{"id":73902,"date":"2025-03-09T00:21:07","date_gmt":"2025-03-08T23:21:07","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=73902"},"modified":"2025-03-08T15:02:13","modified_gmt":"2025-03-08T14:02:13","slug":"rostlinna-latka-z-kvetu-zastavuje-rakovinu-a-progresi-rs","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/03\/09\/rostlinna-latka-z-kvetu-zastavuje-rakovinu-a-progresi-rs\/","title":{"rendered":"Rostlinn\u00e1 l\u00e1tka z kv\u011bt\u016f zastavuje rakovinu a progresi RS"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<p><strong><span>P\u0159evratn\u00fd objev Oregonsk\u00e9 zdravotnick\u00e9 a v\u011bdeck\u00e9 univerzity (OHSU) by mohl zp\u016fsobit revoluci v l\u00e9\u010db\u011b rakoviny a roztrou\u0161en\u00e9 skler\u00f3zy. V\u011bdci identifikovali p\u0159\u00edrodn\u00ed rostlinnou l\u00e1tku, kter\u00e1 blokuje centr\u00e1ln\u00ed chorobn\u00e9 procesy. M\u016f\u017eeme nyn\u00ed o\u010dek\u00e1vat pr\u016flom v l\u00e9\u010db\u011b rakoviny?<\/span><\/strong><\/p>\n<p><span>V\u011bdci objevili rostlinn\u00fd flavonoid zvan\u00fd sulfuretin, kter\u00fd inhibuje aktivitu enzymu, kter\u00fd hraje kl\u00ed\u010dovou roli jak u roztrou\u0161en\u00e9 skler\u00f3zy, tak u rakoviny ve studii publikovan\u00e9 v Journal of Biological Chemistry nazvan\u00e9 \u201e\u00a0<\/span><a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(24)02418-9\/fulltext\"><span>V\u00fdrazn\u00e9 chemick\u00e9 struktury inhibuj\u00ed hyaluronid\u00e1zu CEMIP a<\/span><\/a><span>\u00a0podporuj\u00ed zr\u00e1n\u00ed progenitorov\u00fdch bun\u011bk oligodendrocyt\u016f\u201c. &#8222;V\u011b\u0159\u00edme, \u017ee tato droga by mohla m\u00edt \u00fa\u010dinky v mnoha r\u016fzn\u00fdch oblastech,&#8220;\u00a0<\/span><a href=\"https:\/\/scitechdaily.com\/scientists-discover-natural-compound-that-stops-cancer-progression\/\"><span>vysv\u011btluje profesor Larry Sherman<\/span><\/a><span> z odd\u011blen\u00ed neurov\u011bd v Oregonsk\u00e9m n\u00e1rodn\u00edm v\u00fdzkumn\u00e9m centru prim\u00e1t\u016f OHSU.<\/span><\/p>\n<p><span>Objev je v\u00fdsledkem let pe\u010dliv\u00e9 pr\u00e1ce student\u016f Portlandsk\u00e9 univerzity pod veden\u00edm profesorky chemie v d\u016fchodu Angely Hoffmanov\u00e9. &#8222;V pr\u016fb\u011bhu let jej\u00ed studenti rozem\u00edlali tyto kv\u011btiny, extrahovali molekuly a testovali, zda n\u011bkter\u00e1 z nich blokuje aktivitu hyaluronid\u00e1zy,&#8220; uv\u00e1d\u00ed Sherman. &#8222;P\u0159ed n\u011bkolika lety kone\u010dn\u011b na\u0161li slibnou slou\u010deninu.&#8220;<\/span><\/p>\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\">\n<div class=\"wp-block-embed__wrapper\">\n<div class=\"twitter-tweet twitter-tweet-rendered\"><iframe id=\"twitter-widget-0\" class=\"\" title=\"X Post\" src=\"https:\/\/platform.twitter.com\/embed\/Tweet.html?dnt=true&amp;embedId=twitter-widget-0&amp;features=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%3D%3D&amp;frame=false&amp;hideCard=false&amp;hideThread=false&amp;id=1896779731984368068&amp;lang=cs&amp;origin=https%3A%2F%2Freport24.news%2Fpflanzenstoff-aus-blueten-stoppt-krebs-und-ms-fortschritt%2F&amp;sessionId=693c4528c3d0c2cf9853403e67a92cc70c23533a&amp;theme=light&amp;widgetsVersion=2615f7e52b7e0%3A1702314776716&amp;width=550px\" frameborder=\"0\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\" data-tweet-id=\"1896779731984368068\" data-mce-fragment=\"1\"><\/iframe><\/div>\n<\/div>\n<\/figure>\n<p><span>V\u011bdci zjistili, \u017ee sulfuretin inhibuje aktivitu specifick\u00e9ho enzymu zvan\u00e9ho hyaluronid\u00e1za, kter\u00fd \u0161t\u011bp\u00ed kyselinu hyaluronovou. To je d\u016fle\u017eit\u00e9 ze dvou d\u016fvod\u016f:<\/span><\/p>\n<ul>\n<li><span>Podpora opravy myelinu: P\u0159i RS br\u00e1n\u00ed rozpad kyseliny hyaluronov\u00e9 dozr\u00e1v\u00e1n\u00ed oligodendrocyt\u016f, bun\u011bk, kter\u00e9 produkuj\u00ed myelin \u2013 ochrann\u00fd obal kolem nervov\u00fdch bun\u011bk. Po\u0161kozen\u00ed myelinu je charakteristick\u00e9 pro RS a dal\u0161\u00ed neurodegenerativn\u00ed onemocn\u011bn\u00ed.<\/span><\/li>\n<li><span>Inhibice proliferace rakovinn\u00fdch bun\u011bk: V n\u00e1dorech m\u016f\u017ee aktivita hyaluronid\u00e1zy zp\u016fsobit nekontrolovatelnou proliferaci rakovinn\u00fdch bun\u011bk. &#8222;Nyn\u00ed m\u00e1me inhibitor, kter\u00fd by to mohl zastavit,&#8220; \u0159ekl Sherman.<\/span><\/li>\n<\/ul>\n<p><span>V\u00fdzkum se zam\u011b\u0159uje na inhibici specifick\u00e9ho typu hyaluronid\u00e1zy zn\u00e1m\u00e9 jako CEMIP (Cell Migration-Inducing and Hyaluronan-Binding Protein). Tento enzym je spojen nejen s RS a rakovinou, ale tak\u00e9 s osteoartr\u00f3zou, ko\u017en\u00edmi infekcemi, poran\u011bn\u00edmi mozku souvisej\u00edc\u00edmi s alkoholem a mo\u017en\u00e1 i dal\u0161\u00edmi neurodegenerativn\u00edmi chorobami, jako je Alzheimerova choroba.<\/span><\/p>\n<p><span>Alec Peters, postgradu\u00e1ln\u00ed student v Shermanov\u011b laborato\u0159i, prok\u00e1zal, \u017ee sulfuretin blokuje aktivitu CEMIP jak v n\u00e1dorov\u00e9 bun\u011b\u010dn\u00e9 linii, tak v prekurzorov\u00fdch bu\u0148k\u00e1ch oligodendrocyt\u016f. Dal\u0161\u00edm krokem je testov\u00e1n\u00ed slou\u010deniny na zv\u00ed\u0159ec\u00edch modelech, aby se ur\u010dila jej\u00ed \u00fa\u010dinnost a mo\u017en\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky p\u0159i l\u00e9\u010db\u011b rakoviny a neurodegenerativn\u00edch onemocn\u011bn\u00ed, jako je RS.<\/span><\/p>\n<p><span>&#8222;Tento objev by mohl b\u00fdt u\u017eite\u010dn\u00fd u Alzheimerovy choroby nebo jin\u00fdch neurodegenerativn\u00edch onemocn\u011bn\u00ed,&#8220; \u0159\u00edk\u00e1 Hoffman. &#8222;Dokud z\u00e1kladn\u00ed probl\u00e9m souvis\u00ed s degradac\u00ed kyseliny hyaluronov\u00e9, mohlo by to b\u00fdt pro lidi u\u017eite\u010dn\u00e9.&#8220; V\u00fdzkum byl podpo\u0159en granty od N\u00e1rodn\u00edho institutu zdrav\u00ed, Kongresov\u011b \u0159\u00edzen\u00fdch l\u00e9ka\u0159sk\u00fdch v\u00fdzkumn\u00fdch program\u016f, N\u00e1rodn\u00ed spole\u010dnosti pro roztrou\u0161enou skler\u00f3zu a dal\u0161\u00edch instituc\u00ed.<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-71983\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/02\/aaa.jpg\" alt=\"\" width=\"89\" height=\"23\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>P\u0159evratn\u00fd objev Oregonsk\u00e9 zdravotnick\u00e9 a v\u011bdeck\u00e9 univerzity (OHSU) by mohl zp\u016fsobit revoluci v l\u00e9\u010db\u011b rakoviny&#8230;<\/p>\n","protected":false},"author":2,"featured_media":73903,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[938,1366,5914,1561,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/73902"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=73902"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/73902\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/73903"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=73902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=73902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=73902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}