{"id":72776,"date":"2025-02-21T00:15:55","date_gmt":"2025-02-20T23:15:55","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=72776"},"modified":"2025-02-20T14:45:19","modified_gmt":"2025-02-20T13:45:19","slug":"prolomeni-barier-lipidove-nanocastice-umoznuji-transport-mrna-do-mozku","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/02\/21\/prolomeni-barier-lipidove-nanocastice-umoznuji-transport-mrna-do-mozku\/","title":{"rendered":"Prolomen\u00ed bari\u00e9r \u2013 lipidov\u00e9 nano\u010d\u00e1stice umo\u017e\u0148uj\u00ed transport mRNA do mozku"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><strong>Pr\u016fkopnick\u00e1 studie veden\u00e1 Changem Wangem a kolegy, publikovan\u00e1 17. \u00fanora 2025 v\u00a0<em>Nature Materials<\/em>\u00a0, p\u0159edstavuje nov\u00fd p\u0159\u00edstup k p\u0159ekon\u00e1n\u00ed hematoencefalick\u00e9 bari\u00e9ry (BBB) \u200b\u200ba c\u00edlen\u00ed mRNA na centr\u00e1ln\u00ed nervov\u00fd syst\u00e9m (CNS). V\u00fdzkumn\u00edci vyvinuli 72 r\u016fzn\u00fdch lipidov\u00fdch nano\u010d\u00e1stic (LNP) kombinac\u00ed BBB-crossing modul\u016f s aminolipidy. C\u00edlem bylo zv\u00fd\u0161it efektivitu transportu mRNA do mozku.<\/strong><\/p>\n<p><span>Po rozs\u00e1hl\u00e9m testov\u00e1n\u00ed a optimalizaci identifikovali p\u0159edn\u00ed formulaci LNP, kter\u00e1 umo\u017enila v\u00fdznamn\u011b vy\u0161\u0161\u00ed dod\u00e1n\u00ed mRNA do mozku ne\u017e LNP ji\u017e schv\u00e1len\u00e9 FDA. U my\u0161\u00edch model\u016f se tato nov\u00e1 formulace uk\u00e1zala jako zvl\u00e1\u0161t\u011b \u00fa\u010dinn\u00e1: po intraven\u00f3zn\u00edm pod\u00e1n\u00ed LNP \u00fasp\u011b\u0161n\u011b transfekovaly neurony a astrocyty v cel\u00e9m mozku. Z\u00e1rove\u0148 vykazovaly dobrou sn\u00e1\u0161enlivost p\u0159i r\u016fzn\u00fdch d\u00e1vkovac\u00edch re\u017eimech. Krom\u011b toho byly tyto LNP schopny\u00a0\u00fa\u010dinn\u011b dod\u00e1vat mRNA do vzork\u016f lidsk\u00e9ho mozku\u00a0<\/span><em><span>ex vivo .<\/span><\/em><\/p>\n<p><span>Tento pr\u016flom otev\u00edr\u00e1 nov\u00e9 mo\u017enosti pro l\u00e9\u010dbu r\u016fzn\u00fdch onemocn\u011bn\u00ed CNS* t\u00edm, \u017ee umo\u017e\u0148uje c\u00edlen\u00e9 dod\u00e1v\u00e1n\u00ed mRNA do kritick\u00fdch oblast\u00ed mozku.<\/span><\/p>\n<p><span>Navzdory slibn\u00fdm v\u00fdsledk\u016fm je i nad\u00e1le nutn\u00e1 opatrnost. Vzhledem k tomu, \u017ee studie je zalo\u017eena na zv\u00ed\u0159ec\u00edch modelech a\u00a0<\/span><em><span>ex vivo<\/span><\/em><span>\u00a0tk\u00e1ni, nen\u00ed jasn\u00e9, jak dob\u0159e mohou b\u00fdt v\u00fdsledky p\u0159eneseny do lidsk\u00e9ho organismu. Pro potvrzen\u00ed bezpe\u010dnosti a \u00fa\u010dinnosti t\u00e9to technologie v klinick\u00e9 aplikaci jsou nezbytn\u00e9 dal\u0161\u00ed studie na lidech.<\/span><\/p>\n<p><em><span>V t\u00e9to souvislosti TrialSite<\/span><\/em><span>\u00a0poukazuje na v\u00fdzvy spojen\u00e9 s mRNA vakc\u00ednami COVID-19, kter\u00e9 jsou tak\u00e9 zalo\u017eeny na LNP.<\/span><\/p>\n<p><span style=\"font-size: 18pt;\"><strong>*<\/strong><\/span><\/p>\n<p><span>Onemocn\u011bn\u00ed CNS jsou onemocn\u011bn\u00ed centr\u00e1ln\u00edho\u00a0<\/span><strong><span>nervov\u00e9ho syst\u00e9mu (CNS)<\/span><\/strong><span>\u00a0, kter\u00fd se skl\u00e1d\u00e1 z\u00a0<\/span><strong><span>mozku a m\u00edchy<\/span><\/strong><span>\u00a0. Tato onemocn\u011bn\u00ed mohou b\u00fdt genetick\u00e1, zp\u016fsoben\u00e1 infekcemi, \u00farazy nebo degenerativn\u00edmi procesy. Mezi nej\u010dast\u011bj\u0161\u00ed onemocn\u011bn\u00ed CNS pat\u0159\u00ed:<\/span><\/p>\n<ul class=\"wp-block-list\">\n<li><strong><span>Neurodegenerativn\u00ed onemocn\u011bn\u00ed<\/span><\/strong><span>\u00a0:<\/span>\n<ul class=\"wp-block-list\">\n<li><span>Alzheimer<\/span><\/li>\n<li><span>Parkinson<\/span><\/li>\n<li><span>Amyotrofick\u00e1 later\u00e1ln\u00ed skler\u00f3za (ALS)<\/span><\/li>\n<li><span>Huntingtonova nemoc<\/span><\/li>\n<\/ul>\n<\/li>\n<li><strong><span>Autoimunitn\u00ed onemocn\u011bn\u00ed<\/span><\/strong><span>\u00a0:<\/span>\n<ul class=\"wp-block-list\">\n<li><span>Roztrou\u0161en\u00e1 skler\u00f3za (RS)<\/span><\/li>\n<li><span>porucha optick\u00e9ho spektra neuromyelitis (NMOSD)<\/span><\/li>\n<\/ul>\n<\/li>\n<li><strong><span>mrtvice a poruchy krevn\u00edho ob\u011bhu<\/span><\/strong>\n<ul class=\"wp-block-list\">\n<li><span>ischemick\u00e1 mrtvice<\/span><\/li>\n<li><span>krv\u00e1cen\u00ed do mozku<\/span><\/li>\n<\/ul>\n<\/li>\n<li><strong><span>infekce a z\u00e1n\u011bty<\/span><\/strong>\n<ul class=\"wp-block-list\">\n<li><span>meningitida (z\u00e1n\u011bt mozkov\u00fdch blan)<\/span><\/li>\n<li><span>encefalitida (z\u00e1n\u011bt mozku)<\/span><\/li>\n<\/ul>\n<\/li>\n<li><strong><span>Epilepsie a dal\u0161\u00ed z\u00e1chvatov\u00e9 poruchy<\/span><\/strong><\/li>\n<li><strong><span>n\u00e1dory centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu<\/span><\/strong>\n<ul class=\"wp-block-list\">\n<li><span>glioblastom<\/span><\/li>\n<li><span>meningeom<\/span><\/li>\n<\/ul>\n<\/li>\n<li><strong><span>Psychiatrick\u00e9 a neurologick\u00e9 poruchy s posti\u017een\u00edm CNS<\/span><\/strong>\n<ul class=\"wp-block-list\">\n<li><span>schizofrenie<\/span><\/li>\n<li><span>Deprese s neurologick\u00fdmi p\u0159\u00ed\u010dinami<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span>C\u00edlen\u00e9 dod\u00e1v\u00e1n\u00ed\u00a0<\/span><strong><span>mRNA terapeutik<\/span><\/strong><span>\u00a0do mozku by mohlo umo\u017enit nov\u00e9 l\u00e9\u010debn\u00e9 p\u0159\u00edstupy pro mnoho z t\u011bchto onemocn\u011bn\u00ed.<\/span><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.trialsitenews.com\/a\/breaking-barriers-lipid-nanoparticles-unlock-mrna-delivery-to-the-brain-f3047ad4\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Pr\u016fkopnick\u00e1 studie veden\u00e1 Changem Wangem a kolegy, publikovan\u00e1 17. \u00fanora 2025 v\u00a0Nature Materials\u00a0, p\u0159edstavuje nov\u00fd&#8230;<\/p>\n","protected":false},"author":2,"featured_media":72777,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[8624,2252,694,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/72776"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=72776"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/72776\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/72777"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=72776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=72776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=72776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}