{"id":7121,"date":"2021-12-27T04:15:36","date_gmt":"2021-12-27T03:15:36","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=7121"},"modified":"2021-12-27T04:16:01","modified_gmt":"2021-12-27T03:16:01","slug":"fenomen-protilatkami-zprostredkovaneho-zhorseni-antibody-dependent-enhancement-ade","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2021\/12\/27\/fenomen-protilatkami-zprostredkovaneho-zhorseni-antibody-dependent-enhancement-ade\/","title":{"rendered":"Fenom\u00e9n protil\u00e1tkami zprost\u0159edkovan\u00e9ho zhor\u0161en\u00ed \u2013 Antibody Dependent Enhancement (ADE)"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<p align=\"JUSTIFY\">Laick\u00e1 ani \u0161ir\u0161\u00ed odborn\u00e1 ve\u0159ejnost dnes nejsou dostate\u010dn\u011b a spr\u00e1vn\u011b informov\u00e1ny o jednom ze z\u00e1va\u017en\u00fdch rizik o\u010dkov\u00e1n\u00ed proti virov\u00fdm onemocn\u011bn\u00edm. Jedn\u00e1 se o fenom\u00e9n\u00a0<em>Antibody-Dependent Enhancement<\/em>(ADE). \u010cesky bychom mohli popsat jako:\u00a0<em>Fenom\u00e9n <\/em><em>protil\u00e1tkami zprost\u0159edkovan\u00e9ho zhor\u0161en\u00ed.<\/em>Tento z\u00e1va\u017en\u00fd jev m\u016f\u017ee nastat prakticky u v\u0161ech virov\u00fdch onemocn\u011bn\u00ed a u mnoh\u00fdch byl tak\u00e9 ji\u017e v\u00a0praxi pozorov\u00e1n a pops\u00e1n<strong>. Nezbytnou podm\u00ednkou vzniku ADE jsou ji\u017e existuj\u00edc\u00ed protil\u00e1tky v\u016f\u010di viru a tedy jejich p\u0159\u00edtomnost v\u00a0organismu v\u00a0dob\u011b opakovan\u00e9 n\u00e1kazy v\u00a0budoucnosti (reinfekce nebo primoinfekce po p\u0159edchoz\u00edm o\u010dkov\u00e1n\u00ed).<\/strong>Protektivn\u011b \u00fa\u010dinn\u00e9 protil\u00e1tky vykazuj\u00ed tzv.\u00a0<strong>neutraliza\u010dn\u00ed \u00fa\u010dinek.\u00a0<\/strong>P\u0159i sv\u00e9 spr\u00e1vn\u00e9 struktu\u0159e a dostate\u010dn\u00e9 hladin\u011b p\u016fsob\u00ed proti vzniku a rozvoji infekce tou variantou viru, proti kter\u00e9 byly organismem vytvo\u0159eny.<\/p>\n<p align=\"JUSTIFY\">Co je podstatou ADE? Podstatou fenom\u00e9nu je odli\u0161n\u00fd zp\u016fsob fungov\u00e1n\u00ed protil\u00e1tek za ur\u010dit\u00fdch typick\u00fdch okolnost\u00ed. Mohli bychom jej ozna\u010dit za \u00fa\u010dinek neoptim\u00e1ln\u00ed. V\u00a0odborn\u00e9 terminologii se \u010dast\u011bji u\u017e\u00edv\u00e1 pojem\u00a0<strong>subneutraliza\u010dn\u00ed \u00fa\u010dinek\u00a0<\/strong>protil\u00e1tek. Pokud subneutraliza\u010dn\u00ed \u00fa\u010dinek nastane, v\u00a0imunitn\u00edm syst\u00e9mu organismu se rozvinou jin\u00e9 procesy s\u00a0odli\u0161n\u00fdmi d\u016fsledky, ne\u017e je tomu ve standardn\u00edm p\u0159\u00edpad\u011b. Je to kask\u00e1da netypick\u00fdch imunologick\u00fdch mechanism\u016f a proces\u016f, kter\u00e9\u00a0<strong>zahrnuj\u00ed podporu vta\u017een\u00ed \u017eiv\u00e9ho viru do hostitelsk\u00fdch bun\u011bk a jeho n\u00e1slednou \u00fasp\u011b\u0161nou replikaci. Tedy p\u0159\u00edmou podporu (!) reinfekce.\u00a0<\/strong>P\u0159i v\u00fdskytu ADE doch\u00e1z\u00ed k\u00a0mnohem rychlej\u0161\u00edmu a z\u00e1va\u017en\u011bj\u0161\u00edmu pr\u016fb\u011bhu reinfekce, k \u010dast\u011bj\u0161\u00edm komplikac\u00edm v\u010detn\u011b vy\u0161\u0161\u00ed m\u00edry \u00famrtnosti a trval\u00fdch n\u00e1sledk\u016f.Fenom\u00e9n ADE m\u016f\u017ee vzniknout n\u011bkolika odli\u0161n\u00fdmi mechanismy. Zejm\u00e9na dva z\u00a0nich jsou pot\u00e9 v\u00edce zn\u00e1m\u00e9 a prozkouman\u00e9: &#8230;<\/p>\n<p align=\"JUSTIFY\">cel\u00fd \u010dl\u00e1nek ve form\u011b pdf:\u00a0<a href=\"https:\/\/poockovani.cz\/downloads\/Serial-Rizika2-ADE-C19V.pdf\" target=\"_blank\" rel=\"noopener\">poockovani.cz\/downloads\/Serial-Rizika2-ADE-C19V.pdf<\/a><\/p>\n<p align=\"JUSTIFY\"><a href=\"https:\/\/www.poockovani.cz\/zpravy\/clanky\/serial-ii-fenomen-protilatkami-zprostredkovaneho-zhorseni-antibody\">ZDROJ<\/a><\/p>\n<p align=\"JUSTIFY\">\n","protected":false},"excerpt":{"rendered":"<p>Laick\u00e1 ani \u0161ir\u0161\u00ed odborn\u00e1 ve\u0159ejnost dnes nejsou dostate\u010dn\u011b a spr\u00e1vn\u011b informov\u00e1ny o jednom ze z\u00e1va\u017en\u00fdch&#8230;<\/p>\n","protected":false},"author":2,"featured_media":575,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[1624,1082,213],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/7121"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=7121"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/7121\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/575"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=7121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=7121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=7121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}