{"id":69375,"date":"2025-01-03T00:32:05","date_gmt":"2025-01-02T23:32:05","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=69375"},"modified":"2025-01-02T14:26:42","modified_gmt":"2025-01-02T13:26:42","slug":"vakcina-vyvinuta-billem-gatesem-ktera-se-aplikuje-kousnutim-komarem-nese-bioinzenyrsky-parazit-malarie","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2025\/01\/03\/vakcina-vyvinuta-billem-gatesem-ktera-se-aplikuje-kousnutim-komarem-nese-bioinzenyrsky-parazit-malarie\/","title":{"rendered":"Vakc\u00edna vyvinut\u00e1 Billem Gatesem, kter\u00e1 se aplikuje kousnut\u00edm kom\u00e1rem, nese bioin\u017een\u00fdrsk\u00fd parazit mal\u00e1rie"},"content":{"rendered":"
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Bill Gates financoval nizozemsk\u00e9 l\u00e9ka\u0159sk\u00e9 centrum, kter\u00e9 vyv\u00edj\u00ed vakc\u00edny proti kom\u00e1r\u016fm, u nich\u017e bylo prok\u00e1z\u00e1no, \u017ee infikuj\u00ed lidsk\u00e9 krvinky.<\/strong><\/p>\n

Neobvykl\u00fd experiment financovan\u00fd nadac\u00ed Billa a Melindy Gatesov\u00fdch vyvinul novou o\u010dkovac\u00ed strategii vyu\u017e\u00edvaj\u00edc\u00ed kousnut\u00ed kom\u00e1r\u016f jako vektoru k v\u00fdzkumu vakc\u00edny proti mal\u00e1rii \u201enov\u00e9 generace\u201c.<\/span><\/p>\n

Experiment, kter\u00fd provedli v\u011bdci z Leiden University Medical Center (LUMC) v Nizozemsku, byl ned\u00e1vno publikov\u00e1n v\u00a0<\/span>New England Journal of Medicine<\/span><\/em>\u00a0.<\/span><\/a><\/p>\n

V\u00fdzkumn\u00edci vysv\u011btlili, jak pou\u017eili kousnut\u00ed kom\u00e1r\u016f k dod\u00e1n\u00ed vakc\u00edny proti mal\u00e1rii s kr\u00e1tkou \u017eivotnost\u00ed obsahuj\u00edc\u00ed geneticky modifikovan\u00e9 parazity mal\u00e1rie.<\/span><\/p>\n

\u201eProvedli jsme dvojit\u011b zaslepenou, kontrolovanou klinickou studii, abychom vyhodnotili bezpe\u010dnost, profil vedlej\u0161\u00edch \u00fa\u010dink\u016f a \u00fa\u010dinnost imunizace kom\u00e1\u0159\u00edm kousnut\u00edm druhou generac\u00ed geneticky oslaben\u00e9ho parazita (GA2) \u2013\u00a0<\/span>mei2 single knockout<\/span><\/em>\u00a0P. falciparum parazita NF54 (sporozoitov\u00e1 forma ) s prodlou\u017een\u00fd v\u00fdvoj ve st\u00e1diu jater,\u201c vysv\u011btlili v\u011bdci.<\/span><\/p>\n

Parazit\u00a0<\/span>Plasmodium falciparum<\/span><\/em>\u00a0(P. falciparum) zp\u016fsobuje mal\u00e1rii u lid\u00ed.<\/span><\/p>\n

Metoda byla zam\u011b\u0159ena na podporu imunity prost\u0159ednictv\u00edm kousnut\u00ed kom\u00e1ry pomoc\u00ed geneticky modifikovan\u00fdch parazit\u016f k vyvol\u00e1n\u00ed a zastaven\u00ed infekce mal\u00e1rie.<\/span><\/p>\n

Nejprve v\u00fdzkumn\u00edci vyvinuli dva typy parazit\u016f mal\u00e1rie, GA1 a GA2.<\/span><\/p>\n

GA1 m\u011bl zastavit v\u00fdvoj \u201ep\u0159ibli\u017en\u011b 24 hodin po infekci u lid\u00ed\u201c, ale uk\u00e1zalo se, \u017ee m\u00e1 omezenou \u00fa\u010dinnost, co\u017e vedlo k v\u00fdvoji GA2.<\/span><\/p>\n

GA2 byl „navr\u017een tak, aby zastavil v\u00fdvoj p\u0159ibli\u017en\u011b \u0161est dn\u00ed po infekci, b\u011bhem kl\u00ed\u010dov\u00e9 f\u00e1ze, ve kter\u00e9 se paraziti mno\u017e\u00ed v lidsk\u00fdch jatern\u00edch bu\u0148k\u00e1ch.“<\/span><\/p>\n

Experiment zahrnoval dv\u011b f\u00e1ze.<\/span><\/p>\n

Ve f\u00e1zi A byli \u00fa\u010dastn\u00edci \u201evystaveni kousnut\u00ed 15 nebo 50 infikovan\u00fdch kom\u00e1r\u016f\u201c.<\/span><\/p>\n

Ve f\u00e1zi B byli \u201ezdrav\u00ed dosp\u011bl\u00ed, kte\u0159\u00ed nikdy netrp\u011bli mal\u00e1ri\u00ed, n\u00e1hodn\u011b rozd\u011bleni tak, aby dostali 50 kousnut\u00ed kom\u00e1rem na o\u010dkov\u00e1n\u00ed GA2, p\u0159edchoz\u00edm parazitem (GA1) nebo placebem (neinfikovan\u00ed kom\u00e1\u0159i).<\/span><\/p>\n

Zar\u00e1\u017eej\u00edc\u00ed je, \u017ee v\u011bdci sledovali infekce pouze po dobu 25 dn\u016f, co\u017e znamen\u00e1, \u017ee pozd\u011bj\u0161\u00ed infekce nebyly zaznamen\u00e1ny.<\/span><\/p>\n

Nav\u00edc 20 % \u00fa\u010dastn\u00edk\u016f ve f\u00e1zi B m\u011blo zv\u00fd\u0161en\u00e9 hladiny troponinu T \u2013 biomarkeru po\u0161kozen\u00ed srdce nebo stresu, kter\u00fd vyvol\u00e1v\u00e1 obavy z potenci\u00e1ln\u00edho po\u0161kozen\u00ed srdce.<\/span><\/p>\n

V\u011bdci v\u0161ak uvedli, \u017ee tyto hodnoty \u201enesouvisely se studijn\u00ed intervenc\u00ed\u201c, ani\u017e by podrobn\u011b vysv\u011btlili, jak k tomuto z\u00e1v\u011bru dosp\u011bli.<\/span><\/p>\n

Kritik COVID Dr. Richard Bartlett kritizoval kr\u00e1tkou dobu pozorov\u00e1n\u00ed studie a po\u017eadoval komplexn\u011bj\u0161\u00ed dlouhodob\u00e1 data.<\/span><\/p>\n

„Studie vyvol\u00e1v\u00e1 zna\u010dn\u00e9 obavy,“ \u0159ekl Dr. Bartlett. \u201ePouh\u00e9 n\u011bkolik t\u00fddn\u016f pozorov\u00e1n\u00ed nesta\u010d\u00ed k posouzen\u00ed dlouhodob\u00e9 bezpe\u010dnosti nebo \u00fa\u010dinnosti. Na sledov\u00e1n\u00ed parazit\u00e1rn\u00edch infekc\u00ed a mo\u017en\u00fdch komplikac\u00ed by bylo pot\u0159eba alespo\u0148 \u0161est m\u011bs\u00edc\u016f a\u017e rok. Kde jsou dlouhodob\u00e1 data? Bez toho nelze pozdn\u00ed n\u00e1sledky nebo komplikace adekv\u00e1tn\u011b posoudit.\u201c<\/span><\/p>\n

Zd\u016fraznil, \u017ee zv\u00fd\u0161en\u00e9 hladiny T jsou \u201eextr\u00e9mn\u011b znepokojiv\u00e9\u201c.<\/span><\/p>\n

„Troponin je specifick\u00fd marker po\u0161kozen\u00ed srdce, ne jater,“ \u0159ekl. „To nazna\u010duje potenci\u00e1ln\u00ed po\u0161kozen\u00ed srdce, kter\u00e9 z\u0159ejm\u011b nebylo d\u016fkladn\u011b prozkoum\u00e1no.“ Tento bezpe\u010dnostn\u00ed sign\u00e1l nelze ignorovat.“<\/span><\/p>\n

V t\u00e9to studii je jasn\u011b viditeln\u00fd podpis nadace Bill & Melinda Gates Foundation.<\/span><\/p>\n

Ve stejn\u00e9m m\u011bs\u00edci publikace obdr\u017eela spole\u010dnost LUMC od Gatesovy nadace dar ve v\u00fd\u0161i 2 287 871 USD na v\u00fdvoj \u201ekandid\u00e1t\u016f na vakc\u00ednu proti mal\u00e1rii nov\u00e9 generace\u201c.<\/span><\/p>\n

B\u011bhem pandemie COVID byli kritici experiment\u00e1ln\u00edch mRNA vakc\u00edn cenzurov\u00e1ni a o\u010der\u0148ov\u00e1ni.<\/span><\/p>\n

Nyn\u00ed se zd\u00e1, \u017ee se pozornost p\u0159esouv\u00e1 na kousnut\u00ed kom\u00e1ry jako mo\u017en\u00fd zp\u016fsob dod\u00e1n\u00ed vakc\u00edny, mo\u017en\u00e1 proto, aby se p\u0159ede\u0161lo informovan\u00e9mu souhlasu v budouc\u00edch pl\u00e1nech pandemie.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/a><\/span><\/h3>\n

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Bill Gates financoval nizozemsk\u00e9 l\u00e9ka\u0159sk\u00e9 centrum, kter\u00e9 vyv\u00edj\u00ed vakc\u00edny proti kom\u00e1r\u016fm, u nich\u017e bylo prok\u00e1z\u00e1no,…<\/p>\n","protected":false},"author":2,"featured_media":12314,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[511,2788,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/69375"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=69375"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/69375\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/12314"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=69375"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=69375"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=69375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}