{"id":75262,"date":"2025-03-30T00:17:44","date_gmt":"2025-03-29T23:17:44","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=75262"},"modified":"2025-03-29T13:51:27","modified_gmt":"2025-03-29T12:51:27","slug":"vakcina-mrna-proti-chlamydiim-rychla-cesta-do-bunek-tela","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/03\/30\/vakcina-mrna-proti-chlamydiim-rychla-cesta-do-bunek-tela\/","title":{"rendered":"Vakc\u00edna mRNA proti chlamydi\u00edm: rychl\u00e1 cesta do bun\u011bk t\u011bla?"},"content":{"rendered":"
<\/div>\n

Nov\u00e1 vakc\u00edna mRNA je ve startovac\u00edch bloc\u00edch \u2013 a op\u011bt z\u00e1vratnou rychlost\u00ed. Tentokr\u00e1t nen\u00ed ur\u010dena k ochran\u011b proti viru, ale proti pohlavn\u011b p\u0159enosn\u00e9 bakteri\u00e1ln\u00ed infekci chlamydie, kterou zp\u016fsobuje Chlamydia trachomatis.<\/span><\/strong><\/p>\n

Americk\u00fd \u00fa\u0159ad pro kontrolu potravin a l\u00e9\u010div (FDA)\u00a0<\/span>ud\u011blil<\/span><\/a> kandid\u00e1tovi francouzsk\u00e9ho farmaceutick\u00e9ho gigantu Sanofi tzv. Fast Track status (jako tomu bylo u experiment\u00e1ln\u00edch injekc\u00ed genu mRNA pro Coronu) , kter\u00fd m\u00e1 urychlit v\u00fdvoj a schv\u00e1len\u00ed v rekordn\u00edm \u010dase. Ale zat\u00edmco Sanofi bl\u00e1bol\u00ed o pr\u016flomu v prevenci, z\u016fst\u00e1vaj\u00ed ot\u00e1zky: Jak bezpe\u010dn\u00e1 je tato technologie, kter\u00e1 p\u0159em\u011b\u0148uje na\u0161e bu\u0148ky na mal\u00e1 v\u00fdrobn\u00ed za\u0159\u00edzen\u00ed? A po korona vakc\u00edn\u00e1ch n\u00e1s \u010dek\u00e1 dal\u0161\u00ed experiment s nejist\u00fdm v\u00fdsledkem?<\/span><\/p>\n

Podce\u0148ovan\u00e1 bakterie<\/span><\/h3>\n

Chlamydie nejsou \u017e\u00e1dn\u00e1 mali\u010dkost. Podle Sv\u011btov\u00e9 zdravotnick\u00e9 organizace (WHO) se ro\u010dn\u011b nakaz\u00ed Chlamydia trachomatis kolem 130 milion\u016f lid\u00ed \u2013 \u010dasto ani\u017e by si to uv\u011bdomovali, proto\u017ee infekce je \u010dasto asymptomatick\u00e1. Obzvl\u00e1\u0161t\u011b tvrd\u011b jsou posti\u017eeny \u017eeny: pokud se nel\u00e9\u010d\u00ed, m\u016f\u017ee v\u00e9st k neplodnosti, chronick\u00fdm bolestem b\u0159icha nebo zv\u00fd\u0161en\u00e9mu riziku HIV. Ve Spojen\u00fdch st\u00e1tech byly chlamydie nej\u010dast\u011bji hl\u00e1\u0161en\u00fdm bakteri\u00e1ln\u00edm infek\u010dn\u00edm onemocn\u011bn\u00edm v roce 2021, s obzvl\u00e1\u0161t\u011b vysokou prevalenc\u00ed u lid\u00ed star\u0161\u00edch 24 let,\u00a0<\/span>podle CDC<\/span><\/a>\u00a0. Antibiotika, jako je doxycyklin nebo azithromycin, mohou infekci dob\u0159e l\u00e9\u010dit, ale \u010d\u00edsla st\u00e1le rostou \u2013 jasn\u00fd sign\u00e1l, \u017ee prevence zat\u00edm selh\u00e1v\u00e1.<\/span><\/p>\n

Sanofi to chce nyn\u00ed zm\u011bnit. „Miliony lid\u00ed v sou\u010dasn\u00e9 dob\u011b \u017eij\u00ed s nediagnostikovan\u00fdmi chlamydiemi, v\u010detn\u011b asymptomatick\u00fdch infekc\u00ed, kter\u00e9, pokud se nel\u00e9\u010d\u00ed, mohou m\u00edt tak\u00e9 v\u00e1\u017en\u00e9 dlouhodob\u00e9 zdravotn\u00ed n\u00e1sledky,“ uvedl v\u00a0<\/span>tiskov\u00e9 zpr\u00e1v\u011b<\/span><\/a> Jean-Fran\u00e7ois Toussaint, glob\u00e1ln\u00ed vedouc\u00ed v\u00fdvoje vakc\u00edn ve spole\u010dnosti Sanofi . „Antibiotika nedok\u00e1zala omezit rostouc\u00ed po\u010det infekc\u00ed. S na\u0161\u00edm programem se sna\u017e\u00edme ud\u011blat z chlamydi\u00ed onemocn\u011bn\u00ed, kter\u00fdm lze p\u0159edej\u00edt o\u010dkov\u00e1n\u00edm.“ Zn\u00ed to l\u00e1kav\u011b \u2013 ale metoda za t\u00edm zved\u00e1 obo\u010d\u00ed.<\/span><\/p>\n

mRNA: Od korony k pohlavn\u011b p\u0159enosn\u00fdm chorob\u00e1m<\/span><\/h3>\n

Vakc\u00edna je zalo\u017eena na vysoce kontroverzn\u00ed technologii mRNA, kter\u00e1 byla poprv\u00e9 ve velk\u00e9m m\u011b\u0159\u00edtku pou\u017eita b\u011bhem obdob\u00ed Corona. V t\u00e9 dob\u011b byly vakc\u00edny od BioNTech\/Pfizer a Moderna propu\u0161t\u011bny za pouh\u00fdch 11 m\u011bs\u00edc\u016f \u2013 tempo, kter\u00e9 je norm\u00e1ln\u011b nemysliteln\u00e9, vzhledem k tomu, \u017ee schvalovac\u00ed postupy obvykle trvaj\u00ed 10 a\u017e 15 let. D\u016fvod: \u201epandemick\u00e1 nouze\u201c. Nyn\u00ed m\u00e1 stejn\u00e1 technologie, kter\u00e1 zp\u016fsobuje, \u017ee lidsk\u00e9 bu\u0148ky produkuj\u00ed ciz\u00ed proteiny, tak\u00e9 skoncovat s chlamydiemi. Sanofi v preklinick\u00fdch studi\u00edch hovo\u0159\u00ed o \u201erobustn\u00ed imunitn\u00ed reakci\u201c. Co to ale p\u0159esn\u011b znamen\u00e1 pro t\u011blo?<\/span><\/p>\n

Ve vakc\u00edn\u00e1ch proti koronaviru byly bu\u0148ky instruov\u00e1ny, aby produkovaly spike protein viru \u2013 druh biologick\u00e9 3D tisk\u00e1rny v nanom\u011b\u0159\u00edtku. Imunitn\u00ed syst\u00e9m zareagoval, ale ne bez vedlej\u0161\u00edch \u00fa\u010dink\u016f: p\u0159ib\u00fdvalo hl\u00e1\u0161en\u00ed o myokarditid\u011b, tromb\u00f3ze a menstrua\u010dn\u00edch poruch\u00e1ch, i kdy\u017e je \u00fa\u0159ady odm\u00edtly jako \u201evz\u00e1cn\u00e9\u201c. Kritici se od t\u00e9 doby ptaj\u00ed: Co se stane, kdy\u017e se t\u011blo n\u00e1hle stane m\u00edstem produkce cizorod\u00fdch l\u00e1tek? A v tom je h\u00e1\u010dek: V\u00ed Sanofi, kter\u00fd protein tato nov\u00e1 vakc\u00edna vyr\u00e1b\u00ed na\u0161e bu\u0148ky? Je to chlamydiov\u00fd antigen nebo n\u011bco jin\u00e9ho? Firma zat\u00edm o podrobnostech ml\u010d\u00ed.<\/span><\/p>\n

Fast-track: dal\u0161\u00ed proklet\u00ed?<\/span><\/h3>\n

FDA ud\u011blil Sanofi jakousi VIP vstupenku se statusem Fast Track. Z\u00e1krok p\u016fvodn\u011b ur\u010den\u00fd pro \u017eivot ohro\u017euj\u00edc\u00ed onemocn\u011bn\u00ed umo\u017e\u0148uje u\u017e\u0161\u00ed spolupr\u00e1ci s \u00fa\u0159ady a zkracuje obvykl\u00e9 p\u0159ek\u00e1\u017eky. Je napl\u00e1nov\u00e1no zah\u00e1jen\u00ed studie f\u00e1ze I\/II, kter\u00e1 bude o\u010dkovat dosp\u011bl\u00e9 ve v\u011bku 18 a\u017e 29 let. C\u00edl: Otestovat bezpe\u010dnost, sn\u00e1\u0161enlivost a imunitn\u00ed odpov\u011b\u010f.\u00a0<\/span>Podle ClinicalTrials<\/span><\/a>\u00a0studie zahrnuje t\u0159i \u201esentinelov\u00e9\u201c skupiny testuj\u00edc\u00ed r\u016fzn\u00e9 d\u00e1vky a tak\u00e9 hlavn\u00ed skupinu. \u00da\u010dastn\u00edci budou pozorov\u00e1ni v\u00edce ne\u017e rok se zam\u011b\u0159en\u00edm na vedlej\u0161\u00ed \u00fa\u010dinky, jako jsou injek\u010dn\u00ed reakce, syst\u00e9mov\u00e9 pot\u00ed\u017ee nebo dokonce z\u00e1va\u017en\u00e9 p\u0159\u00edhody.<\/span><\/p>\n

\u010casov\u00e1 t\u00edse\u0148 n\u00e1s ale nut\u00ed b\u00fdt skepti\u010dt\u00ed. V p\u0159\u00edpad\u011b vakc\u00edn proti koronaviru vedl sp\u011bch ke kontroverzi: chyb\u011bly dlouhodob\u00e9 \u00fadaje a mnoho vedlej\u0161\u00edch \u00fa\u010dink\u016f se projevilo a\u017e po schv\u00e1len\u00ed. Je tady d\u00e9j\u00e0 vu? \u201eTechnologie mRNA je experiment, kter\u00e9mu je\u0161t\u011b pln\u011b nerozum\u00edme,\u201c varoval b\u011bhem pandemie n\u011bmeck\u00fd l\u00e9ka\u0159 Wolfgang Wodarg. A skute\u010dn\u011b: Zat\u00edmco Sanofi mluv\u00ed o \u201eimunogenicit\u011b\u201c, z\u016fst\u00e1v\u00e1 nejasn\u00e9, zda m\u00e1 vakc\u00edna podobn\u00e9 \u00fa\u010dinky jako jej\u00ed p\u0159edch\u016fdci Corona. St\u00e1vaj\u00ed se z na\u0161ich bun\u011bk op\u011bt tov\u00e1rny na cizorod\u00e9 l\u00e1tky? A co kdy\u017e imunitn\u00ed syst\u00e9m zareaguje p\u0159ehnan\u011b?<\/span><\/p>\n

Glob\u00e1ln\u00ed z\u00e1vod<\/span><\/h3>\n

Sanofi nen\u00ed sama. Jin\u00ed tak\u00e9 zkoumaj\u00ed vakc\u00edny proti chlamydi\u00edm, nap\u0159\u00edklad v D\u00e1nsku, kde kandid\u00e1t pro\u0161el prvn\u00edmi klinick\u00fdmi zkou\u0161kami v roce 2019. Zrychlen\u00fd stav v\u0161ak d\u00e1v\u00e1 Sanofi n\u00e1skok \u2013 za p\u0159edpokladu, \u017ee studie prob\u011bhne hladce. Projekt je tak\u00e9 podporov\u00e1n vl\u00e1dou Queenslandu a univerzitami Griffith a Queensland v Austr\u00e1lii, jak uv\u00e1d\u00ed Pharmaceutical Technology. A Austr\u00e1lie byla pova\u017eov\u00e1na za obzvl\u00e1\u0161t\u011b negativn\u00ed p\u0159\u00edklad toho, jak dikt\u00e1torsk\u00e9 a represivn\u00ed st\u00e1ty jednaly proti sv\u00fdm vlastn\u00edm ob\u010dan\u016fm b\u011bhem obdob\u00ed Corony. Glob\u00e1ln\u00ed podnik, se kter\u00fdm chce Sanofi nejen bojovat proti chlamydi\u00edm, ale tak\u00e9 upevnit svou pov\u011bst pr\u016fkopn\u00edka vakc\u00edn.<\/span><\/p>\n

Antibiotika vs. o\u010dkov\u00e1n\u00ed: Co je lep\u0161\u00ed?<\/span><\/h3>\n

Dosud l\u00e9ka\u0159i spol\u00e9hali na antibiotika: standardem je doxycyklin (100 mg dvakr\u00e1t denn\u011b po dobu sedmi dn\u016f) nebo jednor\u00e1zov\u00e1 d\u00e1vka azithromycinu (1 g). Rostouc\u00ed po\u010det naka\u017een\u00fdch ale ukazuje, \u017ee to nesta\u010d\u00ed. Ka\u017edoro\u010dn\u00ed screening se doporu\u010duje zejm\u00e9na u mlad\u00fdch, sexu\u00e1ln\u011b aktivn\u00edch \u017een do 25 let, stejn\u011b jako u star\u0161\u00edch \u017een s nov\u00fdmi nebo v\u00edce partnery. Sanofi tvrd\u00ed, \u017ee o\u010dkov\u00e1n\u00ed by zde mohlo p\u0159in\u00e9st obrat \u2013 v\u010detn\u011b ochrany p\u0159ed po\u010d\u00e1te\u010dn\u00ed a reinfekc\u00ed. Pro\u010d ale neinvestovat v\u00edce do vzd\u011bl\u00e1n\u00ed a screeningu? Antibiotika funguj\u00ed, pokud je infekce zji\u0161t\u011bna v\u010das. Opravdu to mus\u00ed b\u00fdt jin\u00e1 vakc\u00edna \u2013 a k tomu experiment s mRNA?<\/span><\/p>\n

\"\"<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Nov\u00e1 vakc\u00edna mRNA je ve startovac\u00edch bloc\u00edch \u2013 a op\u011bt z\u00e1vratnou rychlost\u00ed. Tentokr\u00e1t nen\u00ed ur\u010dena…<\/p>\n","protected":false},"author":2,"featured_media":75264,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[6032,694,651,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/75262"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=75262"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/75262\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/75264"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=75262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=75262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=75262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}