{"id":76034,"date":"2025-04-10T00:23:59","date_gmt":"2025-04-09T22:23:59","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=76034"},"modified":"2025-04-09T12:59:39","modified_gmt":"2025-04-09T10:59:39","slug":"prukopnicka-studie-v-lecbe-rakoviny-vsichni-pacienti-v-remisi-bez-chemoterapie-ozarovani-nebo-operace","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/04\/10\/prukopnicka-studie-v-lecbe-rakoviny-vsichni-pacienti-v-remisi-bez-chemoterapie-ozarovani-nebo-operace\/","title":{"rendered":"Pr\u016fkopnick\u00e1 studie v l\u00e9\u010db\u011b rakoviny: V\u0161ichni pacienti v remisi \u2013 bez chemoterapie, oza\u0159ov\u00e1n\u00ed nebo operace"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><span>V historick\u00e9m l\u00e9ka\u0159sk\u00e9m v\u00fdvoji skupina v\u00fdzkumn\u00edk\u016f\u00a0<\/span><a href=\"https:\/\/www.theepochtimes.com\/epochtv\/100-percent-cancer-remission-of-patients-in-monoclonal-antibody-trial-facts-matter-5620254\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.theepochtimes.com\/epochtv\/100-percent-cancer-remission-of-patients-in-monoclonal-antibody-trial-facts-matter-5620254\"><span>testovala imunoterapii<\/span><\/a><span>\u00a0, kter\u00e1\u00a0vedla ke kompletn\u00ed remisi u\u00a0<\/span><strong><span>v\u0161ech \u00fa\u010dastn\u00edk\u016f s rakovinou kone\u010dn\u00edku \u2013\u00a0<\/span><\/strong><strong><span>bez chemoterapie, oza\u0159ov\u00e1n\u00ed nebo chirurgick\u00e9ho z\u00e1kroku<\/span><\/strong><span>\u00a0. V\u00fdsledky byly\u00a0<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2201445\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2201445\">publikov\u00e1ny<\/a>\u00a0v renomovan\u00e9m\u00a0<\/span><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2201445\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2201445\"><em><span>New England Journal of Medicine<\/span><\/em><\/a><span>\u00a0a jsou pova\u017eov\u00e1ny za potenci\u00e1ln\u00ed zlom v l\u00e9\u010db\u011b rakoviny.<\/span><\/p>\n<p><span>Studie proveden\u00e1 v Memorial Sloan Kettering Cancer Center se zam\u011b\u0159ila na pacienty s takzvan\u00fdm\u00a0<\/span><strong><span>nedostatkem opravy mismatch (dMMR)<\/span><\/strong><span>\u00a0\u2013 genetickou zm\u011bnou, kter\u00e1 se vyskytuje u ur\u010dit\u00fdch typ\u016f rakoviny a vede k obzvl\u00e1\u0161t\u011b dobr\u00e9 odpov\u011bdi na imunoterapie.<\/span><\/p>\n<p><span>Dvan\u00e1ct pacient\u016f dost\u00e1valo ka\u017ed\u00e9 t\u0159i t\u00fddny po dobu \u0161esti m\u011bs\u00edc\u016f\u00a0<\/span><strong><span>monoklon\u00e1ln\u00ed protil\u00e1tku dostarlimab<\/span><\/strong><span>\u00a0, inhibitor PD-1, kter\u00fd specificky aktivuje samol\u00e9\u010debn\u00e9 schopnosti imunitn\u00edho syst\u00e9mu. Po ukon\u010den\u00ed terapie v\u011bdci vy\u0161et\u0159ili pacienty pomoc\u00ed MRI, PET, endoskopie a biopsie \u2013\u00a0<\/span><strong><span>u v\u0161ech n\u00e1dor zcela zmizel<\/span><\/strong><span>\u00a0. Nebylo nutn\u00e9 \u017e\u00e1dn\u00e9 z obvykl\u00fdch, \u010dasto z\u00e1va\u017en\u00fdch opat\u0159en\u00ed jako radioterapie, operace nebo chemoterapie.<\/span><\/p>\n<p><strong><span>&#8222;Nikdy p\u0159edt\u00edm jsme nic takov\u00e9ho nevid\u011bli,&#8220;<\/span><\/strong><span>\u00a0vysv\u011btlila onkologka\u00a0<\/span><strong><span>Andrea Cercek<\/span><\/strong><span>\u00a0, jedna z vedouc\u00edch studie.<\/span><br \/>\n<strong><span>&#8222;Je to opravdu neuv\u011b\u0159iteln\u00e9.&#8220;<\/span><\/strong><\/p>\n<div class=\"twitter-tweet twitter-tweet-rendered\"><iframe id=\"twitter-widget-0\" class=\"\" title=\"X Post\" src=\"https:\/\/platform.twitter.com\/embed\/Tweet.html?dnt=false&amp;embedId=twitter-widget-0&amp;features=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%3D%3D&amp;frame=false&amp;hideCard=false&amp;hideThread=false&amp;id=1909374230585635102&amp;lang=cs&amp;origin=https%3A%2F%2Funcutnews.ch%2Fbahnbrechende-krebsstudie-alle-patienten-in-remission-ohne-chemotherapie-bestrahlung-oder-operation%2F&amp;sessionId=81e23bd2ac4d1660b9c44691d57a6ea20d793f65&amp;theme=light&amp;widgetsVersion=2615f7e52b7e0%3A1702314776716&amp;width=550px\" frameborder=\"0\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\" data-tweet-id=\"1909374230585635102\" data-mce-fragment=\"1\"><\/iframe><\/div>\n<h3 class=\"wp-block-heading\"><strong><span>\u017d\u00e1dn\u00e9 z\u00e1va\u017en\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky<\/span><\/strong><\/h3>\n<p><span>Sn\u00e1\u0161enlivost l\u00e9\u010dby byla v\u00fdborn\u00e1. U \u017e\u00e1dn\u00e9ho z l\u00e9\u010den\u00fdch jedinc\u016f se nevyskytly z\u00e1va\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky (stupe\u0148 3 nebo vy\u0161\u0161\u00ed). Ob\u010das se vyskytly pouze m\u00edrn\u00e9 p\u0159\u00edznaky jako \u00fanava, vyr\u00e1\u017eka nebo sv\u011bd\u011bn\u00ed.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><strong><span>Jisk\u0159i\u010dka nad\u011bje pro miliony<\/span><\/strong><\/h3>\n<p><span>P\u0159esto\u017ee se jedn\u00e1 o\u00a0<\/span><strong><span>malou studii f\u00e1ze 2<\/span><\/strong><span>\u00a0, v\u00fdsledky jsou revolu\u010dn\u00ed. V\u011bdci nyn\u00ed pl\u00e1nuj\u00ed testovat dostarlimab u jin\u00fdch typ\u016f rakoviny \u2013 jako je\u00a0<\/span><strong><span>rakovina \u017ealudku, slinivky a mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e<\/span><\/strong><span>\u00a0\u2013 zejm\u00e9na u pacient\u016f s podobn\u00fdmi genetick\u00fdmi vlastnostmi.<\/span><\/p>\n<p><span>L\u00e9\u010dba m\u00e1 potenci\u00e1l trvale zm\u011bnit terapii rakoviny. Proto\u017ee u\u0161et\u0159\u00ed mnoho pacient\u016f v\u00e1\u017en\u00fdch vedlej\u0161\u00edch \u00fa\u010dink\u016f klasick\u00e9 onkologie a ukazuje, jak siln\u00fd m\u016f\u017ee b\u00fdt imunitn\u00ed syst\u00e9m, kdy\u017e je specificky podporov\u00e1n.<\/span><\/p>\n<p><em><strong>\u201eToto je prvn\u00ed, ale z\u00e1sadn\u00ed krok k personalizovan\u00e9 l\u00e9\u010db\u011b rakoviny s n\u011bkolika vedlej\u0161\u00edmi \u00fa\u010dinky,\u201c<\/strong>\u00a0\u0159\u00edkaj\u00ed auto\u0159i studie.<\/em><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2201445\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>V historick\u00e9m l\u00e9ka\u0159sk\u00e9m v\u00fdvoji skupina v\u00fdzkumn\u00edk\u016f\u00a0testovala imunoterapii\u00a0, kter\u00e1\u00a0vedla ke kompletn\u00ed remisi u\u00a0v\u0161ech \u00fa\u010dastn\u00edk\u016f s rakovinou&#8230;<\/p>\n","protected":false},"author":2,"featured_media":76035,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[938,1366,839],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/76034"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=76034"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/76034\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/76035"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=76034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=76034"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=76034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}