{"id":80281,"date":"2025-06-03T00:12:56","date_gmt":"2025-06-02T22:12:56","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=80281"},"modified":"2025-06-02T09:48:48","modified_gmt":"2025-06-02T07:48:48","slug":"japonska-kazuistika-autoimunitni-onemocneni-se-vraci-tyden-po-ockovani-proti-covidu","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/06\/03\/japonska-kazuistika-autoimunitni-onemocneni-se-vraci-tyden-po-ockovani-proti-covidu\/","title":{"rendered":"Japonsk\u00e1 kazuistika: Autoimunitn\u00ed onemocn\u011bn\u00ed se vrac\u00ed t\u00fdden po o\u010dkov\u00e1n\u00ed proti COVIDu"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><strong><span>Vakc\u00edna proti COVID-19 od spole\u010dnosti Pfizer vedla k propuknut\u00ed Gravesovy choroby u d\u0159\u00edve stabiln\u00edho pacienta<\/span><\/strong><\/p>\n<p><span>Ned\u00e1vno publikovan\u00e1 japonsk\u00e1 kazuistika p\u0159isp\u00edv\u00e1 k rostouc\u00edmu po\u010dtu zdokumentovan\u00fdch autoimunitn\u00edch reakc\u00ed po o\u010dkov\u00e1n\u00ed proti COVID-19 s mRNA. Studie\u00a0Iwamota a kol. Publikace publikovan\u00e1 v\u00a0<\/span><em><span>\u010dasopise Cureus dramaticky zhor\u0161ila\u00a0<\/span><\/em><em><span>Gravesova choroba<\/span><\/em><span>\u00a0kr\u00e1tce po pod\u00e1n\u00ed prvn\u00ed d\u00e1vky vakc\u00edny Pfizer\/BioNTech (BNT162b2\/Comirnaty) po letech stabilizace onemocn\u011bn\u00ed.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span>Klinick\u00fd pr\u016fb\u011bh<\/span><\/h3>\n<p><span>Pacient trp\u011bl Gravesovou chorobou dev\u011bt let a jeho stav byl dob\u0159e kompenzov\u00e1n thiamazolem (MMI) v d\u00e1vce 2,5 mg\/den. Nicm\u00e9n\u011b t\u00fdden po o\u010dkov\u00e1n\u00ed\u00a0se objevily typick\u00e9 p\u0159\u00edznaky\u00a0<\/span><em><span>tyreotoxik\u00f3zy<\/span><\/em><span>\u00a0: \u00fanava, t\u0159es, du\u0161nost. 14. den se objevil otok nohou a zv\u00fd\u0161en\u00e9 palpitace. Pohotovostn\u00ed vy\u0161et\u0159en\u00ed prok\u00e1zalo v\u00fdrazn\u011b zv\u00fd\u0161en\u00e9 hladiny hormon\u016f \u0161t\u00edtn\u00e9 \u017el\u00e1zy, vysok\u00e9 hladiny protil\u00e1tek TRAb, zv\u011bt\u0161enou \u0161t\u00edtnou \u017el\u00e1zu s hyperperfuz\u00ed a po\u010d\u00ednaj\u00edc\u00ed srde\u010dn\u00ed selh\u00e1n\u00ed.<\/span><\/p>\n<p><span>D\u00edky intenzivn\u00ed terapii MMI a klidov\u00e9mu re\u017eimu na l\u016f\u017eku se stav rychle zlep\u0161il, tak\u017ee pacient mohl b\u00fdt po \u010dty\u0159ech dnech propu\u0161t\u011bn.<\/span><\/p>\n<p><span>D\u016fle\u017eit\u00e9 je, \u017ee neexistovaly \u017e\u00e1dn\u00e9 alternativn\u00ed spou\u0161t\u011b\u010de \u2013 \u017e\u00e1dn\u00e1 infekce, \u017e\u00e1dn\u00e9 kou\u0159en\u00ed, \u017e\u00e1dn\u00e9 nedodr\u017eov\u00e1n\u00ed l\u00e9\u010dby.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span>Mo\u017en\u00e9 imunologick\u00e9 mechanismy<\/span><\/h3>\n<p><span>Auto\u0159i diskutuj\u00ed o t\u0159ech pravd\u011bpodobn\u00fdch p\u0159\u00ed\u010din\u00e1ch vypuknut\u00ed n\u00e1kazy:<\/span><\/p>\n<figure class=\"wp-block-table\">\n<table class=\"has-fixed-layout\">\n<thead>\n<tr>\n<th><span>mechanismus<\/span><\/th>\n<th><span>Popis<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong><span>Molekul\u00e1rn\u00ed mimikry<\/span><\/strong><\/td>\n<td><span>Podobnosti mezi spike proteinem SARS-CoV-2 a antigeny \u0161t\u00edtn\u00e9 \u017el\u00e1zy by mohly spustit autoimunitu<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span>ASIA syndrom<\/span><\/strong><\/td>\n<td><span>I bez klasick\u00fdch adjuvanci\u00ed by lipidov\u00e9 nano\u010d\u00e1stice\/PEG ve vakc\u00edn\u011b mohly vyvolat imunitn\u00ed reakce.<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong><span>Zk\u0159\u00ed\u017een\u00e1 reaktivita<\/span><\/strong><\/td>\n<td><span>P\u0159edchoz\u00ed studie ukazuj\u00ed p\u0159ekr\u00fdv\u00e1n\u00ed mezi virov\u00fdmi proteiny a tyreoid\u00e1ln\u00ed peroxid\u00e1zou<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<h3 class=\"wp-block-heading\"><span>Klasifikace a v\u00fdznam<\/span><\/h3>\n<p><span>Zpr\u00e1va navazuje na p\u0159edchoz\u00ed kazuistiky autoimunitn\u00edch reakc\u00ed spojen\u00fdch s mRNA vakc\u00ednou \u2013 v\u010detn\u011b: tyreoid\u00e1ln\u00ed bou\u0159e, lupusu, hepatitidy a Guillain-Barr\u00e9ova syndromu. P\u0159esto\u017ee takov\u00e9 reakce z\u016fst\u00e1vaj\u00ed extr\u00e9mn\u011b vz\u00e1cn\u00e9, auto\u0159i zd\u016fraz\u0148uj\u00ed pot\u0159ebu c\u00edlen\u00e9 opatrnosti:<\/span><\/p>\n<ul>\n<li><strong><span>V\u010dasn\u00e1 detekce u pacient\u016f s anamn\u00e9zou autoimunitn\u00edho onemocn\u011bn\u00ed<\/span><\/strong><\/li>\n<li><strong><span>Individu\u00e1ln\u00ed posouzen\u00ed rizika p\u0159ed o\u010dkov\u00e1n\u00edm<\/span><\/strong><\/li>\n<li><strong><span>Prospektivn\u00ed studie k identifikaci predisponuj\u00edc\u00edch faktor\u016f<\/span><\/strong><\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\"><span>Z\u00e1v\u011br<\/span><\/h3>\n<p><span>Auto\u0159i\u00a0<\/span><strong><span>nezpochyb\u0148uj\u00ed<\/span><\/strong><span>\u00a0obecnou bezpe\u010dnost ani \u00fa\u010dinnost mRNA vakc\u00edn. Volaj\u00ed v\u0161ak po v\u011bt\u0161\u00ed pozornosti, personalizovan\u00fdch rozhodnut\u00edch o o\u010dkov\u00e1n\u00ed a klinick\u00e9 bd\u011blosti v\u016f\u010di rizikov\u00fdm skupin\u00e1m. Kazuistiky, jako je tato, poskytuj\u00ed cenn\u00e9 poznatky pro praxi a v\u00fdzkum, jeliko\u017e technologie mRNA se nad\u00e1le \u0161\u00ed\u0159\u00ed po cel\u00e9m sv\u011bt\u011b.<\/span><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.trialsitenews.com\/a\/pfizer-covid-19-vaccine-linked-to-flare-of-graves-disease-in-previously-stable-patient-e8d2511b\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Vakc\u00edna proti COVID-19 od spole\u010dnosti Pfizer vedla k propuknut\u00ed Gravesovy choroby u d\u0159\u00edve stabiln\u00edho pacienta&#8230;<\/p>\n","protected":false},"author":2,"featured_media":55670,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[105,694,213,651,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/80281"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=80281"}],"version-history":[{"count":1,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/80281\/revisions"}],"predecessor-version":[{"id":80282,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/80281\/revisions\/80282"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/55670"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=80281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=80281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=80281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}