{"id":72014,"date":"2025-02-11T00:33:02","date_gmt":"2025-02-10T23:33:02","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=72014"},"modified":"2025-02-10T12:22:13","modified_gmt":"2025-02-10T11:22:13","slug":"existuje-souvislost-mezi-vakcinou-covid-infekci-a-muzskou-neplodnosti-naznacuje-to-nova-znepokojiva-studie","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/02\/11\/existuje-souvislost-mezi-vakcinou-covid-infekci-a-muzskou-neplodnosti-naznacuje-to-nova-znepokojiva-studie\/","title":{"rendered":"Existuje souvislost mezi vakc\u00ednou COVID, infekc\u00ed a mu\u017eskou neplodnost\u00ed? Nazna\u010duje to nov\u00e1 znepokojiv\u00e1 studie"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><em><span>V\u011bdci z\u00a0<\/span><\/em><a href=\"https:\/\/www.kau.edu.sa\/home_english.aspx\" target=\"_blank\" rel=\"noreferrer noopener\"><em><span>Univerzity kr\u00e1le Abdulazize<\/span><\/em><\/a><em><span>\u00a0v Sa\u00fadsk\u00e9 Ar\u00e1bii, zastoupeni prvn\u00edm autorem Mohammedem Ahmedem Alkireidmim a odpov\u00eddaj\u00edc\u00edm autorem\u00a0<\/span><\/em><a href=\"https:\/\/www.researchgate.net\/profile\/Firoz-Anwar\" target=\"_blank\" rel=\"noreferrer noopener\"><em><span>Firozem Anwarem<\/span><\/em><\/a><em><span>\u00a0, doktorem farmacie, p\u0159edpokl\u00e1daj\u00ed, \u017ee mu\u017esk\u00e1 neplodnost se po pandemii COVID-19 zv\u00fd\u0161ila, zejm\u00e9na po o\u010dkov\u00e1n\u00ed, kv\u016fli imunogenn\u00edmu \u00fa\u010dinku protil\u00e1tek IgA, kter\u00e9 interaguj\u00ed s kl\u00ed\u010dov\u00fdmi proteiny souvisej\u00edc\u00edmi se spermiemi. P\u0159edpokl\u00e1d\u00e1 se, \u017ee protil\u00e1tky proti spermi\u00edm (ASA) produkovan\u00e9 po infekci nebo vakcinaci p\u0159isp\u00edvaj\u00ed ke sn\u00ed\u017een\u00e9 pohyblivosti spermi\u00ed, zm\u011bn\u011b \u010dasu zkapal\u0148ov\u00e1n\u00ed a abnorm\u00e1ln\u00ed morfologii spermi\u00ed. Zkoum\u00e1n\u00edm t\u011bchto molekul\u00e1rn\u00edch interakc\u00ed se studie zam\u011b\u0159uje na stanoven\u00ed p\u0159\u00ed\u010dinn\u00e9 souvislosti mezi imunitn\u00edmi reakcemi souvisej\u00edc\u00edmi s COVID-19 a mu\u017eskou neplodnost\u00ed.<\/span><\/em><\/p>\n<p><span style=\"font-size: 18pt;\"><strong>Design a metody studia<\/strong><\/span><\/p>\n<p><span>Prospektivn\u00ed p\u0159\u00edpadov\u00e1-kontroln\u00ed studie byla provedena na Univerzit\u011b kr\u00e1le Abdulazize ve dvou centrech. V\u011bdci odebrali 133 vzork\u016f spermatu od mu\u017e\u016f s norm\u00e1ln\u00edmi parametry spermi\u00ed, kter\u00e9 byly z\u00edsk\u00e1ny masturbac\u00ed v p\u0159\u00edpadech nevysv\u011btliteln\u00e9 neplodnosti. Byla zkoum\u00e1na pohyblivost spermi\u00ed, doba zkapal\u0148ov\u00e1n\u00ed a pod\u00edl abnorm\u00e1ln\u00edch spermi\u00ed v r\u016fzn\u00fdch v\u011bkov\u00fdch skupin\u00e1ch. Krom\u011b toho v\u011bdci provedli anal\u00fdzu molekul\u00e1rn\u00edho modelov\u00e1n\u00ed in silico, aby analyzovali interakce mezi IgA protil\u00e1tkami a kl\u00ed\u010dov\u00fdmi proteiny spojen\u00fdmi se spermiemi.<\/span><\/p>\n<ul>\n<li><span>IZUMO1 (f\u00fazn\u00ed protein spermie a vaj\u00ed\u010dka),<\/span><\/li>\n<li><span>Alfa2A-adrenoreceptor (souvisej\u00edc\u00ed s funkc\u00ed a pohyblivost\u00ed spermi\u00ed),<\/span><\/li>\n<li><span>Receptor 2 fibroblastov\u00e9ho r\u016fstov\u00e9ho faktoru (FGFR2) (pod\u00edl\u00ed se na bun\u011b\u010dn\u00e9 signalizaci a v\u00fdvoji spermi\u00ed).<\/span><\/li>\n<\/ul>\n<p><span>Pomoc\u00ed technik molekul\u00e1rn\u00edho dokov\u00e1n\u00ed sa\u00fad\u0161t\u00ed v\u011bdci zkoumali interak\u010dn\u00ed vzd\u00e1lenosti, variace aminokyselin a zm\u011bny d\u00e9lky vazby, aby ur\u010dili, jak m\u016f\u017ee IgA ovlivnit funkci spermi\u00ed.<\/span><\/p>\n<p><span style=\"font-size: 18pt;\"><strong>V\u00fdsledky studie<\/strong><\/span><\/p>\n<p><span>Studie uk\u00e1zala, \u017ee mu\u017esk\u00e1 neplodnost je nejvy\u0161\u0161\u00ed mezi 31. a 40. rokem \u017eivota, a to 50 %, zat\u00edmco po\u010det abnormalit spermi\u00ed kles\u00e1 po 41. roce v\u011bku. Z neplodn\u00fdch mu\u017e\u016f bylo 21 % mlad\u0161\u00edch 30 let, 24 % bylo ve v\u011bku 41 a\u017e 50 let a 5 % bylo star\u0161\u00edch 50 let. Motilita spermi\u00ed byla v\u00e1\u017en\u011b naru\u0161ena, s pod\u00edlem nepohybliv\u00fdch spermi\u00ed (stupe\u0148 D) 59,8 %, po \u010dem\u017e n\u00e1sledoval progresivn\u00ed pokles u ostatn\u00edch stup\u0148\u016f motility.<\/span><\/p>\n<ul>\n<li><span>Stupe\u0148 A (rychle progresivn\u00ed motilita): 8,45 %<\/span><\/li>\n<li><span>Stupe\u0148 B (pomalu progresivn\u00ed pohyblivost): 11,1 %<\/span><\/li>\n<li><span>Stupe\u0148 C (neprogresivn\u00ed motilita): 15,8 %<\/span><\/li>\n<\/ul>\n<p><span>Pod\u00edl abnorm\u00e1ln\u00edch spermi\u00ed se pohyboval od 43,85 % do 46,33 %, p\u0159i\u010dem\u017e doba zkapaln\u011bn\u00ed se pohybovala mezi 30 a 36 minutami v z\u00e1vislosti na v\u011bku.<\/span><\/p>\n<p><span>V\u00fdsledky molekul\u00e1rn\u00edho modelov\u00e1n\u00ed uk\u00e1zaly, \u017ee IgA protil\u00e1tky tvo\u0159\u00ed stabiln\u00ed komplexy s proteiny spermi\u00ed, a t\u00edm naru\u0161uj\u00ed norm\u00e1ln\u00ed funkci spermi\u00ed. Interak\u010dn\u00ed vzd\u00e1lenosti byly 25,354 \u00c1 (IZUMO1), 39,049 \u00c1 (Alpha2A) a 41,999 \u00c1 (FGFR2), co\u017e ukazuje na v\u00fdznamn\u00e9 struktur\u00e1ln\u00ed zm\u011bny. Tyto interakce vedly ke zhor\u0161en\u00e9 pohyblivosti, zkapaln\u011bn\u00ed a \u017eivotaschopnosti spermi\u00ed a nazna\u010duj\u00ed mechanickou souvislost mezi imunitn\u00ed aktivac\u00ed po expozici COVID-19 a mu\u017eskou neplodnost\u00ed.<\/span><\/p>\n<p><strong><span>Studie dosp\u011bla k z\u00e1v\u011bru, \u017ee imunogenn\u00ed neplodnost zprost\u0159edkovan\u00e1 IgA se po o\u010dkov\u00e1n\u00ed nebo infekci zvy\u0161uje<\/span><\/strong><span>\u00a0, p\u0159i\u010dem\u017e stabiln\u00ed komplexy IgA-protein naru\u0161uj\u00ed dynamiku spermi\u00ed. Toto zji\u0161t\u011bn\u00ed otev\u00edr\u00e1 nov\u00fd pohled na mu\u017eskou neplodnost v postpandemick\u00e9 \u00e9\u0159e.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span style=\"font-size: 18pt;\"><strong>Aspekty TrialSite<\/strong><\/span><\/h3>\n<p><span>P\u0159esto\u017ee studie poskytuje p\u0159esv\u011bd\u010div\u00e1 data, existuje n\u011bkolik varovn\u00fdch sign\u00e1l\u016f a nesrovnalost\u00ed, kter\u00e9 \u2013 krom\u011b metodologick\u00fdch omezen\u00ed \u2013 vy\u017eaduj\u00ed dal\u0161\u00ed zkoum\u00e1n\u00ed.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span style=\"font-size: 18pt;\"><strong>V\u00fdb\u011brov\u00e9 zkreslen\u00ed a mal\u00e1 velikost vzorku<\/strong><\/span><\/h3>\n<p><span>Studie zahrnuje pouze 133 \u00fa\u010dastn\u00edk\u016f, co\u017e zt\u011b\u017euje zobecn\u011bn\u00ed v\u00fdsledk\u016f na \u0161ir\u0161\u00ed skupiny populace.<\/span><\/p>\n<p><span>Nav\u00edc neexistuje jasn\u00e1 kontroln\u00ed skupina, co\u017e vyvol\u00e1v\u00e1 pochybnosti o srovnatelnosti dat. Proto nen\u00ed jasn\u00e9, jak\u00e1 byla z\u00e1kladn\u00ed m\u00edra neplodnosti p\u0159ed COVID-19.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span style=\"font-size: 18pt;\"><strong>Kauzalita vs. korelace<\/strong><\/span><\/h3>\n<p><span>Studie nazna\u010duje souvislost mezi o\u010dkov\u00e1n\u00edm nebo infekc\u00ed COVID-19 a mu\u017eskou neplodnost\u00ed, ale nem\u016f\u017ee prok\u00e1zat p\u0159\u00ed\u010dinnou souvislost.<\/span><\/p>\n<p><span>Kvalitu spermi\u00ed ovliv\u0148uje \u0159ada faktor\u016f, v\u010detn\u011b stresu, \u017eivotn\u00edho stylu a z\u00e1kladn\u00edch onemocn\u011bn\u00ed. Proto\u017ee nejsou k dispozici \u017e\u00e1dn\u00e9 \u00fadaje z obdob\u00ed p\u0159ed pandemi\u00ed, z\u016fst\u00e1v\u00e1 nejasn\u00e9, zda pozorovan\u00e9 trendy existovaly ji\u017e d\u0159\u00edve.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span style=\"font-size: 18pt;\"><strong>Interpretace IgA protil\u00e1tek<\/strong><\/span><\/h3>\n<p><span>IgA hraje \u00fast\u0159edn\u00ed roli ve slizni\u010dn\u00ed imunit\u011b, ale jeho p\u0159\u00edm\u00e9 zapojen\u00ed do tvorby protil\u00e1tek proti spermi\u00edm z\u016fst\u00e1v\u00e1 kontroverzn\u00ed.<\/span><\/p>\n<p><span>Proto\u017ee nebyla provedena \u017e\u00e1dn\u00e1 kontroln\u00ed m\u011b\u0159en\u00ed hladin IgA, je obt\u00ed\u017en\u00e9 posoudit, zda je zv\u00fd\u0161en\u00ed skute\u010dn\u011b zp\u016fsobeno o\u010dkov\u00e1n\u00edm nebo infekc\u00ed.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span style=\"font-size: 18pt;\"><strong>Nedostatek longitudin\u00e1ln\u00edch dat<\/strong><\/span><\/h3>\n<p><span>Studie poskytuje pouze sn\u00edmek bez sledov\u00e1n\u00ed funkce spermi\u00ed v pr\u016fb\u011bhu m\u011bs\u00edc\u016f nebo let.<\/span><\/p>\n<p><span>Pokud jsou \u00fa\u010dinky IgA zp\u016fsoben\u00e9 o\u010dkov\u00e1n\u00edm pouze do\u010dasn\u00e9, bylo by nutn\u00e9 dlouhodob\u00e9 sledov\u00e1n\u00ed, aby se zjistilo, zda je neplodnost trval\u00e1 nebo reverzibiln\u00ed.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span style=\"font-size: 18pt;\"><strong>Omezen\u00e9 extern\u00ed ov\u011b\u0159en\u00ed<\/strong><\/span><\/h3>\n<p><span>Studie je zalo\u017eena na modelech in silico pro predikci molekul\u00e1rn\u00edch interakc\u00ed. I kdy\u017e jsou takov\u00e9 simulace cenn\u00fdmi n\u00e1stroji, nemohou potvrdit skute\u010dn\u00e9 biologick\u00e9 d\u016fsledky.<\/span><\/p>\n<p><span>Neexistuj\u00ed \u017e\u00e1dn\u00e9 funk\u010dn\u00ed testy ani zv\u00ed\u0159ec\u00ed modely, kter\u00e9 by zkoumaly, jak IgA interaguje se spermiemi za skute\u010dn\u00fdch biologick\u00fdch podm\u00ednek.<\/span><\/p>\n<p><span>Mezi dal\u0161\u00ed omezen\u00ed pat\u0159\u00ed absence kontroln\u00ed skupiny a skute\u010dnost, \u017ee nebyly vylou\u010deny alternativn\u00ed p\u0159\u00ed\u010diny neplodnosti.<\/span><\/p>\n<h3 class=\"wp-block-heading\"><span style=\"font-size: 18pt;\"><strong>D\u016fsledky<\/strong><\/span><\/h3>\n<p><span>Studie vyvol\u00e1v\u00e1 v\u00e1\u017en\u00e9 ot\u00e1zky ohledn\u011b mo\u017en\u00e9 imunitn\u011b zprost\u0159edkovan\u00e9 mu\u017esk\u00e9 neplodnosti po o\u010dkov\u00e1n\u00ed nebo infekci COVID-19. Kauz\u00e1ln\u00ed vztahy v\u0161ak z\u016fst\u00e1vaj\u00ed neprok\u00e1zan\u00e9, a proto jsou k d\u016fkladn\u00e9mu objasn\u011bn\u00ed t\u00e9to problematiky pot\u0159eba v\u011bt\u0161\u00ed, dob\u0159e kontrolovan\u00e9 longitudin\u00e1ln\u00ed studie.<\/span><\/p>\n<p><span>Pokud se v\u00fdsledky potvrd\u00ed, mohou:<\/span><\/p>\n<ul>\n<li><strong><span>Podporujte dal\u0161\u00ed v\u00fdzkum imunitn\u00ed reakce a fyziologie spermi\u00ed,<\/span><\/strong><span>\u00a0abyste l\u00e9pe porozum\u011bli z\u00e1kladn\u00edm mechanism\u016fm.<\/span><\/li>\n<li><strong><span>Stanovte nov\u00e9 pokyny pro reproduk\u010dn\u00ed zdrav\u00ed<\/span><\/strong><span>\u00a0, abyste konkr\u00e9tn\u011bji vyhodnotili mu\u017eskou plodnost po o\u010dkov\u00e1n\u00ed proti COVID-19.<\/span><\/li>\n<li><strong><span>Roz\u0161i\u0159te diskusi o riziku a p\u0159\u00ednosu o vakc\u00edn\u00e1ch<\/span><\/strong><span>\u00a0lep\u0161\u00edm identifikov\u00e1n\u00edm potenci\u00e1ln\u00edch rizikov\u00fdch skupin.<\/span><\/li>\n<\/ul>\n<p><span>Nedostatek definitivn\u00edch kauz\u00e1ln\u00edch d\u016fkaz\u016f v\u0161ak znamen\u00e1, \u017ee alarmistick\u00e9 z\u00e1v\u011bry jsou p\u0159ed\u010dasn\u00e9. A\u017e do dal\u0161\u00ed validace by tyto v\u00fdsledky m\u011bly b\u00fdt interpretov\u00e1ny jako p\u0159edb\u011b\u017en\u00e1 souvislost a nikoli jako potvrzen\u00fd klinick\u00fd d\u016fkaz mu\u017esk\u00e9 neplodnosti souvisej\u00edc\u00ed s vakc\u00ednou.<\/span><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.trialsitenews.com\/a\/is-covid-19-vaccine-and-infection-linked-with-male-infertility-troubling-king-abdulaziz-university-study-suggests-possibly-e8cb49a5\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>V\u011bdci z\u00a0Univerzity kr\u00e1le Abdulazize\u00a0v Sa\u00fadsk\u00e9 Ar\u00e1bii, zastoupeni prvn\u00edm autorem Mohammedem Ahmedem Alkireidmim a odpov\u00eddaj\u00edc\u00edm autorem\u00a0Firozem&#8230;<\/p>\n","protected":false},"author":2,"featured_media":72015,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[694,2631,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/72014"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=72014"}],"version-history":[{"count":1,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/72014\/revisions"}],"predecessor-version":[{"id":72016,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/72014\/revisions\/72016"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/72015"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=72014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=72014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=72014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}