{"id":77372,"date":"2025-04-27T00:11:31","date_gmt":"2025-04-26T22:11:31","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=77372"},"modified":"2025-04-26T11:04:43","modified_gmt":"2025-04-26T09:04:43","slug":"po-miliardach-ockovani-nova-studie-na-zviratech-nyni-dokazuje-mrna-je-distribuovana-systemove-do-zivotne-dulezitych-organu","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/04\/27\/po-miliardach-ockovani-nova-studie-na-zviratech-nyni-dokazuje-mrna-je-distribuovana-systemove-do-zivotne-dulezitych-organu\/","title":{"rendered":"Po miliard\u00e1ch o\u010dkov\u00e1n\u00ed: Nov\u00e1 studie na zv\u00ed\u0159atech nyn\u00ed dokazuje \u2013 mRNA je distribuov\u00e1na syst\u00e9mov\u011b do \u017eivotn\u011b d\u016fle\u017eit\u00fdch org\u00e1n\u016f"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<h3><span>To, co m\u011blo b\u00fdt zn\u00e1mo p\u0159ed za\u010d\u00e1tkem celosv\u011btov\u00e9 o\u010dkovac\u00ed kampan\u011b, bylo zve\u0159ejn\u011bno a\u017e nyn\u00ed<\/span><\/h3>\n<p><span>T\u00e9m\u011b\u0159 p\u011bt let po zah\u00e1jen\u00ed celosv\u011btov\u00e9ho hromadn\u00e9ho o\u010dkov\u00e1n\u00ed proti COVID-19 byla nyn\u00ed zve\u0159ejn\u011bna\u00a0<\/span><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.04.21.649878v1.full.pdf\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.04.21.649878v1.full.pdf\"><span>studie<\/span><\/a><span>\u00a0, kter\u00e1 m\u011bla b\u00fdt podle l\u00e9ka\u0159sk\u00fdch standard\u016f\u00a0provedena\u00a0<\/span><strong><span>d\u00e1vno p\u0159ed jej\u00edm pou\u017eit\u00edm u lid\u00ed<\/span><\/strong><span>\u00a0. V\u00fdbu\u0161n\u00e9 v\u00fdsledky\u00a0studie na zv\u00ed\u0159atech zve\u0159ejn\u011bn\u00e9 na\u00a0<\/span><em><span>bioRxiv ukazuj\u00ed, \u017ee\u00a0<\/span><\/em><strong><span>mRNA lipidov\u00e9 nano\u010d\u00e1stice (LNP)<\/span><\/strong><span>\u00a0z vakc\u00edn Moderna a Pfizer\u00a0<\/span><strong><span>syst\u00e9mov\u011b vstupuj\u00ed do krevn\u00edho \u0159e\u010di\u0161t\u011b<\/span><\/strong><span>\u00a0a\u00a0<\/span><strong><span>ukl\u00e1daj\u00ed se v \u017eivotn\u011b d\u016fle\u017eit\u00fdch org\u00e1nech, jako jsou j\u00e1tra a pl\u00edce.<\/span><\/strong><\/p>\n<p><span>Studie\u00a0<\/span><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.04.21.649878v1\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.04.21.649878v1\"><span>se<\/span><\/a><span>\u00a0jmenuje:<\/span><\/p>\n<p><em><strong>&#8222;Syst\u00e9mov\u00fd obchod s mRNA lipidovou nano\u010d\u00e1sticovou vakc\u00ednou po intramuskul\u00e1rn\u00ed injekci vytv\u00e1\u0159\u00ed silnou tk\u00e1\u0148ov\u011b specifickou T bun\u011b\u010dnou odpov\u011b\u010f&#8220;<\/strong><\/em><\/p>\n<h3 class=\"wp-block-heading\"><span>N\u00e1lez: akumulace org\u00e1n\u016f m\u00edsto lok\u00e1ln\u00edho \u00fa\u010dinku<\/span><\/h3>\n<p><span>P\u016fvodn\u011b se \u0159\u00edkalo, \u017ee mRNA vakc\u00edny budou p\u016fsobit \u201elok\u00e1ln\u011b v m\u00edst\u011b vpichu\u201c a rychle se rozlo\u017e\u00ed. Nov\u00e1 studie na zv\u00ed\u0159atech tento p\u0159\u00edb\u011bh jasn\u011b vyvrac\u00ed:<\/span><\/p>\n<ul>\n<li><strong><span>V\u0161echny testovan\u00e9 p\u0159\u00edpravky LNP (Moderna, Pfizer, kontrola)<\/span><\/strong><span>\u00a0vstoupily\u00a0<\/span><strong><span>do syst\u00e9mov\u00e9 cirkulace<\/span><\/strong><span>\u00a0.<\/span><\/li>\n<li><strong><span>Formulace Pfizer (PBT)<\/span><\/strong><span>\u00a0vykazovala\u00a0<\/span><strong><span>nejvy\u0161\u0161\u00ed akumulaci v j\u00e1trech<\/span><\/strong><span>\u00a0:\u00a0<\/span><em><span>\u201eSedm dn\u00ed po injekci bylo transfekov\u00e1no 39,3 % jatern\u00edch bun\u011bk \u2013 u Moderna (MDN) pouze 5,4 %.<\/span><\/em><\/li>\n<li><strong><span>Vzorec Moderna (MDN)<\/span><\/strong><span>\u00a0na druh\u00e9 stran\u011b vedl ke\u00a0<\/span><strong><span>zv\u00fd\u0161en\u00e9 expresi v plic\u00edch<\/span><\/strong><span>\u00a0.<\/span><\/li>\n<li><span>T\u0159et\u00ed kontroln\u00ed p\u0159\u00edpravek (DI-8) nevykazoval\u00a0<\/span><strong><span>\u017e\u00e1dnou syst\u00e9movou distribuci<\/span><\/strong><span>\u00a0, ale z\u016fstal lok\u00e1ln\u00ed \u2013 co\u017e jasn\u011b ukazuje, \u017ee\u00a0<\/span><strong><span>syst\u00e9mov\u00e1 distribuce nen\u00ed n\u00e1hoda, ale d\u016fsledek specifick\u00e9ho slo\u017een\u00ed LNP.<\/span><\/strong><\/li>\n<\/ul>\n<p><em><span>&#8222;Navzdory rozd\u00edl\u016fm v \u00faniku, jakmile LNP vstoupily do krevn\u00edho \u0159e\u010di\u0161t\u011b, vykazovaly srovnateln\u00e9 vzorce biodistribuce v hlavn\u00edch org\u00e1nech.&#8220;<\/span><\/em><\/p>\n<h3 class=\"wp-block-heading\"><span>Co to znamen\u00e1?<\/span><\/h3>\n<p><span>Lipidov\u00fd\u00a0<\/span><strong><span>obal (LNP)<\/span><\/strong><span>\u00a0nen\u00ed jen transportn\u00edm prost\u0159edkem \u2013\u00a0<\/span><strong><span>aktivn\u011b ur\u010duje, kde se v t\u011ble exprimuje mRNA<\/span><\/strong><span>\u00a0. Studovan\u00e9 formulace (v\u010detn\u011b t\u011bch, kter\u00e9\u00a0se pou\u017e\u00edvaj\u00ed v\u00a0<\/span><strong><span>mRNA vakc\u00edn\u00e1ch od Moderna a Pfizer schv\u00e1len\u00fdch FDA )\u00a0<\/span><\/strong><strong><span>specificky transfekuj\u00ed org\u00e1nov\u00e9 bu\u0148ky<\/span><\/strong><span>\u00a0\u2013 nap\u0159. B. Hepatocyty v j\u00e1trech nebo pneumocyty v plic\u00edch.<\/span><\/p>\n<p><span>Je\u0161t\u011b kriti\u010dt\u011bj\u0161\u00ed:\u00a0<\/span><strong><span>Imunitn\u00ed odpov\u011b\u010f<\/span><\/strong><span>\u00a0se spou\u0161t\u00ed\u00a0<\/span><strong><span>nejen ve svalu<\/span><\/strong><span>\u00a0, ale tak\u00e9\u00a0<\/span><strong><span>v samotn\u00fdch posti\u017een\u00fdch org\u00e1nech<\/span><\/strong><span>\u00a0\u2013 v\u010detn\u011b\u00a0<\/span><strong><span>aktivace CD8+ T bun\u011bk<\/span><\/strong><span>\u00a0, tedy cytotoxick\u00fdch reakc\u00ed proti t\u011blu vlastn\u00edm bu\u0148k\u00e1m, kter\u00e9 exprimuj\u00ed spike protein.<\/span><\/p>\n<p><em><span>&#8222;Nicm\u00e9n\u011b terapeutick\u00e9 d\u016fsledky transportu LNP a ne\u00famysln\u00e9 exprese v nelymfatick\u00fdch org\u00e1nech jsou st\u00e1le \u0161patn\u011b pochopeny.&#8220;<\/span><\/em><\/p>\n<h3 class=\"wp-block-heading\"><span>Pro\u010d je to vysoce problematick\u00e9?<\/span><\/h3>\n<ol class=\"wp-block-list\">\n<li><strong><span>Org\u00e1nov\u011b specifick\u00e9 imunitn\u00ed reakce<\/span><\/strong><span>\u00a0vyvolan\u00e9 mRNA vakc\u00ednami\u00a0<\/span><strong><span>nebyly nikdy systematicky studov\u00e1ny,<\/span><\/strong><span>\u00a0dokud vakc\u00edny nedostaly miliardy lid\u00ed.<\/span><\/li>\n<li><span>Nyn\u00ed bylo prok\u00e1z\u00e1no, \u017ee n\u011bkter\u00e9 LNP\u00a0<\/span><strong><span>specificky transfekuj\u00ed org\u00e1nov\u00e9 bu\u0148ky<\/span><\/strong><span>\u00a0\u2013 s potenci\u00e1ln\u00edmi riziky pro j\u00e1tra, pl\u00edce, srdce a dal\u0161\u00ed tk\u00e1n\u011b.<\/span><\/li>\n<li><span>Studie ukazuje, \u017ee zm\u011bna zp\u016fsobu\u00a0<\/span><strong><span>pod\u00e1n\u00ed (iv m\u00edsto im)\u00a0<\/span><\/strong><strong><span>drasticky m\u011bn\u00ed<\/span><\/strong><span>\u00a0\u00fa\u010dinek a distribuci \u010d\u00e1stic\u00a0\u2013 co\u017e je aspekt, kter\u00fd v praxi \u010dasto z\u016fst\u00e1v\u00e1 nepov\u0161imnut.<\/span><\/li>\n<li><span>Zji\u0161t\u011bn\u00ed\u00a0<\/span><strong><span>jsou v rozporu s \u00fast\u0159edn\u00edmi tvrzen\u00edmi<\/span><\/strong><span>\u00a0v\u00fdrobc\u016f, \u00fa\u0159ad\u016f a m\u00e9di\u00ed \u2013 zejm\u00e9na ohledn\u011b lokalizace mRNA v t\u011ble.<\/span><\/li>\n<\/ol>\n<h3 class=\"wp-block-heading\"><span>Opo\u017ed\u011bn\u00fd pohled do \u010dern\u00e9 sk\u0159\u00ed\u0148ky<\/span><\/h3>\n<p><span>Skute\u010dnost, \u017ee tato studie\u00a0<\/span><strong><span>vych\u00e1z\u00ed a\u017e nyn\u00ed \u2013 v dubnu 2025<\/span><\/strong><span>\u00a0\u2013 vyvol\u00e1v\u00e1 ot\u00e1zky. Pro\u010d\u00a0<\/span><strong><span>na za\u010d\u00e1tku schvalov\u00e1n\u00ed vakc\u00edny<\/span><\/strong><span>\u00a0neprob\u011bhlo \u017e\u00e1dn\u00e9 ve\u0159ejn\u00e9 a transparentn\u00ed vy\u0161et\u0159ov\u00e1n\u00ed :<\/span><\/p>\n<ul>\n<li><span>Kde p\u0159esn\u011b \u010d\u00e1stice dopadnou?<\/span><\/li>\n<li><span>Jak dlouho z\u016fst\u00e1vaj\u00ed v org\u00e1nech?<\/span><\/li>\n<li><span>Jak\u00e9 jsou d\u016fsledky lok\u00e1ln\u00ed exprese pro imunitn\u00ed reakce a integritu tk\u00e1n\u011b?<\/span><\/li>\n<\/ul>\n<p><span>Faktem je: Sou\u010dasn\u00e1 publikace dokumentuje procesy, kter\u00e9 \u2013 kdyby si jich v\u0161imli v\u010das \u2013\u00a0<\/span><strong><span>by masivn\u011b zm\u011bnily debatu o p\u0159ij\u00edmac\u00edm \u0159\u00edzen\u00ed<\/span><\/strong><span>\u00a0.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span>Z\u00e1v\u011br: Co se nikdy nem\u011blo st\u00e1t, se stalo skute\u010dnost\u00ed<\/span><\/h3>\n<p><span>Studie na zv\u00ed\u0159atech potvrzuje to, co kritick\u00ed v\u011bdci p\u0159edpokl\u00e1dali u\u017e l\u00e9ta:<\/span><\/p>\n<p><strong><span>mRNA LNP vakc\u00edny nejsou aktivn\u00ed lok\u00e1ln\u011b, ale syst\u00e9mov\u011b \u2013 s mo\u017en\u00fdm zapojen\u00edm jater, plic a dal\u0161\u00edch org\u00e1n\u016f do imunitn\u00ed odpov\u011bdi.<\/span><\/strong><\/p>\n<p><span>A: Tento v\u00fdzkum m\u011bl b\u00fdt zve\u0159ejn\u011bn\u00a0<\/span><strong><span>ne po, ale p\u0159ed zah\u00e1jen\u00edm<\/span><\/strong><span>\u00a0glob\u00e1ln\u00ed, prob\u00edhaj\u00edc\u00ed lidsk\u00e9 studie zahrnuj\u00edc\u00ed miliardy \u00fa\u010dastn\u00edk\u016f.<\/span><\/p>\n<p><strong><span>P\u016fvodn\u00ed studie (bioRxiv, 24. dubna 2025):<\/span><\/strong><br \/>\n<a href=\"https:\/\/doi.org\/10.1101\/2025.04.21.649878\" target=\"_blank\" rel=\"noreferrer noopener\"><span>Syst\u00e9mov\u00fd obchod s vakc\u00ednou mRNA LNP\u2026 (DOI: 10.1101\/2025.04.21.649878)<\/span><\/a><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.04.21.649878v1\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>To, co m\u011blo b\u00fdt zn\u00e1mo p\u0159ed za\u010d\u00e1tkem celosv\u011btov\u00e9 o\u010dkovac\u00ed kampan\u011b, bylo zve\u0159ejn\u011bno a\u017e nyn\u00ed T\u00e9m\u011b\u0159&#8230;<\/p>\n","protected":false},"author":2,"featured_media":55670,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[694,213,651,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/77372"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=77372"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/77372\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/55670"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=77372"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=77372"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=77372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}