{"id":43797,"date":"2024-01-03T00:40:09","date_gmt":"2024-01-02T23:40:09","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=43797"},"modified":"2024-01-02T16:28:12","modified_gmt":"2024-01-02T15:28:12","slug":"dalsi-studie-varuje-opakovana-ockovani-proti-covidu-narusuji-imunitni-system-a-zvysuji-umrtnost","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2024\/01\/03\/dalsi-studie-varuje-opakovana-ockovani-proti-covidu-narusuji-imunitni-system-a-zvysuji-umrtnost\/","title":{"rendered":"Dal\u0161\u00ed studie varuje: Opakovan\u00e1 o\u010dkov\u00e1n\u00ed proti Covidu naru\u0161uj\u00ed imunitn\u00ed syst\u00e9m a zvy\u0161uj\u00ed \u00famrtnost"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<p><strong>Establi\u0161ment v\u017edy necht\u011bl m\u00edt nic spole\u010dn\u00e9ho s vedlej\u0161\u00edmi \u00fa\u010dinky vakc\u00edn a po\u0161kozen\u00edm vakc\u00edn a propagovalo, \u017ee vakc\u00edny pouze vytv\u00e1\u0159ej\u00ed \u201eimunitu\u201c proti konkr\u00e9tn\u00edmu patogenu.\u00a0Studie zve\u0159ejn\u011bn\u00e1 29. prosince v \u010dasopise \u201eVaccine\u201c analyzovala v\u00fdzkum z posledn\u00edch n\u011bkolika desetilet\u00ed a dosp\u011bla k jin\u00e9mu z\u00e1v\u011bru.\u00a0Zejm\u00e9na se odkazuje na negativn\u00ed \u00fa\u010dinky opakovan\u00e9ho o\u010dkov\u00e1n\u00ed mRNA Covid, kter\u00e9 m\u016f\u017ee zv\u00fd\u0161it \u00famrtnost na jin\u00e1 onemocn\u011bn\u00ed.<\/strong><\/p>\n<p>Auto\u0159i studie \u201e\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0264410X23015062\" target=\"_blank\" rel=\"noreferrer noopener\">Zvy\u0161uj\u00ed nebo sni\u017euj\u00ed vakc\u00edny n\u00e1chylnost k jin\u00fdm nemocem, ne\u017e proti kter\u00fdm chr\u00e1n\u00ed?\u00a0<\/a>\u201d rozli\u0161uj\u00ed ve sv\u00e9 pr\u00e1ci \u017eiv\u00e9 vakc\u00edny a ne\u017eiv\u00e9 vakc\u00edny a uv\u00e1d\u011bj\u00ed, \u017ee jsou to p\u0159edev\u0161\u00edm ty druh\u00e9, kter\u00e9 zp\u016fsobuj\u00ed \u201e\u0161kodliv\u00e9 nespecifick\u00e9 \u00fa\u010dinky\u201c \u2013 tedy \u00fa\u010dinky, kter\u00e9 podporuj\u00ed jin\u00e1 onemocn\u011bn\u00ed, ne\u017e proti kter\u00fdm je o\u010dkov\u00e1n\u00ed ur\u010deno.\u00a0<strong>I kdy\u017e si \u010dlov\u011bk netrouf\u00e1 zaj\u00edt tak daleko, \u017ee by tyto vakc\u00edny ji\u017e nedoporu\u010doval (proto\u017ee se zd\u00e1, \u017ee nekriticky p\u0159ij\u00edm\u00e1 \u00fa\u010dinnost vakc\u00edn zd\u016fraz\u0148ovan\u00fdch v mnoha studi\u00edch), nedoporu\u010dujeme dlouhodob\u00e9 o\u010dkov\u00e1n\u00ed, jak bylo v dob\u011b tzv. naz\u00fdvan\u00e1 pandemie.<\/strong><\/p>\n<p>V t\u00e9to souvislosti se ve skute\u010dnosti zam\u011b\u0159uj\u00ed na \u0161kodliv\u00e9 \u00fa\u010dinky neust\u00e1l\u00fdch \u201ebooster\u016f\u201c vakc\u00edn mRNA Covid a\u00a0<strong>vyvst\u00e1v\u00e1 ot\u00e1zka, zda jsou odpov\u011bdn\u00e9 za nadm\u011brnou \u00famrtnost v zem\u00edch s vysokou proo\u010dkovanost\u00ed.\u00a0<\/strong>To se t\u00fdk\u00e1 n\u011bkolika v\u00fdzkumn\u00fdch studi\u00ed, kter\u00e9 zjistily neobvykle vysok\u00e9 koncentrace protil\u00e1tek IgG4 u lid\u00ed, kte\u0159\u00ed byli n\u011bkolikr\u00e1t o\u010dkov\u00e1ni.\u00a0To nem\u00e1 ochrann\u00fd \u00fa\u010dinek, ale je tak\u00e9 spojeno se sn\u00ed\u017eenou obranou proti infekci jin\u00fdmi vakc\u00ednami (nap\u0159. proti HIV nebo mal\u00e1rii).<\/p>\n<p><a href=\"https:\/\/stranapro.cz\/\"><img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-40285 aligncenter\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2023\/11\/11pro-300x79.png\" alt=\"\" width=\"596\" height=\"157\" srcset=\"https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2023\/11\/11pro-300x79.png 300w, https:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2023\/11\/11pro.png 363w\" sizes=\"(max-width: 596px) 100vw, 596px\" \/><\/a><\/p>\n<p>P\u0159edpokl\u00e1d\u00e1 se, \u017ee vysok\u00e9 hladiny protil\u00e1tek IgG4 mohou p\u0159edstavovat mechanismus imunitn\u00ed tolerance proti spike proteinu.\u00a0<strong>Toto potla\u010den\u00ed imunitn\u00edho syst\u00e9mu je kritick\u00e9 nejen pro obranu proti nemocem Covid, ale tak\u00e9 pro ochranu proti jin\u00fdm infekc\u00edm.\u00a0<\/strong>Auto\u0159i proto vyz\u00fdvaj\u00ed k hloubkov\u00e9mu zkoum\u00e1n\u00ed tohoto probl\u00e9mu.<\/p>\n<p><strong><em>N\u00ed\u017ee si m\u016f\u017eete p\u0159e\u010d\u00edst abstrakt studie (p\u0159elo\u017eeno &#8211; editor):<\/em><\/strong><\/p>\n<p><em>Na rozd\u00edl od za\u017eit\u00e9ho n\u00e1zoru, \u017ee \u00fa\u010dinky vakc\u00edn jsou specifick\u00e9 pro onemocn\u011bn\u00ed, pro kter\u00e9 byly vyvinuty, existuj\u00ed p\u0159esv\u011bd\u010div\u00e9 d\u016fkazy, \u017ee vakc\u00edny mohou zp\u016fsobit prosp\u011b\u0161n\u00e9 nebo \u0161kodliv\u00e9 nespecifick\u00e9 \u00fa\u010dinky (NSE).\u00a0V tomto p\u0159ehledu jsme sestavili v\u00fdzkumn\u00e9 zpr\u00e1vy za posledn\u00edch 40 let, kter\u00e9 byly nalezeny na z\u00e1klad\u011b vyhled\u00e1v\u00e1n\u00ed PubMed epidemiologick\u00fdch a imunologick\u00fdch studi\u00ed o nespecifick\u00fdch \u00fa\u010dinc\u00edch (NSE) nejb\u011b\u017en\u011bj\u0161\u00edch lidsk\u00fdch vakc\u00edn.\u00a0Anal\u00fdza informac\u00ed odhalila, \u017ee \u017eiv\u00e9 vakc\u00edny zp\u016fsobuj\u00ed pozitivn\u00ed NSE, zat\u00edmco ne\u017eiv\u00e9 vakc\u00edny zp\u016fsobuj\u00ed n\u011bkolik negativn\u00edch NSE,\u00a0<strong>v\u010detn\u011b zv\u00fd\u0161en\u00e9 \u00famrtnosti \u017een spojen\u00e9 se zv\u00fd\u0161enou n\u00e1chylnost\u00ed k jin\u00fdm infek\u010dn\u00edm chorob\u00e1m, zejm\u00e9na v rozvojov\u00fdch zem\u00edch.\u00a0<\/strong>Tyto negativn\u00ed NSE jsou d\u00e1ny po\u0159ad\u00edm o\u010dkov\u00e1n\u00ed, koncentrac\u00ed antigenu ve vakc\u00edn\u00e1ch, typem pou\u017eit\u00e9 vakc\u00edny (\u017eiv\u00e1 vakc\u00edna vs. ne\u017eiv\u00e1 vakc\u00edna) a tak\u00e9 opakovan\u00fdmi o\u010dkov\u00e1n\u00edmi.\u00a0Nedoporu\u010dujeme p\u0159eru\u0161it pou\u017e\u00edv\u00e1n\u00ed ne\u017eiv\u00fdch vakc\u00edn, proto\u017ee bylo prok\u00e1z\u00e1no, \u017ee chr\u00e1n\u00ed p\u0159ed c\u00edlov\u00fdm onemocn\u011bn\u00edm.\u00a0P\u0159edpokl\u00e1d\u00e1 se tedy, \u017ee jejich \u0161kodliv\u00e9 NSE mohou b\u00fdt minimalizov\u00e1ny jednodu\u0161e zm\u011bnou aktu\u00e1ln\u00ed sekvence o\u010dkov\u00e1n\u00ed.\u00a0<strong>Vysok\u00e9 hladiny IgG4 protil\u00e1tek produkovan\u00fdch v reakci na opakovan\u00e9 o\u010dkov\u00e1n\u00ed mRNA vakc\u00ednami COVID-19 by mohly b\u00fdt spojeny s vy\u0161\u0161\u00ed \u00famrtnost\u00ed u nesouvisej\u00edc\u00edch nemoc\u00ed a infekc\u00ed prost\u0159ednictv\u00edm potla\u010den\u00ed imunitn\u00edho syst\u00e9mu.\u00a0<\/strong>Vzhledem k tomu, \u017ee v\u011bt\u0161ina zem\u00ed o\u010dkuj\u00edc\u00edch proti COVID-19 uv\u00e1d\u00ed vysok\u00e9 procento nadm\u011brn\u00e9 \u00famrtnosti, kterou nelze p\u0159\u00edmo p\u0159ipsat \u00famrt\u00edm na toto onemocn\u011bn\u00ed, m\u011bly by b\u00fdt NSE mRNA vakc\u00edn na celkov\u00e9 \u00famrtnosti podrobn\u011b prostudov\u00e1ny.<\/em><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-1185\" src=\"http:\/\/www.infokuryr.cz\/n\/wp-content\/uploads\/2021\/04\/kuryr-podpis.png\" alt=\"\" width=\"84\" height=\"24\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Establi\u0161ment v\u017edy necht\u011bl m\u00edt nic spole\u010dn\u00e9ho s vedlej\u0161\u00edmi \u00fa\u010dinky vakc\u00edn a po\u0161kozen\u00edm vakc\u00edn a propagovalo,&#8230;<\/p>\n","protected":false},"author":2,"featured_media":6066,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,454,213,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/43797"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=43797"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/43797\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/6066"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=43797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=43797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=43797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}