{"id":59771,"date":"2024-08-13T00:37:39","date_gmt":"2024-08-12T22:37:39","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=59771"},"modified":"2024-08-12T16:30:24","modified_gmt":"2024-08-12T14:30:24","slug":"vedci-odpalili-bombu-ivermectin-je-ucinny-proti-epilepsii","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2024\/08\/13\/vedci-odpalili-bombu-ivermectin-je-ucinny-proti-epilepsii\/","title":{"rendered":"V\u011bdci odp\u00e1lili bombu: Ivermectin je \u00fa\u010dinn\u00fd proti epilepsii"},"content":{"rendered":"
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Skupina p\u0159edn\u00edch v\u011bdc\u016f z presti\u017en\u00ed Imperial College London ve Velk\u00e9 Brit\u00e1nii zve\u0159ejnila pr\u016flomovou studii potvrzuj\u00edc\u00ed, \u017ee ivermektin je \u00fa\u010dinn\u00fd u ur\u010dit\u00fdch forem epilepsie.<\/strong><\/span><\/p>\n

P\u0159edchoz\u00ed retrospektivn\u00ed kohortov\u00e9 studie proveden\u00e9 v letech 1991 a\u017e 1993 v Kamerunu v z\u00e1padn\u00ed Africe prok\u00e1zaly souvislost mezi d\u011btsk\u00fdm vystaven\u00edm Onchocerca volvulus microfilariae.<\/span><\/p>\n

Navazuj\u00edc\u00ed studie z roku 2017 tak\u00e9 prok\u00e1zala zv\u00fd\u0161en\u00e9 riziko rozvoje epilepsie v pozd\u011bj\u0161\u00edm v\u011bku.<\/span><\/p>\n

Aktu\u00e1ln\u00ed\u00a0<\/span>studii<\/span><\/a>\u00a0publikovanou v \u010dasopise Nature vedli profeso\u0159i Jacob Stapley a Maria-Gloria Bas\u00e1\u00f1ez z Imperial\u00a0<\/span>College London<\/span><\/a>\u00a0.<\/span><\/p>\n

V\u00fdzkumn\u00fd t\u00fdm vy\u0161et\u0159oval d\u011bti ve v\u011bku 3 a\u017e 15 let na onchocerci\u00e1zu p\u0159en\u00e1\u0161enou Simulium damnosum sensu lato.<\/span><\/p>\n

Pou\u017eili nejmodern\u011bj\u0161\u00ed simula\u010dn\u00ed modely EPIONCHO-IBM\u00ae k simulaci 19 let (1998-2017) ro\u010dn\u00edho hromadn\u00e9ho pod\u00e1v\u00e1n\u00ed ivermektinu (MDA), odr\u00e1\u017eej\u00edc\u00edho pokryt\u00ed ve zkouman\u00e9 oblasti, p\u0159i modelov\u00e1n\u00ed prevalence a incidence epilepsie. .<\/span><\/p>\n

Rovn\u011b\u017e byly provedeny simulace zalo\u017een\u00e9 na sc\u00e9n\u00e1\u0159\u00edch 25 let (ro\u010dn\u00ed a pololetn\u00ed) MDA v hyper- a holoendemick\u00fdch oblastech s 65% a 80% terapeutick\u00fdm pokryt\u00edm.<\/span><\/p>\n

Pomoc\u00ed modelu stochastick\u00e9ho p\u0159enosu EPIONCHO-IBM \u200b\u200bv\u011bdci p\u0159edpov\u011bd\u011bli prevalenci epilepsie 7,6 % (oproti 8,2 % v kamerunsk\u00e9 studii) a incidenci 317 p\u0159\u00edpad\u016f\/100 000 osoborok\u016f (oproti 350).<\/span><\/p>\n

Onchocerci\u00e1za, zn\u00e1m\u00e1 tak\u00e9 jako \u0159\u00ed\u010dn\u00ed slepota, je parazit\u00e1rn\u00ed onemocn\u011bn\u00ed zp\u016fsoben\u00e9 mikroskopick\u00fdm \u010dervem Onchocerca volvulus.<\/span><\/p>\n

Na \u010dlov\u011bka se p\u0159en\u00e1\u0161\u00ed kousnut\u00edm infikovan\u00fdch \u010dern\u00fdch mu\u0161ek (rod Simulium), kter\u00e9 se mno\u017e\u00ed v rychle tekouc\u00edch \u0159ek\u00e1ch a potoc\u00edch v bl\u00edzkosti \u00farodn\u00fdch p\u016fd.<\/span><\/p>\n

Jak uv\u00e1d\u00ed americk\u00e9 Centrum pro kontrolu a prevenci nemoc\u00ed (CDC), ivermektin z\u016fst\u00e1v\u00e1 l\u00e9kem volby pro l\u00e9\u010dbu onchocerci\u00e1zy.<\/span><\/p>\n

Bylo prok\u00e1z\u00e1no, \u017ee l\u00e9k sni\u017euje m\u00edru slepoty a sni\u017euje frekvenci a z\u00e1va\u017enost ko\u017en\u00edch p\u0159\u00edznak\u016f.<\/span><\/p>\n

Bez zab\u00edjen\u00ed dosp\u011bl\u00fdch \u010derv\u016f zab\u00edj\u00ed ivermektin mikrofil\u00e1rie.<\/span><\/p>\n

Ivermectin je aktivn\u00ed slo\u017ekou programu Mectizan.<\/span><\/p>\n

Dva v\u011bdci obdr\u017eeli v roce 2015 Nobelovu cenu za fyziologii a medic\u00ednu za objev ivermektinu.<\/span><\/p>\n

Ivermektin je pova\u017eov\u00e1n za druh\u00fd nejv\u011bt\u0161\u00ed l\u00e9ka\u0159sk\u00fd objev v historii po penicilinu.<\/span><\/p>\n

P\u0159i anal\u00fdze v\u00fdsledk\u016f v hyperendemick\u00fdch oblastech auto\u0159i zjistili, \u017ee epilepsie spojen\u00e1 s onchocerci\u00e1zou (OAE) zmizela po 25 letech dvoulet\u00e9ho MDA (80% pokryt\u00ed) a nel\u00e9\u010den\u00e9 d\u011bti byly p\u0159ed t\u00edmto onemocn\u011bn\u00edm chr\u00e1n\u011bny.<\/span><\/p>\n

Pos\u00edlen\u00ed program\u016f onchocerci\u00f3zy, implementace alternativn\u00edch strategi\u00ed a hodnocen\u00ed l\u00e9\u010dby d\u011bt\u00ed mlad\u0161\u00edch p\u011bti let a d\u011bt\u00ed \u0161koln\u00edho v\u011bku jsou z\u00e1sadn\u00ed pro prevenci OAE ve vysoce endemick\u00fdch oblastech, \u0159\u00edkaj\u00ed lond\u00fdn\u0161t\u00ed zdravotn\u00ed v\u011bdci.<\/span><\/p>\n

Tento objev p\u0159ich\u00e1z\u00ed v dob\u011b, kdy ivermektin nep\u0159est\u00e1v\u00e1 udivovat v\u011bdeckou komunitu.<\/span><\/p>\n

Jak uv\u00e1d\u00ed Slay News, \u201ez\u00e1zra\u010dn\u00fd l\u00e9k\u201c se pou\u017e\u00edv\u00e1 k l\u00e9\u010db\u011b rostouc\u00edho seznamu r\u016fzn\u00fdch lidsk\u00fdch nemoc\u00ed.<\/span><\/p>\n

B\u011bhem pandemie se mainstreamov\u00e1 m\u00e9dia a byrokrati\u010dt\u00ed zdravotni\u010dt\u00ed \u00fa\u0159edn\u00edci pokusili Ivermectin odm\u00edtnout jako \u201eod\u010dervova\u010d kon\u00ed\u201c, kdy\u017e se uk\u00e1zal jako \u00fasp\u011b\u0161n\u00fd p\u0159i l\u00e9\u010db\u011b pacient\u016f s Covidienem.<\/span><\/p>\n

Navzdory zpr\u00e1v\u00e1m o \u00fasp\u011b\u0161n\u00e9m pou\u017eit\u00ed levn\u00e9ho a snadno dostupn\u00e9ho ivermektinu p\u0159i l\u00e9\u010db\u011b pacient\u016f p\u0159edstavoval hrozbu pro injekce Covid mRNA farmaceutick\u00e9ho pr\u016fmyslu a zisky z distribuce injekc\u00ed ve\u0159ejnosti.<\/span><\/p>\n

Tato pomlouva\u010dn\u00e1 kampa\u0148 vedla k tomu, \u017ee Ivermectin, l\u00e9k ocen\u011bn\u00fd Nobelovou cenou, pova\u017eovan\u00fd za druh\u00fd nejd\u016fle\u017eit\u011bj\u0161\u00ed l\u00e9ka\u0159sk\u00fd objev po penicilinu, byl ozna\u010den za \u201enebezpe\u010dn\u00fd\u201c.<\/span><\/p>\n

Ivermectin, l\u00e9k z\u00edskan\u00fd z p\u016fdn\u00edho mikroba, se v\u0161ak uk\u00e1zal jako extr\u00e9mn\u011b \u00fa\u010dinn\u00fd p\u0159i l\u00e9\u010db\u011b pacient\u016f s Covidem.<\/span><\/p>\n

Zjistilo se v\u0161ak, \u017ee z\u00e1zra\u010dn\u00fd l\u00e9k lze pou\u017e\u00edt i na nemoci mnohem z\u00e1va\u017en\u011bj\u0161\u00ed ne\u017e Covid.<\/span><\/p>\n

V roce 2022 studie uk\u00e1zala, \u017ee ivermektin inhibuje n\u00e1dorov\u00e9 metast\u00e1zy.<\/span><\/p>\n

Dal\u0161\u00ed studie uk\u00e1zala, \u017ee ivermektin m\u016f\u017ee pomoci p\u0159edch\u00e1zet neurologick\u00fdm onemocn\u011bn\u00edm, jako je roztrou\u0161en\u00e1 skler\u00f3za.<\/span><\/p>\n

Nav\u00edc bylo zji\u0161t\u011bno, \u017ee Ivermectin l\u00e9\u010d\u00ed zran\u011bn\u00ed zp\u016fsoben\u00e1 injekcemi mRNA Covid.<\/span><\/p>\n

Dr. Mary Talley Bowden uvedla, \u017ee ivermektin m\u00e1 v jej\u00ed vlastn\u00ed klinick\u00e9 praxi vynikaj\u00edc\u00ed v\u00fdsledky p\u0159i l\u00e9\u010db\u011b po\u0161kozen\u00ed zp\u016fsoben\u00fdch vakc\u00ednou.<\/span><\/p>\n

Dal\u0161\u00ed studie popsala historii l\u00e9ku, jeho technick\u00e9 vlastnosti a dlouh\u00fd seznam nemoc\u00ed, kter\u00e9 dok\u00e1\u017ee l\u00e9\u010dit.<\/span><\/p>\n

Studie doch\u00e1z\u00ed k z\u00e1v\u011bru, \u017ee ivermektin je u\u017eite\u010dn\u00fd pro l\u00e9\u010dbu:<\/strong><\/p>\n