{"id":81571,"date":"2025-06-18T04:43:52","date_gmt":"2025-06-18T02:43:52","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=81571"},"modified":"2025-06-18T04:43:52","modified_gmt":"2025-06-18T02:43:52","slug":"vyzkumnici-objevili-v-kave-latku-ktera-bojuje-proti-starnuti-a-ubytku-svalu","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/06\/18\/vyzkumnici-objevili-v-kave-latku-ktera-bojuje-proti-starnuti-a-ubytku-svalu\/","title":{"rendered":"V\u00fdzkumn\u00edci objevili v k\u00e1v\u011b l\u00e1tku, kter\u00e1 bojuje proti st\u00e1rnut\u00ed a \u00fabytku sval\u016f"},"content":{"rendered":"
<\/div>\n

Ztr\u00e1ta svalov\u00e9 hmoty a s\u00edly souvisej\u00edc\u00ed s v\u011bkem je stav naz\u00fdv\u00e1n sarkopenie. Obvykle postihuje star\u0161\u00ed dosp\u011bl\u00e9, kter\u00e9 m\u016f\u017ee p\u0159ipravit o nez\u00e1vislost a mobilitu.<\/strong><\/p>\n

V\u00fdzkumn\u00edci nyn\u00ed mo\u017en\u00e1 objevili neo\u010dek\u00e1van\u00e9ho spojence v boji proti \u00fabytku sval\u016f souvisej\u00edc\u00edm s v\u011bkem – trigonelin. Jedn\u00e1 se o p\u0159\u00edrodn\u00ed slou\u010deninu nach\u00e1zej\u00edc\u00ed se v k\u00e1v\u011b, senovce \u0159eck\u00e9 a n\u011bkter\u00fdch dal\u0161\u00edch rostlin\u00e1ch.<\/span><\/p>\n

P\u0159elomov\u00e1 mezin\u00e1rodn\u00ed studie publikovan\u00e1 v odborn\u00e9m \u010dasopise\u00a0<\/span>Nature Metabolism<\/span><\/em>\u00a0odhaluje, \u017ee lid\u00e9 se sarkopeni\u00ed maj\u00ed v krvi ni\u017e\u0161\u00ed ne\u017e norm\u00e1ln\u00ed hladiny trigonelinu, p\u0159i\u010dem\u017e zv\u00fd\u0161en\u00ed jeho p\u0159\u00edjmu prost\u0159ednictv\u00edm suplementace pom\u00e1h\u00e1 zlep\u0161ovat funkci sval\u016f u star\u0161\u00edch lid\u00ed t\u00edm, \u017ee zv\u00fd\u0161\u00ed produkci bun\u011b\u010dn\u00e9 energie.<\/span><\/p>\n

Spojen\u00ed mezi svaly a energi\u00ed<\/span><\/h2>\n

Sarkopenie je postupn\u00e1 ztr\u00e1ta svalov\u00e9 hmoty, s\u00edly a mobility, ke kter\u00e9 doch\u00e1z\u00ed se st\u00e1rnut\u00edm.<\/span><\/p>\n

V\u00fdzkum ukazuje, \u017ee tento stav je zp\u016fsoben \u00fabytkem svalov\u00fdch vl\u00e1ken a \u201ekombinac\u00ed molekul\u00e1rn\u00edch a bun\u011b\u010dn\u00fdch znak\u016f st\u00e1rnut\u00ed, kter\u00e9 spole\u010dn\u011b zhor\u0161uj\u00ed svalovou kontrakci\u201c.<\/span><\/p>\n

Mezi tyto znaky pat\u0159\u00ed pokles mitochondri\u00e1ln\u00ed funkce, co\u017e vede ke sn\u00ed\u017een\u00e9mu mitochondri\u00e1ln\u00edmu d\u00fdch\u00e1n\u00ed a produkci bun\u011b\u010dn\u00e9 energie.<\/span><\/p>\n

Mitochondrie, takzvan\u00e9 tak\u00e9 \u201eelektr\u00e1rn\u00ed bun\u011bk\u201c, s v\u011bkem oslabuj\u00ed, \u010d\u00edm\u017e se sni\u017euje energetick\u00fd v\u00fddej p\u0159isp\u00edvaj\u00edc\u00ed k \u00fabytku svalov\u00e9 hmoty.<\/span><\/p>\n

Tento pokles souvis\u00ed s klesaj\u00edc\u00edmi hladinami nikotinamidadenindinukleotidu (NAD+), \u017eivotn\u011b d\u016fle\u017eit\u00e9 molekuly zapojen\u00e9 do energetick\u00e9ho metabolismu. Pokles hladin NAD+ je kl\u00ed\u010dov\u00fdm znakem st\u00e1rnut\u00ed bun\u011bk a p\u0159edpokl\u00e1d\u00e1 se, \u017ee hraje kl\u00ed\u010dovou roli v celkov\u00e9m procesu st\u00e1rnut\u00ed.<\/span><\/p>\n

Zat\u00edmco posilova\u010de NAD+, jako je nikotinamid ribozid (forma vitam\u00ednu B3, niacinu), si z\u00edsk\u00e1vaj\u00ed pozornost d\u00edky sv\u00e9mu potenci\u00e1lu zpomalit st\u00e1rnut\u00ed, trigonelin v k\u00e1v\u011b nab\u00edz\u00ed novou alternativu na b\u00e1zi potravin.<\/span><\/p>\n

Trigonelin je toti\u017e metylovan\u00e1 forma niacinu, kter\u00e1 se p\u0159irozen\u011b vyskytuje v k\u00e1vov\u00fdch semenech, semenech p\u00edskavice \u0159eck\u00e9, hr\u00e1\u0161ku, konopn\u00fdch semenech a ovsu.<\/span><\/p>\n

Podle studie\u00a0<\/span>Nature Metabolism<\/span><\/em> m\u016f\u017ee trigonelin p\u016fsobit jako prekurzor NAD+ ke zv\u00fd\u0161en\u00ed produkce mitochondri\u00e1ln\u00ed energie a zlep\u0161en\u00ed funkce sval\u016f u star\u0161\u00edch lid\u00ed.<\/span><\/p>\n

Role trigonelinu v boji proti st\u00e1rnut\u00ed<\/span><\/h2>\n

Zde jsou kl\u00ed\u010dov\u00e1 zji\u0161t\u011bn\u00ed studie o trigonelinu:<\/span><\/p>\n

1. Lid\u00e9 se sarkopeni\u00ed maj\u00ed o 30% ni\u017e\u0161\u00ed hladiny trigonelinu ne\u017e jejich zdrav\u00ed vrstevn\u00edci.<\/span><\/p>\n

2. Vy\u0161\u0161\u00ed hladiny trigonelinu korelovaly s v\u011bt\u0161\u00ed silou \u00fachopu, rychlej\u0161\u00ed ch\u016fz\u00ed a zlep\u0161enou funkc\u00ed mitochondri\u00ed.<\/span><\/p>\n

3. U \u010derv\u016f trigonelin prodlou\u017eil jejich \u017eivotnost a sn\u00ed\u017eil \u00fabytek svalov\u00e9 hmoty souvisej\u00edc\u00ed s v\u011bkem.<\/span><\/p>\n

4. Mezit\u00edm star\u0161\u00ed my\u0161i, kter\u00fdm byl pod\u00e1v\u00e1n trigonelin, z\u00edskaly siln\u011bj\u0161\u00ed svaly a vykazovaly sn\u00ed\u017eenou\u00a0<\/span>\u00fanavu<\/span><\/a>\u00a0b\u011bhem cvi\u010den\u00ed.<\/span><\/p>\n

Trigonelin je struktur\u00e1ln\u011b podobn\u00fd vitam\u00ednu B3, ale nezp\u016fsobuje vedlej\u0161\u00ed \u00fa\u010dinek v podob\u011b \u201en\u00e1val\u016f hore\u010dky\u201c, kter\u00e9 jsou spojeny s vysok\u00fdmi d\u00e1vkami niacinov\u00fdch dopl\u0148k\u016f. Nam\u00edsto toho se v tichosti p\u0159em\u011b\u0148uje na NAD+ prost\u0159ednictv\u00edm specializovan\u00e9 metabolick\u00e9 dr\u00e1hy, \u010d\u00edm\u017e revitalizuje mitochondrie.<\/span><\/p>\n

Jednodu\u0161e \u0159e\u010deno, trigonelin funguje jako dob\u00edjen\u00ed bun\u011b\u010dn\u00e9 baterie, kter\u00e9 m\u016f\u017ee pomoci st\u00e1rnouc\u00edm sval\u016fm produkovat v\u00edce energie pro v\u011bt\u0161\u00ed s\u00edlu a vytrvalost.<\/span><\/p>\n

Jeliko\u017e trigonelin je ji\u017e p\u0159irozen\u011b p\u0159\u00edtomen v k\u00e1v\u011b a senovce \u0159eck\u00e9, \u00faprava stravy m\u016f\u017ee star\u0161\u00edm dosp\u011bl\u00fdm pomoci udr\u017eet si zdrav\u00e9 hladiny trigonelinu. Terapeutick\u00e9 d\u00e1vky v\u0161ak pravd\u011bpodobn\u011b vy\u017eaduj\u00ed extra dopl\u0148ov\u00e1n\u00ed \u2013 co\u017e je potenci\u00e1ln\u00ed cesta pro budouc\u00ed l\u00e9\u010dby proti st\u00e1rnut\u00ed.<\/span><\/p>\n

Z\u00e1v\u011br<\/span><\/h2>\n

Na rozd\u00edl od laboratorn\u011b vyroben\u00fdch zesilova\u010d\u016f NAD+ je trigonelin p\u0159\u00edrodn\u00ed, z\u016fst\u00e1v\u00e1 stabiln\u00ed v krevn\u00edm ob\u011bhu a je dob\u0159e tolerov\u00e1n.<\/span><\/p>\n

Krom\u011b boje proti \u00fabytku sval\u016f souvisej\u00edc\u00edm s v\u011bkem studia z roku 2023 na zv\u00ed\u0159ec\u00edm modelu zjistila, \u017ee trigonelin tak\u00e9 zlep\u0161uje kognitivn\u00ed funkce, co\u017e z n\u011bj \u010din\u00ed slibn\u00e9ho kandid\u00e1ta na boj proti poklesu kognitivn\u00edch funkc\u00ed u star\u0161\u00edch lid\u00ed.<\/span><\/p>\n

Autor: Evangelyn Rodriguez, Zdroj:\u00a0<\/span>naturalnews.com<\/span><\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Ztr\u00e1ta svalov\u00e9 hmoty a s\u00edly souvisej\u00edc\u00ed s v\u011bkem je stav naz\u00fdv\u00e1n sarkopenie. Obvykle postihuje star\u0161\u00ed…<\/p>\n","protected":false},"author":2,"featured_media":81572,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[6691,1561,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/81571"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=81571"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/81571\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/81572"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=81571"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=81571"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=81571"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}