{"id":44214,"date":"2024-01-09T00:34:18","date_gmt":"2024-01-08T23:34:18","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=44214"},"modified":"2024-01-08T18:42:33","modified_gmt":"2024-01-08T17:42:33","slug":"spickove-doplnky-pro-mitochondrialni-funkci","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2024\/01\/09\/spickove-doplnky-pro-mitochondrialni-funkci\/","title":{"rendered":"\u0160pi\u010dkov\u00e9 dopl\u0148ky pro mitochondri\u00e1ln\u00ed funkci"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>Historie na prvn\u00ed pohled<\/strong><\/span><\/p>\n<ul>\n<li>Mitochondrie jsou struktury ve va\u0161ich bu\u0148k\u00e1ch, kter\u00e9 produkuj\u00ed asi 90 % energie vyroben\u00e9 ve va\u0161em t\u011ble<\/li>\n<li>Mitochondrie jsou kl\u00ed\u010dem ke zdrav\u00ed a prevenci nemoc\u00ed;\u00a0bez mitochondri\u00e1ln\u00edho zdrav\u00ed m\u016f\u017ee utrp\u011bt va\u0161e pohoda a o\u010dek\u00e1van\u00e1 d\u00e9lka \u017eivota<\/li>\n<li>Mezi dopl\u0148ky stravy, kter\u00e9 m\u016f\u017eete pou\u017e\u00edt speci\u00e1ln\u011b pro podporu sv\u00fdch mitochondri\u00ed, pat\u0159\u00ed vitam\u00edn K2, glycin, CoQ10, vitam\u00edny B a niacinamid a tak\u00e9 PQQ<\/li>\n<li>Spr\u00e1vn\u00e1 v\u00fd\u017eiva, na\u010dasov\u00e1n\u00ed j\u00eddla a cvi\u010den\u00ed jsou dal\u0161\u00ed strategie na podporu mitochondri\u00e1ln\u00edho zdrav\u00ed<\/li>\n<\/ul>\n<p>Mitochondrie jsou struktury ve va\u0161ich bu\u0148k\u00e1ch, kter\u00e9 produkuj\u00ed asi 90 % energie vyroben\u00e9 ve va\u0161em t\u011ble.\u00a0Tato energie je nezbytn\u00e1 pro bun\u011b\u010dnou regeneraci a detoxikaci, stejn\u011b jako svalovou kontrakci a jakoukoli prob\u00edhaj\u00edc\u00ed biochemickou kask\u00e1du.\u00a0Stru\u010dn\u011b \u0159e\u010deno, va\u0161e bu\u0148ky pot\u0159ebuj\u00ed energii, aby fungovaly, a zdrav\u00e9 mitochondrie jsou rozhoduj\u00edc\u00ed pro poskytov\u00e1n\u00ed t\u00e9to energie.<\/p>\n<p>Mitochondrie tak\u00e9 hraj\u00ed d\u016fle\u017eitou roli v apopt\u00f3ze, programovan\u00e9 bun\u011b\u010dn\u00e9 smrti, kter\u00e1 zp\u016fsobuje odum\u00edr\u00e1n\u00ed \u0161patn\u011b funguj\u00edc\u00edch bun\u011bk a jejich odstran\u011bn\u00ed ze syst\u00e9mu.\u00a0Zkr\u00e1tka mitochondrie jsou kl\u00ed\u010dem ke zdrav\u00ed a prevenci nemoc\u00ed.\u00a0Bez mitochondri\u00e1ln\u00edho zdrav\u00ed m\u016f\u017ee utrp\u011bt va\u0161e pohoda a o\u010dek\u00e1van\u00e1 d\u00e9lka \u017eivota.<\/p>\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>6 dopl\u0148k\u016f pro podporu va\u0161eho mitochondri\u00e1ln\u00edho zdrav\u00ed<\/strong><\/span><\/p>\n<p>Existuje mnoho strategi\u00ed pro optimalizaci mitochondri\u00e1ln\u00ed funkce.\u00a0To zahrnuje spr\u00e1vnou v\u00fd\u017eivu, na\u010dasov\u00e1n\u00ed j\u00eddla a cvi\u010den\u00ed.\u00a0Existuj\u00ed v\u0161ak tak\u00e9 dopl\u0148ky, kter\u00e9 m\u016f\u017eete strategicky pou\u017e\u00edt k podpo\u0159e va\u0161ich mitochondri\u00ed.\u00a0Mezi nejlep\u0161\u00ed mo\u017enosti pat\u0159\u00ed n\u00e1sleduj\u00edc\u00ed.<\/p>\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>#1 Vitam\u00edn K2<\/strong><\/span><\/p>\n<p>Existuj\u00ed dva typy vitaminu K: fylochinon (vitamin K1) a menachinon (vitamin K2).\u00a0Vitamin K1 poch\u00e1z\u00ed ze zelen\u00e9 listov\u00e9 zeleniny, jako je \u0161pen\u00e1t, kapusta, brokolice a zel\u00ed, a je nejl\u00e9pe zn\u00e1m\u00fd pro svou roli p\u0159i sr\u00e1\u017een\u00ed krve.<\/p>\n<p>Vitamin K2, kter\u00fd je zn\u00e1m\u011bj\u0161\u00ed pro svou roli ve zdrav\u00ed kost\u00ed a srdce, se nach\u00e1z\u00ed v \u017eivo\u010di\u0161n\u00fdch produktech chovan\u00fdch na tr\u00e1v\u011b, jako je maso, vejce, j\u00e1tra a ml\u00e9\u010dn\u00e9 v\u00fdrobky, stejn\u011b jako ve fermentovan\u00fdch potravin\u00e1ch, jako je kysan\u00e9 zel\u00ed, n\u011bkter\u00e9 s\u00fdry a fermentovan\u00fd s\u00f3jov\u00fd produkt natto.<\/p>\n<p>Vitamin K2, vitamin rozpustn\u00fd v tuc\u00edch, m\u00e1 tak\u00e9 antioxida\u010dn\u00ed a neuroprotektivn\u00ed \u00fa\u010dinky.\u00a0V jedn\u00e9 studii v\u011bdci dokonce zjistili, \u017ee vitam\u00edn K2 moduluje mitochondri\u00e1ln\u00ed dysfunkci zp\u016fsobenou neurotoxiny.\u00a0Vystavili bu\u0148ky SH-SY5Y, kter\u00e9 slou\u017e\u00ed jako model pro neurodegenerativn\u00ed onemocn\u011bn\u00ed, p\u016fsoben\u00ed 6-hydroxydopaminu (6-OHDA), neurotoxick\u00e9 slou\u010denin\u011b pou\u017e\u00edvan\u00e9 k ni\u010den\u00ed nervov\u00fdch bun\u011bk v mozku.<\/p>\n<p>Pot\u00e9 bu\u0148ky o\u0161et\u0159ili vitam\u00ednem K2, co\u017e vedlo k \u010detn\u00fdm zlep\u0161en\u00edm.\u00a0Zat\u00edmco 6-OHDA zp\u016fsobil abnorm\u00e1ln\u00ed mitochondri\u00e1ln\u00ed zm\u011bny, vitam\u00edn K2 v\u00fdznamn\u011b potla\u010doval negativn\u00ed zm\u011bny.<\/p>\n<p>Vitamin K2 tak\u00e9 inhiboval akumulaci reaktivn\u00edch forem kysl\u00edku (ROS) a podporoval mitof\u00e1gii, co\u017e je eliminace po\u0161kozen\u00fdch mitochondri\u00ed autofagi\u00ed \u2013 z\u00e1kladn\u00ed funkce p\u0159i udr\u017eov\u00e1n\u00ed bun\u011b\u010dn\u00e9ho zdrav\u00ed.\u00a0Ve v\u011bdeck\u00e9m \u010dasopise \u201eNutrients\u201c v\u011bdci vysv\u011btlili:<\/p>\n<p><em>\u201e\u2026[V]itam\u00edn K2 m\u016f\u017ee vyvolat po\u0161kozen\u00ed mitochondri\u00ed a\u2026 tento \u00fa\u010dinek je spojen se zapojen\u00edm vitam\u00ednu K2 do regulace mitochondri\u00e1ln\u00ed smy\u010dky kontroly kvality prost\u0159ednictv\u00edm udr\u017eov\u00e1n\u00ed mitochondri\u00e1ln\u00edho syst\u00e9mu kontroly kvality a opravy mitochondri\u00e1ln\u00ed dysfunkce , \u010d\u00edm\u017e se sn\u00ed\u017e\u00ed po\u0161kozen\u00ed zp\u016fsoben\u00e9 po\u0161kozen\u00edm mitochondri\u00ed zprost\u0159edkovan\u00e1 smrt neuronov\u00fdch bun\u011bk.<\/em><\/p>\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>#2 Glycin<\/strong><\/span><\/p>\n<p>Glycin je neesenci\u00e1ln\u00ed aminokyselina, proto\u017ee si ji t\u011blo dok\u00e1\u017ee vyrobit samo.\u00a0V\u011bt\u0161ina z n\u00e1s v\u0161ak nevytv\u00e1\u0159\u00ed dostatek glycinu, aby maximalizovala jeho zdravotn\u00ed p\u0159\u00ednosy, mezi kter\u00e9 pat\u0159\u00ed del\u0161\u00ed \u017eivotnost a ochrana p\u0159ed nemocemi souvisej\u00edc\u00edmi s v\u011bkem.<\/p>\n<p>Zat\u00edmco se dlouho p\u0159edpokl\u00e1dalo, \u017ee mutace v mitochondri\u00e1ln\u00ed DNA souvisej\u00edc\u00ed s v\u011bkem jsou zodpov\u011bdn\u00e9 za to, \u017ee mitochondrie s v\u011bkem funguj\u00ed m\u00e9n\u011b efektivn\u011b, japon\u0161t\u00ed v\u011bdci se domn\u00edvaj\u00ed, \u017ee hlavn\u00ed roli mohou hr\u00e1t epigenetick\u00e9 zm\u011bny.<\/p>\n<p>Dok\u00e1zali tak\u00e9 obnovit genovou regulaci ve st\u00e1rnouc\u00edch mitochondri\u00edch do mladistv\u011bj\u0161\u00edho stavu pomoc\u00ed glycinu.\u00a0Studie uv\u00e1d\u00ed: &#8222;L\u00e9\u010dba star\u0161\u00edch fibroblast\u016f glycinem \u00fa\u010dinn\u011b zabr\u00e1nila expresi t\u011bchto st\u00e1rnouc\u00edch fenotyp\u016f.&#8220;<\/p>\n<p>Kolagen \u2013 nejroz\u0161\u00ed\u0159en\u011bj\u0161\u00ed b\u00edlkovina v na\u0161em t\u011ble \u2013 je v\u011bt\u0161inou tvo\u0159en glycinem.\u00a0Je tak\u00e9 prekurzorem glutathionu, siln\u00e9ho antioxidantu, kter\u00fd se s v\u011bkem sni\u017euje.\u00a0D\u016fvodem \u00fa\u010dink\u016f glycinu proti st\u00e1rnut\u00ed by v\u0161ak mohla b\u00fdt stimulace autofagie a napodobov\u00e1n\u00ed omezen\u00ed methioninu.\u00a0Dokonce i do\u010dasn\u00e9 omezen\u00ed methioninu vede k v\u00fdhod\u00e1m, jako je zlep\u0161en\u00ed homeost\u00e1zy gluk\u00f3zy, sn\u00ed\u017een\u00ed obezity a ochrana proti ztu\u010dn\u011bn\u00ed jater.<\/p>\n<p>V\u00fdzkumn\u00edci z Baylor College of Medicine tak\u00e9 studovali suplementaci kombinac\u00ed glycinu a N-acetylcysteinu (NAC), dvou prekurzor\u016f glutathionu, kter\u00e9 jsou spole\u010dn\u011b zn\u00e1m\u00e9 jako GlyNAC.<\/p>\n<p>Ji\u017e d\u0159\u00edve prok\u00e1zali, \u017ee mlad\u00e9 my\u0161i s deficitem glutathionu maj\u00ed mitochondri\u00e1ln\u00ed dysfunkci a dopln\u011bn\u00ed GlyNAC u star\u0161\u00edch my\u0161\u00ed nejen zlep\u0161ilo nedostatek glutathionu, ale tak\u00e9 po\u0161kozen\u00ed mitochondri\u00ed, oxida\u010dn\u00ed stres a inzul\u00ednovou rezistenci.<\/p>\n<p>Dal\u0161\u00ed v\u00fdzkum byl proveden na pacientech s HIV a zjistil, \u017ee suplementace GlyNAC zlep\u0161ila \u201edeficity spojen\u00e9 s p\u0159ed\u010dasn\u00fdm st\u00e1rnut\u00edm\u201c u t\u00e9to populace.\u00a0Ty zahrnovaly zlep\u0161en\u00ed oxida\u010dn\u00edho stresu, mitochondri\u00e1ln\u00ed dysfunkce, z\u00e1n\u011btu, endoteli\u00e1ln\u00ed dysfunkce, inzul\u00ednov\u00e9 rezistence, genotoxicity, s\u00edly a kognice.<\/p>\n<p>N\u00e1sledn\u00e1 pilotn\u00ed studie u star\u0161\u00edch lid\u00ed zjistila podobn\u00e9 v\u00fdsledky: Suplementace GlyNAC po dobu 24 t\u00fddn\u016f napravila nedostatek glutathionu a zlep\u0161ila n\u011bkolik zdravotn\u00edch marker\u016f, v\u010detn\u011b mitochondri\u00e1ln\u00ed dysfunkce, endoteli\u00e1ln\u00ed dysfunkce, z\u00e1n\u011btu, kognitivn\u00edch schopnost\u00ed, s\u00edly a dal\u0161\u00edch.<\/p>\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>#3 Koenzym Q10 (CoQ10)<\/strong><\/span><\/p>\n<p>CoQ10, antioxidant rozpustn\u00fd v tuc\u00edch, se nach\u00e1z\u00ed t\u00e9m\u011b\u0159 v ka\u017ed\u00e9 bu\u0148ce va\u0161eho t\u011bla, ale je koncentrov\u00e1n v mitochondri\u00edch, kde se pod\u00edl\u00ed na v\u00fdrob\u011b energie.\u00a0Jako kofaktor v elektronov\u00e9m transportn\u00edm \u0159et\u011bzci se CQ10 prim\u00e1rn\u011b pod\u00edl\u00ed na synt\u00e9ze adenosintrifosf\u00e1tu (ATP), kter\u00fd va\u0161e bu\u0148ky pot\u0159ebuj\u00ed k \u017eivotu, oprav\u011b a regeneraci.<\/p>\n<p>Zd\u00e1 se, \u017ee mnoho nemoc\u00ed, v\u010detn\u011b srde\u010dn\u00edch chorob, je zp\u016fsobeno mitochondri\u00e1ln\u00ed dysfunkc\u00ed.\u00a0Bu\u0148ky srde\u010dn\u00edho svalu maj\u00ed p\u0159ibli\u017en\u011b 5 000 mitochondri\u00ed na bu\u0148ku, ve kter\u00fdch je koncentrov\u00e1n CoQ10.\u00a0Pro srovn\u00e1n\u00ed, mitochondrie tvo\u0159\u00ed asi 35 % objemu srde\u010dn\u00ed tk\u00e1n\u011b a pouze 3 a\u017e 8 % objemu tk\u00e1n\u011b kostern\u00edho svalstva.<\/p>\n<p>P\u0159esto\u017ee CoQ10 nestimuluje r\u016fst nov\u00fdch mitochondri\u00ed, je nezbytn\u00fd pro jejich metabolickou funkci.\u00a0Nav\u00edc podle v\u00fdzkumn\u00edk\u016f z Liverpool John Moores University ve Velk\u00e9 Brit\u00e1nii:<\/p>\n<p><em>\u201eSekund\u00e1rn\u00ed nedostatek CoQ10 se typicky vyskytuje u mitochondri\u00e1ln\u00edch myopati\u00ed, kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed, diabetu typu II, chronick\u00e9ho onemocn\u011bn\u00ed ledvin, onemocn\u011bn\u00ed jater a kritick\u00fdch onemocn\u011bn\u00ed.\u00a0Nedostatek CoQ10 u t\u011bchto onemocn\u011bn\u00ed m\u016f\u017ee ovlivnit bun\u011b\u010dn\u00fd antioxida\u010dn\u00ed stav a v\u00e9st k poru\u0161e mitochondri\u00e1ln\u00ed funkce a z\u00e1sobov\u00e1n\u00ed bu\u0148ky energi\u00ed, nap\u0159.\u00a0B. m\u00e1 za n\u00e1sledek srde\u010dn\u00ed selh\u00e1n\u00ed.\u201c<\/em><\/p>\n<p>Ubiquinol je redukovan\u00e1 verze CoQ10.\u00a0Mlad\u00ed lid\u00e9 sn\u00e1\u0161ej\u00ed dopl\u0148ky CoQ10 docela dob\u0159e, ale star\u0161\u00edm lidem je l\u00e9pe s ubiquinolem, proto\u017ee se snadn\u011bji vst\u0159eb\u00e1v\u00e1.\u00a0Koenzym Q10 m\u016f\u017eete z\u00edskat tak\u00e9 j\u00eddlem.\u00a0Mezi zdroje potravy pat\u0159\u00ed voln\u011b uloven\u00fd losos, makrela, sardinky, vejce a svalovina.<\/p>\n<p>M\u016f\u017eete tak\u00e9 zlep\u0161it p\u0159em\u011bnu CoQ10 na ubiquinol v t\u011ble t\u00edm, \u017ee budete j\u00edst hodn\u011b zelen\u00e9 listov\u00e9 zeleniny, kter\u00e1 m\u00e1 vysok\u00fd obsah chlorofylu, a p\u0159itom se vystavit slunci.<\/p>\n<p>Pokud u\u017e\u00edv\u00e1te statinov\u00fd l\u00e9k, budete tak\u00e9 muset u\u017e\u00edvat alespo\u0148 100 a\u017e 200 mg ubiquinolu nebo CoQ10 denn\u011b nebo v\u00edce.\u00a0Suplementace je vhodn\u00e1 i pro osoby s chronick\u00fdmi onemocn\u011bn\u00edmi, jako jsou srde\u010dn\u00ed choroby, cukrovka, amyotrofick\u00e1 later\u00e1ln\u00ed skler\u00f3za (ALS), chronick\u00e1 \u00fanava a autismus.\u00a0V ide\u00e1ln\u00edm p\u0159\u00edpad\u011b byste m\u011bli d\u00e1vku rozd\u011blit tak, abyste ji u\u017e\u00edvali dvakr\u00e1t nebo t\u0159ikr\u00e1t denn\u011b, ne\u017e abyste ji u\u017e\u00edvali najednou, proto\u017ee to bude m\u00edt za n\u00e1sledek vy\u0161\u0161\u00ed hladiny v krvi.<\/p>\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>#4 Pyrrolochinolin Chinon (PQQ)<\/strong><\/span><\/p>\n<p>PQQ je l\u00e1tka podobn\u00e1 vitaminu a bratranec CoQ10, kter\u00fd podporuje mitochondri\u00e1ln\u00ed biogenezi.\u00a0\u010c\u00edm v\u00edce mitochondri\u00ed m\u00e1te, t\u00edm v\u00edce energie mohou va\u0161e bu\u0148ky produkovat a t\u00edm l\u00e9pe funguj\u00ed.\u00a0Dostate\u010dn\u00fd p\u0159\u00edsun PQQ podporuje proliferaci mitochondri\u00ed.<\/p>\n<p>Ve studii na my\u0161\u00edch suplementace PQQ modulovala jak po\u010det, tak funkci mitochondri\u00ed.\u00a0Studie na zv\u00ed\u0159atech a lidech s pou\u017eit\u00edm d\u00e1vek mezi 10 a 20 miligramy (mg) PQQ ukazuj\u00ed v\u00fdznamn\u00e9 zlep\u0161en\u00ed ment\u00e1ln\u00edho zpracov\u00e1n\u00ed a pam\u011bti.\u00a0Nejlep\u0161\u00edch v\u00fdsledk\u016f se dos\u00e1hne p\u0159i u\u017e\u00edv\u00e1n\u00ed PQQ v kombinaci s CoQ10.<\/p>\n<p>Bylo tak\u00e9 prok\u00e1z\u00e1no, \u017ee PQQ chr\u00e1n\u00ed p\u0159ed v\u00fdvojem alfa-synukleinu, proteinu spojen\u00e9ho s Parkinsonovou chorobou, a beta-amyloidu, kter\u00fd je spojov\u00e1n s Alzheimerovou chorobou.\u00a0Jin\u00fd v\u00fdzkum nazna\u010duje, \u017ee denn\u00ed suplementace 20 mg PQQ optimalizuje mitochondri\u00e1ln\u00ed biogenezi u lidsk\u00fdch subjekt\u016f.<\/p>\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>#5 vitam\u00edny skupiny B<\/strong><\/span><\/p>\n<p>Vitam\u00edny B jsou tak\u00e9 pot\u0159ebn\u00e9 pro optim\u00e1ln\u00ed fungov\u00e1n\u00ed mitochondri\u00ed.\u00a0Podle l\u00e9ka\u0159e p\u0159\u00edrodn\u00ed medic\u00edny Dr.\u00a0Frank Shallenberger:<\/p>\n<p><em>\u201eVitaminy B jsou naprosto kl\u00ed\u010dov\u00e9 pro mitochondri\u00e1ln\u00ed funkci \u2013 zejm\u00e9na niacin, riboflavin a fol\u00e1t.\u00a0Or\u00e1ln\u011b \u0159e\u010deno, s niacinem obvykle za\u010d\u00edn\u00e1m se 100 a\u017e 200 miligramy denn\u011b, [ale] u n\u011bkter\u00fdch pacient\u016f m\u016f\u017eete snadno u\u017e\u00edvat a\u017e 2 000 mg.\u00a0Pou\u017e\u00edv\u00e1m B komplex, proto\u017ee to chci vyv\u00e1\u017eit, ale zam\u011b\u0159uji se p\u0159edev\u0161\u00edm na niacin, fol\u00e1t a riboflavin.\u201c<\/em><\/p>\n<p>Nedostatek riboflavinu se m\u016f\u017ee tak\u00e9 pod\u00edlet na mitochondri\u00e1ln\u00ed dysfunkci, kter\u00e1 m\u016f\u017ee zp\u016fsobit poruchy centr\u00e1ln\u00edho nervov\u00e9ho syst\u00e9mu, v\u010detn\u011b potenci\u00e1ln\u011b migr\u00e9n.\u00a0Podle v\u00fdzkumu publikovan\u00e9ho v Frontiers in Neurology \u201eRiboflavin zm\u00edr\u0148uje oxida\u010dn\u00ed stres, mitochondri\u00e1ln\u00ed dysfunkci, neuroz\u00e1n\u011bt a glutam\u00e1tovou excitotoxicitu, kter\u00e9 se v\u0161echny pod\u00edlej\u00ed na patogenezi Parkinsonovy choroby, migr\u00e9ny a dal\u0161\u00edch neurologick\u00fdch poruch.<\/p>\n<p>Bylo prok\u00e1z\u00e1no, \u017ee lid\u00e9 s migr\u00e9nou maj\u00ed vy\u0161\u0161\u00ed \u00farove\u0148 mitochondri\u00e1ln\u00ed dysfunkce a nejm\u00e9n\u011b dva polymorfismy v mitochondri\u00e1ln\u00ed DNA zvy\u0161uj\u00ed n\u00e1chylnost k migr\u00e9n\u00e1m.\u00a0Riboflavin m\u016f\u017ee pomoci napravit tuto mitochondri\u00e1ln\u00ed dysfunkci.\u00a0Mezi potraviny bohat\u00e9 na riboflavin pat\u0159\u00ed \u0161pen\u00e1t, \u010derven\u00e1 \u0159epa, houby crimini a portabella, vejce chovan\u00e1 na pastv\u011b, ch\u0159est, hov\u011bz\u00ed j\u00e1tra a hov\u011bz\u00ed sv\u00ed\u010dkov\u00e1.<\/p>\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>#6 Niacinamid<\/strong><\/span><\/p>\n<p><a href=\"https:\/\/takecontrol.substack.com\/p\/health-benefits-of-niacinamide\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/takecontrol.substack.com\/p\/health-benefits-of-niacinamide\">Niacinamid<\/a>\u00a0, tak\u00e9 zn\u00e1m\u00fd jako nikotinamid, je forma niacinu (vitam\u00edn B3), kter\u00fd hraje d\u016fle\u017eitou roli v energetick\u00e9m metabolismu.\u00a0Je nezbytn\u00fd pro fungov\u00e1n\u00ed elektronov\u00e9ho transportn\u00edho \u0159et\u011bzce v mitochondri\u00edch.\u00a0Bez n\u011bj mitochondrie nemohou produkovat energii.<\/p>\n<p>Niacinamid je tak d\u016fle\u017eit\u00fd, proto\u017ee je prekurzorem NAD+, kter\u00fd se pod\u00edl\u00ed na p\u0159em\u011bn\u011b potravy na energii, udr\u017euje integritu DNA a zaji\u0161\u0165uje spr\u00e1vnou funkci bun\u011bk.\u00a0NAD+ je tak\u00e9 prim\u00e1rn\u00ed palivo pro sirtuiny, proteiny dlouhov\u011bkosti, kter\u00e9 se s v\u011bkem vy\u010derp\u00e1vaj\u00ed.<\/p>\n<p>Niacinamid v d\u00e1vce 50 miligram\u016f t\u0159ikr\u00e1t denn\u011b poskytuje palivo pro enzym, kter\u00fd omezuje rychlost NAD+, NAMPT.\u00a0Niacinamid m\u00e1 tak\u00e9 siln\u00e9 \u00fa\u010dinky proti obezit\u011b, m\u016f\u017ee pomoci p\u0159edch\u00e1zet neurodegeneraci a srde\u010dn\u00edmu selh\u00e1n\u00ed a zvr\u00e1tit prosakov\u00e1n\u00ed st\u0159ev.<\/p>\n<p>Niacinamid m\u016f\u017ee tak\u00e9 pomoci zabr\u00e1nit neurodegeneraci t\u00edm, \u017ee umo\u017en\u00ed vy\u0161\u0161\u00ed energetick\u00e9 hladiny prost\u0159ednictv\u00edm energetick\u00e9ho metabolismu v mitochondri\u00edch.\u00a0\u201eExistuje mnoho desetilet\u00ed trvaj\u00edc\u00edch studi\u00ed, kter\u00e9 ukazuj\u00ed, \u017ee pokles hladin NAD+, a tedy hladin NAD\/NADH, je spole\u010dn\u00fdm rysem prakticky v\u0161ech neurodegenerativn\u00edch onemocn\u011bn\u00ed,\u201c p\u00ed\u0161e v\u00fdzkumn\u00edk v oblasti bioenergetiky Georgi Dinkov.<\/p>\n<p>Doporu\u010duji zakoupit niacinamid ve form\u011b pr\u00e1\u0161ku, proto\u017ee nejni\u017e\u0161\u00ed dostupn\u00e1 d\u00e1vka ve v\u011bt\u0161in\u011b dopl\u0148k\u016f je 500 mg a NAD+ se sni\u017euje kv\u016fli negativn\u00ed zp\u011btn\u00e9 vazb\u011b na NAMPT, co\u017e je opak toho, o co usilujete.\u00a0Niacinamid v\u00e1s bude st\u00e1t jen asi 25 cent\u016f m\u011bs\u00ed\u010dn\u011b, pokud si ho koup\u00edte ve form\u011b pr\u00e1\u0161ku.\u00a0Jedna \u0161edes\u00e1t\u00e1 \u010dtvrt\u00e1 \u010dajov\u00e1 l\u017ei\u010dka pr\u00e1\u0161ku niacinamidu se obvykle rovn\u00e1 asi 50 mg.<\/p>\n<p>Doporu\u010duji tak\u00e9 denn\u011b u\u017e\u00edvat tabletu aspirinu.\u00a0Aspirin hraje roli v mitochondri\u00e1ln\u00ed funkci a m\u00e1 i dal\u0161\u00ed zdravotn\u00ed p\u0159\u00ednosy.\u00a0D\u016fle\u017eit\u00e9 je, \u017ee pom\u00e1h\u00e1 zvy\u0161ovat oxidaci gluk\u00f3zy jako paliva pro t\u011blo a z\u00e1rove\u0148 inhibuje oxidaci mastn\u00fdch kyselin, zejm\u00e9na\u00a0<a href=\"https:\/\/takecontrol.substack.com\/p\/linoleic-acid\" target=\"_blank\" rel=\"noreferrer noopener\" data-type=\"link\" data-id=\"https:\/\/takecontrol.substack.com\/p\/linoleic-acid\">kyseliny linolov\u00e9<\/a>\u00a0.\u00a0Dinkov dod\u00e1v\u00e1:<\/p>\n<p><em>\u201eProto\u017ee je zn\u00e1mo, \u017ee aspirin moduluje autofagii (zvy\u0161uje ji, kdy\u017e je abnorm\u00e1ln\u011b n\u00edzk\u00e1, a sni\u017euje ji, kdy\u017e je abnorm\u00e1ln\u011b vysok\u00e1), a niacinamid je velmi \u00fa\u010dinn\u00fdm prekurzorem NAD, je rozumn\u00e9 vyzkou\u0161et oboj\u00ed v kombinaci, kter\u00e1 by m\u011bla b\u00fdt synergick\u00e1 p\u0159i ochran\u011b mozku (a cel\u00fd organismus) p\u0159ed nemocemi a dokonce i st\u00e1rnut\u00edm.<\/em><\/p>\n<p class=\"has-medium-font-size\"><span style=\"font-size: 18pt;\"><strong>Co je\u0161t\u011b pom\u00e1h\u00e1 zlep\u0161it mitochondri\u00e1ln\u00ed funkce?<\/strong><\/span><\/p>\n<p>Existuje \u0159ada strategi\u00ed, kter\u00e9 m\u016f\u017eete pou\u017e\u00edt k optimalizaci sv\u00e9ho mitochondri\u00e1ln\u00edho zdrav\u00ed a funkce.\u00a0Z\u00e1kladn\u00ed nutri\u010dn\u00ed strategi\u00ed je j\u00edst spr\u00e1vn\u00e9 palivo, zam\u011b\u0159it se na prim\u00e1rn\u00ed stravu a vyh\u00fdbat se vysoce zpracovan\u00fdm potravin\u00e1m.\u00a0Strava pln\u00e1 zpracovan\u00fdch potravin br\u00e1n\u00ed va\u0161emu t\u011blu v efektivn\u00edm spalov\u00e1n\u00ed tuk\u016f jako prim\u00e1rn\u00edho paliva.\u00a0Kdy\u017e se zam\u011b\u0159\u00edte na cel\u00e9 potraviny a stanete se \u00fa\u010dinn\u00fdm spalova\u010dem tuk\u016f, automaticky minimalizujete oxida\u010dn\u00ed stres kladen\u00fd na va\u0161e mitochondrie.<\/p>\n<p>Dal\u0161\u00edm d\u016fle\u017eit\u00fdm faktorem je na\u010dasov\u00e1n\u00ed j\u00eddla.\u00a0Jedna z nejhor\u0161\u00edch v\u011bc\u00ed, kterou m\u016f\u017eete sv\u00fdm mitochondri\u00edm pravideln\u011b d\u011blat, je j\u00edst t\u011bsn\u011b p\u0159ed span\u00edm.\u00a0V ide\u00e1ln\u00edm p\u0159\u00edpad\u011b si dejte posledn\u00ed j\u00eddlo dne alespo\u0148 t\u0159i hodiny p\u0159ed span\u00edm.<\/p>\n<p>Poskytov\u00e1n\u00ed j\u00eddla sv\u00e9mu t\u011blu v dob\u011b, kdy to nejm\u00e9n\u011b pot\u0159ebuje (proto\u017ee sp\u00edte), vytv\u00e1\u0159\u00ed nadm\u011brn\u00e9 mno\u017estv\u00ed voln\u00fdch radik\u00e1l\u016f, kter\u00e9 se pak vyl\u00e9vaj\u00ed a po\u0161kozuj\u00ed mitochondri\u00e1ln\u00ed DNA.\u00a0Zejm\u00e9na p\u0159ebytek sacharid\u016f vede k p\u0159ebytku elektron\u016f, co\u017e zp\u016fsobuje tvorbu superoxidu.<\/p>\n<p>Cvi\u010den\u00ed je tak\u00e9 u\u017eite\u010dn\u00e9, proto\u017ee upreguluje geny jako PGC-1 alfa a jadern\u00e9 genov\u00e9 faktory jako Nrf2.\u00a0Tyto geny pom\u00e1haj\u00ed mitochondri\u00edm st\u00e1t se efektivn\u011bj\u0161\u00edmi.\u00a0Mitochondrie jsou tak\u00e9 zraniteln\u00e9 v\u016f\u010di emo\u010dn\u00edmu stresu a environment\u00e1ln\u00edm toxin\u016fm, jako jsou t\u011b\u017ek\u00e9 kovy.\u00a0Pravideln\u00e9 n\u00e1v\u0161t\u011bvy bl\u00edzk\u00e9 infra\u010derven\u00e9 sauny mohou pomoci jak s detoxikac\u00ed, tak s \u00falevou od stresu.<\/p>\n<p>Dal\u0161\u00ed v\u00fdhodou je, \u017ee 95 % melatoninu je produkov\u00e1no v mitochondri\u00edch v reakci na bl\u00edzk\u00e9 infra\u010derven\u00e9 sv\u011btlo.\u00a0Melatonin je antioxidant, kter\u00fd pom\u00e1h\u00e1 rozkl\u00e1dat ROS, kter\u00e9 po\u0161kozuj\u00ed mitochondrie.\u00a0Kdy\u017e tedy pou\u017e\u00edv\u00e1te hodn\u011b bl\u00edzk\u00e9ho infra\u010derven\u00e9ho sv\u011btla, a\u0165 u\u017e v bl\u00edzk\u00e9 infra\u010derven\u00e9 saun\u011b nebo na slunci b\u011bhem dne, jsou va\u0161e mitochondrie zaplaveny melatoninem, kter\u00fd sni\u017euje oxida\u010dn\u00ed stres.<\/p>\n<p><span style=\"font-size: 18pt;\"><strong>Prameny:<\/strong><\/span><\/p>\n<ul>\n<li><sup>1\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.bitchute.com\/video\/4wFThKNpVcsJ\/\" target=\"_blank\" rel=\"noreferrer noopener\">BitChute 8. b\u0159ezna 2022<\/a><\/li>\n<li><sup>2,\u00a0<\/sup>\u00a0<sup>3\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9003256\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u017diviny.\u00a02022 duben;\u00a014(7): 1504<\/a><\/li>\n<li><sup>4,\u00a0<\/sup>\u00a0<sup>9,\u00a0<\/sup>\u00a0<sup>10\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568163723000818?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">P\u0159ehledy v\u00fdzkumu st\u00e1rnut\u00ed 31. b\u0159ezna 2023<\/a><\/li>\n<li><sup>5,\u00a0<\/sup>\u00a0<sup>7\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.nature.com\/articles\/srep10434\" target=\"_blank\" rel=\"noreferrer noopener\">V\u011bdeck\u00e9 zpr\u00e1vy 22. kv\u011btna 2015<\/a><\/li>\n<li><sup>6,\u00a0<\/sup>\u00a0<sup>20\u00a0<\/sup>\u00a0<a href=\"https:\/\/joshmitteldorf.scienceblog.com\/2017\/02\/06\/glycine-and-mitochondria\/\" target=\"_blank\" rel=\"noreferrer noopener\">Science Blog, Josh Mitteldorf 6. \u00fanora 2017<\/a><\/li>\n<li><sup>8\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3003457\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cold Spring Harb Perspect Biol., leden 2011;\u00a03(1): a004978<\/a><\/li>\n<li><sup>11,\u00a0<\/sup>\u00a0<sup>15\u00a0<\/sup>\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ctm2.372\" target=\"_blank\" rel=\"noreferrer noopener\">Klinick\u00e1 a transla\u010dn\u00ed medic\u00edna 27. b\u0159ezna 2021<\/a><\/li>\n<li><sup>12,\u00a0<\/sup>\u00a0<sup>14\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.mdpi.com\/2227-9059\/8\/10\/390\" target=\"_blank\" rel=\"noreferrer noopener\">Biomedic\u00edna 30. z\u00e1\u0159\u00ed 2020<\/a><\/li>\n<li><sup>13\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.bcm.edu\/news\/glynac-improves-strength-and-cognition-in-older-humans\" target=\"_blank\" rel=\"noreferrer noopener\">Baylor College of Medicine 29. b\u0159ezna 2021<\/a><\/li>\n<li><sup>16,\u00a0<\/sup>\u00a0<sup>22\u00a0<\/sup>\u00a0<a href=\"https:\/\/health.clevelandclinic.org\/what-is-coq10\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cleveland Clinic, Co je CoQ10 28. b\u0159ezna 2022<\/a><\/li>\n<li><sup>17\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4566449\/\" target=\"_blank\" rel=\"noreferrer noopener\">Integr Med (Encinitas).\u00a02014;13(4):35-43<\/a><\/li>\n<li><sup>18\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5967365\/\" target=\"_blank\" rel=\"noreferrer noopener\">PeerJ.\u00a02018;6:e4790<\/a><\/li>\n<li><sup>19\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4121645\/\" target=\"_blank\" rel=\"noreferrer noopener\">Am J Physiol Heart Circ Physiol.\u00a02014;307(3):H346-52<\/a><\/li>\n<li><sup>21\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7555759\/\" target=\"_blank\" rel=\"noreferrer noopener\">Int J Mol Sci.\u00a0z\u00e1\u0159\u00ed 2020;\u00a021(18): 6695., 3. Klinick\u00e9 d\u016fsledky nedostatku CoQ10<\/a><\/li>\n<li><sup>23\u00a0<\/sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22928808\/\" target=\"_blank\" rel=\"noreferrer noopener\">Photochem Photobiol.\u00a02013 b\u0159ezen-duben;89(2):310-3.\u00a0doi: 10.1111\/j.1751-1097.2012.01230.x.\u00a0Epub 2012, 26. z\u00e1\u0159\u00ed<\/a><\/li>\n<li><sup>24\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.youtube.com\/watch?v=FqDDfslIMyQ&amp;t=1s\" target=\"_blank\" rel=\"noreferrer noopener\">NutritionFacts.org 4. dubna 2016<\/a><\/li>\n<li><sup>25\u00a0<\/sup>\u00a0<a href=\"https:\/\/jn.nutrition.org\/article\/S0022-3166(22)08069-5\/fulltext#secsect0022\" target=\"_blank\" rel=\"noreferrer noopener\">The Journal of Nutrition \u00fanor 2006, svazek 136, vyd\u00e1n\u00ed 2, P390-396<\/a><\/li>\n<li><sup>26,\u00a0<\/sup>\u00a0<sup>27\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8533503\/\" target=\"_blank\" rel=\"noreferrer noopener\">Biomolekuly.\u00a0\u0159\u00edjna 2021;\u00a011(10): 1441., 6.4.\u00a0Lid\u00e9<\/a><\/li>\n<li><sup>28\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.bitchute.com\/video\/Oh9lVVccWEwZ\/\" target=\"_blank\" rel=\"noreferrer noopener\">BitChute 17. \u00fanora 2022<\/a><\/li>\n<li><sup>29,\u00a0<\/sup>\u00a0<sup>30\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5517396\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hranice v neurologii 2017;\u00a08:333<\/a><\/li>\n<li><sup>31,\u00a0<\/sup>\u00a0<sup>33\u00a0<\/sup>\u00a0<a href=\"https:\/\/web.archive.org\/web\/20230521184052\/http:\/\/haidut.me\/?p=2202\" target=\"_blank\" rel=\"noreferrer noopener\">Haidut.me 11. kv\u011btna 2023, Niacinamid m\u016f\u017ee zabr\u00e1nit neurodegeneraci<\/a><\/li>\n<li><sup>32\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5195905\/\" target=\"_blank\" rel=\"noreferrer noopener\">Biochem Biophys Res Commun.\u00a08. ledna 2017;\u00a0482(2): 346\u2013351<\/a><\/li>\n<li><sup>34\u00a0<\/sup>\u00a0<a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00034.2019\" target=\"_blank\" rel=\"noreferrer noopener\">Fyziologie 5. \u00fanora 2020 DOI: 10.1152\/physiol.00034.2019<\/a><\/li>\n<li><sup>35\u00a0<\/sup>\u00a0<a href=\"https:\/\/www.youtube.com\/watch?v=5YV_iKnzDRg&amp;feature=emb_title\" target=\"_blank\" rel=\"noreferrer noopener\">YouTube, MedCram, Sunlight: Optimalizace zdrav\u00ed a imunity 21. ledna 2022<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 8pt;\"><a href=\"https:\/\/articles.mercola.com\/sites\/articles\/archive\/2023\/12\/28\/mitochondria-supplements.aspx\" target=\"_blank\" rel=\"nofollow noopener\">ZDROJ<\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/stranapro.cz\/\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-40286 aligncenter\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2023\/11\/12pro-300x87.png\" alt=\"\" width=\"1062\" height=\"308\" srcset=\"https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2023\/11\/12pro-300x87.png 300w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2023\/11\/12pro.png 366w\" sizes=\"(max-width: 1062px) 100vw, 1062px\" \/><\/a><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Historie na prvn\u00ed pohled Mitochondrie jsou struktury ve va\u0161ich bu\u0148k\u00e1ch, kter\u00e9 produkuj\u00ed asi 90 %&#8230;<\/p>\n","protected":false},"author":2,"featured_media":27961,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[5426,5763,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/44214"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=44214"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/44214\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/27961"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=44214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=44214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=44214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}