{"id":70241,"date":"2025-01-16T00:34:33","date_gmt":"2025-01-15T23:34:33","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=70241"},"modified":"2025-01-15T14:01:56","modified_gmt":"2025-01-15T13:01:56","slug":"prukopnicka-studie-mrna-vakciny-a-jejich-ucinky-na-srdce","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/01\/16\/prukopnicka-studie-mrna-vakciny-a-jejich-ucinky-na-srdce\/","title":{"rendered":"Pr\u016fkopnick\u00e1 studie: mRNA vakc\u00edny a jejich \u00fa\u010dinky na srdce"},"content":{"rendered":"
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Senza\u010dn\u00ed\u00a0<\/span>studie<\/span><\/a>\u00a0glob\u00e1ln\u00edho t\u00fdmu 40 mezin\u00e1rodn\u00edch v\u011bdc\u016f zjistila, \u017ee mRNA vakc\u00edny se mohou dostat do srde\u010dn\u00ed tk\u00e1n\u011b a v\u00e9st ke zm\u011bn\u00e1m v proteomu. To by mohlo v\u00e9st k aktivaci imunitn\u00edho syst\u00e9mu a po\u0161kozen\u00ed krevn\u00edch c\u00e9v.<\/span><\/p>\n

Studie s n\u00e1zvem\u00a0<\/span>\u201eZobrazov\u00e1n\u00ed nanonosi\u010d\u016f v rozli\u0161en\u00ed jedn\u00e9 bu\u0148ky nap\u0159\u00ed\u010d cel\u00fdm t\u011blem my\u0161i s hlubok\u00fdm u\u010den\u00edm<\/span><\/em>\u00a0\u201c byla publikov\u00e1na v renomovan\u00e9m \u010dasopise\u00a0<\/span>Nature Biotechnology<\/span><\/em>\u00a0. V\u00fdsledky jsou v rozporu s p\u0159edchoz\u00edm p\u0159edpokladem, \u017ee lipidov\u00e9 nano\u010d\u00e1stice (LNP) nesouc\u00ed mRNA z\u016fst\u00e1vaj\u00ed po injekci ve svalov\u00e9 tk\u00e1ni. V\u00fdzkum ve skute\u010dnosti ukazuje, \u017ee tyto \u010d\u00e1stice putuj\u00ed do \u017eivotn\u011b d\u016fle\u017eit\u00fdch org\u00e1n\u016f, jako je srdce.<\/span><\/p>\n

Kl\u00ed\u010dov\u00e9 v\u00fdsledky studie<\/strong><\/span><\/p>\n

Pod veden\u00edm\u00a0<\/span>Prof. Dr. Ali Maximilian Erturk<\/span><\/a>\u00a0, uzn\u00e1van\u00fd neurolog a \u0159editel Institutu pro tk\u00e1\u0148ov\u00e9 in\u017een\u00fdrstv\u00ed a regenerativn\u00ed medic\u00ednu v Helmholtzov\u011b centru Mnichov, v\u00fdzkumn\u00fd t\u00fdm dosp\u011bl k \u0161okuj\u00edc\u00edm zji\u0161t\u011bn\u00edm. Pomoc\u00ed inovativn\u00ed metody SCP-Nano, kter\u00e1 kombinuje nejmodern\u011bj\u0161\u00ed zobrazovac\u00ed technologie a um\u011blou inteligenci, bylo prok\u00e1z\u00e1no, \u017ee LNP se \u0161\u00ed\u0159\u00ed po cel\u00e9m t\u011ble a ovliv\u0148uj\u00ed zejm\u00e9na srde\u010dn\u00ed tk\u00e1\u0148.<\/span><\/p>\n

Zm\u011bny zji\u0161t\u011bn\u00e9 v srdci<\/strong><\/span><\/p>\n

V\u011bdci pozorovali, \u017ee nano\u010d\u00e1stice zm\u011bnily expresi protein\u016f v srde\u010dn\u00edch tk\u00e1n\u00edch, p\u0159edev\u0161\u00edm v endoteli\u00e1ln\u00edch bu\u0148k\u00e1ch kapil\u00e1r. Tyto zm\u011bny byly spojeny s procesy, jako je z\u00e1n\u011bt a mechanismy bun\u011b\u010dn\u00e9 opravy. Proteiny, kter\u00e9 jsou nezbytn\u00e9 pro funkci a strukturu krevn\u00edch c\u00e9v, vykazovaly znateln\u00e9 abnormality, indikuj\u00edc\u00ed mo\u017en\u00e9 po\u0161kozen\u00ed.<\/span><\/p>\n

Pro\u010d je tento objev relevantn\u00ed<\/strong><\/span><\/p>\n

V\u00fdsledky navazuj\u00ed na p\u0159edchoz\u00ed \u00fadaje, jako jsou \u00fadaje o biodistribuci FOI z Japonska, kter\u00e9 ji\u017e nazna\u010dily, \u017ee LNP se mohou distribuovat po cel\u00e9m t\u011ble. Tato studie v\u0161ak jde je\u0161t\u011b o krok d\u00e1le, kdy\u017e ukazuje, \u017ee zm\u011bny v srde\u010dn\u00ed tk\u00e1ni mohou tak\u00e9 ovlivnit to, jak srdce funguje.<\/span><\/p>\n

Nakahara a kol. ji\u017e zjistili, \u017ee rozd\u00edly byly zji\u0161t\u011bny u 46 % o\u010dkovan\u00fdch srdc\u00ed ve srovn\u00e1n\u00ed s neo\u010dkovan\u00fdmi. Tento nov\u00fd v\u00fdzkum podporuje takov\u00e1 pozorov\u00e1n\u00ed a poskytuje mo\u017en\u00e9 vysv\u011btlen\u00ed z\u00e1kladn\u00edch mechanism\u016f.<\/span><\/p>\n

Kritika a rozhled<\/strong><\/span><\/p>\n

Skeptici podotknou, \u017ee studie byla provedena na my\u0161\u00edch. Ale stejn\u011b jako u v\u00fdvoje nov\u00fdch l\u00e9k\u016f je nezbytn\u00fdm prvn\u00edm krokem v\u00fdzkum na zv\u00ed\u0159ec\u00edch modelech. Zji\u0161t\u011bn\u00ed z takov\u00fdch studi\u00ed poskytuj\u00ed z\u00e1sadn\u00ed informace o tom, zda a jak lze technologii p\u0159en\u00e9st na \u010dlov\u011bka.<\/span><\/p>\n

Po\u017eadavky na transparentnost<\/strong><\/span><\/p>\n

Tyto nov\u00e9 v\u00fdsledky op\u011bt vyvol\u00e1vaj\u00ed ot\u00e1zky o bezpe\u010dnosti mRNA vakc\u00edn a zd\u016fraz\u0148uj\u00ed pot\u0159ebu dal\u0161\u00edho nez\u00e1visl\u00e9ho v\u00fdzkumu. Prof. Erturk a jeho t\u00fdm svou prac\u00ed v\u00fdznamn\u011b p\u0159isp\u00edvaj\u00ed k pochopen\u00ed potenci\u00e1ln\u00edch rizik a obohacuj\u00ed ve\u0159ejnou diskusi.<\/span><\/p>\n

Mezit\u00edm se uvid\u00ed, zda prominentn\u00ed hlasy jako Robert Kennedy Jr. p\u0159ijmou tato zji\u0161t\u011bn\u00ed a budou je d\u00e1le sledovat. Jeho sly\u0161en\u00ed, kter\u00e9 bylo podle v\u0161eho odlo\u017eeno na \u00fanor, by mohlo vyvolat dal\u0161\u00ed politick\u00fd tlak.<\/span><\/p>\n

Diskuse o mRNA vakc\u00edn\u00e1ch nen\u00ed v \u017e\u00e1dn\u00e9m p\u0159\u00edpad\u011b u konce \u2013 ve skute\u010dnosti by mohla teprve za\u010d\u00edt.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Senza\u010dn\u00ed\u00a0studie\u00a0glob\u00e1ln\u00edho t\u00fdmu 40 mezin\u00e1rodn\u00edch v\u011bdc\u016f zjistila, \u017ee mRNA vakc\u00edny se mohou dostat do srde\u010dn\u00ed tk\u00e1n\u011b…<\/p>\n","protected":false},"author":2,"featured_media":17219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[694,1556,839,651,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/70241"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=70241"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/70241\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/17219"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=70241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=70241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=70241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}