{"id":72544,"date":"2025-02-18T00:13:42","date_gmt":"2025-02-17T23:13:42","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=72544"},"modified":"2025-02-17T13:51:13","modified_gmt":"2025-02-17T12:51:13","slug":"cholesterol-jako-zbran-proti-rakovine-prukopnicky-objev","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/02\/18\/cholesterol-jako-zbran-proti-rakovine-prukopnicky-objev\/","title":{"rendered":"Cholesterol jako zbra\u0148 proti rakovin\u011b: Pr\u016fkopnick\u00fd objev"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<p><strong><span>Ze v\u0161ech v\u011bc\u00ed by se mohl ne\u010dekan\u00fdm spojencem v boji proti rakovin\u011b uk\u00e1zat tolik zhoubn\u00fd cholesterol. V\u011bdci z renomovan\u00e9 Icahn School of Medicine na Mount Sinai v New Yorku u\u010dinili objev, kter\u00fd by mohl z\u00e1sadn\u011b zm\u011bnit n\u00e1\u0161 pohled na \u010dasto d\u00e9monizovan\u00fd tuk.<\/span><\/strong><\/p>\n<p><span>Ve sv\u00e9 studii publikovan\u00e9 v \u010dasopise Nature s n\u00e1zvem \u201e\u00a0<\/span><a href=\"https:\/\/www.nature.com\/articles\/s41590-024-02065-8\"><span>Mobilizace cholesterolu reguluje zr\u00e1n\u00ed dendritick\u00fdch bun\u011bk a imunogenn\u00ed odpov\u011b\u010f na rakovinu<\/span><\/a><span> \u201c v\u011bdci prok\u00e1zali, \u017ee cholesterol hraje kl\u00ed\u010dovou roli p\u0159i aktivaci obrann\u00e9ho syst\u00e9mu na\u0161eho t\u011bla proti rakovinn\u00fdm bu\u0148k\u00e1m. D\u016fraz je kladen na dendritick\u00e9 bu\u0148ky \u2013 \u010dichac\u00ed bu\u0148ky na\u0161eho imunitn\u00edho syst\u00e9mu, abych tak \u0159ekl. Aby spr\u00e1vn\u011b fungovaly, pot\u0159ebuj\u00ed cholesterol.<\/span><\/p>\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\">\n<div class=\"wp-block-embed__wrapper\">\n<div class=\"twitter-tweet twitter-tweet-rendered\"><iframe id=\"twitter-widget-0\" class=\"\" title=\"P\u0159\u00edsp\u011bvek X\" src=\"https:\/\/platform.twitter.com\/embed\/Tweet.html?dnt=true&amp;embedId=twitter-widget-0&amp;features=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%3D%3D&amp;frame=false&amp;hideCard=false&amp;hideThread=false&amp;id=1877065296529273142&amp;lang=de&amp;origin=https%3A%2F%2Freport24.news%2Fcholesterin-als-waffe-gegen-krebs-bahnbrechende-entdeckung%2F&amp;sessionId=72a4d54ed8afb83506218227b53bdecbe7fcf180&amp;theme=light&amp;widgetsVersion=2615f7e52b7e0%3A1702314776716&amp;width=550px\" frameborder=\"0\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\" data-tweet-id=\"1877065296529273142\" data-mce-fragment=\"1\"><\/iframe><\/div>\n<\/div>\n<\/figure>\n<p><span>&#8222;Identifikovali jsme metabolismus cholesterolu jako z\u00e1kladn\u00ed sign\u00e1ln\u00ed dr\u00e1hu ve zral\u00fdch dendritick\u00fdch bu\u0148k\u00e1ch,&#8220; vysv\u011btluj\u00ed auto\u0159i studie ve sv\u00e9 pr\u00e1ci. To, co zpo\u010d\u00e1tku zn\u00ed jako such\u00fd v\u011bdeck\u00fd jazyk, by se mohlo uk\u00e1zat jako pr\u016flom v l\u00e9\u010db\u011b rakoviny. Zvl\u00e1\u0161t\u011b zaj\u00edmav\u00fd je objev proteinu zvan\u00e9ho AXL, kter\u00fd p\u016fsob\u00ed jako brzda metabolismu cholesterolu. Pokud se tato brzda uvoln\u00ed, dendritick\u00e9 bu\u0148ky dozr\u00e1vaj\u00ed rychleji a mohou \u00fa\u010dinn\u011bji bojovat proti rakovinn\u00fdm bu\u0148k\u00e1m. V\u011bdci to vid\u00ed jako slibn\u00fd p\u0159\u00edstup pro nov\u00e9 imunoterapie.<\/span><\/p>\n<p><span>V\u00fdzkumn\u00e9mu t\u00fdmu se poda\u0159ilo prok\u00e1zat, \u017ee cholesterol vede k tvorb\u011b speci\u00e1ln\u00edch struktur na bun\u011b\u010dn\u00e9m povrchu \u2013 tzv. lipidov\u00fdch nanodom\u00e9n\u00e1ch. Ty funguj\u00ed jako komunika\u010dn\u00ed centra pro imunitn\u00ed syst\u00e9m. Bez dostate\u010dn\u00e9ho cholesterolu nemohou tato \u201e\u00fast\u0159ed\u00ed\u201c spr\u00e1vn\u011b fungovat, co\u017e v\u00fdrazn\u011b oslabuje obranu proti rakovin\u011b. Zd\u00e1 se, \u017ee je to d\u016fle\u017eit\u00e9 i v jin\u00fdch z\u00e1le\u017eitostech t\u00fdkaj\u00edc\u00edch se srdce a krevn\u00edho ob\u011bhu.<\/span><\/p>\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\">\n<div class=\"wp-block-embed__wrapper\">\n<div class=\"twitter-tweet twitter-tweet-rendered\"><iframe id=\"twitter-widget-1\" class=\"\" title=\"P\u0159\u00edsp\u011bvek X\" src=\"https:\/\/platform.twitter.com\/embed\/Tweet.html?dnt=true&amp;embedId=twitter-widget-1&amp;features=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%3D%3D&amp;frame=false&amp;hideCard=false&amp;hideThread=false&amp;id=1875814557202952491&amp;lang=de&amp;origin=https%3A%2F%2Freport24.news%2Fcholesterin-als-waffe-gegen-krebs-bahnbrechende-entdeckung%2F&amp;sessionId=72a4d54ed8afb83506218227b53bdecbe7fcf180&amp;theme=light&amp;widgetsVersion=2615f7e52b7e0%3A1702314776716&amp;width=550px\" frameborder=\"0\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\" data-tweet-id=\"1875814557202952491\" data-mce-fragment=\"1\"><\/iframe><\/div>\n<\/div>\n<\/figure>\n<p><span>Ironie p\u0159\u00edb\u011bhu: Po cel\u00e1 desetilet\u00ed byl cholesterol ozna\u010dov\u00e1n za zdravotn\u00ed hrozbu \u010d\u00edslo jedna. Nyn\u00ed se ukazuje, \u017ee tuto p\u0159enosovou l\u00e1tku m\u016f\u017eeme nal\u00e9hav\u011b pot\u0159ebovat, abychom byli schopni \u00fa\u010dinn\u011b bojovat s rakovinou. Zji\u0161t\u011bn\u00ed, kter\u00e9 by mohlo postavit na hlavu nejen l\u00e9ka\u0159sk\u00fd v\u00fdzkum, ale i na\u0161i p\u0159edstavu o zdrav\u00e9m stravov\u00e1n\u00ed. Tento objev otev\u00edr\u00e1 zcela nov\u00e9 perspektivy pro imunoterapii rakoviny. Specifickou manipulac\u00ed metabolismu cholesterolu a \u0159\u00edzen\u00edm proteinu AXL by mohly b\u00fdt v budoucnu vyvinuty v\u00fdrazn\u011b \u00fa\u010dinn\u011bj\u0161\u00ed l\u00e9\u010debn\u00e9 metody.<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-71983\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2025\/02\/aaa.jpg\" alt=\"\" width=\"89\" height=\"23\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ze v\u0161ech v\u011bc\u00ed by se mohl ne\u010dekan\u00fdm spojencem v boji proti rakovin\u011b uk\u00e1zat tolik zhoubn\u00fd&#8230;<\/p>\n","protected":false},"author":2,"featured_media":72545,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[6252,1366,839],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/72544"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=72544"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/72544\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/72545"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=72544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=72544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=72544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}