivermectin-shows-striking\"><span>Dosud nejv\u011bt\u0161\u00ed studie<\/span><\/a><\/strong><span>\u00a0o\u00a0u\u017e\u00edv\u00e1n\u00ed ivermektinu u pacient\u016f s rakovinou neshledala\u00a0<\/span><strong><span>\u017e\u00e1dn\u00e9 bezpe\u010dnostn\u00ed probl\u00e9my<\/span><\/strong><span>\u00a0,\u00a0<\/span><strong><span>slibn\u00e9 neofici\u00e1ln\u00ed zpr\u00e1vy<\/span><\/strong><span>\u00a0a\u00a0<\/span><strong><span>siln\u00e9 preklinick\u00e9 d\u016fkazy o potla\u010den\u00ed n\u00e1doru<\/span><\/strong><span>\u00a0.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span>L\u00e9\u010div\u00e9 houby<\/span><\/h3>\n<p><span>jsou slibn\u00e9 v prevenci\u00a0<strong>a l\u00e9\u010db\u011b\u00a0<\/strong><\/span><strong><a href=\"https:\/\/www.thefocalpoints.com\/p\/the-remarkable-anti-cancer-potential?utm_source=publication-searchhttps:\/\/www.thefocalpoints.com\/p\/the-remarkable-anti-cancer-potential\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.thefocalpoints.com\/p\/the-remarkable-anti-cancer-potential?utm_source=publication-searchhttps:\/\/www.thefocalpoints.com\/p\/the-remarkable-anti-cancer-potential\"><span>rakoviny<\/span><\/a><\/strong><span>\u00a0\u2013 podpo\u0159en\u00e9 mechanistick\u00fdmi, epidemiologick\u00fdmi a nov\u00fdmi klinick\u00fdmi poznatky.<\/span><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/substackcdn.com\/image\/fetch\/$s_!QMmS!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep\/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F73a7f6dd-ed40-4c91-a7b5-0223481f5fe8_1270x1180.png\" alt=\"\" width=\"899\" height=\"835\" \/><\/figure>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h4><em>Nicolas Hulscher, MPH<\/em><\/h4>\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.thefocalpoints.com\/p\/breaking-chemotherapy-reactivates?utm_source=post-email-title&amp;publication_id=1119676&amp;post_id=169058357&amp;utm_campaign=email-post-title&amp;isFreemail=false&amp;r=3uby4s&amp;triedRedirect=true&amp;utm_medium=email\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nov\u00e1 pr\u016flomov\u00e1 studie ukazuje, \u017ee standardn\u00ed l\u00e9\u010dba rakoviny se m\u016f\u017ee obr\u00e1tit proti nim \u2013 s&#8230;<\/p>\n","protected":false},"author":2,"featured_media":48273,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[6787,518,8264,1366],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/84307"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=84307"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/84307\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/48273"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=84307"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=84307"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=84307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}