{"id":82146,"date":"2025-06-25T06:16:43","date_gmt":"2025-06-25T04:16:43","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=82146"},"modified":"2025-06-25T06:16:43","modified_gmt":"2025-06-25T04:16:43","slug":"pust-versus-rakovina-preprogramovani-imunitnich-bunek-pro-boj-proti-rakovine","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/06\/25\/pust-versus-rakovina-preprogramovani-imunitnich-bunek-pro-boj-proti-rakovine\/","title":{"rendered":"P\u016fst versus rakovina: P\u0159eprogramov\u00e1n\u00ed imunitn\u00edch bun\u011bk pro boj proti rakovin\u011b"},"content":{"rendered":"
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P\u016fst se ukazuje jako slibn\u00fd spojenec v l\u00e9\u010db\u011b rakoviny, uv\u00e1d\u00ed pr\u016flomov\u00fd v\u00fdzkum publikovan\u00fd v odborn\u00e9m medic\u00ednsk\u00e9m \u010dasopise\u00a0Immunity<\/em>\u00a0.<\/strong><\/p>\n

Studie na my\u0161\u00edch veden\u00e1 organizac\u00ed\u00a0<\/span>Memorial Sloan Kettering Cancer Center<\/span><\/em> (MSK) odhalila, \u017ee 24hodinov\u00fd p\u016fst dvakr\u00e1t t\u00fddn\u011b p\u0159eprogramuje p\u0159irozen\u00e9 bu\u0148ky zabij\u00e1k\u016f (druh b\u00edl\u00fdch krvinek) a zv\u00fd\u0161\u00ed jejich schopnost infiltrovat a ni\u010dit n\u00e1dory.<\/span><\/p>\n

Tato zji\u0161t\u011bn\u00ed spolu se souvisej\u00edc\u00edmi klinick\u00fdmi studiemi na lidech nazna\u010duj\u00ed, \u017ee \u00faprava stravy dok\u00e1\u017ee zes\u00edlit \u00fa\u010dinnost l\u00e9\u010dby rakoviny \u2013 co\u017e je kl\u00ed\u010dov\u00e9, proto\u017ee terapeutick\u00e9 p\u0159\u00edstupy se st\u00e1vaj\u00ed st\u00e1le sofistikovan\u011bj\u0161\u00ed.<\/span><\/p>\n

Studie zjistila, \u017ee p\u016fst p\u0159ekonfiguruje metabolismus imunitn\u00edch bun\u011bk zabij\u00e1k\u016f, co\u017e jim umo\u017e\u0148uje prosperovat v n\u00e1dorov\u00e9m prost\u0159ed\u00ed bez gluk\u00f3zy \u2013 typick\u00e9ho zdroje energie pro imunitn\u00ed bu\u0148ky.<\/span><\/p>\n

P\u0159echodem na mastn\u00e9 kyseliny jako palivo imunitn\u00ed bu\u0148ky zv\u00fd\u0161ily produkci interferonu-gama, siln\u00e9ho cytokinu potla\u010duj\u00edc\u00edho r\u016fst n\u00e1doru.<\/span><\/p>\n

\u201eN\u00e1dory jsou velmi hladov\u00e9,\u201c<\/span><\/em>\u00a0\u0159\u00edk\u00e1 vedouc\u00ed autor studie Dr. Joseph Sun a zd\u016fraz\u0148uje, jak p\u016fst tr\u00e9nuje imunitn\u00ed bu\u0148ky, aby p\u0159e\u017eily metabolick\u00fd stres. Toto metabolick\u00e9 p\u0159eprogramov\u00e1n\u00ed m\u016f\u017ee tak\u00e9 zlep\u0161it imunitn\u00ed reakce na terapie jako imunoterapie, a\u010dkoli k potvrzen\u00ed t\u011bchto \u00fa\u010dink\u016f u lid\u00ed jsou zapot\u0159eb\u00ed dal\u0161\u00ed klinick\u00e9 zkou\u0161ky.<\/span><\/p>\n

Jako p\u016fst p\u0159eprogramuje obranyschopnost t\u011bla proti rakovin\u011b<\/span><\/h2>\n

Imunitn\u00ed bu\u0148ky zabij\u00e1ci, kl\u00ed\u010dov\u00e1 slo\u017eka vrozen\u00e9ho imunitn\u00edho syst\u00e9mu t\u011bla, dok\u00e1\u017eou rozpoznat a zni\u010dit rakovinn\u00e9 bu\u0148ky bez p\u0159edchoz\u00edho vystaven\u00ed se jim.<\/span><\/p>\n

Studie MSK prok\u00e1zala, \u017ee p\u016fst vyvol\u00e1v\u00e1 metabolickou flexibilitu \u2013 my\u0161i vystaven\u00e9 cyklick\u00e9mu hladov\u011bn\u00ed zaznamenaly pokles hladiny\u00a0<\/span>gluk\u00f3zy v krvi<\/span><\/a>\u00a0, co\u017e vedlo imunitn\u00ed bu\u0148ky zabij\u00e1k\u016f ve slezin\u011b a kostn\u00ed d\u0159eni k adaptaci na metabolizov\u00e1n\u00ed mastn\u00fdch kyselin.<\/span><\/p>\n

V kostn\u00ed d\u0159eni p\u016fst zes\u00edlil signalizaci IL-12, neboli cytokinovou dr\u00e1hu, kter\u00e1 je kl\u00ed\u010dov\u00e1 pro aktivaci produkce interferonu gama, zat\u00edmco imunitn\u00ed bu\u0148ky ve slezin\u011b se staly metabolicky flexibiln\u00ed a vyu\u017e\u00edvaly mastn\u00e9 kyseliny k udr\u017een\u00ed sv\u00e9 cytotoxick\u00e9 aktivity.<\/span><\/p>\n

\u201eP\u016fst funguje jako tr\u00e9ninkov\u00e9 h\u0159i\u0161t\u011b pro imunitn\u00ed bu\u0148ky zabij\u00e1k\u016f,\u201c<\/span><\/em>\u00a0vysv\u011btlila jedna z autorek studie Dr. Rebecca Delconteov\u00e1.\u00a0<\/span>\u201eU\u010d\u00ed se prosperovat v nehostinn\u00e9m prost\u0159ed\u00ed.\u201c<\/span><\/em><\/p>\n

Tyto metabolick\u00e9 zm\u011bny m\u011bly jasn\u011b m\u011b\u0159iteln\u00e9 \u00fa\u010dinky. U my\u0161\u00ed, kter\u00e9 postily, se vyvinuly men\u0161\u00ed n\u00e1dory a m\u00e9n\u011b metast\u00e1z ve srovn\u00e1n\u00ed s kontroln\u00edmi skupinami.<\/span><\/p>\n

Mal\u00e1 studie na lidech s p\u011btidenn\u00ed dietou napodobuj\u00edc\u00ed p\u016fst (500 a\u017e 600 kalori\u00ed\/den) spolu s chemoterapi\u00ed potvrdila zji\u0161t\u011bn\u00ed na my\u0161\u00edch. Pacienti prok\u00e1zali zlep\u0161enou protin\u00e1dorovou imunitu, a\u010dkoli dlouhodob\u00e9 v\u00fdsledky v progresi rakoviny z\u016fst\u00e1vaj\u00ed nejasn\u00e9.<\/span><\/p>\n

Vyv\u00e1\u017een\u00e1 strava: Strategie pro optim\u00e1ln\u00ed zdrav\u00ed<\/span><\/h2>\n

P\u0159esto\u017ee p\u0159irozen\u00fd proces autofagie v t\u011ble, kter\u00fd rozkl\u00e1d\u00e1 bun\u011b\u010dn\u00fd odpad, je podporov\u00e1n p\u016fstem, zdravotni\u010dt\u00ed pracovn\u00edci varuj\u00ed p\u0159ed extr\u00e9my.<\/span><\/p>\n

Dr. Liao Zhiying, radia\u010dn\u00ed onkolog citovan\u00fd agenturou AP, \u0159\u00edk\u00e1, \u017ee strategie jako p\u0159eru\u0161ovan\u00fd p\u016fst \u201e16\/8\u201c (16 hodin hladov\u011bn\u00ed denn\u011b, jeden\u00ed jen b\u011bhem 8-hodinov\u00e9ho okna) nebo dlouhodob\u011bj\u0161\u00ed vodn\u00ed p\u016fsty (3 a\u017e 5 dn\u00ed) mohou bezpe\u010dn\u011b podporovat autofagii.<\/span><\/p>\n

\u201eSimulovan\u00e1 dieta poskytuje z\u00e1kladn\u00ed \u017eiviny pot\u0159ebn\u00e9 pro norm\u00e1ln\u00ed bu\u0148ky,\u201c<\/span><\/em>\u00a0vysv\u011btlil Dr. Zhiyng a zd\u016fraznil, \u017ee pacienti by se m\u011bli vyh\u00fdbat ne\u0159\u00edzen\u00fdm re\u017eim\u016fm.<\/span><\/p>\n

Popsal svou vlastn\u00ed zku\u0161enost s p\u011btidenn\u00ed dietou se 600 kaloriemi denn\u011b, kter\u00e1 mu zp\u016fsobila po\u010d\u00e1te\u010dn\u00ed \u00fanavu, ale po metabolick\u00e9 adaptaci zlep\u0161ila vytrvalost.<\/span><\/p>\n

Krom\u011b samotn\u00e9ho p\u016fstu zd\u016fraz\u0148uje i omezen\u00ed asparaginu, aby se rakovinov\u00fdm bu\u0148k\u00e1m omezily \u017eiviny pot\u0159ebn\u00e9 k r\u016fstu a z\u00e1rove\u0148 se pos\u00edlila imunitn\u00ed \u00fa\u010dinnost.<\/span><\/p>\n

Tchajwansk\u00e1 studie v odborn\u00e9m \u010dasopise\u00a0<\/span>Nature Metabolism<\/span><\/em>\u00a0to potvrdila a uk\u00e1zala, \u017ee sn\u00ed\u017een\u00fd p\u0159\u00edjem asparaginu zmen\u0161uje n\u00e1dory nosohltanu a zvy\u0161uje aktivitu pam\u011b\u0165ov\u00fdch T-bun\u011bk.<\/span><\/p>\n

Vyu\u017eit\u00ed tohoto poznatku v klinick\u00e9 praxi je v\u0161ak je\u0161t\u011b n\u011bkolik m\u011bs\u00edc\u016f vzd\u00e1leno, proto\u017ee studie pr\u00e1v\u011b hodnot\u00ed, jak bezpe\u010dn\u011b blokovat synt\u00e9zu asparaginu bez po\u0161kozen\u00ed zdrav\u00fdch bun\u011bk.<\/span><\/p>\n

Etika a v\u011bda: P\u0159\u00edb\u011bh slibn\u00e9ho pokroku a \u00fastupu<\/span><\/h2>\n

I kdy\u017e v\u00fdzkum p\u016fstu z\u00edsk\u00e1v\u00e1 na popularit\u011b, v\u011bdeck\u00e1 komunita \u010del\u00ed p\u0159ipom\u00ednk\u00e1m d\u016fle\u017eitosti d\u016fkladn\u00e9 validace.<\/span><\/p>\n

P\u0159elomov\u00e1 studie o Alzheimerov\u011b chorob\u011b z roku 2006, kter\u00e1 navrhla terapie zalo\u017een\u00e9 na beta-amyloidu, byla aktu\u00e1ln\u00ed sta\u017een\u00ed pot\u00e9, co \u010dasopis\u00a0<\/span>Nature<\/span><\/em>\u00a0p\u0159iznal zfal\u0161ovan\u00e9 mikroskopick\u00e9 sn\u00edmky pou\u017eit\u00e9 ve studii.<\/span><\/p>\n

Vedouc\u00ed redaktor \u010dl\u00e1nku potvrdil tuto skute\u010dnost na PubPeer online f\u00f3ru pro v\u011bdeckou diskusi a zd\u016fraznil rizika kompromitovan\u00e9ho v\u00fdzkumu.<\/span><\/p>\n

\u201eToto je v ostr\u00e9m kontrastu se studiemi p\u016fstu, kde byla zji\u0161t\u011bn\u00ed v\u00edcekr\u00e1t zopakov\u00e1na nap\u0159\u00ed\u010d r\u016fzn\u00fdmi \u017eivo\u010di\u0161n\u00fdmi druhy,\u201c<\/span><\/em>\u00a0\u0159ekla Dr. May Daher z MD Anderson Cancer Center, kter\u00e1 spolupracuje na v\u00fdzkumu imunoterapie.<\/span><\/p>\n

\u201eJe to bud\u00ed\u010dek, abychom zajistili, \u017ee ka\u017ed\u00fd krok medic\u00ednsk\u00e9 inovace obstoj\u00ed pod drobnohledem.\u201c<\/span><\/em><\/p>\n

Vyv\u00e1\u017een\u00ed nad\u011bje a opatrnosti<\/span><\/h2>\n

Dr. Neil Iyengar z MSK, odborn\u00edk na stravu a onkologii, zd\u016fraz\u0148uje, \u017ee p\u0159\u00ednosy poskytovan\u00e9 p\u016fstem mus\u00ed b\u00fdt vyv\u00e1\u017eeny individu\u00e1ln\u00edmi zdravotn\u00edmi pot\u0159ebami.<\/span><\/p>\n

\u201ePacienti podstupuj\u00edc\u00ed l\u00e9\u010dbu by nem\u011bli vylu\u010dovat j\u00eddlo bez konzultace s l\u00e9ka\u0159em,\u201c<\/span><\/em>\u00a0varoval.<\/span><\/p>\n

P\u0159esto\u017ee metaanal\u00fdzy nazna\u010duj\u00ed bezpe\u010dnost p\u016fstu pro v\u011bt\u0161inu zdrav\u00fdch dosp\u011bl\u00fdch, pacienti s rakovinou pot\u0159ebuj\u00ed personalizovan\u00e9 re\u017eimy, aby se p\u0159ede\u0161lo jejich podv\u00fd\u017eiv\u011b nebo p\u0159\u00edli\u0161n\u00e9 \u00fanav\u011b.<\/span><\/p>\n

Budouc\u00ed v\u00fdzkum se zam\u011b\u0159uje na identifikaci l\u00e9k\u016f a extern\u00edch terapi\u00ed imunitn\u00edch bun\u011bk zabij\u00e1k\u016f, kter\u00e9 napodobuj\u00ed \u00fa\u010dinky p\u016fstu a obch\u00e1zej\u00ed dietn\u00ed po\u017eadavky. Av\u0161ak a\u017e do ukon\u010den\u00ed t\u0159et\u00ed f\u00e1ze klinick\u00fdch zkou\u0161ek z\u016fst\u00e1v\u00e1 p\u016fst experiment\u00e1ln\u00ed terapi\u00ed.<\/span><\/p>\n

\u201eTohle je pravd\u011bpodobn\u011b aplikovateln\u00e9 i na lidi,\u201c<\/span><\/em>\u00a0\u0159ekl Delconte, \u201e\u00a0<\/span>ale porota zat\u00edm definitivn\u011b nerozhodla.\u201c<\/span><\/em><\/p>\n

Nov\u00e1 kapitola v bun\u011b\u010dn\u00e9 v\u00e1lce proti rakovin\u011b<\/span><\/h2>\n

Schopnost p\u016fstu p\u0159eprogramovat imunitn\u00ed bu\u0148ky otev\u00edr\u00e1 nov\u00e9 hranice v onkologii, ale jeho cesta k rutinn\u00edmu pou\u017e\u00edv\u00e1n\u00ed je opatrn\u00e1 a klikat\u00e1.<\/span><\/p>\n

Zat\u00edm je d\u016fraz kladen na spolupr\u00e1ci \u2013 mezi pacientem, l\u00e9ka\u0159em a v\u00fdzkumn\u00edkem \u2013 s c\u00edlem p\u0159ekonat tenkou hranici mezi pokrokem a nebezpe\u010d\u00edm.<\/span><\/p>\n

Autor: Willow Thoi, Zdroj:\u00a0<\/span>naturalnews.com<\/span><\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

P\u016fst se ukazuje jako slibn\u00fd spojenec v l\u00e9\u010db\u011b rakoviny, uv\u00e1d\u00ed pr\u016flomov\u00fd v\u00fdzkum publikovan\u00fd v odborn\u00e9m…<\/p>\n","protected":false},"author":2,"featured_media":82147,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[3218,1366,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/82146"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=82146"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/82146\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/82147"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=82146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=82146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=82146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}