{"id":4468,"date":"2021-09-01T07:41:28","date_gmt":"2021-09-01T05:41:28","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=4468"},"modified":"2021-09-01T07:41:29","modified_gmt":"2021-09-01T05:41:29","slug":"velky-utok-na-srdce-nasich-deti","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2021\/09\/01\/velky-utok-na-srdce-nasich-deti\/","title":{"rendered":"Velk\u00fd \u00fatok na srdce na\u0161ich d\u011bt\u00ed"},"content":{"rendered":"
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Tak tohle v\u00e1m ty \u0161mejdi Babi\u0161 a spol. nikdy ne\u0159eknou!<\/strong><\/span><\/p>\n

EudraVigilance (EMA) uv\u00e1d\u00ed 11 \u00famrt\u00ed, 544 pobyt\u016f v nemocnici, 1 466 z\u00e1va\u017en\u00fdch p\u0159\u00edpad\u016f a 2 938 p\u0159\u00edpad\u016f ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f u dosp\u00edvaj\u00edc\u00edch ve v\u011bkov\u00e9 skupin\u011b 12\u201317 [1].\u00a0Kampa\u0148 o\u010dkov\u00e1n\u00ed ml\u00e1de\u017ee pr\u00e1v\u011b za\u010dala.<\/span><\/p>\n

S ohledem na n\u00edzk\u00fd po\u010det \u00famrt\u00ed na Covid-19 a v\u00e1\u017en\u00e1 onemocn\u011bn\u00ed mezi dosp\u00edvaj\u00edc\u00edmi jsou ne\u017e\u00e1douc\u00ed \u00fa\u010dinky znepokojiv\u011b vysok\u00e9.<\/span><\/p>\n<\/div>\n

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Jednozna\u010dn\u011b dominuj\u00edc\u00edm z\u00e1va\u017en\u00fdm vedlej\u0161\u00edm \u00fa\u010dinkem u dosp\u00edvaj\u00edc\u00edch je z\u00e1n\u011bt srde\u010dn\u00edho svalu, myokarditida.\u00a0Je to hlavn\u00ed p\u0159\u00ed\u010dina \u00famrt\u00ed, hospitalizace a \u017eivot ohro\u017euj\u00edc\u00edch stav\u016f.\u00a0Profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f se zde velmi v\u00fdrazn\u011b li\u0161\u00ed od profilu star\u0161\u00edch lid\u00ed, u nich\u017e jsou \u010dast\u011bj\u0161\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky trombotick\u00e9ho a myelitick\u00e9ho typu.<\/span><\/p>\n

V\u00fdrobce (Pfizer-BioNTech) v p\u0159\u00edbalov\u00e9 informaci uzn\u00e1v\u00e1, \u017ee o\u010dkov\u00e1n\u00ed m\u016f\u017ee zp\u016fsobit myokarditidu [2].\u00a0Je tam naps\u00e1no:<\/span><\/p>\n

„\u00dadaje po uveden\u00ed na trh ukazuj\u00ed zv\u00fd\u0161en\u00e9 riziko myokarditidy a perikarditidy, zejm\u00e9na do 7 dn\u016f od druh\u00e9 d\u00e1vky. Pozorovan\u00e9 riziko je vy\u0161\u0161\u00ed u mu\u017e\u016f mlad\u0161\u00edch 40 let ne\u017e u \u017een a star\u0161\u00edch mu\u017e\u016f. Pozorovan\u00e9 riziko je nejvy\u0161\u0161\u00ed u mu\u017e\u016f ve v\u011bku 12 a\u017e 17 let.“ . P\u0159esto\u017ee v n\u011bkter\u00fdch p\u0159\u00edpadech byla vy\u017eadov\u00e1na intenzivn\u00ed p\u00e9\u010de, dostupn\u00e9 \u00fadaje z kr\u00e1tkodob\u00e9ho sledov\u00e1n\u00ed nazna\u010duj\u00ed, \u017ee symptomy u v\u011bt\u0161iny subjekt\u016f s konzervativn\u00ed l\u00e9\u010dbou odezn\u011bly. U n\u011bkter\u00fdch lid\u00ed p\u0159\u00edznaky neustoupily). O mo\u017en\u00e9m dlouhodob\u00e9m dlouhodob\u00e9m p\u016fsoben\u00ed nejsou zat\u00edm k dispozici \u017e\u00e1dn\u00e9 informace. efekty (pozn. autora: dlouhodob\u00e9 efekty jsou tedy mo\u017en\u00e9). \u201c<\/em><\/p><\/blockquote>\n

Uklid\u0148uj\u00edc\u00ed t\u00f3n p\u0159\u00edbalov\u00e9ho let\u00e1ku kontrastuje s l\u00e9ka\u0159sk\u00fdmi zku\u0161enostmi: Myokarditidy se ob\u00e1v\u00e1me, proto\u017ee ve t\u0159etin\u011b a\u017e polovin\u011b v\u0161ech p\u0159\u00edpad\u016f z\u016fst\u00e1v\u00e1 n\u00e1sledn\u00e1 po\u0161kozen\u00ed, jako je srde\u010dn\u00ed dilatace, srde\u010dn\u00ed selh\u00e1n\u00ed a srde\u010dn\u00ed arytmie [3].<\/span><\/p>\n

Z 11 p\u0159\u00edpad\u016f podez\u0159en\u00ed na smrteln\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky o\u010dkov\u00e1n\u00ed v evidenci EudraVigilance je v 8 ozna\u010dena konkr\u00e9tn\u00ed p\u0159\u00ed\u010dina smrti.\u00a0Z toho 6 souvis\u00ed s chorobami srdce – srde\u010dn\u00ed z\u00e1stava, myokarditida, perikardi\u00e1ln\u00ed v\u00fdpotek.\u00a0Dal\u0161\u00ed dva jsou p\u0159\u00edpad plicn\u00ed embolie a sebevra\u017eda souvisej\u00edc\u00ed s v\u00e1\u017en\u00fdm p\u0159\u00edpadem Covid-19.\u00a0P\u0159i jedn\u00e9 smrti do\u0161lo k \u00famrt\u00ed ve stejn\u00fd den jako o\u010dkov\u00e1n\u00ed;\u00a0v jin\u00e9m p\u0159\u00edpad\u011b do\u0161lo ke smrti jeden den po o\u010dkov\u00e1n\u00ed.\u00a0V obou p\u0159\u00edpadech jde o z\u00e1stavu srdce.<\/span><\/p>\n

Ze 70 \u017eivot ohro\u017euj\u00edc\u00edch reakc\u00ed (nepo\u010d\u00edtaje \u00famrt\u00ed) ve v\u011bku 12-17 let je nej\u010dast\u011bj\u0161\u00ed reakc\u00ed myokarditida (15 p\u0159\u00edpad\u016f).\u00a0Nalezena jsou i dal\u0161\u00ed z\u00e1va\u017en\u00e1 onemocn\u011bn\u00ed srdce – z\u00e1stava srdce (2), infarkt myokardu (2), atrioventrikul\u00e1rn\u00ed blok (1), perikarditida (2), perikardi\u00e1ln\u00ed v\u00fdpotek (2), tachykardie (1) a bradykardie (2) .<\/span><\/p>\n

Mezi 544 hospitalizovan\u00fdmi p\u0159\u00edpady (nepo\u010d\u00edtaje \u00famrt\u00ed) je 152 p\u0159\u00edpad\u016f s myokarditidou, plus perikarditida (17), tachykardie (11), perikardi\u00e1ln\u00ed v\u00fdpotek (8), palpitace (7), abnorm\u00e1ln\u00ed elektrokardiogram (4), infarkt myokardu (3) a sinusov\u00e1 tachykardie (2).<\/span><\/p>\n

Celkov\u011b je ve v\u011bkov\u00e9 skupin\u011b 12 a\u017e 17 let 2938 p\u0159\u00edpad\u016f ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.\u00a0Asi polovina z nich (1466) jsou z\u00e1va\u017en\u00e9 p\u0159\u00edpady.\u00a0Krom\u011b b\u011b\u017en\u011bj\u0161\u00edch p\u0159\u00edznak\u016f, jako je bolest hlavy a hore\u010dka, je jedn\u00edm z nej\u010dast\u011bj\u0161\u00edch vedlej\u0161\u00edch \u00fa\u010dink\u016f 177 p\u0159\u00edpad\u016f myokarditidy.\u00a0Lze tak\u00e9 nal\u00e9zt perikarditidu (43) a dal\u0161\u00ed poruchy srdce.<\/span><\/p>\n

662 p\u0159\u00edpad\u016f s bolest\u00ed hlavy a 565 p\u0159\u00edpad\u016f s hore\u010dkou EudraVigilance umo\u017e\u0148uje hrub\u00fd odhad \u010detnosti 177 p\u0159\u00edpad\u016f myokarditidy, kter\u00e9 se pohybovaly od 5 do 10, v souvislosti s \u010detnostmi zaznamenan\u00fdmi ve schvalovac\u00ed studii (64,9% a 17,8% , v uveden\u00e9m po\u0159ad\u00ed) % lze extrapolovat.\u00a0Nejde tedy v \u017e\u00e1dn\u00e9m p\u0159\u00edpad\u011b o vz\u00e1cn\u00fd vedlej\u0161\u00ed \u00fa\u010dinek – a p\u0159\u00edbalov\u00fd let\u00e1k [2] to v\u016fbec netvrd\u00ed (na rozd\u00edl od prohl\u00e1\u0161en\u00ed n\u011bkter\u00fdch lid\u00ed na ve\u0159ejnosti).<\/strong><\/span><\/p>\n

V\u011bt\u0161ina p\u0159\u00edpad\u016f je hl\u00e1\u0161ena pro BioNTech, proto\u017ee vakc\u00edna byla schv\u00e1lena pro d\u011bti ve v\u011bku 12-17 let ji\u017e 28. kv\u011btna 2021;\u00a0vakc\u00edna Moderna pouze 23. \u010dervence, p\u0159i\u010dem\u017e by m\u011blo b\u00fdt rovn\u011b\u017e vzato v \u00favahu, \u017ee od o\u010dkov\u00e1n\u00ed po ozn\u00e1men\u00ed zpr\u00e1vy o vedlej\u0161\u00edch \u00fa\u010dinc\u00edch uplyne n\u011bkolik t\u00fddn\u016f.\u00a0Vzhledem k tomu, \u017ee molekul\u00e1rn\u00ed slo\u017een\u00ed vakc\u00edny Moderna je velmi podobn\u00e9 vakc\u00edn\u011b BioNTech, lze p\u0159edpokl\u00e1dat podobn\u00fd profil vedlej\u0161\u00edch \u00fa\u010dink\u016f.\u00a0N\u011bkolik p\u0159\u00edpad\u016f hl\u00e1\u0161en\u00fdch ve v\u011bkov\u00e9 skupin\u011b pro AstraZeneca a Janssen pravd\u011bpodobn\u011b souvis\u00ed se studiemi.<\/span><\/p>\n

Zdroje a reference:<\/span><\/em>
\n[1]\u00a0<\/span>https:\/\/www.adrreports.eu\/de\/index.html<\/span><\/a>\u00a0, p\u0159\u00edstupn\u00e9 21. srpna 2021.<\/span><\/em>
\n[2]\u00a0<\/span>P\u0159\u00edbalov\u00fd let\u00e1k Corminaty<\/span><\/a>\u00a0, 5.2 Myokarditida a perikarditida „<\/span><\/em>
\n[3] D’Ambrosio a kol.: Osud akutn\u00ed myokarditidy mezi spont\u00e1nn\u00edm zlep\u0161en\u00edm a v\u00fdvojem k dilata\u010dn\u00ed kardiomyopatii: p\u0159ehled. In: Heart. 2001 kv\u011bten, 85 (5) ., S. 499-504<\/span><\/em>
\n[4]\u00a0<\/span>bezpe\u010dnostn\u00ed zpr\u00e1va Paul-Ehrlich-institutu od 19.08.2021<\/span><\/p>\n

<\/a>ko\u0161em<\/span><\/a>\u00a0: d\u011btem rozv\u00edjet dlouhodobou imunitu proti COVID-19<\/span><\/em><\/p>\n

Pozn\u00e1mka k [1]: Uveden\u00e9 \u00fadaje se t\u00fdkaj\u00ed cel\u00e9ho obsahu EudraVigilance, kombinace informac\u00ed od n\u00e1rodn\u00edch agentur EU a v\u00fdrobc\u016f, kte\u0159\u00ed tak\u00e9 hl\u00e1s\u00ed p\u0159\u00edpady ze zem\u00ed mimo EU.\u00a0Po\u010det o\u010dkovan\u00fdch dosp\u00edvaj\u00edc\u00edch, kte\u0159\u00ed by mohli m\u00edt potenci\u00e1ln\u011b vedlej\u0161\u00ed \u00fa\u010dinky, nelze spolehliv\u011b ur\u010dit.\u00a0<\/strong>Syst\u00e9m EudraVigilance je nav\u00edc pouze pasivn\u00ed hl\u00e1\u0161en\u00ed, o kter\u00e9m je zn\u00e1mo, \u017ee typicky zachyt\u00ed 10 a\u017e 100kr\u00e1t m\u00e9n\u011b p\u0159\u00edpad\u016f ne\u017e aktivn\u00ed hl\u00e1\u0161en\u00ed. Odhad relativn\u00ed frekvence proto nelze odvodit.<\/strong><\/span><\/p>\n<\/div>\n

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Tak tohle v\u00e1m ty \u0161mejdi Babi\u0161 a spol. nikdy ne\u0159eknou! EudraVigilance (EMA) uv\u00e1d\u00ed 11 \u00famrt\u00ed,…<\/p>\n","protected":false},"author":2,"featured_media":3283,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[213,523,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/4468"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=4468"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/4468\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/3283"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=4468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=4468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=4468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}