{"id":80572,"date":"2025-06-06T00:16:18","date_gmt":"2025-06-05T22:16:18","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=80572"},"modified":"2025-06-05T10:25:52","modified_gmt":"2025-06-05T08:25:52","slug":"italska-studie-vyvolava-poplach-samotny-protein-spike-by-mohl-preprogramovat-telo","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/06\/06\/italska-studie-vyvolava-poplach-samotny-protein-spike-by-mohl-preprogramovat-telo\/","title":{"rendered":"Italsk\u00e1 studie vyvol\u00e1v\u00e1 poplach – samotn\u00fd protein Spike by mohl „p\u0159eprogramovat“ t\u011blo"},"content":{"rendered":"
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Recenzovan\u00e1\u00a0<\/span>studie<\/span><\/a>\u00a0veden\u00e1 Dr. Giovannim Colonnou (Katedra l\u00e9ka\u0159sk\u00e9 informatiky \u2013 AOU Luigi Vanvitelli, Univerzita v Kamp\u00e1nii), publikovan\u00e1 v \u010dasopise\u00a0<\/span>Biomolecules<\/span><\/em>\u00a0(prosinec 2024), ukazuje, \u017ee podjednotka S1 spike proteinu SARS-CoV-2 \u2013 a\u0165 u\u017e produkovan\u00e1 b\u011bhem p\u0159irozen\u00e9 infekce nebo mRNA vakcinac\u00ed \u2013 m\u016f\u017ee p\u016fsobit nez\u00e1visle na zbytku viru a spou\u0161t\u011bt lidsk\u00e9 bun\u011b\u010dn\u00e9 mechanismy neo\u010dek\u00e1van\u00fdmi zp\u016fsoby.<\/span><\/p>\n

Anal\u00fdzou tis\u00edc\u016f experiment\u00e1ln\u011b ov\u011b\u0159en\u00fdch proteinov\u00fdch interakc\u00ed Colonna prok\u00e1zal, \u017ee samotn\u00fd S1 m\u016f\u017ee spustit v\u00edce ne\u017e 2 500 biologick\u00fdch proces\u016f \u2013 co\u017e je o v\u00edce ne\u017e 40 % vy\u0161\u0161\u00ed \u00farove\u0148 aktivity, ne\u017e jak\u00e9 dosahuje jako sou\u010d\u00e1st kompletn\u00edho virov\u00e9ho komplexu.<\/span><\/p>\n

Obzvl\u00e1\u0161t\u011b alarmuj\u00edc\u00ed na recenzi\u00a0<\/span>TrialSiteNews<\/span><\/em>\u00a0je, \u017ee S1 p\u0159\u00edmo interaguje s proteiny zapojen\u00fdmi do sign\u00e1ln\u00edch drah relevantn\u00edch pro rakovinu, jako jsou mTOR a PI3K \u2013 a zd\u00e1 se, \u017ee po\u0161kozuje gen supresoru n\u00e1doru\u00a0<\/span>TP53<\/span><\/strong>\u00a0.<\/span><\/p>\n

Z\u00e1rove\u0148 S1 vykazoval afinitu k sign\u00e1ln\u00edm drah\u00e1m spojen\u00fdm s dysfunkc\u00ed jater \u2013 v\u010detn\u011b t\u011bch pozorovan\u00fdch u hepatitidy B \u2013 a \u00fazkou propojenost s nervov\u00fdmi okruhy, kter\u00e9 jsou kl\u00ed\u010dov\u00e9 pro pam\u011b\u0165 a kognitivn\u00ed funkce. To podporuje hypot\u00e9zu, \u017ee S1 hraje kl\u00ed\u010dovou roli v dlouhodob\u00fdch symptomech COVID-19, jako je mozkov\u00e1 mlha, chronick\u00e1 \u00fanava nebo zm\u011bn\u011bn\u00fd metabolismus gluk\u00f3zy v mozku.<\/span><\/p>\n

Studie je obzvl\u00e1\u0161t\u011b explozivn\u00ed z toho d\u016fvodu, \u017ee fragment spike proteinu S1 \u2013 kl\u00ed\u010dov\u00fd mechanismus vstupu viru, kter\u00fd je detekovateln\u00fd v krevn\u00edm \u0159e\u010di\u0161ti i po o\u010dkov\u00e1n\u00ed \u2013 by mohl p\u016fsobit jako nez\u00e1visl\u00fd molekul\u00e1rn\u00ed disruptor. A\u010dkoli data nejsou p\u0159esv\u011bd\u010div\u00e1, je zapot\u0159eb\u00ed nal\u00e9hav\u00e9ho vy\u0161et\u0159en\u00ed, aby se zjistilo, zda samotn\u00fd S1 m\u016f\u017ee spustit chronick\u00fd z\u00e1n\u011bt, imunitn\u00ed dysregulaci nebo dokonce procesy podporuj\u00edc\u00ed rakovinu.<\/span><\/p>\n

Colonnova pr\u00e1ce vyvol\u00e1v\u00e1 nep\u0159\u00edjemn\u00e9 ot\u00e1zky \u2013 ohledn\u011b v\u00fdvoje vakc\u00edn, terapie po COVIDu a na\u0161eho z\u00e1kladn\u00edho ch\u00e1p\u00e1n\u00ed \u00fa\u010dink\u016f virov\u00fdch protein\u016f mimo aktivn\u00ed infek\u010dn\u00ed proces.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/a><\/span><\/h3>\n

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Recenzovan\u00e1\u00a0studie\u00a0veden\u00e1 Dr. Giovannim Colonnou (Katedra l\u00e9ka\u0159sk\u00e9 informatiky \u2013 AOU Luigi Vanvitelli, Univerzita v Kamp\u00e1nii), publikovan\u00e1…<\/p>\n","protected":false},"author":2,"featured_media":35388,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,1589,839,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/80572"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=80572"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/80572\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/35388"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=80572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=80572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=80572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}