{"id":42925,"date":"2023-12-20T00:35:11","date_gmt":"2023-12-19T23:35:11","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=42925"},"modified":"2023-12-19T17:11:08","modified_gmt":"2023-12-19T16:11:08","slug":"japonske-studium-covid-varianty-byly-vytvoreny-v-laboratori","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2023\/12\/20\/japonske-studium-covid-varianty-byly-vytvoreny-v-laboratori\/","title":{"rendered":"Japonsk\u00e9 studium. Covid varianty byly vytvo\u0159eny v laborato\u0159i"},"content":{"rendered":"
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V\u00fdbu\u0161n\u00e1 studie p\u0159edn\u00edch japonsk\u00fdch v\u011bdc\u016f uk\u00e1zala, \u017ee varianty viru Covid se produkuj\u00ed i \u200b\u200bv laborato\u0159i. V\u011bdc\u016fm se poda\u0159ilo prok\u00e1zat, \u017ee mutace SARS-Cov-2 jsou nesynonymn\u00ed varianty, co\u017e znamen\u00e1, \u017ee \u017e\u00e1dn\u00e1 z nich nevznikla z n\u00e1hodn\u00fdch mutac\u00ed v p\u0159\u00edrod\u011b. Poukazuj\u00ed tak\u00e9 na to, \u017ee ve sv\u011btle nov\u00fdch poznatk\u016f je t\u0159eba celou pandemii p\u0159ehodnotit s p\u0159ihl\u00e9dnut\u00edm k hypot\u00e9ze dob\u0159e napl\u00e1novan\u00e9ho experimentu.<\/span><\/p>\n

Komplexn\u00ed studie japonsk\u00fdch v\u011bdc\u016f Atsushe Tanaky z L\u00e9ka\u0159sk\u00e9 a farmaceutick\u00e9 univerzity v \u00d3sace a Takayuki Miyazawa z Kj\u00f3tsk\u00e9 univerzity dok\u00e1zala vyvr\u00e1tit v\u0161echny ofici\u00e1ln\u00ed hypot\u00e9zy o pandemii Covid-19.<\/span><\/p>\n

Studie s n\u00e1zvem \u201e<\/span>Nep\u0159irozen\u00e9 evolu\u010dn\u00ed procesy variant SARS-CoV-2 a mo\u017enost z\u00e1m\u011brn\u00e9ho p\u0159\u00edrodn\u00edho v\u00fdb\u011bru<\/span><\/a>\u201c (Nep\u0159irozen\u00e9 evolu\u010dn\u00ed procesy Varianty SARS-CoV-2 a mo\u017enost z\u00e1m\u011brn\u00e9ho p\u0159irozen\u00e9ho v\u00fdb\u011bru) ukazuje, \u017ee v\u0161echny varianty Covid-19 byly um\u011ble vytvo\u0159eny. V\u00fdzkumn\u00edci ukazuj\u00ed, \u017ee t\u011b\u017ek\u00fd akutn\u00ed respira\u010dn\u00ed syndrom coronavirus 2 (SARS-CoV-2) v posledn\u00edch t\u0159ech letech opakovan\u011b spustil pandemie, p\u0159i\u010dem\u017e se objevily r\u016fzn\u00e9 mutovan\u00e9 varianty od alfa po omikronov\u00e9.<\/span><\/p>\n

\u201eV t\u00e9to studii jsme se zam\u011b\u0159ili na objasn\u011bn\u00ed evolu\u010dn\u00edch proces\u016f, kter\u00e9 vedou k tvorb\u011b omikronov\u00e9 varianty SARS-CoV-2, se zam\u011b\u0159en\u00edm na omikronov\u00e9 varianty s vysok\u00fdmi mutacemi aminokyselin v spike proteinu mezi izol\u00e1ty SARS-CoV-2. Abychom ur\u010dili po\u0159ad\u00ed mutac\u00ed vedouc\u00edch ke vzniku omikronov\u00fdch variant SARS-CoV-2, porovnali jsme sekvence izol\u00e1t\u016f omikron\u016f BA.1, 141 BA.1.1 a BA.2 a pokusili jsme se porozum\u011bt evolu\u010dn\u00edm proces\u016fm SARS -CoV-2 omikronov\u00e9 varianty, v\u010detn\u011b po\u0159ad\u00ed mutac\u00ed vedouc\u00edch k jejich vzniku a v\u00fdskytu homologn\u00ed rekombinace. V d\u016fsledku toho jsme dosp\u011bli k z\u00e1v\u011bru, \u017ee tvorba \u010d\u00e1sti izol\u00e1t\u016f omikron\u016f BA.1, BA.1.1 a BA.2 nebyla produktem evoluce genomu, jak je b\u011b\u017en\u011b pozorov\u00e1no v p\u0159\u00edrod\u011b, nap\u0159. akumulace mutac\u00ed.“ auto\u0159i studie.<\/span><\/p>\n

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Zkoum\u00e1n\u00ed 35 rekombinantn\u00edch izol\u00e1t\u016f omikronov\u00fdch variant BA.1 a BA.2 d\u00e1le potvrdilo, \u017ee omikronov\u00e9 varianty existovaly ji\u017e v roce 2020. Anal\u00fdza uk\u00e1zala, \u017ee omikronov\u00e9 varianty vznikly prost\u0159ednictv\u00edm zcela nov\u00e9ho mechanismu, kter\u00fd nelze vysv\u011btlit sou\u010dasnou biologi\u00ed, co\u017e vy\u017eaduje p\u0159ehodnocen\u00ed pandemie SARS-CoV-2, uvedli japon\u0161t\u00ed v\u011bdci.<\/span><\/p>\n

Glob\u00e1ln\u00ed experiment<\/strong><\/span><\/p>\n

Auto\u0159i studie odm\u00edtaj\u00ed z\u00e1v\u011br, \u017ee tyto viry byly vytvo\u0159eny a distribuov\u00e1ny se zl\u00fdm \u00famyslem. Upozor\u0148uj\u00ed v\u0161ak, \u017ee SARS-CoV-2 pro\u0161el mutacemi, kter\u00e9 by byly na z\u00e1klad\u011b konven\u010dn\u00edch koronavirov\u00fdch muta\u010dn\u00edch mechanism\u016f nemysliteln\u00e9, a doufaj\u00ed, \u017ee mo\u017enost um\u011bl\u00e9ho vytvo\u0159en\u00ed bude v\u00e1\u017en\u011b zahrnuta do diskus\u00ed o vzniku SARS-CoV-2. zahrnuta. \u201eNa\u0161e anal\u00fdza doch\u00e1z\u00ed k z\u00e1v\u011bru, \u017ee omikronov\u00e9 varianty vznikly prost\u0159ednictv\u00edm zcela nov\u00e9ho mechanismu, kter\u00fd sou\u010dasn\u00e1 biologie nedok\u00e1\u017ee vysv\u011btlit. Pokud je epidemick\u00fd kmen SARS-CoV-2 um\u011ble zmutovan\u00fd virus a katastrofa Corona-Hoopla byla dob\u0159e napl\u00e1novan\u00fdm glob\u00e1ln\u00edm pokusem o o\u010dkov\u00e1n\u00ed lid\u00ed a soci\u00e1ln\u00edm experimentem, pak design tohoto experimentu a typ pou\u017eit\u00e9ho viru nazna\u010duj\u00ed, \u017ee Japonci v\u00fdzkumn\u00edci varuj\u00ed, \u017ee tento experiment byl p\u0159edb\u011b\u017en\u00fd.<\/span><\/p>\n

Op\u011btovn\u00e9 zrychlen\u00ed viru<\/strong><\/span><\/p>\n

Podle Atsushi Tanaka a Takayuki Miyazawa byl b\u011bhem t\u0159\u00ed let od roku 2019 do roku 2022 SARS-CoV-2 znovu urychlen nov\u00fdmi variantami, kter\u00e9 se objevily b\u011bhem n\u011bkolika m\u011bs\u00edc\u016f v r\u016fzn\u00fdch geografick\u00fdch oblastech a roz\u0161\u00ed\u0159ily se po cel\u00e9m sv\u011bt\u011b, aby opakovan\u011b vyvolaly pandemii. Na za\u010d\u00e1tku prvn\u00ed pandemie byla nejd\u016fle\u017eit\u011bj\u0161\u00ed mutac\u00ed SARS-CoV-2 nesynonymn\u00ed mutace D614G v proteinu S. Tato mutace, kter\u00e1 nebyla p\u0159\u00edtomna v progenitorov\u00e9 linii, kter\u00e1 zp\u016fsobila vypuknut\u00ed Wuhanu, se rychle roz\u0161\u00ed\u0159ila po cel\u00e9m sv\u011bt\u011b.<\/span><\/p>\n

Kr\u00e1tce pot\u00e9 se objevila alfa varianta, charakterizovan\u00e1 17 unik\u00e1tn\u00edmi mutacemi s deseti aminokyselinov\u00fdmi rozd\u00edly v S proteinu. Poprv\u00e9 byl objeven v jihov\u00fdchodn\u00ed Anglii na konci z\u00e1\u0159\u00ed 2020 a pot\u00e9 dominoval ve v\u011bt\u0161in\u011b evropsk\u00fdch zem\u00ed. Tak\u00e9 v roce 2020 byla varianta Beta objevena v Ji\u017en\u00ed Africe v \u0159\u00edjnu a varianta Gamma byla objevena v prosinci v Braz\u00edlii. Varianta Delta byla identifikov\u00e1na v Indii v \u00fanoru 2021 a varianta Lambda se objevila v Peru v srpnu 2020, ale byla ozn\u00e1mena a\u017e WHO v \u010dervnu 2021. Kone\u010dn\u011b v listopadu 2021 se varianta Omicron objevila v Ji\u017en\u00ed Africe a roz\u0161\u00ed\u0159ila se po cel\u00e9m sv\u011bt\u011b, podle studie japonsk\u00fdch v\u011bdc\u016f.<\/span><\/p>\n<\/div>\n<\/div>\n

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ZDROJ<\/a><\/span><\/h3>\n<\/div>\n

 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

V\u00fdbu\u0161n\u00e1 studie p\u0159edn\u00edch japonsk\u00fdch v\u011bdc\u016f uk\u00e1zala, \u017ee varianty viru Covid se produkuj\u00ed i \u200b\u200bv laborato\u0159i….<\/p>\n","protected":false},"author":2,"featured_media":11050,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,105,1361,839],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/42925"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=42925"}],"version-history":[{"count":1,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/42925\/revisions"}],"predecessor-version":[{"id":42926,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/42925\/revisions\/42926"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/11050"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=42925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=42925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=42925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}