{"id":71213,"date":"2025-01-30T00:37:23","date_gmt":"2025-01-29T23:37:23","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=71213"},"modified":"2025-01-29T17:06:33","modified_gmt":"2025-01-29T16:06:33","slug":"vakciny-pfizer-kontaminovane-rizikovymi-zbytky-dna-odhaleni-zesilovacu-sv40-a-promotoru-t7-vyvolava-vazne-bezpecnostni-otazky","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/01\/30\/vakciny-pfizer-kontaminovane-rizikovymi-zbytky-dna-odhaleni-zesilovacu-sv40-a-promotoru-t7-vyvolava-vazne-bezpecnostni-otazky\/","title":{"rendered":"Vakc\u00edny Pfizer kontaminovan\u00e9 rizikov\u00fdmi zbytky DNA: odhalen\u00ed zesilova\u010d\u016f SV40 a promotor\u016f T7 vyvol\u00e1v\u00e1 v\u00e1\u017en\u00e9 bezpe\u010dnostn\u00ed ot\u00e1zky"},"content":{"rendered":"
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Ned\u00e1vn\u00fd\u00a0<\/span>\u010dl\u00e1nek<\/span><\/a>\u00a0odhalil objev velk\u00e9ho mno\u017estv\u00ed zbytk\u016f DNA v mRNA vakc\u00edn\u00e1ch Pfizer. Pat\u0159\u00ed mezi n\u011b sekvence\u00a0<\/span>zesilova\u010de SV40<\/span><\/strong>\u00a0, kter\u00e9 jsou pova\u017eov\u00e1ny za potenci\u00e1ln\u011b rizikov\u00e9, proto\u017ee jsou schopny ovlivnit genovou expresi. Je zn\u00e1mo, \u017ee tyto zesilova\u010de podporuj\u00ed transkripci gen\u016f, co\u017e v n\u011bkter\u00fdch kontextech p\u0159edstavuje zdravotn\u00ed rizika, jako nap\u0159\u00edklad: B. by mohla b\u00fdt spojena s mo\u017enou onkogenitou.<\/span><\/p>\n

Krom\u011b toho \u010dl\u00e1nek zd\u016fraz\u0148uje\u00a0<\/span>promotor T7<\/span><\/strong>\u00a0, dal\u0161\u00ed genetick\u00fd prvek p\u0159\u00edtomn\u00fd ve vakc\u00edn\u011b Pfizer. Promotor T7 se \u010dasto pou\u017e\u00edv\u00e1 v molekul\u00e1rn\u00ed biologii k umo\u017en\u011bn\u00ed synt\u00e9zy RNA ve velk\u00e9m m\u011b\u0159\u00edtku. Jeho p\u0159\u00edtomnost ve vakc\u00edn\u011b by v\u0161ak mohla m\u00edt nezam\u00fd\u0161len\u00e9 n\u00e1sledky, pokud by byla integrov\u00e1na nebo aktivov\u00e1na do lidsk\u00fdch bun\u011bk.<\/span><\/p>\n

Auto\u0159i \u010dl\u00e1nku zd\u016fraz\u0148uj\u00ed, \u017ee objev takov\u00fdch zbytk\u016f DNA vyvol\u00e1v\u00e1 ot\u00e1zky o\u00a0<\/span>kvalit\u011b v\u00fdroby<\/span><\/strong>\u00a0a dodr\u017eov\u00e1n\u00ed regula\u010dn\u00edch norem. Zbytky DNA by mohly nazna\u010dovat bu\u010f kontaminaci, nebo nedostate\u010dn\u00e9 \u010distic\u00ed procesy b\u011bhem v\u00fdroby. Zejm\u00e9na kombinace mRNA, DNA zbytk\u016f a specifick\u00fdch promotorov\u00fdch sekvenc\u00ed, kter\u00e9 mohou ovlivnit genovou expresi, je zm\u00edn\u011bna jako mo\u017en\u00fd rizikov\u00fd faktor, kter\u00fd vy\u017eaduje hlub\u0161\u00ed zkoum\u00e1n\u00ed.<\/span><\/p>\n

V\u011bdci volaj\u00ed po\u00a0<\/span>okam\u017eit\u00e9m zastaven\u00ed v\u0161ech biologick\u00fdch p\u0159\u00edpravk\u016f na b\u00e1zi RNA,<\/span><\/strong>\u00a0dokud nebudou l\u00e9pe pochopeny dlouhodob\u00e9 \u00fa\u010dinky takov\u00fdch zbytk\u016f DNA. \u010cl\u00e1nek poznamen\u00e1v\u00e1, \u017ee sou\u010dasn\u00e9 hodnocen\u00ed bezpe\u010dnosti mRNA vakc\u00edn nemus\u00ed b\u00fdt dostate\u010dn\u00e9 k pokryt\u00ed t\u011bchto specifick\u00fdch rizik a vy\u017eaduje komplexn\u00ed p\u0159ezkum schvalovac\u00edch proces\u016f a kontroly kvality.<\/span><\/p>\n

I kdy\u017e n\u011bkte\u0159\u00ed odborn\u00edci tvrd\u00ed, \u017ee takov\u00e1to rezidua DNA se vyskytuj\u00ed v mal\u00fdch mno\u017estv\u00edch a b\u011b\u017en\u011b nep\u0159edstavuj\u00ed bezpe\u010dnostn\u00ed probl\u00e9m, auto\u0159i \u010dl\u00e1nku po\u017eaduj\u00ed transparentnost a nez\u00e1visl\u00e9 vy\u0161et\u0159ov\u00e1n\u00ed, aby se vylou\u010dila potenci\u00e1ln\u00ed ohro\u017een\u00ed ve\u0159ejn\u00e9ho zdrav\u00ed.<\/span><\/p>\n

\u010cl\u00e1nek kon\u010d\u00ed zd\u016frazn\u011bn\u00edm, \u017ee tato zji\u0161t\u011bn\u00ed by mohla nejen podkopat d\u016fv\u011bru v technologii mRNA, ale mohla by m\u00edt tak\u00e9 dalekos\u00e1hl\u00e9 d\u016fsledky pro v\u00fdvoj budouc\u00edch terapi\u00ed a vakc\u00edn na b\u00e1zi RNA.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/a><\/span><\/h3>\n

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Ned\u00e1vn\u00fd\u00a0\u010dl\u00e1nek\u00a0odhalil objev velk\u00e9ho mno\u017estv\u00ed zbytk\u016f DNA v mRNA vakc\u00edn\u00e1ch Pfizer. Pat\u0159\u00ed mezi n\u011b sekvence\u00a0zesilova\u010de SV40\u00a0,…<\/p>\n","protected":false},"author":2,"featured_media":63912,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,4515,651,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/71213"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=71213"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/71213\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/63912"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=71213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=71213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=71213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}