{"id":83318,"date":"2025-07-12T00:17:07","date_gmt":"2025-07-11T22:17:07","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=83318"},"modified":"2025-07-11T14:56:00","modified_gmt":"2025-07-11T12:56:00","slug":"studie-o-sprejove-vakcine-proti-covidu-vyvolava-vyznamne-bezpecnostni-obavy","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/07\/12\/studie-o-sprejove-vakcine-proti-covidu-vyvolava-vyznamne-bezpecnostni-obavy\/","title":{"rendered":"Studie o sprejov\u00e9 vakc\u00edn\u011b proti COVIDu vyvol\u00e1v\u00e1 \u201ev\u00fdznamn\u00e9 bezpe\u010dnostn\u00ed obavy\u201c"},"content":{"rendered":"
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Nov\u00e1 intranaz\u00e1ln\u00ed mRNA vakc\u00edna proti COVID-19 s n\u00e1zvem CVXGA1, vyvinut\u00e1 spole\u010dnost\u00ed CyanVac LLC, prok\u00e1zala prvn\u00ed d\u016fkazy \u00fa\u010dinnosti ve f\u00e1zi 1 klinick\u00e9 studie. Studie publikovan\u00e1 v \u010dasopise\u00a0<\/span>Science Advances<\/span><\/em>\u00a0popisuje CVXGA1 jako potenci\u00e1ln\u011b \u00fa\u010dinnou vakc\u00ednu, kter\u00e1 vyvol\u00e1v\u00e1 imunitn\u00ed odpov\u011b\u010f s minim\u00e1ln\u00edmi vedlej\u0161\u00edmi \u00fa\u010dinky. Klinick\u00e9 studie se v\u0161ak z\u00fa\u010dastnilo pouze 72 \u00fa\u010dastn\u00edk\u016f, kte\u0159\u00ed byli rozd\u011bleni do dvou skupin, z nich\u017e ka\u017ed\u00e1 dostala vysokou nebo n\u00edzkou d\u00e1vku. Neo\u010dkovan\u00e1 kontroln\u00ed skupina zcela chyb\u011bla.<\/span><\/p>\n

Kritici obvi\u0148uj\u00ed studii ze z\u00e1va\u017en\u00fdch metodologick\u00fdch nedostatk\u016f. Investigativn\u00ed novin\u00e1\u0159ka Sonia Elijahov\u00e1 zd\u016fraznila, \u017ee studie nezkoumala, zda by vylu\u010dovan\u00e9 slo\u017eky viru mohly b\u00fdt p\u0159en\u00e1\u0161eny na jin\u00e9 lidi prost\u0159ednictv\u00edm sekret\u016f. Kladen\u00ed takov\u00fdch ot\u00e1zek, ani\u017e by se jimi studie zab\u00fdvala, je podle n\u00ed nezodpov\u011bdn\u00e9, zejm\u00e9na proto, \u017ee design vakc\u00edny \u2013 nosn\u00ed pod\u00e1n\u00ed \u2013 nazna\u010duje potenci\u00e1ln\u00ed p\u0159enos. Elijahov\u00e1 v\u00fdslovn\u011b varovala p\u0159ed potenci\u00e1ln\u00edmi riziky replikace a vylu\u010dov\u00e1n\u00ed.<\/span><\/p>\n

Dr. Karl Jablonowski, vedouc\u00ed v\u011bdeck\u00fd pracovn\u00edk organizace Children’s Health Defense, rovn\u011b\u017e vyj\u00e1d\u0159il siln\u00e9 obavy. CVXGA1 je zalo\u017een na viru parainfluenzy typu 5, kter\u00fd slou\u017e\u00ed jako p\u0159ena\u0161e\u010d a je p\u0159enosn\u00fd jak mezi lidmi, tak mezi lidmi a zv\u00ed\u0159aty. Tento virus se m\u016f\u017ee vyhnout imunitn\u00edmu syst\u00e9mu, uvedl Jablonowski. Pou\u017eit\u00ed takov\u00e9ho p\u0159ena\u0161e\u010de zvy\u0161uje riziko nekontrolovan\u00e9 distribuce \u201evakc\u00edny\u201c. To p\u0159edstavuje riziko, \u017ee kojenci, d\u011bti, t\u011bhotn\u00e9 \u017eeny nebo osoby s oslabenou imunitou by mohly b\u00fdt vystaveny n\u00e1kaze bez jejich v\u011bdom\u00ed nebo souhlasu.<\/span><\/p>\n

Mikrobiolo\u017eka Karina Acevedo Whitehouse z Autonomn\u00ed univerzity v Quer\u00e9taru v Mexiku popsala vakc\u00ednu jako potenci\u00e1ln\u011b nebezpe\u010dnou. Studie s podobn\u00fdmi produkty nazna\u010duj\u00ed \u201evysokou pravd\u011bpodobnost\u201c p\u0159etrv\u00e1vaj\u00edc\u00edho vylu\u010dov\u00e1n\u00ed viru. Uvedla studii z roku 2023 o intranaz\u00e1ln\u00ed vakc\u00edn\u011b proti RSV, kter\u00e1 zjistila vylu\u010dov\u00e1n\u00ed viru u 17 procent \u00fa\u010dastn\u00edk\u016f.<\/span><\/p>\n

CVXGA1 produkuje spike protein viru SARS-CoV-2 \u2013 protein, kter\u00fd se nach\u00e1z\u00ed tak\u00e9 v mRNA vakc\u00edn\u00e1ch od spole\u010dnost\u00ed Pfizer a Moderna. Dlouhodob\u011b se p\u0159edpokl\u00e1d\u00e1, \u017ee spike protein m\u00e1 z\u00e1va\u017en\u00e9 \u00fa\u010dinky na lidsk\u00e9 zdrav\u00ed. Jablonowski pouk\u00e1zal na to, \u017ee by bylo bezohledn\u00e9 geneticky modifikovat infek\u010dn\u00ed virus tak, aby exprimoval spike protein. Imunitn\u00ed syst\u00e9m s spike proteinem energicky bojuje \u2013 co\u017e m\u016f\u017ee m\u00edt nebezpe\u010dn\u00e9 n\u00e1sledky.<\/span><\/p>\n

Navzdory pozitivn\u00ed prezentaci v publikovan\u00e9 studii \u0159ada odborn\u00edk\u016f pouk\u00e1zala na kl\u00ed\u010dov\u00e9 metodologick\u00e9 nedostatky. Whitehouse vysv\u011btlil, \u017ee bez kontroln\u00ed skupiny nelze vyvodit \u017e\u00e1dn\u00e9 z\u00e1v\u011bry o bezpe\u010dnosti ani \u00fa\u010dinnosti. Mal\u00fd po\u010det \u00fa\u010dastn\u00edk\u016f tak\u00e9 znemo\u017e\u0148oval spolehliv\u00e9 z\u00e1v\u011bry. Nav\u00edc nebyla provedena \u017e\u00e1dn\u00e1 anal\u00fdza skute\u010dn\u00e9 infek\u010dnosti vylu\u010dovan\u00e9ho materi\u00e1lu.<\/span><\/p>\n

Elijah dodala, \u017ee nebyla shrom\u00e1\u017ed\u011bna \u017e\u00e1dn\u00e1 data o detekci RNA, o p\u0159enosu viru ani o specifick\u00fdch hodnocen\u00edch dosp\u00edvaj\u00edc\u00edch. Kritizovala tak\u00e9 otev\u0159en\u00fd design studie \u2013 v n\u011bm\u017e jak v\u00fdzkumn\u00edci, tak \u00fa\u010dastn\u00edci v\u011bd\u011bli, kdo vakc\u00ednu dostal \u2013 co\u017e vynucuje zna\u010dn\u00e9 zkreslen\u00ed.<\/span><\/p>\n

Subjekty byly pozorov\u00e1ny pouze po omezenou dobu. To podle Whitehouse sn\u00ed\u017eilo pravd\u011bpodobnost pozd\u011bj\u0161\u00edho odhalen\u00ed z\u00e1va\u017en\u00fdch vedlej\u0161\u00edch \u00fa\u010dink\u016f. Podle autor\u016f studie nebyly pozorov\u00e1ny \u017e\u00e1dn\u00e9 z\u00e1va\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky, ale doba pozorov\u00e1n\u00ed byla p\u0159\u00edli\u0161 kr\u00e1tk\u00e1 na to, aby bylo mo\u017en\u00e9 spolehliv\u011b odhalit dlouhodob\u00e9 \u00fa\u010dinky.<\/span><\/p>\n

Dal\u0161\u00ed f\u00e1ze si klade za c\u00edl zapojit p\u0159ibli\u017en\u011b 10 000 \u00fa\u010dastn\u00edk\u016f. Imunolo\u017eka Jessica Rose ji\u017e varuje, \u017ee pokud budou tyto klinick\u00e9 studie \u00fasp\u011b\u0161n\u00e9, mohly by se v budoucnu \u0161\u00ed\u0159it i d\u00fdchac\u00edmi cestami vakc\u00edny na b\u00e1zi gen\u016f (mRNA, RNA, DNA) \u2013 bez nutnosti injekce.<\/span><\/p>\n

Existuj\u00ed tak\u00e9 st\u0159ety z\u00e1jm\u016f: Studie byla pln\u011b financov\u00e1na v\u00fdrobcem CyanVac. Mnoho autor\u016f je bu\u010f p\u0159\u00edmo zam\u011bstn\u00e1no spole\u010dnost\u00ed, akcion\u00e1\u0159i, nebo pracuje pro CyanVac na smluvn\u00edm z\u00e1klad\u011b. Krom\u011b toho n\u011bkte\u0159\u00ed z nich dost\u00e1vaj\u00ed finan\u010dn\u00ed prost\u0159edky na v\u00fdzkum od spole\u010dnost\u00ed Pfizer, Moderna nebo AstraZeneca.<\/span><\/p>\n

Studie byla provedena v D\u011btsk\u00e9 nemocnici v Cincinnati. Studii vedl Dr. Paul Spearman, kter\u00fd se d\u0159\u00edve pod\u00edlel na studi\u00edch vakc\u00edny Pfizer s dosp\u00edvaj\u00edc\u00edmi. V roce 2021 utrp\u011bla tehdy dvan\u00e1ctilet\u00e1 Maddie de Garay po druh\u00e9 d\u00e1vce t\u011b\u017ek\u00e1 zran\u011bn\u00ed a od t\u00e9 doby je upout\u00e1na na invalidn\u00ed voz\u00edk. L\u00e9ka\u0159i v nemocnici v\u0161ak jakoukoli souvislost s vakc\u00ednou odm\u00edtli a m\u00edsto toho diagnostikovali \u201efunk\u010dn\u00ed bolest b\u0159icha\u201c.<\/span><\/p>\n

V t\u00e9to souvislosti si odborn\u00edci kladou ot\u00e1zku, zda je vakc\u00edna s potenci\u00e1lem samo\u0161\u00ed\u0159en\u00ed v\u016fbec etick\u00e1 \u2013 zejm\u00e9na pokud neexistuj\u00ed komplexn\u00ed dlouhodob\u00e9 \u00fadaje a nez\u00e1visl\u00e9 hodnocen\u00ed.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/a><\/span><\/h3>\n

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Nov\u00e1 intranaz\u00e1ln\u00ed mRNA vakc\u00edna proti COVID-19 s n\u00e1zvem CVXGA1, vyvinut\u00e1 spole\u010dnost\u00ed CyanVac LLC, prok\u00e1zala prvn\u00ed…<\/p>\n","protected":false},"author":2,"featured_media":83319,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[694,9464,839,46],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/83318"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=83318"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/83318\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/83319"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=83318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=83318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=83318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}