{"id":63767,"date":"2024-10-08T00:41:06","date_gmt":"2024-10-07T22:41:06","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=63767"},"modified":"2024-10-07T15:17:58","modified_gmt":"2024-10-07T13:17:58","slug":"studie-na-17-milionu-ockovanych-deti-a-dospivajicich-ukazala-ze-myoperikarditida-se-vyskytla-pouze-u-ockovanych-skupin","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2024\/10\/08\/studie-na-17-milionu-ockovanych-deti-a-dospivajicich-ukazala-ze-myoperikarditida-se-vyskytla-pouze-u-ockovanych-skupin\/","title":{"rendered":"Studie na 1,7 milionu o\u010dkovan\u00fdch d\u011bt\u00ed a dosp\u00edvaj\u00edc\u00edch uk\u00e1zala, \u017ee myoperikarditida se vyskytla pouze u o\u010dkovan\u00fdch skupin"},"content":{"rendered":"
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P\u0159edti\u0161t\u011bn\u00e1 pozorovac\u00ed studie zalo\u017een\u00e1 na \u00fadaj\u00edch ze zdravotnick\u00e9ho syst\u00e9mu Spojen\u00e9ho kr\u00e1lovstv\u00ed tak\u00e9 zjistila, \u017ee vakc\u00edna Pfizer-BioNtech COVID-19 chr\u00e1n\u00ed d\u011bti a dosp\u00edvaj\u00edc\u00ed p\u0159ed pozitivn\u00edm testov\u00e1n\u00edm na virus pouze po dobu 14 a\u017e 15 t\u00fddn\u016f.<\/strong><\/p>\n

Vakc\u00edna Pfizer-BioNTech COVID-19 chr\u00e1n\u00ed d\u011bti a mlad\u00e9 lidi v Anglii p\u0159ed pozitivn\u00edm testov\u00e1n\u00edm na virus pouze po dobu asi 14 a\u017e 15 t\u00fddn\u016f, podle p\u0159edti\u0161t\u011bn\u00e9 studie v\u00edce ne\u017e 1,7 milionu d\u011bt\u00ed ve v\u011bku 5 a\u017e 15 let v anglick\u00e9m n\u00e1rodn\u00edm zdravotn\u00edm syst\u00e9mu. (NHS).<\/p>\n

V\u011bdci zkoumaj\u00edc\u00ed bezpe\u010dnost a \u00fa\u010dinnost\u00a0vakc\u00edny Pfizer<\/a>\u00a0u pln\u011b o\u010dkovan\u00fdch, \u010d\u00e1ste\u010dn\u011b o\u010dkovan\u00fdch a neo\u010dkovan\u00fdch d\u011bt\u00ed a mladistv\u00fdch tak\u00e9 zjistili p\u0159\u00edpady\u00a0myokarditidy<\/a>\u00a0a perikarditidy pouze u o\u010dkovan\u00fdch d\u011bt\u00ed.<\/p>\n

\u201eTato studie jasn\u011b ukazuje, \u017ee vakc\u00edna Pfizer COVID neposkytuje d\u011btem a dosp\u00edvaj\u00edc\u00edm t\u00e9m\u011b\u0159 \u017e\u00e1dn\u00fd p\u0159\u00ednos, ale zvy\u0161uje jejich riziko myokarditidy a perikarditidy,\u201c \u0159ekl Brian Hooker, Ph.D., hlavn\u00ed v\u011bdeck\u00fd \u0159editel Children’s Health Defense. \u201eTo vyvol\u00e1v\u00e1 ot\u00e1zku: Pro\u010d CDC nad\u00e1le doporu\u010duje d\u011btem tato neschv\u00e1len\u00e1 o\u010dkov\u00e1n\u00ed? Kde jsou data na podporu jejich tvrzen\u00ed, \u017ee p\u0159\u00ednosy t\u011bchto vakc\u00edn p\u0159eva\u017euj\u00ed nad riziky?<\/p>\n

Studie zjistila, \u017ee o\u010dkovan\u00e9 d\u011bti vy\u017eadovaly o n\u011bco m\u00e9n\u011b n\u00e1v\u0161t\u011bv na pohotovosti a hospitalizac\u00ed, ale \u017ee tyto v\u00fdsledky byly extr\u00e9mn\u011b vz\u00e1cn\u00e9 u d\u011bt\u00ed a dosp\u00edvaj\u00edc\u00edch nap\u0159\u00ed\u010d v\u0161emi skupinami.<\/p>\n

Zdravotnick\u00e9 \u00fa\u0159ady ve Spojen\u00e9m kr\u00e1lovstv\u00ed a USA schv\u00e1lily\u00a0vakc\u00edny<\/a>\u00a0Pfizer na z\u00e1klad\u011b klinick\u00fdch studi\u00ed, kter\u00e9 m\u011b\u0159ily imunogenicitu \u2013 jak dob\u0159e vakc\u00edna spou\u0161t\u00ed imunitn\u00ed odpov\u011b\u010f v t\u011ble \u2013 a \u00fa\u010dinnost proti infekci.<\/p>\n

Mezi \u00fa\u010dastn\u00edky studie nedo\u0161lo k \u017e\u00e1dn\u00e9mu\u00a0\u00famrt\u00ed\u00a0<\/a>na COVID-19<\/a>\u00a0.<\/p>\n

Zdravotnick\u00e9 \u00fa\u0159ady ve Spojen\u00e9m kr\u00e1lovstv\u00ed a USA schv\u00e1lily\u00a0vakc\u00edny<\/a>\u00a0Pfizer na z\u00e1klad\u011b klinick\u00fdch studi\u00ed, kter\u00e9 m\u011b\u0159ily imunogenicitu \u2013 jak dob\u0159e vakc\u00edna spou\u0161t\u00ed imunitn\u00ed odpov\u011b\u010f v t\u011ble \u2013 a \u00fa\u010dinnost proti infekci.<\/p>\n

Studie nezkoumaly,<\/a>\u00a0jak dob\u0159e vakc\u00edny chr\u00e1n\u00ed p\u0159ed v\u00e1\u017en\u00fdmi nemocemi. Nav\u00edc nebyly posouzeny n\u011bkter\u00e9 bezpe\u010dnostn\u00ed koncov\u00e9 body, jako je myokarditida a perikarditida, kter\u00e9 byly hl\u00e1\u0161eny po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Jejich v\u00fdzkum potvrdil jasnou souvislost mezi o\u010dkov\u00e1n\u00edm proti COVID-19 a myokarditidou a perikarditidou, zejm\u00e9na u dosp\u00edvaj\u00edc\u00edch. Zjistili tak\u00e9, \u017ee ji\u017e v roce 2021, kdy byla vakc\u00edna schv\u00e1lena pro d\u011bti a dosp\u00edvaj\u00edc\u00ed, nebyla tato v\u011bkov\u00e1 skupina vystavena vysok\u00e9mu riziku z\u00e1va\u017en\u00fdch n\u00e1sledk\u016f COVID-19, jako je smrt, neodkladn\u00e1 p\u00e9\u010de, hospitalizace nebo intenzivn\u00ed p\u00e9\u010de. Od t\u00e9 doby se toto riziko je\u0161t\u011b sn\u00ed\u017eilo.<\/p>\n

V\u00fdzkum byl zalo\u017een na datech z datab\u00e1ze NHS OpenSAFELY TPP, kter\u00e1 pokr\u00fdv\u00e1 40 % anglick\u00fdch prax\u00ed praktick\u00fdch l\u00e9ka\u0159\u016f a je propojena s n\u00e1rodn\u00edmi daty z registru nemocnic a \u00famrt\u00ed. Tato platforma je podporov\u00e1na granty od Wellcome Trust, nejv\u011bt\u0161\u00edho sponzora l\u00e9ka\u0159sk\u00e9ho v\u00fdzkumu ve Spojen\u00e9m kr\u00e1lovstv\u00ed.<\/p>\n

Studie zahrnovala v\u00edce ne\u017e 1,7 milionu d\u011bt\u00ed ve v\u011bku 5 a\u017e 15 let k 31. srpnu 2021, co\u017e je datum schv\u00e1len\u00ed vakc\u00edny pro tuto v\u011bkovou skupinu.<\/p>\n

Aby se d\u011bti mohly z\u00fa\u010dastnit studie, musely b\u00fdt registrov\u00e1ny u z\u00fa\u010dastn\u011bn\u00e9ho praktick\u00e9ho l\u00e9ka\u0159e, pou\u017e\u00edvat datab\u00e1zi alespo\u0148 42 dn\u00ed, nem\u011bly \u017e\u00e1dnou infekci COVID-19 do 30 dn\u016f od o\u010dkov\u00e1n\u00ed a poskytly kompletn\u00ed demografick\u00e9 \u00fadaje. D\u011bti s klinick\u00fdm rizikem byly vylou\u010deny.<\/p>\n

V\u011bdci zkoumali \u00fa\u010dinnost prvn\u00ed d\u00e1vky vakc\u00edny ve srovn\u00e1n\u00ed s \u017e\u00e1dnou vakc\u00ednou a \u00fa\u010dinnost dvou d\u00e1vek ve srovn\u00e1n\u00ed s jednou d\u00e1vkou. Za t\u00edmto \u00fa\u010delem byly o\u010dkovan\u00e9 d\u011bti porovn\u00e1ny s neo\u010dkovan\u00fdmi podle v\u011bku, pohlav\u00ed, regionu, p\u0159edchoz\u00edho testu na COVID-19 a stavu o\u010dkov\u00e1n\u00ed.<\/p>\n

Celkem 410 463 dosp\u00edvaj\u00edc\u00edch s jednou d\u00e1vkou bylo porovn\u00e1no s neo\u010dkovan\u00fdmi kontrolami a 220 929 dosp\u00edvaj\u00edc\u00edch s dv\u011bma d\u00e1vkami bylo srovn\u00e1no s kontrolami s jednou d\u00e1vkou. Z 1 262 784 d\u011bt\u00ed v dosp\u00edvaj\u00edc\u00ed \u010d\u00e1sti studie bylo 72 n\u00e1v\u0161t\u011bv na pohotovosti, 90 hospitalizac\u00ed souvisej\u00edc\u00edch s COVID-19 \u2013 v\u010detn\u011b t\u0159\u00ed na jednotk\u00e1ch intenzivn\u00ed p\u00e9\u010de neo\u010dkovan\u00fdch d\u011bt\u00ed \u2013 a \u017e\u00e1dn\u00e9 \u00famrt\u00ed.<\/p>\n

V o\u010dkovan\u00e9 skupin\u011b bylo dev\u011bt p\u0159\u00edpad\u016f perikarditidy a t\u0159i p\u0159\u00edpady myokarditidy. Zpo\u010d\u00e1tku byly pozitivn\u00ed testy na COVID-19 ni\u017e\u0161\u00ed u o\u010dkovan\u00e9 skupiny, ale po 15 t\u00fddnech byla m\u00edra v obou skupin\u00e1ch podobn\u00e1.<\/p>\n

V\u00fdskyt hospitalizace byl m\u00edrn\u011b vy\u0161\u0161\u00ed ve skupin\u011b s jednou d\u00e1vkou vakc\u00edny ne\u017e ve skupin\u011b s dv\u011bma d\u00e1vkami. Hooker to vysv\u011btlil takzvan\u00fdm \u201eefektem zdrav\u00e9 vakc\u00edny\u201c, kdy ne\u017e\u00e1douc\u00ed \u00fa\u010dinky po prvn\u00ed d\u00e1vce vedou k vy\u0161\u0161\u00edmu po\u010dtu hospitalizac\u00ed. Tito lid\u00e9 \u010dasto nedostanou druhou d\u00e1vku, co\u017e sni\u017euje pravd\u011bpodobnost negativn\u00edch reakc\u00ed na n\u00e1sleduj\u00edc\u00ed d\u00e1vku.<\/p>\n

Ve v\u011bkov\u00e9 skupin\u011b 5 a\u017e 12 let bylo 177 360 d\u011bt\u00ed, kter\u00e9 dostaly jednu d\u00e1vku vakc\u00edny, porovn\u00e1no s neo\u010dkovan\u00fdmi kontrolami a 66 231 d\u011bt\u00ed, kter\u00e9 dostaly dv\u011b d\u00e1vky, bylo srovn\u00e1no s kontrolami, kter\u00e9 dostaly pouze jednu d\u00e1vku. Nebyly provedeny \u017e\u00e1dn\u00e9 nouzov\u00e9 n\u00e1v\u0161t\u011bvy, pouze \u0161est hospitalizac\u00ed souvisej\u00edc\u00edch s COVID-19 a \u017e\u00e1dn\u00e1 \u00famrt\u00ed v \u017e\u00e1dn\u00e9 skupin\u011b. U o\u010dkovan\u00fdch d\u011bt\u00ed se vyskytly t\u0159i p\u0159\u00edpady perikarditidy.<\/p>\n

Ve skupin\u011b se dv\u011bma d\u00e1vkami proti jedn\u00e9 d\u00e1vce nebyly \u017e\u00e1dn\u00e9 nouzov\u00e9 n\u00e1v\u0161t\u011bvy, hospitalizace ani \u00famrt\u00ed souvisej\u00edc\u00ed s COVID-19.<\/p>\n

V\u011bdci do\u0161li k z\u00e1v\u011bru, \u017ee u dosp\u00edvaj\u00edc\u00edch bylo sn\u00ed\u017een\u00ed hospitalizac\u00ed z vakc\u00edny v\u011bt\u0161\u00ed ne\u017e riziko myokarditidy a perikarditidy, zat\u00edmco u mlad\u0161\u00edch d\u011bt\u00ed riziko perikarditidy p\u0159evy\u0161ovalo sn\u00ed\u017een\u00e9 riziko hospitalizace.<\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

P\u0159edti\u0161t\u011bn\u00e1 pozorovac\u00ed studie zalo\u017een\u00e1 na \u00fadaj\u00edch ze zdravotnick\u00e9ho syst\u00e9mu Spojen\u00e9ho kr\u00e1lovstv\u00ed tak\u00e9 zjistila, \u017ee vakc\u00edna…<\/p>\n","protected":false},"author":2,"featured_media":63768,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[245,8029,213,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/63767"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=63767"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/63767\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/63768"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=63767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=63767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=63767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}