{"id":78063,"date":"2025-05-06T00:18:59","date_gmt":"2025-05-05T22:18:59","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=78063"},"modified":"2025-05-05T13:22:47","modified_gmt":"2025-05-05T11:22:47","slug":"vybusna-studie-ockovane-tehotne-zeny-v-ranych-stadiich-tehotenstvi-jsou-18krat-nachylnejsi-k-potratu","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/05\/06\/vybusna-studie-ockovane-tehotne-zeny-v-ranych-stadiich-tehotenstvi-jsou-18krat-nachylnejsi-k-potratu\/","title":{"rendered":"V\u00fdbu\u0161n\u00e1 studie: O\u010dkovan\u00e9 t\u011bhotn\u00e9 \u017eeny v ran\u00fdch st\u00e1di\u00edch t\u011bhotenstv\u00ed jsou 18kr\u00e1t n\u00e1chyln\u011bj\u0161\u00ed k potratu"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><strong>\u0160pan\u011blsk\u00e1 studie porovn\u00e1v\u00e1 pr\u016fb\u011bhy COVID-19 u o\u010dkovan\u00fdch a neo\u010dkovan\u00fdch t\u011bhotn\u00fdch \u017een \u2013 sign\u00e1l zv\u00fd\u0161en\u00e9ho rizika potratu<\/strong><\/p>\n<p>Nov\u00e1 recenzovan\u00e1\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1186\/s12884-025-07630-z\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/link.springer.com\/article\/10.1186\/s12884-025-07630-z\">studie<\/a>\u00a0veden\u00e1 Dr. Noeli\u00ed Rodr\u00edguez-Blanco a Dr. Jes\u00fasem S\u00e1nchezem-M\u00e1sem a dal\u0161\u00edmi v\u00fdzkumn\u00edky ze \u0160pan\u011blska poskytuje d\u016fle\u017eit\u00e9 srovn\u00e1vac\u00ed \u00fadaje o mate\u0159sk\u00fdch a neonat\u00e1ln\u00edch v\u00fdsledc\u00edch u o\u010dkovan\u00fdch a neo\u010dkovan\u00fdch t\u011bhotn\u00fdch \u017een s infekc\u00ed SARS-CoV-2. Retrospektivn\u00ed kohortov\u00e1 anal\u00fdza byla publikov\u00e1na v \u010dasopise\u00a0<em>BMC Pregnancy and Childbirth<\/em>\u00a0dne 30. dubna 2025 . Vyvol\u00e1v\u00e1 to kl\u00ed\u010dov\u00e9 ot\u00e1zky ve\u0159ejn\u00e9ho zdrav\u00ed a poukazuje na potenci\u00e1ln\u00ed bezpe\u010dnostn\u00ed sign\u00e1l, kter\u00fd nal\u00e9hav\u011b vy\u017eaduje dal\u0161\u00ed zkoum\u00e1n\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Design a metodologie studie<\/h3>\n<p>Byla analyzov\u00e1na data 156 t\u011bhotn\u00fdch \u017een pozitivn\u00edch na virus SARS-CoV-2, kter\u00e9 byly l\u00e9\u010deny ve dvou ve\u0159ejn\u00fdch nemocnic\u00edch ve Valencijsk\u00e9 komunit\u011b v letech 2020 a\u017e 2022. Z nich 45 \u017een (28,8 %) dostalo p\u0159ed infekc\u00ed alespo\u0148 jednu d\u00e1vku vakc\u00edny proti COVID-19, zejm\u00e9na od spole\u010dnost\u00ed Pfizer-BioNTech (67 %) nebo Moderna (24 %). V\u00fdzkumn\u00edci k zaznamen\u00e1v\u00e1n\u00ed symptom\u016f a v\u00fdsledk\u016f vyu\u017eili klinick\u00e9 z\u00e1znamy pacient\u016f, registry o\u010dkov\u00e1n\u00ed a syst\u00e9my epidemiologick\u00e9ho sledov\u00e1n\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Kl\u00ed\u010dov\u00e9 v\u00fdsledky<\/h3>\n<ul>\n<li><strong>M\u00edrn\u011bj\u0161\u00ed p\u0159\u00edznaky u o\u010dkovan\u00fdch osob<\/strong>\u00a0: O\u010dkovan\u00e9 \u017eeny trp\u011bly v\u00fdrazn\u011b m\u00e9n\u011b bolestmi hlavy a zvracen\u00edm (pom\u011br rizik R = 1,38 v ka\u017ed\u00e9m p\u0159\u00edpad\u011b). U \u017e\u00e1dn\u00e9 z nich se neprok\u00e1zal z\u00e1pal plic, zat\u00edmco p\u011bt neo\u010dkovan\u00fdch \u017een onemocn\u011blo \u2013 dv\u011b z nich musely b\u00fdt p\u0159ijaty na jednotku intenzivn\u00ed p\u00e9\u010de.<\/li>\n<li><strong>Ochrana z\u00e1visl\u00e1 na d\u00e1vce<\/strong>\u00a0: \u017deny, kter\u00e9 dostaly dv\u011b nebo v\u00edce d\u00e1vek vakc\u00edny, hl\u00e1sily m\u00e9n\u011b p\u0159\u00edznak\u016f ne\u017e ty, kter\u00e9 dostaly pouze jednu d\u00e1vku.<\/li>\n<li><strong>Srovnateln\u00e9 novorozeneck\u00e9 v\u00fdsledky<\/strong>\u00a0: Apgar sk\u00f3re a frekvence pobyt\u016f novorozenc\u016f na jednotce intenzivn\u00ed p\u00e9\u010de se mezi skupinami neli\u0161ily.<\/li>\n<li><strong>\u017d\u00e1dn\u00fd n\u00e1r\u016fst porodnick\u00fdch komplikac\u00ed<\/strong>\u00a0: Celkov\u011b nedo\u0161lo k \u017e\u00e1dn\u00e9mu n\u00e1r\u016fstu porodnick\u00fdch komplikac\u00ed u o\u010dkovan\u00fdch \u017een.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">Znepokojiv\u00fd sign\u00e1l: riziko potratu v ran\u00e9m t\u011bhotenstv\u00ed<\/h3>\n<p>Navzdory celkov\u011b pozitivn\u00edm v\u00fdsledk\u016fm t\u00fdkaj\u00edc\u00edm se ochrann\u00e9ho \u00fa\u010dinku o\u010dkov\u00e1n\u00ed studie uv\u00e1d\u00ed p\u0159ekvapiv\u00e9 zji\u0161t\u011bn\u00ed: u o\u010dkovan\u00fdch \u017een, kter\u00e9 se nakazily v prvn\u00edm nebo druh\u00e9m trimestru t\u011bhotenstv\u00ed, do\u0161lo k p\u011bti potrat\u016fm (10,4 %). Ve t\u0159et\u00edm trimestru byl zdokumentov\u00e1n pouze jeden p\u0159\u00edpad (2,7 %). To m\u00e1 za n\u00e1sledek v\u00fdznamn\u011b zv\u00fd\u0161en\u00e9 riziko potratu (R = 18,5; 95% interval spolehlivosti: 2,38\u2013144,2; p &lt; 0,001). A\u010dkoli tyto \u00fadaje vych\u00e1zej\u00ed z mal\u00e9ho vzorku, nazna\u010duj\u00ed potenci\u00e1ln\u011b kritickou souvislost, kter\u00e1 by m\u011bla b\u00fdt zkoum\u00e1na ve v\u011bt\u0161\u00edch prospektivn\u00edch studi\u00edch.<\/p>\n<p>Naproti tomu u neo\u010dkovan\u00fdch \u017een nebyl mezi trimestry zji\u0161t\u011bn \u017e\u00e1dn\u00fd v\u00fdznamn\u00fd rozd\u00edl v riziku potratu. Kauzalita nebyla proklamov\u00e1na \u2013 ale zejm\u00e9na na pozad\u00ed proo\u010dkovac\u00edho r\u00e1mce studie je statistick\u00fd sign\u00e1l pozoruhodn\u00fd a vy\u017eaduje diferencovanou anal\u00fdzu bezpe\u010dnosti specifickou pro dan\u00fd trimestr.<\/p>\n<h3 class=\"wp-block-heading\">Omezen\u00ed studie<\/h3>\n<ul>\n<li><strong>Mal\u00e1 skupina o\u010dkovan\u00fdch osob (n = 45)<\/strong>\u00a0: To sni\u017euje v\u00fdznamnost, zejm\u00e9na u vz\u00e1cn\u00fdch ud\u00e1lost\u00ed, jako jsou potraty nebo l\u00e9\u010dba na jednotk\u00e1ch intenzivn\u00ed p\u00e9\u010de.<\/li>\n<li><strong>Design retrospektivn\u00ed studie<\/strong>\u00a0: Kauz\u00e1ln\u00ed vztahy je obt\u00ed\u017en\u00e9 odvodit; Krom\u011b toho jsou mo\u017en\u00e9 nepozorovan\u00e9 matouc\u00ed faktory.<\/li>\n<li><strong>Ne\u00fapln\u00e1 data<\/strong>\u00a0: V n\u011bkter\u00fdch p\u0159\u00edpadech chyb\u011bly informace o relevantn\u00edch prom\u011bnn\u00fdch, jako je pH pupe\u010dn\u00ed \u0161\u0148\u016fry nebo virov\u00e1 n\u00e1lo\u017e.<\/li>\n<li><strong>Bez rozli\u0161en\u00ed variant<\/strong>\u00a0: Studie zahrnuje n\u011bkolik vln COVID-19 bez rozli\u0161en\u00ed mezi variantami SARS-CoV-2.<\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">D\u016fsledky<\/h3>\n<p>V\u00fdzkumn\u00edci zd\u016fraz\u0148uj\u00ed, \u017ee o\u010dkov\u00e1n\u00ed mRNA proti COVID-19 z\u0159ejm\u011b \u00fa\u010dinn\u011b chr\u00e1n\u00ed t\u011bhotn\u00e9 \u017eeny p\u0159ed z\u00e1va\u017en\u00fdm pr\u016fb\u011bhem onemocn\u011bn\u00ed, jako je z\u00e1pal plic.<\/p>\n<p>P\u0159ekvapiv\u011b vysok\u00e9 riziko potratu v \u010dasn\u00e9m t\u011bhotenstv\u00ed u o\u010dkovan\u00fdch \u017een v\u0161ak nelze ignorovat \u2013 i p\u0159es omezen\u00fd po\u010det \u2013 a m\u011blo by b\u00fdt d\u00e1le intenzivn\u011b zkoum\u00e1no.<\/p>\n<p>Zdravotnick\u00e9 org\u00e1ny, kter\u00e9 se zasazuj\u00ed o o\u010dkov\u00e1n\u00ed b\u011bhem t\u011bhotenstv\u00ed, by m\u011bly uznat existuj\u00edc\u00ed mezery v datech a ve\u0159ejn\u011b financovat rozs\u00e1hl\u00e9 studie bezpe\u010dnosti specifick\u00e9 pro dan\u00fd trimestr. Vzhledem k klesaj\u00edc\u00ed proo\u010dkovanosti a nov\u00fdm variant\u00e1m viru je kontinu\u00e1ln\u00ed dlouhodob\u00e9 sledov\u00e1n\u00ed mate\u0159sk\u00fdch a fet\u00e1ln\u00edch v\u00fdsledk\u016f nal\u00e9hav\u011bj\u0161\u00ed ne\u017e kdy jindy.<\/p>\n<h3 class=\"wp-block-heading\">Koment\u00e1\u0159 od TrialSite<\/h3>\n<p>Jak ji\u017e d\u0159\u00edve informoval TrialSite, americk\u00fd \u00da\u0159ad pro kontrolu potravin a l\u00e9\u010div (FDA) st\u00e1le nezahrnul do ofici\u00e1ln\u00edch p\u0159\u00edbalov\u00fdch let\u00e1k\u016f informace o dlouhodob\u00e9 bezpe\u010dnosti vakc\u00edn s mRNA proti COVID-19 \u2013 co\u017e je po \u010dty\u0159ech letech o\u010dkovac\u00ed kampan\u011b znepokojiv\u00fd fakt. Skute\u010dnost, \u017ee SARS-CoV-2 je nyn\u00ed m\u00edrn\u011bj\u0161\u00ed a rizika pro t\u011bhotn\u00e9 \u017eeny, koj\u00edc\u00ed \u017eeny a d\u011bti st\u00e1le nejsou pln\u011b pochopena, vyvol\u00e1v\u00e1 z\u00e1sadn\u00ed ot\u00e1zky ohledn\u011b posouzen\u00ed rizik a p\u0159\u00ednos\u016f.<\/p>\n<h3 class=\"wp-block-heading\">Vedouc\u00ed studie \/ Auto\u0159i<\/h3>\n<ul>\n<li><strong>Noelia Rodr\u00edguez-Blanco<\/strong>\u00a0\u2013 Fakulta zdravotnick\u00fdch v\u011bd, University Europea de Valencia, V\u00fdzkumn\u00e1 skupina pro kvalitu \u017eivota a zdrav\u00ed, Elche<\/li>\n<li><strong>Jes\u00fas S\u00e1nchez-M\u00e1s<\/strong>\u00a0\u2013 Fakulta zdravotnick\u00fdch v\u011bd, Universidad CEU Cardenal-Herrera, Elche (odpov\u00eddaj\u00edc\u00ed autor)<\/li>\n<li><strong>Estela Gimenez Herrero<\/strong>\u00a0\u2013 Gynekologicko-porodnick\u00e9 odd\u011blen\u00ed, Hospital de Manises, Valencia<\/li>\n<li><strong>Paloma Calvo Moreno<\/strong>\u00a0\u2013 Gynekologicko-porodnick\u00e9 odd\u011blen\u00ed, Nemocnice Universitario La Paz, Madrid<\/li>\n<li><strong>Macarena Mateo Gonzalez-Rom\u00e1n<\/strong>\u00a0\u2013 Gynekologicko-porodnick\u00e9 odd\u011blen\u00ed, Nemocnice Universitario 12 de Octubre, Madrid<\/li>\n<li><strong>Jos\u00e9 Luis Duro-Torrijos<\/strong>\u00a0\u2013 v\u00fdukov\u00e9 odd\u011blen\u00ed, Hospital Universitario del Vinalopo, Elche<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.trialsitenews.com\/a\/spanish-study-compares-covid-19-outcomes-in-vaccinated-vs.-unvaccinated-pregnant-womentroubling-miscarriage-signal-6f7897fb\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u0160pan\u011blsk\u00e1 studie porovn\u00e1v\u00e1 pr\u016fb\u011bhy COVID-19 u o\u010dkovan\u00fdch a neo\u010dkovan\u00fdch t\u011bhotn\u00fdch \u017een \u2013 sign\u00e1l zv\u00fd\u0161en\u00e9ho rizika&#8230;<\/p>\n","protected":false},"author":2,"featured_media":35283,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[188,839,2317,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/78063"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=78063"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/78063\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/35283"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=78063"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=78063"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=78063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}