{"id":40045,"date":"2023-11-11T01:12:57","date_gmt":"2023-11-11T00:12:57","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=40045"},"modified":"2023-11-10T19:05:32","modified_gmt":"2023-11-10T18:05:32","slug":"leky-na-cholesterol-jsou-nejvice-predepisovane-leky-se-zvelicovanymi-prinosy-a-zlehcovanymi-vedlejsimi-ucinky","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2023\/11\/11\/leky-na-cholesterol-jsou-nejvice-predepisovane-leky-se-zvelicovanymi-prinosy-a-zlehcovanymi-vedlejsimi-ucinky\/","title":{"rendered":"L\u00e9ky na cholesterol jsou nejv\u00edce p\u0159edepisovan\u00e9 l\u00e9ky se zveli\u010dovan\u00fdmi p\u0159\u00ednosy a zleh\u010dovan\u00fdmi vedlej\u0161\u00edmi \u00fa\u010dinky"},"content":{"rendered":"
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Nejv\u00edce p\u0159edepisovan\u00e1 t\u0159\u00edda l\u00e9k\u016f na sv\u011bt\u011b jsou l\u00e9ky proti vysok\u00e9mu cholesterolu zvan\u00e9 statiny, kter\u00e9 se staly jednou z nejkontroverzn\u011bj\u0161\u00edch intervenc\u00ed modern\u00ed medic\u00edny.<\/span><\/p>\n

Inhibitory hydroxymethyl glutaryl koenzym A redukt\u00e1zy (HMG-CoA), tedy mezi\u010dl\u00e1nku tvorby cholesterolu v t\u011ble, se ji\u017e v\u00edce ne\u017e dvacet let pova\u017euj\u00ed za bezpe\u010dn\u00e9 a \u00fa\u010dinn\u00e9.\u00a0L\u00e9ka\u0159i p\u0159itom \u010dasto p\u0159eh\u00e1n\u011bj\u00ed jejich v\u00fdhody a bagatelizuj\u00ed negativn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky.<\/span><\/p>\n

V sou\u010dasnosti je na trhu dostupn\u00fdch \u0161est statinov\u00fdch l\u00e9k\u016f s \u00fa\u010dinn\u00fdmi l\u00e1tkami \u2013 pitavastatin, atorvastatin, rosuvastatin, pravastatin, simvastatin a fluvastatin (obchodn\u00ed n\u00e1zvy l\u00e9k\u016f se mohou li\u0161it od n\u00e1zv\u016f \u00fa\u010dinn\u00fdch l\u00e1tek).<\/span><\/p>\n

Tyto l\u00e9ky \u00fa\u010dinkuj\u00ed tak, \u017ee sni\u017euj\u00ed hladinu lipoproteinov\u00e9ho cholesterolu o n\u00edzk\u00e9 hustot\u011b (LDL-C) p\u0159ibli\u017en\u011b o 20 a\u017e 50%.\u00a0Sni\u017euj\u00ed tak\u00e9 hladiny triglycerid\u016f o 10 a\u017e 20% a zp\u016fsobuj\u00ed mo\u017en\u00e9 zv\u00fd\u0161en\u00ed hladin cholesterolu o vysok\u00e9 hustot\u011b lipoproteinu (HDL-C) v s\u00e9ru o 5 a\u017e 10%.<\/span><\/p>\n

Farmaceutick\u00e9 firmy tvrd\u00ed, \u017ee podle jejich studi\u00ed statiny sni\u017euj\u00ed riziko kardiovaskul\u00e1rn\u00edch p\u0159\u00edhod a \u00famrtnosti ze v\u0161ech p\u0159\u00ed\u010din o 10% na ka\u017ed\u00e9 sn\u00ed\u017een\u00ed hladiny LDL-C o 1,0 mmol\/l.<\/span><\/p>\n

Existuje v\u0161ak n\u011bkolik zn\u00e1m\u00fdch v\u00e1\u017en\u00fdch rizik t\u011bchto l\u00e9k\u016f a jejich dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed p\u0159edstavuje dal\u0161\u00ed \u017eivot ohro\u017euj\u00edc\u00ed stavy, kter\u00e9 mohou zcela negovat jejich p\u0159eh\u00e1n\u011bn\u00e9 klinick\u00e9 v\u00fdhody.<\/span><\/p>\n

Mezi p\u00e1r z mnoha rizik pat\u0159\u00ed myalgie (svalov\u00e9 bolesti) a rhabdomyol\u00fdza (rozpad svalov\u00fdch vl\u00e1ken), nov\u011b vznikl\u00e1 cukrovka typu 2 a akutn\u00ed po\u0161kozen\u00ed ledvin vedouc\u00ed k hospitalizaci.<\/span><\/p>\n

1. Chronick\u00e1 bolest, myalgie a rhabdomyol\u00fdza<\/span><\/h2>\n

Jedn\u00edm z m\u00e9n\u011b zn\u00e1m\u00fdch vedlej\u0161\u00edch \u00fa\u010dink\u016f statin\u016f je rhabdomyol\u00fdza.\u00a0I kdy\u017e je jej\u00ed riziko vz\u00e1cn\u011bj\u0161\u00ed, zp\u016fsobuje rychl\u00fd rozpad kostern\u00edho svalstva, co\u017e vede ke svalov\u00fdm bolestem, slabosti, zvracen\u00ed a zmatenosti, kter\u00e9 ovliv\u0148uj\u00ed ka\u017edodenn\u00ed \u017eivot.<\/span><\/p>\n

Cochran\u016fv p\u0159ehled, kter\u00fd zahrnoval dev\u011bt v\u011bdeck\u00fdch studi\u00ed, zjistil, \u017ee u 3 551 z 37 939 (9,4 %) pacient\u016f se vyvinuly symptomy myalgie.<\/span><\/p>\n

V\u00fdskyt rhabdomyol\u00fdzy se zdvojn\u00e1sobil u pacient\u016f, kte\u0159\u00ed byli ve skupin\u011b u\u017e\u00edvaj\u00edc\u00ed vy\u0161\u0161\u00ed d\u00e1vky statin\u016f v porovn\u00e1n\u00ed se skupinou u\u017e\u00edvaj\u00edc\u00ed ni\u017e\u0161\u00ed d\u00e1vky statin\u016f.\u00a0Tyto p\u0159\u00edpady rhabdomyol\u00fdzy mohou tak\u00e9 vyvolat tubul\u00e1rn\u00ed obstrukci (selh\u00e1n\u00ed ledvin) zp\u016fsobuj\u00edc\u00ed tubul\u00e1rn\u00ed po\u0161kozen\u00ed a ischemii (nedokrven\u00ed), co\u017e vede k proteinurii a dal\u0161\u00edm probl\u00e9m\u016fm s ledvinami.<\/span><\/p>\n

Dal\u0161\u00edm m\u00e9n\u011b zn\u00e1m\u00fdm vedlej\u0161\u00edm \u00fa\u010dinkem statin\u016f je myopatie (nervov\u00e9 onemocn\u011bn\u00ed kostern\u00edch sval\u016f) s v\u00fdznamn\u00fdm zv\u00fd\u0161en\u00edm s\u00e9rov\u00e9 \u200b\u200bkreatinkin\u00e1zy (metablick\u00e1 porucha p\u0159i v\u00fdrob\u011b energie).\u00a0Tento stav postihuje a\u017e 1 z 1000 pacient\u016f u\u017e\u00edvaj\u00edc\u00edch statiny.<\/span><\/p>\n

2. Po\u0161kozen\u00ed bun\u011bk a cukrovka typu 2<\/span><\/h2>\n

Statiny se tradi\u010dn\u011b spojuj\u00ed s mitochondri\u00e1ln\u00ed dysfunkc\u00ed a poklesem energie, jako\u017e i se sn\u00ed\u017een\u00edm hladin koenzymu Q10, kter\u00e9 jsou d\u016fle\u017eit\u00e9 pro kardiovaskul\u00e1rn\u00ed funkce.<\/span><\/p>\n

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M\u00e9n\u011b zn\u00e1m\u00fdm probl\u00e9mem se statiny je jejich n\u00e1chylnost na ni\u017e\u0161\u00ed farnezylpyrofosf\u00e1t a geranylgeranylpyrofosf\u00e1t.\u00a0Jsou to kone\u010dn\u00e9 produkty meulon\u00e1tov\u00e9 dr\u00e1hy, kter\u00e1 je \u017eivotn\u011b d\u016fle\u017eit\u00e1 pro r\u016fst bun\u011bk.<\/span><\/p>\n

Sn\u00ed\u017een\u00ed t\u011bchto l\u00e1tek, spolu se zm\u011bnami v obsahu cholesterolu v bu\u0148k\u00e1ch kostern\u00edho svalstva, v kone\u010dn\u00e9m d\u016fsledku m\u011bn\u00ed tok iontov\u00fdch kan\u00e1l\u016f.\u00a0To pak vede ke slab\u00e9mu vychyt\u00e1v\u00e1n\u00ed v\u00e1pn\u00edku, rychl\u00e9mu po\u0161kozen\u00ed bun\u011bk a bun\u011b\u010dn\u00e9 smrti.<\/span><\/p>\n

Farmakologick\u00fd \u00fa\u010dinek statin\u016f m\u016f\u017ee tak\u00e9 naru\u0161it sign\u00e1ln\u00ed dr\u00e1hy inzul\u00ednu, po\u0161kodit funkci beta bun\u011bk slinivky b\u0159i\u0161n\u00ed a v\u00e9st k inzul\u00ednov\u00e9 rezistenci s pln\u011b rozvinut\u00fdm diabetes mellitus (cukrovkou).<\/span><\/p>\n

V metaanal\u00fdze 13 klinick\u00fdch studi\u00ed se vyskytl nov\u00fd p\u0159\u00edpad cukrovky na ka\u017ed\u00fdch 255 pacient\u016f u\u017e\u00edvaj\u00edc\u00edch nejm\u00e9n\u011b \u010dty\u0159i roky statinov\u00e9 l\u00e9ky.<\/span><\/p>\n

Dal\u0161\u00ed metaanal\u00fdza 5 studi\u00ed tak\u00e9 zjistila souvislost mezi u\u017e\u00edv\u00e1n\u00edm statin\u016f a zv\u00fd\u0161en\u00fdm rizikem vzniku\u00a0<\/span>cukrovky<\/span><\/a>\u00a0.\u00a0Vy\u0161\u0161\u00ed d\u00e1vka statin\u016f zv\u00fd\u0161ila riziko, \u017ee pacientovi bude diagnostikov\u00e1n nov\u011b vznikl\u00e1 cukrovka typu 2.<\/span><\/p>\n

3. Akutn\u00ed poran\u011bn\u00ed ledvin vedouc\u00ed k hospitalizaci<\/span><\/h2>\n

Velk\u00e1 retrospektivn\u00ed observa\u010dn\u00ed anal\u00fdza zjistila vy\u0161\u0161\u00ed riziko hospitalizace kv\u016fli akutn\u00edm po\u0161kozen\u00edm ledvin u pacient\u016f u\u017e\u00edvaj\u00edc\u00edch statiny.\u00a0Anal\u00fdza zahrnovala v\u00edce ne\u017e 2 miliony statinov\u00fdch pacient\u016f bez p\u0159edchoz\u00ed anamn\u00e9zy chronick\u00e9ho onemocn\u011bn\u00ed ledvin a dal\u0161\u00edch 59 636 statinov\u00fdch pacient\u016f s chronick\u00fdm onemocn\u011bn\u00edm ledvin.<\/span><\/p>\n

Za pouh\u00e9 \u010dty\u0159i m\u011bs\u00edce od za\u010d\u00e1tku u\u017e\u00edv\u00e1n\u00ed statin\u016f bylo ve skupin\u011b s chronick\u00fdm onemocn\u011bn\u00edm ledvin v anamn\u00e9ze 1 896 hospitalizac\u00ed (3,2%) pro akutn\u00ed po\u0161kozen\u00ed ledvin.<\/span><\/p>\n

Dal\u0161\u00edch 4 691 hospitalizac\u00ed bylo pro akutn\u00ed po\u0161kozen\u00ed ledvin u pacient\u016f, kte\u0159\u00ed nem\u011bli v anamn\u00e9ze onemocn\u011bn\u00ed ledvin (0,2%).\u00a0Vy\u0161\u0161\u00ed d\u00e1vka statin\u016f byla spojena s vy\u0161\u0161\u00edm po\u010dtem hospitalizac\u00ed.<\/span><\/p>\n

Jak vid\u00edme, existuje mnoho zp\u016fsob\u016f, kter\u00fdmi tyto popul\u00e1rn\u00ed l\u00e9ky na p\u0159edpis doslova rozkl\u00e1daj\u00ed lidi zevnit\u0159, ni\u010d\u00ed mitochondri\u00e1ln\u00ed funkce, br\u00e1n\u00ed r\u016fstu bun\u011bk, zvy\u0161uj\u00ed bun\u011b\u010dnou smrt, naru\u0161uj\u00ed muskuloskelet\u00e1ln\u00ed syst\u00e9m a pos\u00edlaj\u00ed lidi do nemocnice s komplikacemi diabetu a akutn\u00edm po\u0161kozen\u00edm ledvin.<\/span><\/p>\n

Z\u00e1v\u011br<\/span><\/h2>\n

T\u00e9matu vysok\u00e9ho cholesterolu a jeho p\u0159\u00edrodn\u00ed l\u00e9\u010db\u011b se samostatn\u011b v\u011bnujeme v elektronick\u00e9 knize, kterou jsme p\u0159ed \u010dasem publikovali.\u00a0V\u00edce informac\u00ed o n\u00ed najdete\u00a0<\/span>ZDE<\/span><\/strong><\/a>\u00a0ao \u010desk\u00e9 verzi e-knihy\u00a0<\/span>ZDE<\/span><\/strong><\/a>\u00a0.<\/span><\/p>\n

V knize se dozv\u00edte v\u011bci jako nap\u0159\u00edklad to, jak\u00e1 jsou v\u0161echna rizika l\u00e9k\u016f proti cholesterolu (statin\u016f), co d\u011blat, pokud v\u00e1m l\u00e9ka\u0159 nechce dovolit tyto l\u00e9ky vysadit, jak\u00e1 je pravda o n\u00edzkotu\u010dn\u00e9 strav\u011b, jak\u00e9 jsou p\u0159\u00edznaky a co je skute\u010dn\u00e1 p\u0159\u00ed\u010dina ucp\u00e1v\u00e1n\u00ed krevn\u00edch c\u00e9v , jak c\u00e9vy vy\u010distit, pokud ji\u017e jsou ucpan\u00e9 a \u0159adu dal\u0161\u00edch u\u017eite\u010dn\u00fdch informac\u00ed.<\/span><\/p>\n

Autor: Lance D. Johnson,\u00a0<\/span>naturalnews.com<\/span><\/a><\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

Nejv\u00edce p\u0159edepisovan\u00e1 t\u0159\u00edda l\u00e9k\u016f na sv\u011bt\u011b jsou l\u00e9ky proti vysok\u00e9mu cholesterolu zvan\u00e9 statiny, kter\u00e9 se…<\/p>\n","protected":false},"author":2,"featured_media":40046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[6252,6253,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/40045"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=40045"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/40045\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/40046"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=40045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=40045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=40045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}