{"id":68366,"date":"2024-12-18T00:34:32","date_gmt":"2024-12-17T23:34:32","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=68366"},"modified":"2024-12-17T16:27:55","modified_gmt":"2024-12-17T15:27:55","slug":"studie-cdc-zasahla-jako-bomba-ockovani-vakcinou-pfizer-mrna-neposkytuje-ochranu-detem-ve-veku-od-6-mesicu-do-4-let","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2024\/12\/18\/studie-cdc-zasahla-jako-bomba-ockovani-vakcinou-pfizer-mrna-neposkytuje-ochranu-detem-ve-veku-od-6-mesicu-do-4-let\/","title":{"rendered":"Studie CDC zas\u00e1hla jako bomba: O\u010dkov\u00e1n\u00ed vakc\u00ednou Pfizer mRNA neposkytuje ochranu d\u011btem ve v\u011bku od 6 m\u011bs\u00edc\u016f do 4 let"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p><em><span>Ned\u00e1vn\u00e1 studie publikovan\u00e1 v Journal of the Pediatric Infectious Diseases Society zkoumala roli o\u010dkov\u00e1n\u00ed proti COVID-19 a p\u0159edchoz\u00edch infekc\u00ed v prevenci SARS-CoV-2 u d\u011bt\u00ed ve v\u011bku od 6 m\u011bs\u00edc\u016f do 4 let ve Spojen\u00fdch st\u00e1tech v obdob\u00ed od z\u00e1\u0159\u00ed 2022 do dubna 2023. Studie shrom\u00e1\u017edila \u00fadaje ze t\u0159\u00ed kohortov\u00fdch studi\u00ed (PROTECT, CASCADIA a CoVE) za \u00fa\u010delem posouzen\u00ed rizik infekce, v\u010detn\u011b symptomatick\u00fdch Infekce COVID-19 b\u011bhem obdob\u00ed omikronov\u00e9 prevalence. Kl\u00ed\u010dov\u00e1 zji\u0161t\u011bn\u00ed nazna\u010duj\u00ed, \u017ee p\u0159edchoz\u00ed infekce poskytuje v\u00fdznamnou ochranu p\u0159ed infekc\u00ed SARS-CoV-2 a symptomatick\u00fdm onemocn\u011bn\u00edm, zat\u00edmco o\u010dkov\u00e1n\u00ed, zejm\u00e9na vakc\u00ednou Pfizer-BioNTech, tato rizika trvale nesni\u017euje. Ve skute\u010dnosti se zd\u00e1, \u017ee o\u010dkovan\u00e9 d\u011bti se nakaz\u00ed \u010dast\u011bji. Vezmeme-li v \u00favahu omezen\u00ed, tato studie vzbuzuje v\u00e1\u017en\u00e9 obavy a m\u011bla by b\u00fdt zohledn\u011bna p\u0159i p\u0159izp\u016fsobov\u00e1n\u00ed politik.<\/span><\/em><\/p>\n<h2 class=\"wp-block-heading\"><strong><span>Studium hypot\u00e9zy a metodologie<\/span><\/strong><\/h2>\n<p><span>Studie p\u0159edpokl\u00e1dala, \u017ee o\u010dkov\u00e1n\u00ed proti COVID-19 a p\u0159edchoz\u00ed infekce sn\u00ed\u017e\u00ed po\u010det infekc\u00ed SARS-CoV-2 a symptomatick\u00fdch infekc\u00ed COVID-19. V\u00fdzkumn\u00edci sledovali infekce pomoc\u00ed t\u00fddenn\u00edho testov\u00e1n\u00ed RT-PCR, kategorizovali \u00fa\u010dastn\u00edky podle jejich stavu o\u010dkov\u00e1n\u00ed (neo\u010dkovan\u00ed, \u010d\u00e1ste\u010dn\u011b o\u010dkovan\u00ed nebo s dokon\u010denou z\u00e1kladn\u00ed s\u00e9ri\u00ed) a p\u0159edchoz\u00edho stavu infekce. Pro odhad rizika infekce byly vypo\u010dteny pom\u011bry rizik (HR).<\/span><\/p>\n<h2 class=\"wp-block-heading\"><strong><span>V\u00fdsledky<\/span><\/strong><\/h2>\n<p><span>Za prv\u00e9, auto\u0159i na\u0161li robustn\u00ed ochranu proti p\u0159edchoz\u00ed infekci.\u00a0<\/span><span>D\u011bti s p\u0159edchoz\u00ed infekc\u00ed m\u011bly v\u00fdznamn\u011b ni\u017e\u0161\u00ed riziko infekce SARS-CoV-2 (HR: 0,28; 95% CI: 0,16-0,49) a symptomatick\u00e9ho COVID-19 (HR: 0,21; 95% CI: 0,08-0,54).<\/span><\/p>\n<p><span>Samotn\u00e1 vakc\u00edna m\u011bla omezenou \u00fa\u010dinnost.\u00a0<\/span><strong>\u00a0<\/strong><span>O\u010dkov\u00e1n\u00ed bez p\u0159edchoz\u00ed infekce neprok\u00e1zalo v\u00fdznamn\u00e9 sn\u00ed\u017een\u00ed rizika infekce (HR: 1,23; 95% CI: 0,69-2,16) nebo symptomatick\u00e9ho onemocn\u011bn\u00ed (HR: 1,61; 95% CI: -4,03).<\/span><\/p>\n<p><span>Podobn\u011b auto\u0159i pod veden\u00edm Leory Feldstein z Centra pro kontrolu a prevenci nemoc\u00ed (CDC) zjistili, \u017ee\u00a0<\/span><span>mezi \u201enaivn\u00edmi\u201c d\u011btmi (bez p\u0159edchoz\u00ed infekce) m\u011bly d\u011bti o\u010dkovan\u00e9 Pfizer-BioNTech vy\u0161\u0161\u00ed pravd\u011bpodobnost infekce (HR: 2 0,59; 95% CI: 1,27-5,28) a symptomatick\u00e9 onemocn\u011bn\u00ed COVID-19 (HR: 3,57; 95% CI: 1.10-11.63) ne\u017e neo\u010dkovan\u00ed vrstevn\u00edci.<\/span><\/p>\n<p><span>Jak je to s \u00fa\u010dinkem p\u0159eo\u010dkov\u00e1n\u00ed?\u00a0<\/span><span>Bivalentn\u00ed posilovac\u00ed vakcinace nevykazovaly \u017e\u00e1dn\u00fd v\u00fdznamn\u00fd ochrann\u00fd \u00fa\u010dinek proti infekci nebo symptomatick\u00e9mu onemocn\u011bn\u00ed.<\/span><\/p>\n<h2 class=\"wp-block-heading\"><strong><span>Studijn\u00ed omezen\u00ed a p\u0159edpoklady<\/span><\/strong><\/h2>\n<p><span>Studie m\u00e1 v\u00fdznamn\u00e1 omezen\u00ed:<\/span><\/p>\n<ul class=\"wp-block-list\">\n<li><span>Velikost vzorku: Mal\u00e1 velikost vzorku omezuje podskupinov\u00e9 anal\u00fdzy a statistickou s\u00edlu, zejm\u00e9na u posilovac\u00edch \u00fa\u010dink\u016f a ur\u010dit\u00fdch typ\u016f vakc\u00edn.<\/span><\/li>\n<li><span>Detekce p\u0159edchoz\u00edch infekc\u00ed: Spol\u00e9h\u00e1n\u00ed se na testov\u00e1n\u00ed anti-N protil\u00e1tek a sami nahl\u00e1\u0161en\u00e9 infekce mohly podcenit p\u0159edchoz\u00ed expozici.<\/span><\/li>\n<li><span>Dopad variant: P\u0159evl\u00e1daj\u00edc\u00ed varianty (nap\u0159. XBB) byly geneticky odli\u0161n\u00e9 od vakcina\u010dn\u00edch kmen\u016f, co\u017e sni\u017eovalo potenci\u00e1ln\u00ed \u00fa\u010dinnost vakc\u00edny.<\/span><\/li>\n<li><span>Behavior\u00e1ln\u00ed a matouc\u00ed faktory: V\u00fdsledky mohou ovlivnit nem\u011b\u0159en\u00e9 prom\u011bnn\u00e9, jako je expozice dom\u00e1cnosti, doch\u00e1zka do \u0161kolky a frekvence testov\u00e1n\u00ed.<\/span><\/li>\n<\/ul>\n<p><span>Studie p\u0159edpokl\u00e1d\u00e1, \u017ee neo\u010dkovan\u00e9 a o\u010dkovan\u00e9 skupiny m\u011bly srovnatelnou m\u00edru expozice viru, co\u017e nemus\u00ed b\u00fdt pravda kv\u016fli rozd\u00edl\u016fm v rodinn\u00e9m chov\u00e1n\u00ed nebo vn\u00edm\u00e1n\u00ed rizika.<\/span><\/p>\n<h2 class=\"wp-block-heading\"><strong><span>P\u0159\u00edpady a kritick\u00e9 ot\u00e1zky<\/span><\/strong><\/h2>\n<p><span>Zat\u00edmco v\u00fdsledky zd\u016fraz\u0148uj\u00ed d\u016fle\u017eit\u00e9 trendy, berou se v \u00favahu i p\u0159edsudky, jako je p\u0159edpojatost zdrav\u00fdch u\u017eivatel\u016f. To znamen\u00e1, \u017ee rodi\u010de, kte\u0159\u00ed se rozhodnou o\u010dkovat, se mohou chovat jinak, co\u017e ovliv\u0148uje expozici a riziko. Reverzn\u00ed kauzalita, to znamen\u00e1, \u017ee o\u010dkovan\u00e9 d\u011bti mohly b\u00fdt testov\u00e1ny \u010dast\u011bji, co\u017e zvy\u0161uje pravd\u011bpodobnost detekce infekc\u00ed.<\/span><\/p>\n<p><span>Nakonec si v\u0161imneme mo\u017enosti zpravodajsk\u00e9 a publika\u010dn\u00ed zaujatosti. Studie by mohla b\u00fdt interpretov\u00e1na selektivn\u011b, aby odpov\u00eddala narativ\u016fm, zejm\u00e9na vakc\u00edn\u00e1m Pfizer-BioNTech.<\/span><\/p>\n<p><strong><span>Vyvst\u00e1vaj\u00ed nejd\u016fle\u017eit\u011bj\u0161\u00ed ot\u00e1zky<\/span><\/strong><span>\u00a0: Pro\u010d byly d\u011bti o\u010dkovan\u00e9 spole\u010dnost\u00ed Pfizer-BioNTech vystaveny vy\u0161\u0161\u00edmu riziku? Je to zp\u016fsobeno imunologick\u00fdm otiskem, nesouladem variant nebo jin\u00fdmi nezn\u00e1m\u00fdmi faktory? Jak zobecniteln\u00e9 jsou tyto v\u00fdsledky vzhledem k mal\u00e9mu specifick\u00e9mu vzorku?<\/span><\/p>\n<h2 class=\"wp-block-heading\"><span>Financov\u00e1n\u00ed<\/span><\/h2>\n<p><span>Tato studie byla podpo\u0159ena N\u00e1rodn\u00edm centrem pro imunizaci a respira\u010dn\u00ed nemoci Centra pro kontrolu a prevenci nemoc\u00ed pod t\u011bmito \u010d\u00edsly smlouvy: 75D30121C12297 (Kaiser Foundation Hospitals), 75D30122C13149 (University of Michigan), 75D30121C1220C As010120C As010120C 75D30122C14188 (Arizonsk\u00e1 univerzita). Projekt byl nav\u00edc \u010d\u00e1ste\u010dn\u011b podpo\u0159en feder\u00e1ln\u00edm financov\u00e1n\u00edm z N\u00e1rodn\u00edho institutu pro alergie a infek\u010dn\u00ed nemoci N\u00e1rodn\u00edho institutu zdrav\u00ed na ministerstvu zdravotnictv\u00ed a soci\u00e1ln\u00edch slu\u017eeb.<\/span><\/p>\n<h2 class=\"wp-block-heading\"><strong><span>Z\u00e1v\u011br<\/span><\/strong><\/h2>\n<p><strong><span>Studie poskytuje d\u016fle\u017eit\u00e9 poznatky: zd\u00e1 se, \u017ee p\u0159edchoz\u00ed infekce SARS-CoV-2 poskytuje solidn\u00ed ochranu, zat\u00edmco samotn\u00e9 o\u010dkov\u00e1n\u00ed \u2013 zejm\u00e9na to Pfizer-BioNTech \u2013 nesni\u017euje riziko infekce a m\u016f\u017ee b\u00fdt dokonce spojeno s vy\u0161\u0161\u00edm v\u00fdskytem u naivn\u00edch d\u011bt\u00ed.<\/span><\/strong><span>\u00a0Je v\u0161ak d\u016fle\u017eit\u00e9 zd\u016fraznit, \u017ee ve v\u011bt\u0161\u00edch studi\u00edch, kter\u00e9 nebyly v t\u00e9to studii zkoum\u00e1ny, bylo prok\u00e1z\u00e1no, \u017ee o\u010dkov\u00e1n\u00ed je \u00fa\u010dinn\u00e9 v prevenci z\u00e1va\u017en\u00e9ho onemocn\u011bn\u00ed COVID-19.<\/span><\/p>\n<p><span>Do budoucna tato studie zd\u016fraz\u0148uje pot\u0159ebu vylep\u0161en\u00fdch vakc\u00edn zam\u011b\u0159en\u00fdch na nov\u00e9 varianty a dal\u0161\u00ed v\u00fdzkum hybridn\u00ed imunity (p\u0159edchoz\u00ed infekce + o\u010dkov\u00e1n\u00ed) u mal\u00fdch d\u011bt\u00ed. Rodi\u010de, tv\u016frci politik a l\u00e9ka\u0159i mus\u00ed tyto v\u00fdsledky pe\u010dliv\u011b interpretovat v \u0161ir\u0161\u00edm kontextu rizika COVID-19 a p\u0159\u00ednosu vakc\u00edny u d\u011bt\u00ed.<\/span><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.trialsitenews.com\/a\/cdc-study-bombshell-pfizer-mrna-vaccination-not-affording-protection-for-children-aged-6-months-to-4-years-0877a5e7\" target=\"_blank\" rel=\"nofollow noopener\">Zdroj<\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ned\u00e1vn\u00e1 studie publikovan\u00e1 v Journal of the Pediatric Infectious Diseases Society zkoumala roli o\u010dkov\u00e1n\u00ed proti&#8230;<\/p>\n","protected":false},"author":2,"featured_media":68367,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[245,315,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/68366"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=68366"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/68366\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/68367"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=68366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=68366"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=68366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}