{"id":34117,"date":"2023-08-16T01:01:12","date_gmt":"2023-08-15T23:01:12","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=34117"},"modified":"2023-08-15T14:42:23","modified_gmt":"2023-08-15T12:42:23","slug":"po-ockovani-proti-covid-je-hlasen-stale-vetsi-pocet-pripadu-lepry","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2023\/08\/16\/po-ockovani-proti-covid-je-hlasen-stale-vetsi-pocet-pripadu-lepry\/","title":{"rendered":"Po o\u010dkov\u00e1n\u00ed proti COVID je hl\u00e1\u0161en st\u00e1le v\u011bt\u0161\u00ed po\u010det p\u0159\u00edpad\u016f lepry"},"content":{"rendered":"
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Po o\u010dkov\u00e1n\u00ed proti COVID-19 je hl\u00e1\u0161en rostouc\u00ed po\u010det p\u0159\u00edpad\u016f lepry, v\u010detn\u011b dvou p\u0159\u00edpad\u016f ve Spojen\u00e9m kr\u00e1lovstv\u00ed, kter\u00e9 podle v\u011bdc\u016f mohly b\u00fdt zp\u016fsobeny vakc\u00ednami.<\/span><\/p>\n

V\u011bdci zkoumali z\u00e1znamy kliniky pro lepru v lond\u00fdnsk\u00e9 nemocnici pro tropick\u00e9 choroby.\u00a0Zjistili, \u017ee z 52 lid\u00ed, kte\u0159\u00ed nav\u0161t\u011bvovali kliniku v roce 2021, bylo nejm\u00e9n\u011b 49 o\u010dkov\u00e1no.<\/span><\/p>\n

Definice studie ne\u017e\u00e1douc\u00ed reakce na lepru v souvislosti s vakc\u00ednou COVID-19 zahrnovala rozvoj lepry nebo lepry b\u011bhem 12 t\u00fddn\u016f po o\u010dkov\u00e1n\u00ed, kdy subjekt nem\u011bl v anamn\u00e9ze lepru nebo lepru.<\/span><\/p>\n

Definici p\u0159\u00edpadu splnili dva lid\u00e9.\u00a0U jedn\u00e9 osoby se t\u00fdden po druh\u00e9 d\u00e1vce rozvinula hrani\u010dn\u00ed tuberkuloidn\u00ed lepra (BT).\u00a0Druh\u00e1 osoba m\u011bla odpov\u011b\u010f 56 dn\u00ed po jedn\u00e9 d\u00e1vce.\u00a0Ob\u011b d\u00e1vky byly vakc\u00edny BNT162b2 spole\u010dnosti Pfizer.\u00a0Spole\u010dnost Pfizer na \u017e\u00e1dost o koment\u00e1\u0159 nereagovala.<\/span><\/p>\n

„V\u00fdvoj lepry BT a reakce typu 1 u jin\u00e9ho jedince kr\u00e1tce po d\u00e1vce vakc\u00edny BNT162b2 by mohl souviset s reakcemi T-bun\u011bk zprost\u0159edkovan\u00fdmi vakc\u00ednou,“ uvedli v\u011bdci.<\/span><\/p>\n

Vakc\u00edny COVID-19 mohou vyvolat reakci b\u00edl\u00fdch krvinek, T bun\u011bk.\u00a0P\u0159edpokl\u00e1d\u00e1 se, \u017ee tyto bu\u0148ky chr\u00e1n\u00ed p\u0159ed COVID-19.<\/span><\/p>\n

T bu\u0148ky mohou teoreticky spustit Mycobacterium leprae, bakterii, kter\u00e1 zp\u016fsobuje lepru, co\u017e m\u00e1 za n\u00e1sledek lepru nebo lepru, uvedli v\u011bdci.<\/span><\/p>\n

Jin\u00e9 vakc\u00edny, v\u010detn\u011b vakc\u00edn proti tuberkul\u00f3ze, mohou tak\u00e9 zp\u016fsobit lepru nebo lepru a u n\u011bkter\u00fdch lid\u00ed, kte\u0159\u00ed byli opakovan\u011b o\u010dkov\u00e1ni proti COVID-19, bylo zji\u0161t\u011bno, \u017ee maj\u00ed oslaben\u00fd imunitn\u00ed syst\u00e9m.<\/span><\/p>\n

Studie byla publikov\u00e1na 4. srpna v\u00a0<\/span>PLOS Neglected Tropical Diseases<\/span><\/a>\u00a0.<\/span><\/p>\n

V\u00edce o v\u00fdsledc\u00edch<\/strong><\/span><\/p>\n

Mu\u017e s diagn\u00f3zou lepra m\u00e1 80 let a \u017eije ve Spojen\u00e9m kr\u00e1lovstv\u00ed 49 let.\u00a0Trp\u011bl p\u0159\u00edznaky jako ztlu\u0161t\u011bl\u00e9 nervy.\u00a0Diagn\u00f3za lepry byla potvrzena ko\u017en\u00ed biopsi\u00ed.\u00a0Mu\u017e m\u016f\u017ee b\u00fdt prvn\u00edm \u010dlov\u011bkem, u kter\u00e9ho se ve Spojen\u00e9m kr\u00e1lovstv\u00ed od roku 1954 vyvinula lepra.<\/span><\/p>\n

Postupem \u010dasu se zlep\u0161il a dokonce dostal t\u0159et\u00ed d\u00e1vku vakc\u00edny Pfizer.<\/span><\/p>\n

\u201eZaj\u00edmav\u00e9 je, \u017ee dostal t\u0159et\u00ed d\u00e1vku vakc\u00edny BNT162b2 \u0161est m\u011bs\u00edc\u016f po druh\u00e9 d\u00e1vce po zah\u00e1jen\u00ed antibakteri\u00e1ln\u00ed terapie.\u00a0Ko\u017en\u00ed l\u00e9ze a ztlu\u0161t\u011bn\u00ed nerv\u016f vymizely do konce \u0161esti m\u011bs\u00edc\u016f antimikrobi\u00e1ln\u00ed terapie.\u00a0Po 12 m\u011bs\u00edc\u00edch se plaky ani nervov\u00e9 zm\u011bny nevr\u00e1tily,\u201c uvedli v\u011bdci.<\/span><\/p>\n

Reakce byla pozorov\u00e1na u 27let\u00e9ho mu\u017ee, kter\u00fd v minulosti u\u017e\u00edval v\u00edcel\u00e9kovou terapii, l\u00e9k na lepru.\u00a0P\u0159ed vstupem do Spojen\u00e9ho kr\u00e1lovstv\u00ed z nezn\u00e1m\u00e9 zem\u011b se mu vytvo\u0159ily \u010derven\u00e9 plaky a zhoustly nervy.\u00a0Biopsie potvrdila diagn\u00f3zu.\u00a0Bral l\u00e9ky a jeho p\u0159\u00edznaky se zlep\u0161ily.<\/span><\/p>\n

Souvislost mezi o\u010dkov\u00e1n\u00edm a probl\u00e9mem ve druh\u00e9m p\u0159\u00edpad\u011b byla podpo\u0159ena studiemi, kter\u00e9 prok\u00e1zaly, \u017ee u lid\u00ed, kte\u0159\u00ed byli o\u010dkov\u00e1ni p\u0159ed t\u0159emi nebo v\u00edce lety, je nepravd\u011bpodobn\u00e9, \u017ee by se znovu objevila reakce, uvedli v\u011bdci.<\/span><\/p>\n

Z 52 lid\u00ed, kte\u0159\u00ed v roce 2021 p\u0159i\u0161li na kliniku pro l\u00e9\u010dbu lepry za \u00fa\u010delem diagn\u00f3zy a\/nebo l\u00e9\u010dby, v\u0161ichni krom\u011b dvou nahl\u00e1sili stav o\u010dkov\u00e1n\u00ed.\u00a0Z t\u011bchto 50 osob bylo 49 o\u010dkov\u00e1no.<\/span><\/p>\n

U p\u011bti pacient\u016f na klinice byla v roce 2021 nov\u011b diagnostikov\u00e1na lepra.\u00a0P\u011bt dal\u0161\u00edch m\u011blo reakci 1. typu.\u00a0V\u0161ichni byli o\u010dkov\u00e1ni, ale pouze u jednoho z nich byla diagnostikov\u00e1na mo\u017en\u00e1 souvislost s vakc\u00ednou do 12 t\u00fddn\u016f po o\u010dkov\u00e1n\u00ed.\u00a0Nebylo jasn\u00e9, kdy byli dal\u0161\u00ed \u010dty\u0159i o\u010dkov\u00e1ni.<\/span><\/p>\n

Dr\u00a0Barbara de Barros, korespondentka studie, na \u017e\u00e1dost o koment\u00e1\u0159 nereagovala.\u00a0Auto\u0159i nezve\u0159ejnili \u017e\u00e1dn\u00e9 financov\u00e1n\u00ed ani konkuren\u010dn\u00ed z\u00e1jmy.<\/span><\/p>\n

Dr\u00a0de Barros a dal\u0161\u00ed britsk\u00ed v\u011bdci vysv\u011btlili, \u017ee l\u00e9ka\u0159i by si m\u011bli b\u00fdt v\u011bdomi toho, \u017ee vakc\u00edna COVID-19 m\u016f\u017ee zp\u016fsobit lepru, ale \u017ee podle jejich n\u00e1zoru v\u00fdhody vakc\u00edny COVID-19 \u201ep\u0159eva\u017euj\u00ed nad t\u011bmito ne\u017e\u00e1douc\u00edmi \u00fa\u010dinky\u201c.\u00a0Neposkytly \u017e\u00e1dn\u00e9 informace o p\u0159\u00ednosu o\u010dkov\u00e1n\u00ed, kter\u00fd se s p\u0159\u00edchodem nov\u011bj\u0161\u00edch variant drasticky sn\u00ed\u017eil a v n\u011bkter\u00fdch zem\u00edch vedl k diferencovan\u011bj\u0161\u00edm doporu\u010den\u00edm.\u00a0O rozsahu \u0161kod bylo mimo jin\u00e9 citov\u00e1no doporu\u010den\u00ed z Indie z roku 2021, aby se malomocn\u00ed nechat o\u010dkovat proti COVID-19.<\/span><\/p>\n

Jin\u00e9 p\u0159\u00edpady<\/strong><\/span><\/p>\n

V literatu\u0159e bylo hl\u00e1\u0161eno nejm\u00e9n\u011b 14 dal\u0161\u00edch p\u0159\u00edpad\u016f lepry nebo lepry b\u011bhem 14 dn\u016f po o\u010dkov\u00e1n\u00ed proti COVID-19, z toho osm v Indii.\u00a0V\u0161ichni pacienti se \u00fadajn\u011b uzdravili a n\u011bkte\u0159\u00ed dostali dal\u0161\u00ed d\u00e1vky vakc\u00edny.<\/span><\/p>\n

V \u010dl\u00e1nku zve\u0159ejn\u011bn\u00e9m v roce 2021 brazil\u0161t\u00ed v\u011bdci po o\u010dkov\u00e1n\u00ed proti COVID-19 uvedli dv\u011b reakce lepry, naz\u00fdvan\u00e9 erythema nodosum leprosum.\u00a0Poznamenali, \u017ee l\u00e9ka\u0159i by m\u011bli b\u00fdt upozorn\u011bni na v\u00fdskyt erythema nodosum leprosum u o\u010dkovan\u00fdch pacient\u016f a m\u011bli by sledovat zn\u00e1mky aktivn\u00ed lepry u t\u011bchto pacient\u016f, aby mohli potenci\u00e1ln\u011b diagnostikovat nov\u00fd p\u0159\u00edpad lepry, recidivy nebo reinfekce.<\/span><\/p>\n

V prosinci 2021 singapur\u0161t\u00ed v\u011bdci ozn\u00e1mili novou diagn\u00f3zu lepry po o\u010dkov\u00e1n\u00ed proti COVID-19 a uvedli, \u017ee probl\u00e9m \u201epravd\u011bpodobn\u011b odhalila vakc\u00edna proti COVID-19\u201c.<\/span><\/p>\n

Tak\u00e9 v roce 2021 indon\u00e9\u0161t\u00ed v\u011bdci informovali o pacientovi, kter\u00fd m\u011bl reakci po o\u010dkov\u00e1n\u00ed proti COVID-19.<\/span><\/p>\n

V lednu 2022 indi\u010dt\u00ed v\u011bdci ohl\u00e1sili lepru a uvedli, \u017ee l\u00e9ka\u0159i by si m\u011bli d\u00e1vat pozor na reakce u pacient\u016f s neurologick\u00fdmi komplikacemi.<\/span><\/p>\n

V b\u0159eznu 2022 ohl\u00e1sili izrael\u0161t\u00ed v\u011bdci reakci s odkazem na d\u016fle\u017eitost v\u010dasn\u00e9 diagn\u00f3zy a l\u00e9\u010dby.<\/span><\/p>\n

V s\u00e9rii p\u0159\u00edpad\u016f zve\u0159ejn\u011bn\u00e9 v roce 2022 indi\u010dt\u00ed v\u011bdci uvedli \u010dty\u0159i mu\u017ee, u kter\u00fdch se do 11 dn\u016f po o\u010dkov\u00e1n\u00ed proti COVID-19 vyvinula lepra nebo reakce.\u00a0V\u011bdci uvedli, \u017ee rozmanitost klinick\u00e9 prezentace reakc\u00ed lepry po o\u010dkov\u00e1n\u00ed proti COVID-19 vy\u017eaduje dal\u0161\u00ed rozs\u00e1hl\u00e9 molekul\u00e1rn\u00ed studie.<\/span><\/p>\n

V jin\u00e9m dokumentu z roku 2022 jin\u00ed v\u011bdci uvedli, \u017ee t\u0159i z 35 pacient\u016f, kte\u0159\u00ed nav\u0161t\u00edvili jejich kliniku mezi \u010dervencem 2021 a prosincem 2021, za\u017eili kr\u00e1tce po o\u010dkov\u00e1n\u00ed proti COVID-19 komplikace nebo reakci lepry.<\/span><\/p>\n<\/div>\n<\/div>\n

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Po o\u010dkov\u00e1n\u00ed proti COVID-19 je hl\u00e1\u0161en rostouc\u00ed po\u010det p\u0159\u00edpad\u016f lepry, v\u010detn\u011b dvou p\u0159\u00edpad\u016f ve Spojen\u00e9m…<\/p>\n","protected":false},"author":2,"featured_media":575,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[593,5674,213,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/34117"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=34117"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/34117\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/575"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=34117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=34117"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=34117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}