{"id":35384,"date":"2023-09-03T01:05:42","date_gmt":"2023-09-02T23:05:42","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=35384"},"modified":"2023-09-02T16:10:43","modified_gmt":"2023-09-02T14:10:43","slug":"nova-studie-zda-se-ze-vsechny-varianty-covidu-pochazeji-z-laboratore","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2023\/09\/03\/nova-studie-zda-se-ze-vsechny-varianty-covidu-pochazeji-z-laboratore\/","title":{"rendered":"Nov\u00e1 studie: Zd\u00e1 se, \u017ee v\u0161echny \u201evarianty\u201c Covidu poch\u00e1zej\u00ed z laborato\u0159e"},"content":{"rendered":"
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Pokud by ned\u00e1vno zve\u0159ejn\u011bn\u00e1 japonsk\u00e1 studie o tzv. Covidov\u00fdch \u201evariant\u00e1ch\u201c obst\u00e1la v akademick\u00e9m zkoum\u00e1n\u00ed, byla by to \u201ebomba\u201c.\u00a0To toti\u017e na z\u00e1klad\u011b jednotliv\u00fdch mutac\u00ed ur\u010duje, \u017ee ka\u017ed\u00e1 z t\u011bchto \u201evariant\u201c mohla b\u00fdt vlastn\u011b vyrobena pouze um\u011ble.<\/strong><\/p>\n

Nov\u00fd\u00a0p\u0159edtisk<\/a>\u00a0zve\u0159ejn\u011bn\u00fd 5. srpna 2023 nazna\u010duje, \u017ee japonsk\u00fd v\u00fdzkumn\u00fd t\u00fdm zjistil, \u017ee t\u00e9m\u011b\u0159 v\u0161echny varianty Covid byly vytvo\u0159eny v laborato\u0159\u00edch.\u00a0Atsuki Tanaka a Takayuki Miyazawa z \u00d3sack\u00e9 l\u00e9ka\u0159sk\u00e9 univerzity a Kj\u00f3tsk\u00e9 univerzity zkoumali virov\u00e9 sekvence nalezen\u00e9 ve ve\u0159ejn\u00fdch datab\u00e1z\u00edch a v p\u0159irozen\u00e9m prost\u0159ed\u00ed, aby sledovali historick\u00fd v\u00fdvoj Omicron verze SARS-CoV-2.<\/p>\n

Sv\u00fdm v\u00fdzkumem na\u0161li kolem 100 unik\u00e1tn\u00edch omikronov\u00fdch podtyp\u016f, kter\u00e9 se v p\u0159\u00edrod\u011b ve skute\u010dnosti nemohly vyskytovat.\u00a0Tyto mutace jsou jasn\u00fdm vod\u00edtkem pro roz\u0161\u00ed\u0159enou teorii, \u017ee tyto viry Covid byly vytvo\u0159eny v laborato\u0159\u00edch a odtud se \u0161\u00ed\u0159ily.\u00a0<\/strong>Krom\u011b toho tyto variace obsahuj\u00ed \u0161irokou \u0161k\u00e1lu mutac\u00ed, kter\u00e9 se b\u011b\u017en\u011b pou\u017e\u00edvaj\u00ed ve studi\u00edch reverzn\u00ed genetiky k systematick\u00e9 anal\u00fdze r\u016fzn\u00fdch \u010d\u00e1st\u00ed viru.<\/p>\n

P\u0159ed ozn\u00e1men\u00edm objevu omikronu v Ji\u017en\u00ed Africe na\u0161li v\u011bdci p\u0159esn\u00e9 shody s variacemi omikron\u016f v sekvenc\u00edch z Portorika ulo\u017een\u00fdch v datab\u00e1z\u00edch v roce 2020.\u00a0Tanaka a Miyazawa tvrd\u00ed, \u017ee je tomu tak u v\u0161ech variant, kter\u00e9 se objevily ve Wu-chanu od po\u010d\u00e1te\u010dn\u00edho vypuknut\u00ed.\u00a0To nen\u00ed p\u0159irozen\u00e9, a proto navrhuj\u00ed, \u017ee jsou sou\u010d\u00e1st\u00ed experiment\u00e1ln\u00edho programu k testov\u00e1n\u00ed faktor\u016f ovliv\u0148uj\u00edc\u00edch infek\u010dnost a z\u00e1va\u017enost SARS-CoV-2 v b\u011b\u017en\u00e9 populaci.\u00a0<\/strong>Tuto hypot\u00e9zu zakl\u00e1daj\u00ed na sv\u00e9m pozorov\u00e1n\u00ed neobvykle mal\u00e9ho po\u010dtu \u201etich\u00fdch\u201c mutac\u00ed v t\u011bchto variant\u00e1ch.<\/p>\n

Tento v\u00fdzkum zkoum\u00e1 v\u00fdvoj vir\u016f a \u017eiv\u00fdch tvor\u016f se zvl\u00e1\u0161tn\u00edm d\u016frazem na my\u0161lenku genetick\u00fdch dat.\u00a0SARS-CoV-2 je virus zalo\u017een\u00fd na RNA, kter\u00fd ukl\u00e1d\u00e1 informace v \u0159et\u011bzc\u00edch znak\u016f.\u00a0Genetick\u00fd materi\u00e1l se skl\u00e1d\u00e1 z gen\u016f, kter\u00e9 obsahuj\u00ed instrukce pro tvorbu protein\u016f.\u00a0Bu\u0148ky pou\u017e\u00edvaj\u00ed tyto geny jako vod\u00edtka pro produkci aktivn\u00edch molekul naz\u00fdvan\u00fdch proteiny.\u00a0Genetick\u00fd k\u00f3d je duplikov\u00e1n a p\u0159ed\u00e1n budouc\u00edm generac\u00edm, ale v pr\u016fb\u011bhu \u010dasu mohou nastat zm\u011bny, kter\u00e9 vedou k mutac\u00edm.<\/p>\n

Chcete-li porozum\u011bt r\u016fzn\u00fdm typ\u016fm mutac\u00ed a tomu, jak ovliv\u0148uj\u00ed organismy, zva\u017ete n\u00e1sleduj\u00edc\u00ed informace: V\u011bt\u0161ina mutac\u00ed, kter\u00e9 m\u011bn\u00ed jedno p\u00edsmeno v DNA nebo RNA, neovliv\u0148uje proteinovou sekvenci a naz\u00fdv\u00e1 se \u201esynonymn\u00ed\u201c mutace.\u00a0Tyto mutace nemaj\u00ed \u017e\u00e1dn\u00e9 n\u00e1sledky a v pr\u016fb\u011bhu \u010dasu se hromad\u00ed p\u0159irozen\u00fdm v\u00fdvojem.<\/p>\n

Absence synonymn\u00edch mutac\u00ed je kl\u00ed\u010dov\u00fdm indik\u00e1torem toho, \u017ee k v\u00fdskytu nov\u00fdch variac\u00ed, jako je Omicron, nedoch\u00e1z\u00ed spont\u00e1nn\u011b.\u00a0<\/strong>V\u011bt\u0161ina mutac\u00ed, kter\u00e9 maj\u00ed \u00fa\u010dinek, je v\u0161ak pravd\u011bpodobn\u011b \u0161kodliv\u00e1 a rychle zmiz\u00ed.\u00a0Ve vz\u00e1cn\u00fdch p\u0159\u00edpadech m\u016f\u017ee mutace vy\u00fastit v prosp\u011b\u0161nou zm\u011bnu, kter\u00e1 organismu umo\u017en\u00ed \u00fasp\u011b\u0161n\u011bj\u0161\u00ed p\u0159e\u017eit\u00ed a reprodukci, co\u017e vede k jeho \u0161\u00ed\u0159en\u00ed v dal\u0161\u00edch generac\u00edch.\u00a0Toto postupn\u00e9 hromad\u011bn\u00ed tich\u00fdch a prosp\u011b\u0161n\u00fdch mutac\u00ed poh\u00e1n\u00ed evoluci v\u0161ech forem \u017eivota.<\/p>\n

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V\u00fdzkumn\u00edci pou\u017eili ve\u0159ejn\u00e9 datab\u00e1ze ke sledov\u00e1n\u00ed evolu\u010dn\u00ed historie spike proteinu Omicron BA1 a ur\u010den\u00ed po\u0159ad\u00ed, ve kter\u00e9m se vyskytlo jeho 37 mutac\u00ed.\u00a0Za t\u00edmto \u00fa\u010delem hledali sekvence, kter\u00fdm jedna z mutac\u00ed chyb\u011bla, a p\u0159edpokl\u00e1dali, \u017ee jedna z nich bude odpov\u00eddat posledn\u00ed mutaci v s\u00e9rii.\u00a0Provedli 37 datab\u00e1zov\u00fdch dotaz\u016f se sekvencemi postr\u00e1daj\u00edc\u00edmi ka\u017edou z mutac\u00ed Omicron BA1 v nad\u011bji, \u017ee najdou shodu, kter\u00e1 indikuje posledn\u00ed mutaci v s\u00e9rii.\u00a0V\u00fdsledky uk\u00e1zaly, \u017ee v\u0161echny mutace krom\u011b jedn\u00e9 byly nov\u00e9 a nezp\u016fsobily \u017e\u00e1dn\u00fd v\u00fdznamn\u00fd rozd\u00edl.<\/strong><\/p>\n

Nen\u00ed mo\u017en\u00e9, aby se p\u0159irozen\u011b vyskytovala skupina variant s reverzn\u00edmi omikronov\u00fdmi BA1 mutacemi.\u00a0V diagramu ve studii auto\u0159i ukazuj\u00ed, \u017ee v\u0161echny mutace a\u017e na jednu v omikronov\u00e9 subvariant\u011b BA1 se nach\u00e1zej\u00ed v kmeni bez mutace.\u00a0To podtrhuje d\u016fle\u017eitost pochopen\u00ed v\u00fdvoje spike proteinu a jeho role ve v\u00fdvoji SARS-CoV-2.\u00a0V\u00fdzkum Tanaky a Miyazawy zkoum\u00e1 pravd\u011bpodobnost rekombinace ve v\u00fdvoji varianty SARS-CoV-2.\u00a0Tvrd\u00ed, \u017ee rekombinace by vy\u017eadovala koexistenci vir\u016f Omicron BA1 a dal\u0161\u00edch vir\u016f p\u0159edk\u016f ve stejn\u00e9 bu\u0148ce, co\u017e by bylo vysoce nepravd\u011bpodobn\u00e9 vzhledem k zahrnut\u00fdm frekvenc\u00edm a pot\u0159eb\u011b \u010detn\u00fdch reverzn\u00edch mutac\u00ed.<\/p>\n

Pro vysv\u011btlen\u00ed zvrat\u016f pozorovan\u00fdch u Omicron BA1 by bylo nutn\u00e9, aby specifick\u00e1 \u010d\u00e1st RNA obsahuj\u00edc\u00ed mutaci byla obr\u00e1cena rekombinac\u00ed.\u00a0To by vy\u017eadovalo \u010distou v\u00fdm\u011bnu sekce bez ovlivn\u011bn\u00ed mutac\u00ed na obou stran\u00e1ch.\u00a0N\u011bkter\u00e9 mutace v\u0161ak nelze zarovnat kv\u016fli nedostatku spole\u010dn\u00fdch sekvenc\u00ed mezi t\u011bmito dv\u011bma kmeny.Rekombinace by tak\u00e9 m\u011bla zanechat stopy v p\u0159ilehl\u00fdch oblastech viru, ale \u017e\u00e1dn\u00e9 nebyly nalezeny.\u00a0Tanaka a Miyazawa objevili 29 variant p\u0159ipisovan\u00fdch Portoriku, kter\u00e9 odpov\u00eddaj\u00ed Omicron BA1 nebo BA2 na z\u00e1klad\u011b spike proteinov\u00fdch sekvenc\u00ed, co\u017e vyvol\u00e1v\u00e1 ot\u00e1zky o historii Omicron, proto\u017ee tyto sekvence p\u0159edch\u00e1zely objevu Omicron v Ji\u017en\u00ed Africe v listopadu 2021 o v\u00edce ne\u017e rok datab\u00e1ze. byly ulo\u017eeny.<\/strong><\/p>\n

Absence \u201esynonymn\u00edch\u201c mutac\u00ed siln\u011b nazna\u010duje, \u017ee varianty SARS-CoV-2 byly vytvo\u0159eny \u010dlov\u011bkem.\u00a0Auto\u0159i tvrd\u00ed, \u017ee p\u0159irozen\u00e1 evoluce by produkovala neutr\u00e1ln\u011bj\u0161\u00ed synonymn\u00ed mutace ne\u017e nesynonymn\u00ed mutace, kter\u00e9 mohou p\u0159etrv\u00e1vat pouze zlep\u0161en\u00edm proteinu, kter\u00fd k\u00f3duj\u00ed.\u00a0<\/strong>Toto pozorov\u00e1n\u00ed je nepravd\u011bpodobn\u00e9, proto\u017ee v p\u0159edchoz\u00edch variant\u00e1ch, jako jsou Alfa, Beta, Gamma, Delta nebo Mu, nebyly \u017e\u00e1dn\u00e9 synonymn\u00ed mutace a pouze jedna v Lambda a Omicron.\u00a0P\u0159\u00edtomnost jednotliv\u00fdch reverz\u00ed ka\u017ed\u00e9 mutace ve t\u0159ech omikronov\u00fdch lini\u00edch se zd\u00e1 b\u00fdt z\u00e1m\u011brn\u00fdm cvi\u010den\u00edm v reverzn\u00ed genetice, aby se otestovaly \u00fa\u010dinky ka\u017ed\u00e9 mutace na chov\u00e1n\u00ed viru. Absence synonymn\u00edch mutac\u00ed v jin\u00fdch variant\u00e1ch nazna\u010duje, \u017ee v\u0161echny varianty po p\u016fvodn\u00edm kmeni Wuhan jsou um\u011bl\u00e9ho p\u016fvodu.<\/strong><\/p>\n

Auto\u0159i v\u011b\u0159\u00ed, \u017ee mutace, kter\u00e9 objevili, byly sou\u010d\u00e1st\u00ed experimentu, kter\u00fd m\u011bl studovat spike protein a jak mutace ovliv\u0148uj\u00ed chov\u00e1n\u00ed viru.\u00a0<\/strong>Skute\u010dnost, \u017ee neexistuje \u017e\u00e1dn\u00fd d\u016fkaz, \u017ee mnoho z mutac\u00ed, zejm\u00e9na v \u010dasn\u00fdch variant\u00e1ch, je spojeno se zv\u00fd\u0161enou virovou infekc\u00ed, nazna\u010duje, \u017ee ka\u017ed\u00e1 varianta byla navr\u017eena tak, aby identifikovala, kter\u00e9 aminokyseliny v proteinu S jsou zodpov\u011bdn\u00e9 za infek\u010dnost a patogenitu.\u00a0Pokud jsou z\u00e1v\u011bry vyvozen\u00e9 v tomto dokumentu spr\u00e1vn\u00e9, byl by to nezvratn\u00fd d\u016fkaz, \u017ee v\u0161e o SARS-CoV-2 bylo um\u011ble zmanipulov\u00e1no od doby, kdy se poprv\u00e9 objevil.<\/p>\n

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Pozn\u00e1mka redakce InfoKur\u00fdru:<\/strong><\/span><\/p>\n

Ji\u017e dlouhodob\u011b je zn\u00e1mo, \u017ee vir covidu byl vytvo\u0159en v laborato\u0159i, jak to od sam\u00e9ho po\u010d\u00e1tku tvrdila \u010desk\u00e1 v\u011bdeck\u00e1 pracovnice MUDr. So\u0148a Pekov\u00e1 Ph.D., kter\u00e1 byla provl\u00e1dn\u00edmi dezinforma\u010dn\u00edmi m\u00e9dii jako je nap\u0159\u00edklad Forum 24, \u010ceskou televiz\u00ed , Seznam Zpr\u00e1vy, Aktu\u00e1ln\u011b.cz\u00a0 a dal\u0161\u00edmi medi\u00e1ln\u00edmi \u017eumpami skandalizov\u00e1na. Omluv\u00ed se tato m\u00e9dia za sv\u00e9 nen\u00e1vistn\u00e9 koment\u00e1\u0159e a dezinformace? Asi t\u011b\u017eko! Speci\u00e1ln\u011b i tato m\u00e9dia \u00fato\u010dila proti ka\u017ed\u00e9mu , kdo odhaloval pravdu o covidu, vakc\u00edn\u00e1ch a cel\u00e9 t\u00e9 globalistick\u00e9 akci proti svobodn\u00fdm lidem, v\u010detn\u011b na\u0161eho\u00a0 internetov\u00e9mu <\/b>zpravodajsk\u00e9mu<\/b><\/span> port\u00e1lu.\u00a0\u00a0<\/b><\/span><\/p>\n

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Pokud by ned\u00e1vno zve\u0159ejn\u011bn\u00e1 japonsk\u00e1 studie o tzv. Covidov\u00fdch \u201evariant\u00e1ch\u201c obst\u00e1la v akademick\u00e9m zkoum\u00e1n\u00ed, byla…<\/p>\n","protected":false},"author":2,"featured_media":35385,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,1361,1518,1589,839,579],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/35384"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=35384"}],"version-history":[{"count":1,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/35384\/revisions"}],"predecessor-version":[{"id":35386,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/35384\/revisions\/35386"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/35385"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=35384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=35384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=35384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}