{"id":76657,"date":"2025-04-18T00:20:52","date_gmt":"2025-04-17T22:20:52","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=76657"},"modified":"2025-04-17T13:17:50","modified_gmt":"2025-04-17T11:17:50","slug":"studie-covid-mrna-boostery-vypinaji-imunitni-obranu-a-zkracuji-dobu-preziti-na-polovinu-u-rakoviny-slinivky","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/04\/18\/studie-covid-mrna-boostery-vypinaji-imunitni-obranu-a-zkracuji-dobu-preziti-na-polovinu-u-rakoviny-slinivky\/","title":{"rendered":"Studie: COVID mRNA boostery vyp\u00ednaj\u00ed imunitn\u00ed obranu a zkracuj\u00ed dobu p\u0159e\u017eit\u00ed na polovinu u rakoviny slinivky"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><span>Nov\u00e1\u00a0<\/span><a href=\"https:\/\/www.preprints.org\/manuscript\/202504.1167\/v1\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.preprints.org\/manuscript\/202504.1167\/v1\"><span>studie<\/span><\/a><span>\u00a0z Japonska s 272 pacienty s rakovinou slinivky ukazuje:\u00a0<\/span><strong><span>T\u0159i nebo v\u00edce o\u010dkov\u00e1n\u00ed mRNA COVID-19<\/span><\/strong><span>\u00a0je spojeno s\u00a0<\/span><strong><span>50% sn\u00ed\u017een\u00edm p\u0159e\u017eit\u00ed<\/span><\/strong><span>\u00a0a\u00a0<\/span><strong><span>masivn\u00ed dysregulac\u00ed imunitn\u00edho syst\u00e9mu<\/span><\/strong><span>\u00a0. Zd\u00e1 se, \u017ee boostery potla\u010duj\u00ed protin\u00e1dorovou obranu prost\u0159ednictv\u00edm indukovan\u00e9ho\u00a0<\/span><strong><span>p\u0159esmyku t\u0159\u00eddy IgG4<\/span><\/strong><span>\u00a0.<\/span><\/p>\n<div class=\"twitter-tweet twitter-tweet-rendered\"><iframe id=\"twitter-widget-0\" class=\"\" title=\"P\u0159\u00edsp\u011bvek X\" src=\"https:\/\/platform.twitter.com\/embed\/Tweet.html?dnt=false&amp;embedId=twitter-widget-0&amp;features=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%3D%3D&amp;frame=false&amp;hideCard=false&amp;hideThread=false&amp;id=1912304881399922879&amp;lang=de&amp;origin=https%3A%2F%2Funcutnews.ch%2Fstudie-covid-mrna-booster-schalten-immunabwehr-ab-und-halbieren-ueberlebenszeit-bei-bauchspeicheldruesenkrebs%2F&amp;sessionId=7d49c45e8dc7d4cfb006cf8bd8a7dd96eabaf2c4&amp;theme=light&amp;widgetsVersion=2615f7e52b7e0%3A1702314776716&amp;width=550px\" frameborder=\"0\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\" data-tweet-id=\"1912304881399922879\" data-mce-fragment=\"1\"><\/iframe><\/div>\n<h3 class=\"wp-block-heading\"><span>Pozad\u00ed<\/span><\/h3>\n<p><span>Studie s n\u00e1zvem\u00a0<\/span><strong><span>\u201eOpakovan\u00e9 o\u010dkov\u00e1n\u00ed proti COVID-19 jako \u0161patn\u00fd prognostick\u00fd faktor u rakoviny slinivky b\u0159i\u0161n\u00ed\u201c byla zve\u0159ejn\u011bna na\u00a0<\/span><\/strong><em><span>Preprints.org<\/span><\/em><span>\u00a0dne 16. dubna 2025\u00a0. Zkoum\u00e1, jak opakovan\u00e9 o\u010dkov\u00e1n\u00ed mRNA ovliv\u0148uje progn\u00f3zu rakoviny slinivky a zda\u00a0se na n\u00ed pod\u00edl\u00ed zv\u00fd\u0161en\u00ed imunosupresivn\u00ed protil\u00e1tky\u00a0<\/span><strong><span>IgG4 .<\/span><\/strong><\/p>\n<h3 class=\"wp-block-heading\"><span>Kl\u00ed\u010dov\u00e9 v\u00fdsledky<\/span><\/h3>\n<ul>\n<li><strong><span>P\u0159e\u017eit\u00ed polovi\u010dn\u00ed:<\/span><\/strong><br \/>\n<span>Pacienti s d\u00e1vkami \u22653 mRNA \u017eili medi\u00e1n pouze\u00a0<\/span><strong><span>10,3 m\u011bs\u00edce<\/span><\/strong><span>\u00a0, zat\u00edmco pacienti s 0\u20132 d\u00e1vkami\u00a0p\u0159e\u017eili\u00a0<\/span><strong><span>20,8 m\u011bs\u00edce (\u00a0<\/span><\/strong><em><span>p<\/span><\/em><span>\u00a0&lt; 0,001).<\/span><\/li>\n<li><strong><span>Zv\u00fd\u0161en\u00ed IgG4:<\/span><\/strong><br \/>\n<span>S po\u010dtem vakcinac\u00ed se\u00a0<\/span><strong><span>celkov\u00e9 hladiny IgG4<\/span><\/strong><span>\u00a0zv\u00fd\u0161ily . Pacienti s vysokou hladinou IgG4 m\u011bli v\u00fdznamn\u011b hor\u0161\u00ed progn\u00f3zu (\u00a0<\/span><em><span>p<\/span><\/em><span>\u00a0= 0,042).<\/span><\/li>\n<li><strong><span>Imunitn\u00ed tolerance v n\u00e1doru:<\/span><\/strong><br \/>\n<span>O\u010dkovan\u00ed jedinci vykazovali v\u00edce\u00a0<\/span><strong><span>Foxp3-pozitivn\u00edch Tregs<\/span><\/strong><span>\u00a0v n\u00e1dorov\u00e9 tk\u00e1ni \u2013 indikace potla\u010den\u00e9 imunitn\u00ed obrany proti rakovin\u011b.<\/span><\/li>\n<li><strong><span>Booster jako rizikov\u00fd faktor:<\/span><\/strong><br \/>\n<span>V multivaria\u010dn\u00ed anal\u00fdze byla \u22653 vakcinace\u00a0<\/span><strong><span>nez\u00e1visl\u00fdm prediktorem \u010dasn\u00e9ho \u00famrt\u00ed<\/span><\/strong><span>\u00a0(pom\u011br rizika = 4,08,\u00a0<\/span><em><span>p<\/span><\/em><span>\u00a0&lt; 0,001).<\/span><\/li>\n<li><strong><span>Korelace spike-IgG4:<\/span><\/strong><br \/>\n<span>IgG4 specificky nam\u00ed\u0159en\u00fd proti spike proteinu byl tak\u00e9 zv\u00fd\u0161en \u2013 a zvy\u0161ov\u00e1n s ka\u017edou dal\u0161\u00ed d\u00e1vkou.<\/span><\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\"><span>Mechanismus (zjednodu\u0161en\u00fd)<\/span><\/h3>\n<p><strong><span>Opakovan\u00e9 o\u010dkov\u00e1n\u00ed mRNA<\/span><\/strong><br \/>\n<span>\u2192\u00a0<\/span><strong><span>spike protein \u2192 zv\u00fd\u0161en\u00ed IgG4 \u2192 aktivace Treg \u2192 imunosuprese<\/span><\/strong><br \/>\n<span>\u2192\u00a0<\/span><strong><span>slab\u0161\u00ed protirakovinn\u00e1 obrana \u2192 krat\u0161\u00ed p\u0159e\u017eit\u00ed<\/span><\/strong><\/p>\n<h3 class=\"wp-block-heading\"><span>Kontext<\/span><\/h3>\n<p><span>Auto\u0159i poukazuj\u00ed na to, \u017ee jejich v\u00fdsledky jsou v souladu s p\u0159edchoz\u00ed prac\u00ed\u00a0<\/span><em><span>Pereze et al.<\/span><\/em><span>\u00a0a\u00a0<\/span><em><span>Uversky a kol.<\/span><\/em><span>\u00a0kte\u0159\u00ed tak\u00e9 identifikovali\u00a0<\/span><strong><span>o\u010dkov\u00e1n\u00ed mRNA jako p\u0159\u00ed\u010dinu syst\u00e9mov\u00e9 imunosuprese<\/span><\/strong><span>\u00a0se zv\u00fd\u0161en\u00fdm rizikem\u00a0<\/span><strong><span>rakoviny, autoimunity a infekc\u00ed<\/span><\/strong><span>\u00a0.<\/span><\/p>\n<p><span>Poukazuj\u00ed tak\u00e9 na prudk\u00fd\u00a0<\/span><strong><span>n\u00e1r\u016fst \u00famrt\u00ed souvisej\u00edc\u00edch s rakovinou<\/span><\/strong><span>\u00a0od zaveden\u00ed mRNA vakc\u00edn v USA \u2013 asi\u00a0<\/span><strong><span>100 000 dal\u0161\u00edch \u00famrt\u00ed na rakovinu<\/span><\/strong><span>\u00a0, podle \u00fadaj\u016f CDC (analyzovan\u00fdch The Ethical Skeptic).<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span>Z\u00e1v\u011br<\/span><\/h3>\n<p><strong><span>Tato studie poprv\u00e9 p\u0159in\u00e1\u0161\u00ed klinick\u00fd d\u016fkaz: COVID mRNA boostery v\u00fdznamn\u011b zhor\u0161uj\u00ed progn\u00f3zu pacient\u016f s rakovinou.<\/span><\/strong><span>\u00a0Zd\u00e1 se, \u017ee centr\u00e1ln\u00edm mechanismem je zv\u00fd\u0161en\u00ed IgG4 vyvolan\u00e9 opakovanou vakcinac\u00ed.<\/span><\/p>\n<p><span>Dal\u0161\u00ed siln\u00fd argument pro\u00a0<\/span><strong><span>okam\u017eit\u00e9 sta\u017een\u00ed mRNA vakc\u00edn z trhu<\/span><\/strong><span>\u00a0\u2013 alespo\u0148 pro vysoce rizikov\u00e9 skupiny, jako jsou pacienti s rakovinou.<\/span><\/p>\n<p><em><span>Nicolas Hulscher, MPH<\/span><\/em><br \/>\n<span>McCullough Foundation<\/span><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.thefocalpoints.com\/p\/breaking-study-finds-covid-19-mrna?utm_source=post-email-title&amp;publication_id=1119676&amp;post_id=161420416&amp;utm_campaign=email-post-title&amp;isFreemail=true&amp;r=3uby4s&amp;triedRedirect=true&amp;utm_medium=email\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nov\u00e1\u00a0studie\u00a0z Japonska s 272 pacienty s rakovinou slinivky ukazuje:\u00a0T\u0159i nebo v\u00edce o\u010dkov\u00e1n\u00ed mRNA COVID-19\u00a0je spojeno&#8230;<\/p>\n","protected":false},"author":2,"featured_media":5619,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,1366,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/76657"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=76657"}],"version-history":[{"count":1,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/76657\/revisions"}],"predecessor-version":[{"id":76658,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/76657\/revisions\/76658"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/5619"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=76657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=76657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=76657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}