{"id":6010,"date":"2021-11-08T04:19:40","date_gmt":"2021-11-08T03:19:40","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=6010"},"modified":"2021-11-08T04:19:40","modified_gmt":"2021-11-08T03:19:40","slug":"sedmdesat-dolaru-za-pilulku","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2021\/11\/08\/sedmdesat-dolaru-za-pilulku\/","title":{"rendered":"Sedmdes\u00e1t dolar\u016f za pilulku"},"content":{"rendered":"
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Farmaceutick\u00fd gigant Merck uv\u00e1d\u00ed na trh \u0161pi\u010dkovou pilulku, pok\u0159t\u011bnou Molnupiravir, kter\u00e1, v\u011b\u0159te nebo ne, m\u00e1 nahradit vakc\u00ednu proti coronaviru. M\u016f\u017ee v\u00e1m zachr\u00e1nit \u017eivot, ale onemocn\u011bn\u00ed Covidem nezabr\u00e1n\u00ed. Ostatn\u011b cokoli chr\u00e1n\u00ed \u010dlov\u011bka od nemoci Big Pharmu nezaj\u00edm\u00e1, nebo\u0165 to kaz\u00ed farmaceutick\u00fd byznys.<\/p>\n<\/section>\n
Podle jedn\u00e9 klinick\u00e9 studie ty z\u00e1zra\u010dn\u00e9 pilulky prokazateln\u011b sn\u00ed\u017eily pobyt v\u00a0nemocnici ze 14,1 % na 7,3 % a \u00famrtnost ve sledovan\u00e9 skupin\u011b 775 lid\u00ed poklesla z\u00a0osmi pacient\u016f na nulu. \u010cau vakc\u00edn\u00e1m a mo\u017en\u00e1 zdravotn\u00edm pas\u016fm. \u010cau tak\u00e9 p\u0159eo\u010dkov\u00e1n\u00edm, proto\u017ee Molnupiravir pokr\u00fdv\u00e1 v\u0161echny varianty.<\/p>\n

\u201eTo je fenomen\u00e1ln\u00ed v\u00fdsledek,\u201c zaj\u00e1sal Dr. Scott Gottlieb, b\u00fdval\u00fd \u0159editel americk\u00e9 spr\u00e1vy pro potraviny a l\u00e9ky (FDA). \u201e Tahle pilulka znamen\u00e1 p\u0159evrat v\u00a0l\u00e9\u010db\u011b coronaviru, zvl\u00e1\u0161t\u011b pro pacienty z\u00a0vysok\u00e9 rizikov\u00e9 skupiny.\u201c<\/p>\n

P\u0159eh\u00e1n\u011bt chv\u00e1lu m\u00e1 Dr. Gottlieb v\u00a0popisu pr\u00e1ce, je toti\u017e placenou hl\u00e1snou troubou Big Pharma. Nicm\u00e9n\u011b v\u00a0jeho slovech je kus pravdy. P\u0159edstavte si, \u017ee v\u00e1s polapil coronavirus, jste u l\u00e9ka\u0159e, kter\u00fd prav\u00ed: \u201eNi\u010deho se nebojte, d\u00e1m v\u00e1m pilulky, co ten virus zahub\u00ed. Budete br\u00e1t dv\u011b denn\u011b, p\u011bt dn\u00ed. Z\u016fstanete doma v\u00a0izolaci, \u017e\u00e1dn\u00e9 n\u00e1v\u0161t\u011bvy a pro jistotu \u017e\u00e1dn\u00e9 sexu\u00e1ln\u00ed hr\u00e1tky, pros\u00edm. Dnes je \u00fater\u00fd, p\u0159\u00ed\u0161t\u00ed pond\u011bl\u00ed mi p\u0159edvedete, \u017ee jste zase mu\u017esk\u00fd na \u017een\u011bn\u00ed.\u201c<\/p>\n

Na burze p\u0159\u00edchod Molnupiraviru vyvolal Pavlovovsk\u00fd reflex. Akcie jeho v\u00fdrobc\u016f stouply o deset procent. Zato akcie v\u00fdrobc\u016f vakc\u00edn proti Covidu za\u010daly padat. Nap\u0159\u00edklad Pfizer ztratil t\u0159in\u00e1ct procent a Moderna \u0161est procent.<\/p>\n

N\u011bkte\u0159\u00ed burzi\u00e1ni hl\u00e1s\u00ed, \u017ee tahle tendence je setrval\u00e1 a \u017ee v\u00fdhledov\u011b se bude zvy\u0161ovat. Jin\u00ed tomu nev\u011b\u0159\u00ed, proto\u017ee Pfizer tak\u00e9 kucht\u00ed z\u00e1zra\u010dnou pilulku, jej\u00ed\u017e v\u00fdnos jist\u011b v\u00edc ne\u017e vynahrad\u00ed \u00fabytky z\u00a0prodeje vakc\u00edn. Jeho pilulka \u2013PF-073213232\u2014m\u00e1 zabr\u00e1nit infekci u lidi vystaven\u00fdch viru anebo l\u00e9\u010dit pacienty v\u00a0dom\u00e1c\u00edm o\u0161et\u0159en\u00ed. Roche a Alea nejsou o moc pozadu ve v\u00fdvoji nov\u00fdch antivirov\u00fdch l\u00e9k\u016f a zanedlouho cel\u00e1 Big Pharma je bude n\u00e1sledovat.<\/p>\n

Mus\u00edme zvednout klobouk p\u0159ed farmaceutick\u00fdmi \u017eraloky, proto\u017ee jejich obchodn\u00ed strategie nem\u00e1 vadu. Nejd\u0159\u00edve odrovnali konkurenci dvou osv\u011bd\u010den\u00fdch l\u00e9k\u016f Hydroxichloroquinu a Ivermectinu . Maj\u00ed velkou vadu: jsou levn\u00e9, moc nevyn\u00e1\u0161ej\u00ed a kdyby v\u00fdrobci zvedli ceny, byl by z\u00a0toho skand\u00e1l. Ve v\u011bt\u0161in\u011b chud\u00fdch zem\u00edch jsou \u00fasp\u011b\u0161n\u011b pou\u017e\u00edv\u00e1ny i dnes, ale v \u00a0Evrop\u011b a USA byly d\u00e1ny na \u010dernou listinu nedoporu\u010dovan\u00fdch medikament\u016f. M\u00edsto nich m\u00e1me drah\u00e9 vakc\u00edny a po nich p\u0159ijdou je\u0161t\u011b dra\u017e\u0161\u00ed antivirov\u00e9 pilulky. U\u017e stoj\u00ed ve dve\u0159\u00edch, ale budou sm\u011bt vstoupit teprve tehdy, a\u017e v\u011bt\u0161ina lid\u00ed bude oo\u010dkov\u00e1na, aby farmaceuti\u010dt\u00ed \u017eraloci si p\u0159i\u0161li na sv\u00e9. V\u00a0tom spo\u010d\u00edv\u00e1 jedno z\u00a0hlavn\u00edch vysv\u011btlen\u00ed, pro\u010d jsme pod takov\u00fdm obrovsk\u00fdm n\u00e1tlakem, abychom se nechali p\u00edchnout. Big Pharma se chce zbavit vakc\u00edn ne\u017e je za\u010dne nahrazovat antivirov\u00fdmi pilulkami. \u00dalohu bi\u0159ic\u016f, kte\u0159\u00ed hrozbami exkomunikace ze spole\u010dnosti a ztr\u00e1ty ob\u017eivy n\u00e1s nut\u00ed d\u00e1t se p\u00edchnout, hraj\u00ed vl\u00e1dy, zdravotnick\u00e9 byrokracie, sd\u011blovac\u00ed prost\u0159edky a ochotn\u00ed p\u0159isluhova\u010di s\u00a0akademick\u00fdmi tituly. Budouc\u00ed generace mohou posoudit, zda rozs\u00e9vali s\u00e9m\u011b bo\u017e\u00ed nebo \u010f\u00e1blovo.<\/p>\n

Po zku\u0161enostech s\u00a0vakc\u00ednami, na\u0161e hlavn\u00ed starost je, zda nebudeme op\u011bt vyh\u00e1n\u011bt \u010derta belzebubem. V\u00edme, \u017ee Molnupiravir zp\u016fsobuje mutace virusu, kter\u00e9 vedou k\u00a0jeho zni\u010den\u00ed. Tato mutagenese m\u016f\u017ee b\u00fdt pro pacienta zna\u010dn\u00fdm rizikem, kter\u00e9 spo\u010d\u00edv\u00e1 v\u00a0tom, \u017ee l\u00e9k m\u016f\u017ee metabolizovat do DNA, dostat se do bun\u011b\u010dn\u00e9ho j\u00e1dra a vyvolat rakovinu. Merck samoz\u0159ejm\u011b jakoukoli takovou mo\u017enost kategoricky pop\u00edr\u00e1. Fakt ale je, \u017ee podobn\u00fd l\u00e9k na hepatitidu C byl sta\u017een z\u00a0v\u00fdzkumu pr\u00e1v\u011b kv\u016fli riziku, \u017ee by mohl zp\u016fsobit mutace.<\/p>\n

Jin\u00e9 nebezpe\u010d\u00ed signalizuje zji\u0161t\u011bn\u00ed, \u017ee l\u00e9ky ve stejn\u00e9 t\u0159\u00edd\u011b jako Molnupiravir vyvolaly p\u0159i pokusech se zv\u00ed\u0159aty vrozen\u00e9 vady plod\u016f Tak\u017ee, \u017e\u00e1dn\u00fd sex b\u011bhem l\u00e9\u010debn\u00e9 k\u016fry, p\u00e1nov\u00e9. D\u00e1m\u00e1m v\u00a0plodn\u00e9m v\u011bku se p\u0159edepisuje pou\u017e\u00edvat velice spolehliv\u00e9 antikoncep\u010dn\u00ed prost\u0159edky nebo abstinence b\u011bhem 28 dn\u00ed od za\u010d\u00e1tku l\u00e9\u010dby.<\/p>\n

To jist\u011b nen\u00ed v\u0161e. Jak\u00e1 jin\u00e1 p\u0159ekvapen\u00ed a vedlej\u0161\u00ed neblah\u00e9 \u00fa\u010dinky pilulky v\u00a0sob\u011b skr\u00fdvaj\u00ed se uk\u00e1\u017ee a\u017e b\u011bhem ur\u010dit\u00e9 doby jejich pou\u017e\u00edv\u00e1n\u00ed. Chce to bd\u011blost a ostra\u017eitost p\u0159i hodnocen\u00ed v\u00fdsledk\u016f antivirov\u00e9 l\u00e9\u010dby. Mus\u00edme se pou\u010dit ze zku\u0161enost\u00ed s\u00a0(ne)v\u011brohodnost\u00ed \u00fadaj\u016f a statistick\u00fdch dat o vakc\u00edn\u00e1ch.<\/p>\n

Molnupiravir byl p\u016fvodn\u011b vyvinut Univerzitou Emory pro l\u00e9\u010dbu kon\u00ed infikovan\u00fdch venezuelskou ko\u0148skou encefalitidou a pak zkou\u0161en jako prost\u0159edek proti ch\u0159ipce. Vznikl s pomoc\u00ed grantu 10 milion\u016f dolar\u016f od Ministerstva obrany (DOD) a 19 milion\u016f dolar\u016f od N\u00e1rodn\u00edho institutu zdrav\u00ed (NHI).\u00a0Jin\u00fdmi slovy,\u00a0 jeho vyn\u00e1lez byl zaplacen z\u00a0pen\u011bz americk\u00fdch poplatn\u00edk\u016f. Univerzita Emory prodala patent na Molnupiravir mal\u00e9 spole\u010dnosti Ridgeback Biotherapeutics, kter\u00e1 jej n\u00e1sledn\u011b prodala farmaceutick\u00e9mu gigantu Merck. Za kolik se nikdo nikdy nedozv\u00ed, av\u0161ak z\u00a0hlediska kone\u010dn\u00e9ho finan\u010dn\u00edho p\u0159\u00ednosu tohoto l\u00e9ku to jist\u011b byly bursk\u00e9 o\u0159\u00ed\u0161ky.<\/p>\n

V\u00fdrobn\u00ed n\u00e1klady Molnupiraviru se\u00a0 pohybuj\u00ed kolem\u00a017,74 USD za p\u011btidenn\u00ed\u00a0l\u00e9\u010dbu. Spole\u010dnost Merck pr\u00e1v\u011b podepsala smlouvu s feder\u00e1ln\u00ed vl\u00e1dou na prodej 1,7 milionu l\u00e9\u010debn\u00fdch d\u00e1vek pro vl\u00e1du, aby je distribuovala infikovan\u00fdm lidem … podr\u017ete se\u2026 ka\u017edou d\u00e1vku za 712,00 dolar\u016f.<\/p>\n

Tento cenotvorn\u00fd rau\u0161 byl umo\u017en\u011bn z\u00e1konem schv\u00e1len\u00fdm v roce 1980, kter\u00fd dal univerzit\u00e1m mo\u017enost prod\u00e1vat patenty a vyn\u00e1lezy financovan\u00e9 z feder\u00e1ln\u00edch pen\u011bz neziskov\u00fdm organizac\u00edm a mal\u00fdm podnik\u016fm … ale ne velk\u00fdm spole\u010dnostem.\u00a0Od t\u00e9 doby slou\u017e\u00ed mal\u00e9 podniky jako Ridgeback jako prost\u0159edn\u00edci, kte\u0159\u00ed p\u0159ed\u00e1vaj\u00ed ziskov\u00e9 l\u00e9ky vyvinut\u00e9 z da\u0148ov\u00fdch dolar\u016f ob\u0159\u00edm korporac\u00edm, aby na nich je\u0161t\u011b v\u00edce zbohatly.<\/p>\n

V\u00a0Kongresu byla pod\u00e1na \u0159ada n\u00e1vrh\u016f, jak d\u00e1t feder\u00e1ln\u00ed vl\u00e1d\u011b pr\u00e1vo \u0159\u00edci: \u201eZaplatili jsme za v\u00fdvoj t\u00e9to drogy, tak\u017ee n\u00e1m ji mus\u00edte prodat za rozumnou cenu; mysl\u00edme si, \u017ee n\u00e1s pr\u00e1v\u011b te\u010f okr\u00e1d\u00e1te, tak\u017ee v\u00e1m ten patent vezmeme a p\u0159id\u011bl\u00edme jej n\u011bkomu jin\u00e9mu.\u201c Jen\u017ee farmaceutick\u00e9 lobby je f\u00edkan\u00e9. Vybere si a zaplat\u00ed jednoho nebo dva z\u00e1konod\u00e1rce, kter\u00e9 pot\u0159ebuje k zablokov\u00e1n\u00ed n\u00e1vrh\u016f v p\u0159\u00edslu\u0161n\u00fdch v\u00fdborech nebo v p\u0159\u00edslu\u0161n\u00e9m \u010dase, a tak n\u00e1vrh za n\u00e1vrhem skon\u010dil v\u00a0d\u00ed\u0159e zapomn\u011bn\u00ed.<\/p>\n

Merck dod\u00e1 na trh deset milion\u016f d\u00e1vek do konce leto\u0161n\u00edho roku za stejn\u011b sprostou cenu 70 dolar\u016f za pilulku. Kritici ji pova\u017euj\u00ed za absurdn\u00ed, proto\u017ee v\u011bt\u0161ina lid\u00ed m\u00e1 p\u0159\u00edli\u0161 hluboko do kapsy. \u201eKdy\u017e si nem\u016f\u017eete zaplatit l\u00e9\u010dbu, proto\u017ee je tis\u00edckr\u00e1t dra\u017e\u0161\u00ed ne\u017eli si m\u016f\u017eete dovolit, nebo, \u017ee je stokr\u00e1t dra\u017e\u0161\u00ed, vyjde to nastejno. Oboj\u00ed je vyd\u00edr\u00e1n\u00ed,\u201c \u0159ekla Melissa Barber z\u00a0harwardsk\u00e9 university, autorka zpr\u00e1vy o Molnupiraviru. \u201cKdyby Merck si po\u010d\u00edtal za jednu d\u00e1vku 19.99 dolar\u016f, m\u011bl by slu\u0161n\u00fd desetiprocentn\u00ed zisk a drtiv\u00e1 v\u011bt\u0161ina lid\u00ed by si mohla l\u00e9\u010dbu dop\u0159\u00e1t.\u201c<\/p>\n

Podle jednoho odhadu z\u00e1zra\u010dn\u00e9 pilulky obohat\u00ed v\u00fdrobce do konce roku, tj. zhruba b\u011bhem dvou m\u011bs\u00edc\u016f, o 14 miliard dolar\u016f.<\/p>\n

A to je jenom sn\u011bhov\u00e1 koule, kter\u00e1 spust\u00ed lavinu\u2026<\/p>\n<\/section>\n

Jan V\u00edtek<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Farmaceutick\u00fd gigant Merck uv\u00e1d\u00ed na trh \u0161pi\u010dkovou pilulku, pok\u0159t\u011bnou Molnupiravir, kter\u00e1, v\u011b\u0159te nebo ne, m\u00e1…<\/p>\n","protected":false},"author":2,"featured_media":1830,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[1088,29,1020,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/6010"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=6010"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/6010\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/1830"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=6010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=6010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=6010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}