{"id":71406,"date":"2025-02-03T00:32:53","date_gmt":"2025-02-02T23:32:53","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=71406"},"modified":"2025-02-02T15:13:27","modified_gmt":"2025-02-02T14:13:27","slug":"prulom-japonsko-vyviji-zazracny-lek-na-prirozene-rostouci-zuby","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/02\/03\/prulom-japonsko-vyviji-zazracny-lek-na-prirozene-rostouci-zuby\/","title":{"rendered":"Pr\u016flom: Japonsko vyv\u00edj\u00ed z\u00e1zra\u010dn\u00fd l\u00e9k na p\u0159irozen\u011b rostouc\u00ed zuby"},"content":{"rendered":"
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Japon\u0161t\u00ed v\u011bdci vyvinuli l\u00e9k, kter\u00fd dok\u00e1\u017ee dor\u016fst ztracen\u00fdch zub\u016f. Po osmi letech v\u00fdvoje se nyn\u00ed revolu\u010dn\u00ed l\u00e9k chyst\u00e1 podstoupit klinick\u00e9 testy na lidech.<\/strong><\/p>\n

Osoba odpov\u011bdn\u00e1 za tento\u00a0p\u0159evratn\u00fd v\u00fdvoj<\/a> je Dr. Katsu Takahashi z Medical Research Institute Kitano Hospital v \u00d3sace. Jeho v\u00fdzkum je zalo\u017een na fascinuj\u00edc\u00edm evolu\u010dn\u00edm biologick\u00e9m zji\u0161t\u011bn\u00ed: lid\u00e9 st\u00e1le maj\u00ed biologick\u00e9 \u201ez\u00e1rodky\u201c pro t\u0159et\u00ed sadu zub\u016f \u2013 ve v\u00fdvoji jim br\u00e1n\u00ed pouze molekula zvan\u00e1 USAG-1.<\/p>\n

\u201eV pr\u016fb\u011bhu evoluce jsme my lid\u00e9 ztratili schopnost vyvinout t\u0159et\u00ed sadu zub\u016f po na\u0161ich ml\u00e9\u010dn\u00fdch zubech a trval\u00fdch zubech. Ale z\u00e1kladn\u00ed struktury pro to st\u00e1le existuj\u00ed,\u201c vysv\u011btluje Takahashi. Jeho t\u00fdm vyvinul l\u00e9k na b\u00e1zi RNA, kter\u00fd specificky deaktivuje inhibi\u010dn\u00ed molekulu USAG-1.<\/p>\n

Klinick\u00e9 studie na lidech za\u010daly v \u0159\u00edjnu 2024 v Kj\u00f3tsk\u00e9 univerzitn\u00ed nemocnici. Nejprve bude bezpe\u010dnost l\u00e9ku testov\u00e1na na zdrav\u00fdch dosp\u011bl\u00fdch osob\u00e1ch s alespo\u0148 jedn\u00edm chyb\u011bj\u00edc\u00edm zubem. Ve druh\u00e9 f\u00e1zi budou o\u0161et\u0159eny d\u011bti ve v\u011bku od dvou do sedmi let, kter\u00fdm chyb\u00ed alespo\u0148 \u010dty\u0159i zuby.<\/p>\n

WHO odhaduje, \u017ee asi 23 procent lid\u00ed star\u0161\u00edch 60 let na cel\u00e9m sv\u011bt\u011b trp\u00ed \u00faplnou ztr\u00e1tou zub\u016f. Tito lid\u00e9 maj\u00ed zat\u00edm pouze um\u011bl\u00e1 \u0159e\u0161en\u00ed jako implant\u00e1ty nebo sn\u00edmateln\u00e9 prot\u00e9zy. To by se nyn\u00ed mohlo z\u00e1sadn\u011b zm\u011bnit. \u201eDouf\u00e1me, \u017ee do roku 2030 bude na\u0161e metoda k dispozici jako t\u0159et\u00ed mo\u017enost vedle zubn\u00edch prot\u00e9z a implant\u00e1t\u016f,\u201c \u0159\u00edk\u00e1 Takahashi. \u201eMy\u0161lenka na p\u011bstov\u00e1n\u00ed nov\u00fdch zub\u016f je snem ka\u017ed\u00e9ho zuba\u0159e. Od za\u010d\u00e1tku jsem byl p\u0159esv\u011bd\u010den, \u017ee to zvl\u00e1dneme.“<\/p>\n

V\u011bdci po cel\u00e9m sv\u011bt\u011b p\u0159itom pracuj\u00ed na dal\u0161\u00edch slibn\u00fdch p\u0159\u00edstupech: Na Washingtonsk\u00e9 univerzit\u011b se v\u011bdc\u016fm ji\u017e poda\u0159ilo vyp\u011bstovat organoidn\u00ed struktury z kmenov\u00fdch bun\u011bk, kter\u00e9 produkuj\u00ed proteiny tvo\u0159\u00edc\u00ed sklovinu. „To by mohlo zah\u00e1jit stolet\u00ed \u017eiv\u00fdch v\u00fdpln\u00ed a regenerativn\u00ed stomatologie,“ p\u0159edpov\u00edd\u00e1 biochemi\u010dka Hannele Ruohola-Baker, kter\u00e1 se na tom pod\u00edlela.<\/p>\n

Etick\u00e9 ot\u00e1zky, kter\u00e9 vyvst\u00e1vaj\u00ed p\u0159i pou\u017e\u00edv\u00e1n\u00ed kmenov\u00fdch bun\u011bk, se zdaj\u00ed \u0159e\u0161iteln\u00e9. Dr. David Obree z University of Edinburgh vid\u00ed velk\u00fd potenci\u00e1l zejm\u00e9na ve vyu\u017eit\u00ed t\u011blu vlastn\u00edch kmenov\u00fdch bun\u011bk: \u201eBu\u0148ky z extrahovan\u00fdch zub\u016f moudrosti by se mohly uk\u00e1zat jako ide\u00e1ln\u00ed zdroj pro regeneraci org\u00e1n\u016f a zub\u016f.\u201c<\/p>\n

Zda budou tyto revolu\u010dn\u00ed terapie dostupn\u00e9 pro ka\u017ed\u00e9ho, se v\u0161ak teprve uvid\u00ed. Jedna v\u011bc je jist\u00e1: stomatologie \u010del\u00ed zm\u011bn\u011b paradigmatu. To, co bylo v\u010dera pova\u017eov\u00e1no za nemo\u017en\u00e9, m\u016f\u017ee b\u00fdt z\u00edtra realitou \u2013 p\u0159irozen\u00fd op\u011btovn\u00fd r\u016fst ztracen\u00fdch zub\u016f.<\/p>\n

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Japon\u0161t\u00ed v\u011bdci vyvinuli l\u00e9k, kter\u00fd dok\u00e1\u017ee dor\u016fst ztracen\u00fdch zub\u016f. Po osmi letech v\u00fdvoje se nyn\u00ed…<\/p>\n","protected":false},"author":2,"featured_media":71407,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[105,1453,4860],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/71406"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=71406"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/71406\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/71407"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=71406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=71406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=71406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}