{"id":20404,"date":"2022-12-29T01:01:43","date_gmt":"2022-12-29T00:01:43","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=20404"},"modified":"2022-12-28T15:28:22","modified_gmt":"2022-12-28T14:28:22","slug":"izraelska-studie-ukazuje-ze-ctvrta-davka-vakciny-covid-ma-maly-ucinek-proti-nove-infekci","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2022\/12\/29\/izraelska-studie-ukazuje-ze-ctvrta-davka-vakciny-covid-ma-maly-ucinek-proti-nove-infekci\/","title":{"rendered":"Izraelsk\u00e1 studie ukazuje, \u017ee \u010dtvrt\u00e1 d\u00e1vka vakc\u00edny Covid m\u00e1 mal\u00fd \u00fa\u010dinek proti nov\u00e9 infekci"},"content":{"rendered":"
<\/div>\n

O\u010dkov\u00e1n\u00ed od spole\u010dnosti Pfizer nab\u00edz\u00ed men\u0161\u00ed ochranu ne\u017e Moderna!<\/span><\/h2>\n
\n
\n

TrialSite News uvedl, \u017ee samotn\u00fd Izrael slou\u017eil jako testovac\u00ed m\u00edsto pro pandemii Covid a m\u011bl obzvl\u00e1\u0161t\u011b \u00fazk\u00e9 spojen\u00ed se spole\u010dnost\u00ed Pfizer.\u00a0Zem\u011b na Bl\u00edzk\u00e9m v\u00fdchod\u011b m\u00e1 vysoce proo\u010dkovanou populaci, kter\u00e1 byla na za\u010d\u00e1tku pandemie uzav\u0159ena a neust\u00e1le vyhodnocuje dopad nemoci i o\u010dkov\u00e1n\u00ed proti Covidu.\u00a0V Izraeli byla nyn\u00ed zve\u0159ejn\u011bna nov\u00e1 studie o \u00fa\u010dinnosti a imunologii \u010dtvrt\u00e9 d\u00e1vky antivirov\u00e9ho o\u010dkov\u00e1n\u00ed proti koron\u011b.\u00a0Jak se dalo o\u010dek\u00e1vat, \u010dtvrt\u00e1 vakcinace jen m\u00e1lo zastavila p\u0159enos viru, ale byla spojena s celkov\u011b m\u00edrn\u011bj\u0161\u00edm v\u00fdskytem Covidu.<\/span><\/p>\n

Bivalentn\u00ed vakc\u00edna nebyla do studie zahrnuta<\/strong><\/span><\/p>\n

Studie byla zalo\u017eena na pozorov\u00e1n\u00ed 772 zdravotnick\u00fdch pracovn\u00edk\u016f v Sheba Medical Center v Tel HaShomer v Izraeli, p\u0159i\u010dem\u017e sledov\u00e1n\u00ed trvalo 180 dn\u00ed.\u00a0Za\u010dalo to koncem roku 2021\/za\u010d\u00e1tkem roku 2022, na vrcholu omikronov\u00e9 vlny v Izraeli.\u00a0Byly pou\u017eity boostery Pfizer (BNT162b2) i Moderna (mRNA1273).\u00a0Studie zjistila, \u017ee \u201epo celou dobu studie ob\u011b vakc\u00edny vykazovaly n\u00edzkou \u00fa\u010dinnost proti infekci, ale vysokou \u00fa\u010dinnost proti v\u00fdznamn\u00e9mu symptomatick\u00e9mu onemocn\u011bn\u00ed.\u201c Jin\u00fdmi slovy, \u010dtvrt\u00e9 o\u010dkov\u00e1n\u00ed nezabr\u00e1nilo dal\u0161\u00ed infekci, ale pokud se u jednoho pacienta vyskytl p\u0159\u00edpad Covid, nemoc byla m\u00edrn\u011bj\u0161\u00ed.\u00a0\u201eNa\u0161e studie to neprok\u00e1zala<\/span>
\nL\u00e9ka\u0159sk\u00e9 centrum Sheba<\/span><\/p>\n

Pfizer nen\u00ed tak \u00fa\u010dinn\u00fd jako Moderna<\/strong><\/span><\/p>\n

Ve studii v\u011bdci hl\u00e1s\u00ed: \u201eZjistili jsme, \u017ee maxim\u00e1ln\u00ed imunitn\u00ed odpov\u011b\u010f ve skupin\u011b BNT162b2 byla ni\u017e\u0161\u00ed a klesala rychleji.\u201c BNT162b2 je vakc\u00edna spole\u010dnosti Pfizer-BioNTech a spole\u010dnost Pfizer byla hlavn\u00edm dodavatelem vakc\u00edny Covid do Izraele.\u00a0TrialSite News minul\u00fd t\u00fdden informovalo, \u017ee dohodu mezi bl\u00edzkov\u00fdchodn\u00ed zem\u00ed a farmaceutickou spole\u010dnost\u00ed se nepoda\u0159ilo nal\u00e9zt.<\/span><\/p>\n

Nez\u00e1visle na tom studie zjistila \u201esn\u00ed\u017een\u00ed imunitn\u00ed odpov\u011bdi po \u010dtvrt\u00e9 d\u00e1vce vakc\u00edny\u201c.\u00a0Po t\u0159ech m\u011bs\u00edc\u00edch ob\u011b vakc\u00edny vyk\u00e1zaly v\u00fdznamn\u00fd pokles IgG, IgA a neutraliza\u010dn\u00edch protil\u00e1tek, s dal\u0161\u00edm poklesem IgG a neutraliza\u010dn\u00edch protil\u00e1tek ve skupin\u011b BNT162b2.\u00a0Poda\u0159ilo se n\u00e1m prok\u00e1zat, \u017ee po t\u0159ech m\u011bs\u00edc\u00edch testovan\u00e9 imunologick\u00e9 markery ztratily v\u011bt\u0161inu n\u00e1r\u016fstu dosa\u017een\u00e9ho po \u010dtvrt\u00e9 d\u00e1vce a \u017ee n\u011bkter\u00e9 z nich se t\u00e9m\u011b\u0159 vr\u00e1tily na v\u00fdchoz\u00ed hodnotu nam\u011b\u0159enou \u010dty\u0159i m\u011bs\u00edce po t\u0159et\u00ed d\u00e1vce vakc\u00edny.\u00a0Ji\u017e d\u0159\u00edve bylo hl\u00e1\u0161eno sn\u00ed\u017een\u00ed imunitn\u00ed odpov\u011bdi po druh\u00e9 i t\u0159et\u00ed d\u00e1vce vakc\u00edny.\u00a0Ji\u017e d\u0159\u00edve jsme prok\u00e1zali podobn\u00fd pokles IgG a neutraliza\u010dn\u00edch protil\u00e1tek po t\u0159et\u00ed d\u00e1vce BNT162b2.\u00a0Zde uveden\u00e1 data proto podporuj\u00ed na\u0161e p\u0159edchoz\u00ed zji\u0161t\u011bn\u00ed, \u017ee \u010dtvrt\u00e1 d\u00e1vka vakc\u00edny p\u0159echodn\u011b obnov\u00ed hladiny protil\u00e1tek, ale nem\u011bn\u00ed dynamiku protil\u00e1tek.\u00a0Z imunologick\u00e9ho hlediska to nazna\u010duje, \u017ee k udr\u017een\u00ed vysok\u00fdch hladin protil\u00e1tek budou nutn\u00e9 pravideln\u00e9 posilovac\u00ed d\u00e1vky.<\/span><\/p>\n

Krom\u011b toho izraelsk\u00fd t\u00fdm uv\u00e1d\u00ed, \u017ee po \u010dtvrt\u00e9 vakc\u00edn\u011b Pfizer\u00a0<\/span>byla ochrana proti infekci pouze 3 %<\/span><\/strong>\u00a0, zat\u00edmco \u010dtvrt\u00e1 vakc\u00edna Moderna poskytovala 25% ochranu proti infekci.\u00a0Studie dosp\u011bla k z\u00e1v\u011bru, \u017ee \u201edata poskytuj\u00ed d\u016fkaz o poklesu imunitn\u00edch odpov\u011bd\u00ed b\u011bhem t\u0159\u00ed m\u011bs\u00edc\u016f po \u010dtvrt\u00e9 d\u00e1vce vakc\u00edny mRNA-COVID-19, s rozd\u00edlem ve prosp\u011bch vakc\u00edny mRNA1273.\u00a0Bylo zji\u0161t\u011bno, \u017ee ob\u011b vakc\u00edny maj\u00ed n\u00edzkou \u00fa\u010dinnost proti infekci COVID-19 b\u011bhem obdob\u00ed sledov\u00e1n\u00ed, ale vysokou \u00fa\u010dinnost v prevenci v\u00fdznamn\u00e9ho symptomatick\u00e9ho onemocn\u011bn\u00ed, co\u017e m\u016f\u017ee m\u00edt d\u016fle\u017eit\u00e9 d\u016fsledky jak na \u00farovni osobn\u00edho, tak ve\u0159ejn\u00e9ho zdrav\u00ed.<\/span><\/p>\n

Odborn\u00edci poukazuj\u00ed na to, \u017ee \u00fa\u010delem vakc\u00edny bylo minimalizovat infekci virem Covid, nikoli ji blokovat, a jak TrialSite neust\u00e1le zd\u016fraz\u0148uje, vakc\u00edny nejsou l\u00e9kem, ale prevenc\u00ed, kter\u00e1 se \u010dasem vytr\u00e1c\u00ed.\u00a0\u00dasp\u011bch vakc\u00edny z\u00e1vis\u00ed na \u00fahlu pohledu.\u00a0Z tohoto pohledu produkt splnil svou pr\u00e1ci jako nouzov\u00e9 opat\u0159en\u00ed a otupil ostrou hranu smrt\u00edc\u00edho no\u017ee pandemie.\u00a0Na druhou stranu, doba pou\u017eitelnosti mRNA vakc\u00edn je jist\u011b probl\u00e9m pro kritick\u00e9 mysli, i kdy\u017e v\u011bt\u0161ina mainstreamov\u00fdch m\u00e9di\u00ed se takov\u00e9 obavy neodva\u017euje.<\/span><\/p>\n

Vzhledem k tomu, \u017ee bylo o\u010dkov\u00e1no p\u0159es 7 milion\u016f Izraelc\u016f, z nich\u017e v\u011bt\u0161ina dostala vakc\u00ednu od spole\u010dnosti Pfizer, nezd\u00e1 se, \u017ee by \u00fadaje studie spole\u010dnosti Sheba podporovaly spole\u010dnost Pfizer.\u00a0Vzhledem k tomu, \u017ee Pfizer m\u00e1 za sebou historii prosazov\u00e1n\u00ed dohod a Izraelci najednou nejsou schopni naj\u00edt dohodu s farmaceutick\u00fdm gigantem, mohla by se bl\u00edzkov\u00fdchodn\u00ed zem\u011b pohnout d\u00e1l.<\/span><\/p>\n

Prof. Gili Regev-Yochay<\/strong><\/p>\n

\n

ZDROJ<\/a><\/span><\/h3>\n

\"\"<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n

<\/h3>\n","protected":false},"excerpt":{"rendered":"

O\u010dkov\u00e1n\u00ed od spole\u010dnosti Pfizer nab\u00edz\u00ed men\u0161\u00ed ochranu ne\u017e Moderna! TrialSite News uvedl, \u017ee samotn\u00fd Izrael…<\/p>\n","protected":false},"author":2,"featured_media":15695,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[107,573,315,839,46],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/20404"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=20404"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/20404\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/15695"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=20404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=20404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=20404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}