{"id":73831,"date":"2025-03-08T00:18:29","date_gmt":"2025-03-07T23:18:29","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=73831"},"modified":"2025-03-07T15:13:58","modified_gmt":"2025-03-07T14:13:58","slug":"vybusna-berlinska-studie-odhaluje-mezery-v-lecbe-post-covid-a-post-vakcinacniho-syndromu","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/03\/08\/vybusna-berlinska-studie-odhaluje-mezery-v-lecbe-post-covid-a-post-vakcinacniho-syndromu\/","title":{"rendered":"V\u00fdbu\u0161n\u00e1 berl\u00ednsk\u00e1 studie odhaluje mezery v l\u00e9\u010db\u011b post-COVID a post-vakcina\u010dn\u00edho syndromu"},"content":{"rendered":"
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Pr\u016fkopnick\u00e1 zpr\u00e1va zve\u0159ejn\u011bn\u00e1 v\u00a0<\/span>German Journal of Acupuncture<\/span><\/em>\u00a0vrh\u00e1 sv\u011btlo na rostouc\u00ed krizi kolem\u00a0<\/span>post-COVID syndromu (PCS)<\/span><\/strong>\u00a0a\u00a0<\/span>post-vakc\u00ednov\u00e9ho syndromu (PVS)<\/span><\/strong>\u00a0. Hlavn\u00ed autor,\u00a0<\/span>Harald Matthes<\/span><\/strong>\u00a0z\u00a0<\/span>Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin<\/span><\/strong>\u00a0a\u00a0<\/span>nemocnice Havelh\u00f6he<\/span><\/strong>\u00a0, ukazuje, \u017ee v N\u011bmecku podle odhad\u016f\u00a0<\/span>600 000 a\u017e 1,4 milionu lid\u00ed<\/span><\/strong>\u00a0trp\u00ed p\u0159etrv\u00e1vaj\u00edc\u00edmi p\u0159\u00edznaky po infekci nebo o\u010dkov\u00e1n\u00ed COVID-19.<\/span><\/p>\n

Navzdory tomuto vysok\u00e9mu po\u010dtu v\u0161ak chyb\u00ed konzistentn\u00ed p\u0159\u00edstup k\u00a0<\/span>diagnostice, l\u00e9\u010db\u011b a zdravotn\u00ed p\u00e9\u010di<\/span><\/strong>\u00a0, tak\u017ee mnoho posti\u017een\u00fdch lid\u00ed z\u016fst\u00e1v\u00e1 bez odpov\u00eddaj\u00edc\u00ed l\u00e9ka\u0159sk\u00e9 podpory. V\u00edce ne\u017e\u00a0<\/span>milion lid\u00ed<\/span><\/strong>\u00a0m\u00e1 jen malou p\u0159\u00edle\u017eitost naj\u00edt kompetentn\u00ed l\u00e9ka\u0159skou pomoc.<\/span><\/p>\n

Nal\u00e9hav\u00e1 pot\u0159eba v\u00fdzkumu: Prob\u00edh\u00e1 komplexn\u00ed studie<\/span><\/strong><\/h2>\n

Matthes a jeho t\u00fdm provedli rozs\u00e1hlou\u00a0<\/span>observa\u010dn\u00ed studii<\/span><\/strong>\u00a0zalo\u017eenou na sv\u00fdch zku\u0161enostech s\u00a0<\/span>600 pacienty s PCS\/PVS<\/span><\/strong>\u00a0a v\u00edce ne\u017e\u00a0<\/span>1800 dotazech<\/span><\/strong>\u00a0na tato onemocn\u011bn\u00ed. Vyvinuli\u00a0<\/span>strukturovan\u00fd diagnostick\u00fd r\u00e1mec<\/span><\/strong>\u00a0, kter\u00fd zahrnuje standardizovan\u00e9 n\u00e1stroje, jako je\u00a0<\/span>zdravotn\u00ed pr\u016fzkum SF-36<\/span><\/strong>\u00a0,\u00a0<\/span>Bell sk\u00f3re<\/span><\/strong>\u00a0,\u00a0<\/span>kanadsk\u00e1 krit\u00e9ria<\/span><\/strong>\u00a0a\u00a0<\/span>vy\u0161et\u0159en\u00ed po z\u00e1t\u011b\u017ei (PEM)<\/span><\/strong>\u00a0.<\/span><\/p>\n

Pacienti byli klasifikov\u00e1ni podle z\u00e1va\u017enosti, p\u0159i\u010dem\u017e\u00a0priorita byla d\u00e1na\u00a0<\/span>st\u0159edn\u011b t\u011b\u017ek\u00fdm a\u017e t\u011b\u017ek\u00fdm p\u0159\u00edpad\u016fm<\/span><\/strong>\u00a0. Mnoho pacient\u016f bylo nejprve vy\u0161et\u0159eno\u00a0<\/span>telemedic\u00ednou,<\/span><\/strong>\u00a0ne\u017e byli o\u0161et\u0159eni na m\u00edst\u011b.<\/span><\/p>\n

V\u011bdeck\u00e9 zji\u0161t\u011bn\u00ed: Patofyziologick\u00e1 krize<\/span><\/strong><\/h2>\n

Studie ukazuje, \u017ee\u00a0<\/span>PCS a PVS<\/span><\/strong>\u00a0jsou si patofyziologicky n\u00e1padn\u011b podobn\u00e9. Ob\u011b onemocn\u011bn\u00ed jsou spojena s\u00a0<\/span>imunitn\u00ed dysfunkc\u00ed, p\u0159etrv\u00e1vaj\u00edc\u00edm spike proteinem a mikrovaskul\u00e1rn\u00edmi komplikacemi<\/span><\/strong>\u00a0. Matthes popisuje t\u0159i hlavn\u00ed mechanismy:<\/span><\/p>\n

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  1. Autoprotil\u00e1tky GPCR (80\u201390 % pacient\u016f):<\/span><\/strong>
    \nTyto\u00a0protil\u00e1tky, spou\u0161t\u011bn\u00e9\u00a0<\/span>spike proteinem, se v\u00e1\u017eou na\u00a0<\/span><\/strong>d\u016fle\u017eit\u00e9 receptory,<\/span><\/strong>\u00a0jako je\u00a0<\/span>ACE2, adrenergn\u00ed a muskarinov\u00e9 receptory<\/span><\/strong>\u00a0. To vede k\u00a0<\/span>dysautonomii, myopatii, chronick\u00e9 \u00fanav\u011b a kognitivn\u00ed dysfunkci<\/span><\/strong>\u00a0. Neust\u00e1l\u00e1 p\u0159estimulace zp\u016fsobuje\u00a0<\/span>metabolick\u00e9 vy\u010derp\u00e1n\u00ed<\/span><\/strong>\u00a0, kter\u00e9 se projevuje\u00a0<\/span>poz\u00e1t\u011b\u017eovou mal\u00e1tnost\u00ed<\/span><\/strong>\u00a0\u2013 poklesem v\u00fdkonu po n\u00e1maze.<\/span><\/li>\n
  2. Perzistence spike proteinu (15-30 % pacient\u016f):<\/span><\/strong>
    \nU n\u011bkter\u00fdch posti\u017een\u00fdch jedinc\u016f\u00a0<\/span>spike protein p\u0159etrv\u00e1v\u00e1 v\u00a0<\/span><\/strong>imunitn\u00edch bu\u0148k\u00e1ch, plazm\u011b a exozomech<\/span><\/strong>\u00a0dlouho po infekci nebo vakcinaci\u00a0. To je\u00a0spojeno s\u00a0<\/span>vaskul\u00e1rn\u00edm z\u00e1n\u011btem, kognitivn\u00edmi poruchami a omezen\u00edm mobility .<\/span><\/strong><\/li>\n
  3. Mikrotromb\u00f3za (5\u201315 % pacient\u016f):<\/span><\/strong>
    \nV n\u011bkter\u00fdch p\u0159\u00edpadech se\u00a0<\/span>mikrokapil\u00e1ry<\/span><\/strong>\u00a0ucpou usazeninami\u00a0<\/span>fibrinu<\/span><\/strong>\u00a0, co\u017e vede k\u00a0<\/span>nedostatku kysl\u00edku, stresu org\u00e1n\u016f a syst\u00e9mov\u00e9mu z\u00e1n\u011btu<\/span><\/strong>\u00a0. K detekci t\u011bchto\u00a0mikrotrombotick\u00fdch zm\u011bn<\/strong>\u00a0byla pou\u017eita\u00a0<\/span>kapil\u00e1rn\u00ed mikroskopie<\/span><\/strong>\u00a0neht\u016f\u00a0.<\/span><\/li>\n<\/ol>\n

    Diagnostika a l\u00e9\u010dba probl\u00e9m\u016f v N\u011bmecku<\/span><\/strong><\/h2>\n

    Studie odhaluje v\u00fdznamn\u00e9\u00a0<\/span>deficity v diagnostice PCS a PVS<\/span><\/strong>\u00a0. Navzdory \u010detn\u00fdm indikac\u00edm\u00a0<\/span>poruch imunity<\/span><\/strong>\u00a0chyb\u00ed\u00a0<\/span>laboratorn\u00ed za\u0159\u00edzen\u00ed<\/span><\/strong>\u00a0schopn\u00e1\u00a0spolehliv\u011b detekovat\u00a0<\/span>GPCR autoprotil\u00e1tky nebo persistentn\u00ed spike proteiny .<\/span><\/strong><\/p>\n

    Pouze\u00a0<\/span>t\u0159i specializovan\u00e9 laborato\u0159e<\/span><\/strong>\u00a0nab\u00edzej\u00ed testy na\u00a0<\/span>bioaktivn\u00ed GPCR protil\u00e1tky<\/span><\/strong>\u00a0(\u00a0<\/span>ERDE, Berlin Cures, Cell-Trend<\/span><\/em>\u00a0), zat\u00edmco\u00a0<\/span>MMD laborato\u0159 v Magdeburgu<\/span><\/strong>\u00a0je jednou z m\u00e1la, kter\u00e1 dok\u00e1\u017ee detekovat\u00a0<\/span>spike proteiny v imunitn\u00edch bu\u0148k\u00e1ch<\/span><\/strong>\u00a0.<\/span><\/p>\n

    Experiment\u00e1ln\u00ed terapeutick\u00e9 p\u0159\u00edstupy<\/span><\/strong><\/h3>\n

    V sou\u010dasn\u00e9 dob\u011b neexistuje \u017e\u00e1dn\u00e1\u00a0<\/span>univerz\u00e1ln\u00ed l\u00e9\u010dba<\/span><\/strong>\u00a0, ale\u00a0testuje se n\u011bkolik\u00a0<\/span>experiment\u00e1ln\u00edch terapi\u00ed :<\/span><\/strong><\/p>\n

    \n\n\n\n\n\n\n\n\n\n
    terapie<\/span><\/strong><\/th>\nPopis<\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
    vrcholov\u00e1 eliminace b\u00edlkovin<\/span><\/strong><\/td>\nKombinace\u00a0<\/span>ivermektinu, nattokin\u00e1zy, bromelainu a acetylcysteinu<\/span><\/strong>\u00a0k odstran\u011bn\u00ed spike proteinu z krve.<\/span><\/td>\n<\/tr>\n
    monocyt\u00e1rn\u00ed terapie<\/span><\/strong><\/td>\nPokud je\u00a0<\/span>spike protein<\/span><\/strong>\u00a0nalezen v monocytech CX3CR1,\u00a0pou\u017e\u00edv\u00e1 se po dobu 2-4 t\u00fddn\u016f\u00a0<\/span>HIV l\u00e9k Maraviroc (inhibitor CCR5).<\/span><\/strong><\/td>\n<\/tr>\n
    exosomov\u00e1 terapie<\/span><\/strong><\/td>\nHypertermick\u00e1 terapie (\u00a0<\/span>zah\u0159\u00e1t\u00ed t\u011bla na 39,5 \u00b0C<\/span><\/strong>\u00a0) je ur\u010dena ke zni\u010den\u00ed zachycen\u00fdch spike protein\u016f.<\/span><\/td>\n<\/tr>\n
    odstran\u011bn\u00ed autoprotil\u00e1tek<\/span><\/strong><\/td>\nImunoadsorp\u010dn\u00ed afer\u00e9za (IA)<\/span><\/strong>\u00a0\u2013 \u010di\u0161t\u011bn\u00ed krve k odstran\u011bn\u00ed \u0161kodliv\u00fdch autoprotil\u00e1tek.<\/span><\/td>\n<\/tr>\n
    l\u00e9\u010dba mikrotromb\u00f3zy<\/span><\/strong><\/td>\nPacienti s\u00a0<\/span>po\u0161kozen\u00edm c\u00e9v<\/span><\/strong>\u00a0dost\u00e1vaj\u00ed\u00a0<\/span>klopidogrel nebo p\u0159\u00edm\u00e1 peror\u00e1ln\u00ed antikoagulancia (DOAC)<\/span><\/strong>\u00a0.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n

    Krom\u011b toho se zkoumaj\u00ed\u00a0<\/span>antroposofick\u00e9 a bylinn\u00e9 terapie<\/span><\/strong>\u00a0, jejich\u017e \u00fa\u010dinnost v\u0161ak zat\u00edm nebyla potvrzena.<\/span><\/p>\n

    Omezen\u00ed studia<\/span><\/strong><\/h2>\n

    Navzdory p\u0159evratn\u00fdm zji\u0161t\u011bn\u00edm st\u00e1le existuj\u00ed\u00a0<\/span>otev\u0159en\u00e9 ot\u00e1zky<\/span><\/strong>\u00a0:<\/span><\/p>\n