{"id":80477,"date":"2025-06-05T00:12:26","date_gmt":"2025-06-04T22:12:26","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=80477"},"modified":"2025-06-04T14:36:45","modified_gmt":"2025-06-04T12:36:45","slug":"nova-studie-ukazuje-znepokojivy-signal-davka-vakciny-a-telesna-hmotnost-prehlizena-promenna","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/06\/05\/nova-studie-ukazuje-znepokojivy-signal-davka-vakciny-a-telesna-hmotnost-prehlizena-promenna\/","title":{"rendered":"Nov\u00e1 studie ukazuje znepokojiv\u00fd sign\u00e1l: d\u00e1vka vakc\u00edny a t\u011blesn\u00e1 hmotnost \u2013 p\u0159ehl\u00ed\u017een\u00e1 prom\u011bnn\u00e1"},"content":{"rendered":"
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O\u010dkov\u00e1n\u00ed proti COVID-19 a Hashimotova choroba \u2013 Kdy\u017e imunitn\u00ed syst\u00e9m sel\u017ee<\/span><\/strong><\/h3>\n

Ned\u00e1vn\u00e1 l\u00e9ka\u0159sk\u00e1\u00a0<\/span>kazuistika<\/span><\/a>\u00a0ze Srbska vyvol\u00e1v\u00e1 v\u00e1\u017en\u00e9 ot\u00e1zky ohledn\u011b bezpe\u010dnosti vakc\u00edn proti COVID-19 \u2013 zejm\u00e9na ve vztahu k autoimunitn\u00edm reakc\u00edm. Auto\u0159i dokumentuj\u00ed dva p\u0159\u00edpady Hashimotovy tyreoiditidy, kter\u00e9 se vyskytly v p\u0159\u00edm\u00e9 \u010dasov\u00e9 souvislosti s r\u016fzn\u00fdmi vakc\u00ednami proti COVID-19. A\u010dkoli studie nen\u00ed recenzovan\u00e1, poskytuje relevantn\u00ed klinick\u00e1 data a nastoluje d\u016fle\u017eit\u00e9 hypot\u00e9zy k diskusi.<\/span><\/p>\n

Dva pacienti, jedna diagn\u00f3za<\/span><\/h3>\n

Prvn\u00ed p\u0159\u00edpad se t\u00fdk\u00e1 47let\u00e9 \u017eeny s norm\u00e1ln\u00ed t\u011blesnou hmotnost\u00ed, kter\u00e1 dostala dv\u011b d\u00e1vky vakc\u00edny AstraZeneca a jednu d\u00e1vku vakc\u00edny Pfizer-BioNTech. O n\u011bkolik m\u011bs\u00edc\u016f pozd\u011bji j\u00ed byl diagnostikov\u00e1n prudk\u00fd n\u00e1r\u016fst protil\u00e1tek proti TPO a p\u0159\u00edznaky hypotyre\u00f3zy \u2013 diagn\u00f3za Hashimotovy tyreoiditidy.<\/span><\/p>\n

V druh\u00e9m p\u0159\u00edpad\u011b byl u 47let\u00e9ho mu\u017ee po t\u0159ech d\u00e1vk\u00e1ch p\u0159\u00edpravku Sinopharm diagnostikov\u00e1n zv\u00fd\u0161en\u00fd titr protil\u00e1tek proti tk\u00e1ni \u0161t\u00edtn\u00e9 \u017el\u00e1zy. A\u010dkoli nevykazoval \u017e\u00e1dn\u00e9 klinick\u00e9 p\u0159\u00edznaky, ultrazvukov\u00e9 a laboratorn\u00ed v\u00fdsledky nazna\u010duj\u00ed po\u010d\u00ednaj\u00edc\u00ed autoimunitn\u00ed reakci.<\/span><\/p>\n

D\u00e1vka vakc\u00edny a t\u011blesn\u00e1 hmotnost \u2013 p\u0159ehl\u00ed\u017een\u00e1 prom\u011bnn\u00e1?<\/span><\/h3>\n

\u00dast\u0159edn\u00ed argument autor\u016f se t\u00fdk\u00e1 d\u00e1vkovac\u00ed strategie: V\u0161ichni pacienti dost\u00e1vaj\u00ed stejnou d\u00e1vku vakc\u00edny bez ohledu na t\u011blesnou hmotnost. Podle autor\u016f to vede ke zv\u00fd\u0161en\u00e9 koncentraci antigenu v krvi u jedinc\u016f s ni\u017e\u0161\u00ed t\u011blesnou hmotnost\u00ed \u2013 a t\u00edm k siln\u011bj\u0161\u00ed imunitn\u00ed odpov\u011bdi.<\/span><\/p>\n

Tato hypot\u00e9za je zalo\u017eena na vztahu mezi t\u011blesnou hmotnost\u00ed, objemem krve a antigenn\u00ed z\u00e1t\u011b\u017e\u00ed. Zat\u00edmco t\u011b\u017e\u0161\u00ed lid\u00e9 maj\u00ed v\u011bt\u0161\u00ed objem krve, u leh\u010d\u00edch lid\u00ed je antigen distribuov\u00e1n koncentrovan\u011bji. P\u0159edpokl\u00e1d\u00e1 se, \u017ee to m\u016f\u017ee podporovat nadm\u011brn\u00e9 imunitn\u00ed reakce.<\/span><\/p>\n

Technologie mRNA a adjuvancia jako spou\u0161t\u011b\u010de?<\/span><\/h3>\n

Zejm\u00e9na mRNA vakc\u00edny se staly ter\u010dem kritiky. \u010c\u00e1stice mRNA zapouzd\u0159en\u00e9 v lipidech mohou teoreticky proniknout do jak\u00e9koli somatick\u00e9 bu\u0148ky \u2013 v\u010detn\u011b bun\u011bk \u0161t\u00edtn\u00e9 \u017el\u00e1zy. Pokud tyto bu\u0148ky n\u00e1sledn\u011b na sv\u00e9m povrchu exprimuj\u00ed virov\u00e9 proteiny, imunitn\u00ed syst\u00e9m je rozpozn\u00e1 jako ciz\u00ed a zni\u010d\u00ed je.<\/span><\/p>\n

Nav\u00edc adjuvans, jako je polyethylenglykol (PEG) nebo jin\u00e9 pomocn\u00e9 l\u00e1tky, mohou zp\u016fsobit nadm\u011brnou aktivaci imunitn\u00edho syst\u00e9mu. Opakovan\u00e9 pod\u00e1v\u00e1n\u00ed posiluj\u00edc\u00edch d\u00e1vek by mohlo imunitn\u00ed syst\u00e9m nadm\u011brn\u011b stimulovat a dlouhodob\u011b destabilizovat.<\/span><\/p>\n

Opakovan\u00e9 o\u010dkov\u00e1n\u00ed \u2013 zdravotn\u00ed p\u0159\u00ednos, nebo zbyte\u010dn\u00e1 z\u00e1t\u011b\u017e?<\/span><\/h3>\n

Auto\u0159i tak\u00e9 zpochyb\u0148uj\u00ed l\u00e9ka\u0159skou logiku opakovan\u00fdch o\u010dkovac\u00edch cykl\u016f. Protil\u00e1tky se po ka\u017ed\u00e9 d\u00e1vce v\u00fdznamn\u011b zvy\u0161uj\u00ed, zejm\u00e9na v t\u0159\u00edd\u011b IgG \u2013 dlouhodob\u00e9 d\u016fsledky t\u011bchto zv\u00fd\u0161en\u00fdch cirkuluj\u00edc\u00edch protil\u00e1tek v\u0161ak z\u016fst\u00e1vaj\u00ed nejasn\u00e9. To vyvol\u00e1v\u00e1 ot\u00e1zku, zda jsou neust\u00e1l\u00e9 posilovac\u00ed o\u010dkov\u00e1n\u00ed skute\u010dn\u011b nezbytn\u00e9, nebo zda zvy\u0161uj\u00ed riziko autoimunitn\u00edch proces\u016f.<\/span><\/p>\n

Predispozice jako rizikov\u00fd faktor<\/span><\/h3>\n

Auto\u0159i rovn\u011b\u017e kritizuj\u00ed strategii o\u010dkov\u00e1n\u00ed u osob s genetickou nebo famili\u00e1rn\u00ed predispozic\u00ed. Podle studie by se nikdo s rodinnou anamn\u00e9zou Hashimotovy choroby, diabetu 1. typu, lupusu nebo revmatoidn\u00ed artritidy nem\u011bl nechat o\u010dkovat v\u016fbec \u2013 alespo\u0148 ne bez p\u0159edchoz\u00edho posouzen\u00ed rizika.<\/span><\/p>\n

Tich\u00fd n\u00e1stup chronick\u00e9ho onemocn\u011bn\u00ed<\/span><\/h3>\n

Hashimotova choroba \u010dasto za\u010d\u00edn\u00e1 z\u00e1ke\u0159n\u011b a bez pov\u0161imnut\u00ed. D\u00edky tomu je toto onemocn\u011bn\u00ed obzvl\u00e1\u0161t\u011b z\u00e1ke\u0159n\u00e9. Srbsk\u00e1 zpr\u00e1va proto vyz\u00fdv\u00e1 k tomu, aby o\u010dkovan\u00ed jedinci \u2013 zejm\u00e9na ti ve vysoce rizikov\u00fdch skupin\u00e1ch \u2013 byli pravideln\u011b testov\u00e1ni na protil\u00e1tky proti \u0161t\u00edtn\u00e9 \u017el\u00e1ze, aby se v\u010das odhalila tich\u00e1 autoimunitn\u00ed reakce.<\/span><\/p>\n

Znepokojiv\u00fd sign\u00e1l \u2013 nikoli ojedin\u011bl\u00fd n\u00e1zor<\/span><\/h3>\n

A\u010dkoli studie dokumentuje pouze dva p\u0159\u00edpady, auto\u0159i uv\u00e1d\u011bj\u00ed \u0159adu podobn\u00fdch pozorov\u00e1n\u00ed ve sv\u00e9m klinick\u00e9m prost\u0159ed\u00ed. Domn\u00edvaj\u00ed se, \u017ee o\u010dkov\u00e1n\u00ed m\u016f\u017ee u n\u011bkter\u00fdch jedinc\u016f \u2013 pravd\u011bpodobn\u011b u t\u011bch s genetickou predispozic\u00ed nebo u t\u011bch, kte\u0159\u00ed jsou nadm\u011brn\u011b stimulov\u00e1ni p\u0159ed\u00e1vkov\u00e1n\u00edm \u2013 vyvolat autoimunitn\u00ed \u0159et\u011bzovou reakci, kter\u00e1 nakonec vede k chronick\u00e9mu onemocn\u011bn\u00ed \u0161t\u00edtn\u00e9 \u017el\u00e1zy.<\/span><\/p>\n

Z\u00e1v\u011br<\/span><\/h3>\n

P\u0159edlo\u017een\u00e9 \u00fadaje neposkytuj\u00ed d\u016fkazy o \u0161irok\u00e9m riziku, ale poskytuj\u00ed z\u00e1va\u017en\u00e9 d\u016fkazy o d\u0159\u00edve nedostate\u010dn\u011b prozkouman\u00e9m vedlej\u0161\u00edm \u00fa\u010dinku vakc\u00edny. V tomto kontextu se v\u00fdzva k systematick\u00e9mu n\u00e1sledn\u00e9mu monitorov\u00e1n\u00ed autoimunitn\u00edch marker\u016f u o\u010dkovan\u00fdch jedinc\u016f jev\u00ed stejn\u011b opr\u00e1vn\u011bn\u00e1 jako debata o \u00faprav\u011b d\u00e1vky a krit\u00e9ri\u00edch pro vylou\u010den\u00ed geneticky zraniteln\u00fdch jedinc\u016f.<\/span><\/p>\n

V o\u010dkovac\u00ed politice, kter\u00e1 se zam\u011b\u0159uje na rychlost a kvantitu, hroz\u00ed, \u017ee tich\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky, jako je Hashimotova choroba, budou p\u0159ehl\u00ed\u017eeny. O to d\u016fle\u017eit\u011bj\u0161\u00ed je d\u00e1t jim hlas ve v\u011bd\u011b a zdravotn\u00ed politice \u2013 d\u0159\u00edve, ne\u017e se tich\u00e9 reakce rozvinou v chronick\u00e1 onemocn\u011bn\u00ed.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/a><\/span><\/h3>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

O\u010dkov\u00e1n\u00ed proti COVID-19 a Hashimotova choroba \u2013 Kdy\u017e imunitn\u00ed syst\u00e9m sel\u017ee Ned\u00e1vn\u00e1 l\u00e9ka\u0159sk\u00e1\u00a0kazuistika\u00a0ze Srbska vyvol\u00e1v\u00e1…<\/p>\n","protected":false},"author":2,"featured_media":15695,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[9261,213,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/80477"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=80477"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/80477\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/15695"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=80477"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=80477"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=80477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}