{"id":47544,"date":"2024-02-21T00:47:34","date_gmt":"2024-02-20T23:47:34","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=47544"},"modified":"2024-02-20T18:26:34","modified_gmt":"2024-02-20T17:26:34","slug":"vedci-varuji-pred-zazracnymi-leky-na-alzheimerovu-chorobu","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2024\/02\/21\/vedci-varuji-pred-zazracnymi-leky-na-alzheimerovu-chorobu\/","title":{"rendered":"V\u011bdci varuj\u00ed p\u0159ed \u201ez\u00e1zra\u010dn\u00fdmi\u201c l\u00e9ky na Alzheimerovu chorobu"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<p><span style=\"font-size: 18pt;\"><strong>Lecanemab a donanemab mohou zp\u016fsobit smr\u0161\u0165ov\u00e1n\u00ed, otoky a krv\u00e1cen\u00ed do mozku, co\u017e m\u016f\u017ee b\u00fdt smrteln\u00e9, \u0159ekli l\u00e9ka\u0159i m\u00e9di\u00edm<\/strong><\/span><\/p>\n<p><span>Drogy oslavovan\u00e9 jako z\u00e1sadn\u00ed zm\u011bny v l\u00e9\u010db\u011b Alzheimerovy choroby, co\u017e je typ demence, s sebou nesou rizika, kter\u00e1 mohou p\u0159ev\u00e1\u017eit jak\u00fdkoli p\u0159\u00ednos, varovali v\u011bdci v ned\u011bli britsk\u00e1 m\u00e9dia.<\/span><\/p>\n<p><span>O\u010dek\u00e1v\u00e1 se, \u017ee britsk\u00e9 regula\u010dn\u00ed org\u00e1ny p\u0159\u00ed\u0161t\u00ed t\u00fdden rozhodnou o tom, zda schv\u00e1l\u00ed \u010di neschv\u00e1l\u00ed l\u00e9k lecanemab, kter\u00fd byl minul\u00fd rok americk\u00fdmi regul\u00e1tory osv\u00edcen zelenou, a donanemab, kter\u00fd v sou\u010dasnosti \u010dek\u00e1 na schv\u00e1len\u00ed v USA.\u00a0<\/span><\/p>\n<p><span>Je v\u0161ak zn\u00e1mo, \u017ee l\u00e9ky, kter\u00e9 podle v\u00fdrobc\u016f zpomaluj\u00ed kognitivn\u00ed \u00fapadek t\u00edm, \u017ee vylu\u010duj\u00ed amyloidn\u00ed protein v \u0161ed\u00e9 hmot\u011b pacient\u016f, zmen\u0161uj\u00ed mozky pacient\u016f a a\u017e t\u0159etina t\u011bch, kte\u0159\u00ed je u\u017e\u00edvaj\u00ed, m\u00e1 tak\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky klasifikovan\u00e9 jako \u201e\u00a0<\/span><em><span>amyloid -related imaging abnormalities\u201c<\/span><\/em><span>\u00a0(ARIA) \u2013 v\u0161eobecn\u00fd term\u00edn, kter\u00fd zahrnuje otoky a krv\u00e1cen\u00ed do mozku.<\/span><\/p>\n<p><span>Asi 1 % pacient\u016f m\u00e1 vedlej\u0161\u00ed \u00fa\u010dinky tak z\u00e1va\u017en\u00e9, \u017ee jsou smrteln\u00e9 nebo vy\u017eaduj\u00ed hospitalizaci, a americk\u00fd \u00da\u0159ad pro kontrolu potravin a l\u00e9\u010div (Food and Drug Administration) po\u017eadoval od v\u00fdrobce lecanemab Esai, aby na sv\u016fj \u0161t\u00edtek za\u0159adil\u00a0<\/span><em><span>\u201evarov\u00e1n\u00ed \u010dern\u00e9 sk\u0159\u00ed\u0148ky\u201c<\/span><\/em><span>\u00a0signalizuj\u00edc\u00ed mo\u017enost z\u00e1va\u017en\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/span><\/p>\n<p><em><span>&#8222;Kdy\u017e se pod\u00edv\u00e1m na vy\u0161et\u0159en\u00ed magnetickou rezonanc\u00ed, kter\u00e1 ukazuje ARIA, p\u0159ipom\u00edn\u00e1 mi to pohled na sn\u00edmky magnetickou rezonanc\u00ed pacient\u016f, kte\u0159\u00ed m\u011bli mrtvici nebo n\u011bjak\u00e9 traumatick\u00e9 poran\u011bn\u00ed mozku,&#8220;<\/span><\/em><span>\u00a0\u0159ekl novin\u00e1\u0159\u016fm profesor Rob Howard z University College of London Institute of Mental Health. dod\u00e1v\u00e1, \u017ee zobrazovac\u00ed data ukazuj\u00ed, \u017ee pacienti u\u017e\u00edvaj\u00edc\u00ed l\u00e9ky\u00a0<\/span><em><span>\u201eve skute\u010dnosti ztr\u00e1cej\u00ed pravd\u011bpodobn\u011b o n\u011bco v\u00edce ne\u017e l\u017ei\u010dku plnou mozku\u201c.<\/span><\/em><span>\u00a0Podle Dr. Madhava Thambisettyho, hlavn\u00edho klinick\u00e9ho v\u00fdzkumn\u00edka z americk\u00e9ho N\u00e1rodn\u00edho institutu pro st\u00e1rnut\u00ed, pacienti, kte\u0159\u00ed dost\u00e1vaj\u00ed nejv\u011bt\u0161\u00ed d\u00e1vku, ztratili a\u017e t\u0159i \u010dajov\u00e9 l\u017ei\u010dky objemu mozku.\u00a0<\/span><\/p>\n<p><span>Zat\u00edmco v\u00fdrobci l\u00e9k\u016f chv\u00e1l\u00ed jejich p\u0159edpokl\u00e1dan\u00fd potenci\u00e1l zpomalit kognitivn\u00ed pokles u pacient\u016f s Alzheimerovou chorobou o 27 % (lecanemab) a 35 % (donanemab) ve srovn\u00e1n\u00ed s placebem, na 18bodov\u00e9 \u0161k\u00e1le hodnocen\u00ed p\u0159\u00edznak\u016f Alzheimerovy choroby se to prom\u00edtlo pouze ke zlep\u0161en\u00ed o 0,45 bodu. &#8211; kde je nepravd\u011bpodobn\u00e9, \u017ee by l\u00e9ka\u0159 ani pacient poc\u00edtil zlep\u0161en\u00ed pod jeden bod, podle Thambisettyho. Dokonce i vlastn\u00ed propaga\u010dn\u00ed materi\u00e1ly drog p\u0159ipou\u0161t\u011bj\u00ed, \u017ee nemohou obnovit pam\u011b\u0165 nebo kognitivn\u00ed funkce, kter\u00e9 ji\u017e byly ztraceny.<\/span><\/p>\n<p><span>Mezit\u00edm je zmen\u0161en\u00ed mozku pova\u017eov\u00e1no za indik\u00e1tor samotn\u00e9 Alzheimerovy choroby, co\u017e vyvol\u00e1v\u00e1 ot\u00e1zky o u\u017eite\u010dnosti\u00a0<\/span><em><span>\u201el\u00e9\u010dby\u201c<\/span><\/em><span>\u00a0, kter\u00e1 m\u016f\u017ee zhor\u0161it z\u00e1kladn\u00ed patologii. U n\u011bkter\u00fdch pacient\u016f s ARIA do\u0161lo podle \u00fadaj\u016f z klinick\u00fdch studi\u00ed k p\u011btin\u00e1sobn\u00e9mu zhor\u0161en\u00ed kognitivn\u00edch schopnost\u00ed ne\u017e u nel\u00e9\u010den\u00e9ho pacienta s Alzheimerovou chorobou a jedna \u017eena ve studii Lecanemab zem\u0159ela v nemocnici se 7 cm krv\u00e1cen\u00edm do mozku.\u00a0<\/span><\/p>\n<p><span>Podobn\u00fd l\u00e9k byl tak\u00e9 oslavov\u00e1n jako z\u00e1zra\u010dn\u00e1 l\u00e9\u010dba Alzheimerovy choroby, kdy\u017e byl schv\u00e1len v roce 2021, aducanumab, jeho\u017e v\u00fdrobce letos p\u0159estane vyr\u00e1b\u011bt. P\u0159ezkoum\u00e1n\u00ed klinick\u00fdch \u00fadaj\u016f uk\u00e1zalo, \u017ee u pacient\u016f u\u017e\u00edvaj\u00edc\u00edch l\u00e9k ve vysok\u00fdch d\u00e1vk\u00e1ch byla v\u00edce ne\u017e 15kr\u00e1t vy\u0161\u0161\u00ed pravd\u011bpodobnost v\u00fdskytu otoku mozku ne\u017e u pacient\u016f u\u017e\u00edvaj\u00edc\u00edch placebo a t\u00e9m\u011b\u0159 t\u0159ikr\u00e1t vy\u0161\u0161\u00ed pravd\u011bpodobnost krv\u00e1cen\u00ed do mozku.<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-1185\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2021\/04\/kuryr-podpis.png\" alt=\"\" width=\"84\" height=\"24\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lecanemab a donanemab mohou zp\u016fsobit smr\u0161\u0165ov\u00e1n\u00ed, otoky a krv\u00e1cen\u00ed do mozku, co\u017e m\u016f\u017ee b\u00fdt smrteln\u00e9,&#8230;<\/p>\n","protected":false},"author":2,"featured_media":39345,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[2958,1020,1402,1561],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/47544"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=47544"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/47544\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/39345"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=47544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=47544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=47544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}