{"id":44528,"date":"2024-01-12T00:30:31","date_gmt":"2024-01-11T23:30:31","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=44528"},"modified":"2024-01-11T18:59:03","modified_gmt":"2024-01-11T17:59:03","slug":"vedci-z-wef-aktualne-z-potracenych-deti-vytvareji-minimozky-odolne-vuci-rakovine","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2024\/01\/12\/vedci-z-wef-aktualne-z-potracenych-deti-vytvareji-minimozky-odolne-vuci-rakovine\/","title":{"rendered":"V\u011bdci z WEF aktu\u00e1ln\u011b z potracen\u00fdch d\u011bt\u00ed vytv\u00e1\u0159ej\u00ed minimozky odoln\u00e9 v\u016f\u010di rakovin\u011b"},"content":{"rendered":"
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T\u00fdm v\u011bdc\u016f ze Sv\u011btov\u00e9ho ekonomick\u00e9ho f\u00f3ra (WEF) ozn\u00e1mil, \u017ee \u00fasp\u011b\u0161n\u011b vytvo\u0159ili v laborato\u0159i mozek odoln\u00fd v\u016f\u010di rakovin\u011b vyp\u011bstovan\u00fd z \u010d\u00e1st\u00ed potracen\u00fdch d\u011bt\u00ed.<\/span><\/p>\n

V\u011bdci z\u00a0<\/span>Centra pro d\u011btskou onkologii princezny M\u00e1xima<\/span><\/em>\u00a0v Nizozemsku, kter\u00e9 kontroluje WEF, tvrd\u00ed, \u017ee mozek jim vyrostl z plodu, kter\u00fd byl potracen mezi 12. a\u017e 15. t\u00fddnem t\u011bhotenstv\u00ed.<\/span><\/p>\n

Britsk\u00fd den\u00edk\u00a0<\/span>Dailymail.co.uk<\/span><\/a>\u00a0k t\u00e9matu uv\u00e1d\u00ed:<\/span><\/p>\n

A\u017e dosud v\u011bdci p\u0159i p\u011bstov\u00e1n\u00ed jin\u00fdch mini-org\u00e1n\u016f rozkl\u00e1dali p\u016fvodn\u00ed tk\u00e1n\u011b na jednotliv\u00e9 bu\u0148ky pomoc\u00ed embryon\u00e1ln\u00edch nebo pluripotentn\u00edch kmenov\u00fdch bun\u011bk pro r\u016fst a replikaci specifick\u00fdch oblast\u00ed mozku.<\/span><\/p>\n

Tento objev vedl v\u011bdce k \u00favaze o pou\u017eit\u00ed mini-org\u00e1nu k modelov\u00e1n\u00ed rakoviny mozku a specificky se zam\u011b\u0159ili na to, jak se vyv\u00edj\u00ed u d\u011bt\u00ed v nad\u011bji, \u017ee povede k vyl\u00e9\u010den\u00ed.<\/span><\/p>\n

\u201eTyto nov\u00e9 organoidy z\u00edskan\u00e9 z tk\u00e1n\u011b plodu mohou nab\u00eddnout nov\u00fd pohled na to, co formuje r\u016fzn\u00e9 oblasti mozku a co vytv\u00e1\u0159\u00ed bun\u011b\u010dnou diverzitu,\u201c<\/span><\/em>\u00a0\u0159\u00edk\u00e1 Dr.\u00a0Delilah Hendriksov\u00e1, vedouc\u00ed skupiny v\u00a0<\/span>Centru pro d\u011btskou onkologii princezny M\u00e1xima<\/span><\/em>\u00a0a postdoktorandsk\u00e1 v\u00fdzkumnice v Hubrechtov\u011b institutu, kter\u00e1 je spoluautorkou studie.<\/span><\/p>\n

Anonymn\u00ed d\u00e1rci (mysl\u00ed t\u00edm z\u0159ejm\u011b matky potracen\u00fdch plod\u016f) souhlasili s t\u00edm, aby v\u011bdci pou\u017eili tk\u00e1n\u011b pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely.\u00a0V\u011bdci cht\u011bli v\u011bd\u011bt, jestli dok\u00e1\u017e\u00ed vytvo\u0159it dlouhodob\u011b rostouc\u00ed org\u00e1n se stejnou komplexnost\u00ed bun\u011bk jako v lidsk\u00e9m mozku.<\/span><\/p>\n

Postup vytvo\u0159en\u00ed minimozg\u016f<\/span><\/h2>\n

Pomoc\u00ed mozkov\u00e9 tk\u00e1n\u011b plodu t\u00fdm nejprve roz\u0159ezal tk\u00e1\u0148 na mal\u00e9 kousky a uspo\u0159\u00e1dal je do misky.\u00a0N\u00e1sledn\u011b um\u00edstil kultury na orbit\u00e1ln\u00ed t\u0159epa\u010dku.<\/span><\/p>\n

B\u011bhem prvn\u00edch \u010dty\u0159 a\u017e osmi dn\u016f si v\u00fdzkumn\u00edci v\u0161imli, \u017ee se vytv\u00e1\u0159ej\u00ed n\u011bkolik 3D struktury a pokra\u010duj\u00ed v r\u016fstu, p\u0159i\u010dem\u017e st\u00e1le p\u0159ipom\u00ednali mozkovou tk\u00e1\u0148.\u00a0T\u00fdm zjistil, \u017ee roz\u0161t\u011bpen\u00edm organoidu mozku plodu se znovu zformuje na dvojn\u00e1sobek p\u016fvodn\u00ed velikosti do 20 a\u017e 30 dn\u016f od kultivace.<\/span><\/p>\n

Cel\u00fd tento proces pokra\u010doval b\u011bhem osmi m\u011bs\u00edc\u016f, p\u0159i\u010dem\u017e minimozgy nakonec narostly na velikost 1500 kubick\u00fdch centimetr\u016f.\u00a0V tomto bod\u011b se jejich r\u016fst sice zpomalil, ale bylo mo\u017en\u00e9 jej d\u00e1le udr\u017eet.<\/span><\/p>\n

V\u011bdci se pak zam\u011b\u0159ili na sv\u016fj prim\u00e1rn\u00ed c\u00edl v boji proti rakovin\u011b mozku a pou\u017eili n\u011bkter\u00e9 z nov\u011b vytvo\u0159en\u00fdch organoid\u016f k \u200b\u200bv\u00fdvoji minin\u00e1dor\u016f.\u00a0Pou\u017eili techniku \u200b\u200b\u00fapravy gen\u016f CRISPR-Cas9, pomoc\u00ed kter\u00e9 do mal\u00e9ho po\u010dtu bun\u011bk v organoidech zavedli rakovinn\u00fd gen naz\u00fdvan\u00fd TP53 pro modelov\u00e1n\u00ed rakoviny mozku.<\/span><\/p>\n

Pozn\u00e1mka: Crispr-Cas9 je n\u00e1stroj pro p\u0159esn\u00e9 \u00fapravy DNA objeven\u00fd v bakteri\u00edch.<\/span><\/p>\n

Trvalo t\u0159i m\u011bs\u00edce, ne\u017e gen zcela p\u0159evzal zdrav\u00e9 bu\u0148ky, replikoval stejn\u00e9 vlastnosti typick\u00fdch rakovinn\u00fdch bun\u011bk a uk\u00e1zal sv\u016fj potenci\u00e1l pro v\u00fdzkum\u00a0<\/span>l\u00e9k\u016f na rakovinu<\/span><\/a>\u00a0.<\/span><\/p>\n

Zji\u0161t\u011bn\u00ed v\u011bdc\u016f publikovan\u00e1 v recenzovan\u00e9m \u010dasopise Cell odhalila, \u017ee by mohlo b\u00fdt mo\u017en\u00e9 pou\u017e\u00edt organoidy k hled\u00e1n\u00ed l\u00e9\u010dby rakoviny a \u201emohlo by to zp\u016fsobit revoluci ve v\u00fdzkumu mozku\u201c.<\/span><\/p>\n

\u201eMozkov\u00e9 organoidy z tk\u00e1n\u011b plodu jsou neoceniteln\u00fdm nov\u00fdm n\u00e1strojem ke studiu v\u00fdvoje lidsk\u00e9ho mozku,\u201c<\/span><\/em>\u00a0\u0159ekla spoluautorka Dr.\u00a0Benedetta Artegianiov\u00e1.<\/span><\/p>\n

\u201eN\u00e1\u0161 nov\u00fd model mozku odvozen\u00fd z tk\u00e1n\u011b n\u00e1m umo\u017e\u0148uje l\u00e9pe pochopit, jak vyv\u00edjej\u00edc\u00ed se mozek reguluje identitu bun\u011bk.<\/span><\/em><\/p>\n

Mohlo by to tak\u00e9 pomoci pochopit, jak mohou chyby v tomto procesu v\u00e9st k neurov\u00fdvinov\u00fdm chorob\u00e1m, jako je mikrocefalie (zakrsl\u00fd mozek), jako\u017e i jin\u00fdm chorob\u00e1m, kter\u00e9 mohou pramenit z naru\u0161en\u00e9ho v\u00fdvoje, v\u010detn\u011b d\u011btsk\u00e9 rakoviny mozku.\u201c<\/span><\/em><\/p>\n

T\u00e9m\u011b\u0159 16 000 d\u011bt\u00ed ve v\u011bku od narozen\u00ed do 19 let je v USA ka\u017edoro\u010dn\u011b diagnostikov\u00e1no s rakovinou, p\u0159i\u010dem\u017e 4 000 z nich m\u00e1 diagnostikovan\u00e9 n\u00e1dory mozku a m\u00edchy.<\/span><\/p>\n

Z\u00e1v\u011br<\/span><\/h2>\n

N\u00e1dory mozku a m\u00edchy p\u0159edstavuj\u00ed zhruba jedno ze \u010dty\u0159 d\u011btsk\u00fdch rakovinov\u00fdch onemocn\u011bn\u00ed a asi jedno ze \u010dty\u0159 d\u011bt\u00ed s diagnostikovanou rakovinou mozku to podle organizace\u00a0\u00a0<\/span>American Cancer Society<\/span><\/em>\u00a0nezvl\u00e1dne.<\/span><\/p>\n

Z tohoto d\u016fvodu\u00a0<\/span>Centrum princezny M\u00e1ximy<\/span><\/em>\u00a0\u0159\u00edk\u00e1, \u017ee je motivov\u00e1no naj\u00edt \u0159e\u0161en\u00ed a v\u011b\u0159\u00ed, \u017ee \u00fasp\u011b\u0161n\u00fd v\u00fdvoj minimozg\u016f p\u0159ivede v\u011bdce o krok bl\u00ed\u017ee k vyl\u00e9\u010den\u00ed.<\/span><\/p>\n

\u201eKa\u017ed\u00fd den pracujeme s v\u00e1\u0161n\u00ed a bez omezen\u00ed, abychom zlep\u0161ili m\u00edru p\u0159e\u017eit\u00ed a kvalitu \u017eivota d\u011bt\u00ed s rakovinou, proto\u017ee tyto d\u011bti maj\u00ed cel\u00fd \u017eivot p\u0159ed sebou.\u201c<\/span><\/em><\/p>\n

Autor: Sean Tabatabai, Zdroj:\u00a0<\/span>thepeoplesvoice.tv<\/span><\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00fdm v\u011bdc\u016f ze Sv\u011btov\u00e9ho ekonomick\u00e9ho f\u00f3ra (WEF) ozn\u00e1mil, \u017ee \u00fasp\u011b\u0161n\u011b vytvo\u0159ili v laborato\u0159i mozek odoln\u00fd…<\/p>\n","protected":false},"author":2,"featured_media":44529,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[895,29,188,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/44528"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=44528"}],"version-history":[{"count":1,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/44528\/revisions"}],"predecessor-version":[{"id":44530,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/44528\/revisions\/44530"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/44529"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=44528"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=44528"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=44528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}