{"id":19259,"date":"2022-12-06T01:04:11","date_gmt":"2022-12-06T00:04:11","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=19259"},"modified":"2022-12-05T18:25:00","modified_gmt":"2022-12-05T17:25:00","slug":"pandemie-neskonci-dokud-se-nezastavi-hromadne-ockovani","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2022\/12\/06\/pandemie-neskonci-dokud-se-nezastavi-hromadne-ockovani\/","title":{"rendered":"Pandemie neskon\u010d\u00ed, dokud se nezastav\u00ed hromadn\u00e9 o\u010dkov\u00e1n\u00ed"},"content":{"rendered":"
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V\u00fdzkum publikovan\u00fd v \u010dasopise ACS Infectious Diseases ukazuje, \u017ee hromadn\u00e9 o\u010dkov\u00e1n\u00ed proti COVID-19 selh\u00e1v\u00e1, proto\u017ee SARS-CoV-2 snadno mutuje a prosp\u00edv\u00e1 u t\u011bch, kte\u0159\u00ed jsou o\u010dkovan\u00ed.<\/strong><\/p>\n

Principem v oblasti infek\u010dn\u00edch onemocn\u011bn\u00ed je \u201eantimikrobi\u00e1ln\u00ed dohled\u201c, tj. v\u00fdb\u011br spr\u00e1vn\u00e9ho antibiotika pro spr\u00e1vn\u00e9ho pacienta a vyvarov\u00e1n\u00ed se nadm\u011brn\u00e9mu p\u0159edepisov\u00e1n\u00ed nebo plo\u0161n\u00e9mu pod\u00e1v\u00e1n\u00ed pacient\u016fm, kte\u0159\u00ed l\u00e9\u010dbu nepot\u0159ebuj\u00ed.<\/span><\/p>\n

Dal\u0161\u00edm principem je \u201ez\u00fa\u017een\u00ed spektra\u201c l\u00e9ku, jakmile je organismus identifikov\u00e1n kultivac\u00ed nebo jin\u00fdmi metodami.<\/span><\/p>\n

Tyto z\u00e1kladn\u00ed p\u0159\u00edstupy k pou\u017e\u00edv\u00e1n\u00ed antibiotik pom\u00e1haj\u00ed omezit probl\u00e9m bakteri\u00e1ln\u00ed rezistence a v\u00fdvoj superbakteri\u00ed.<\/span><\/p>\n

Nemocnice ka\u017edoro\u010dn\u011b vyhotovuj\u00ed antibiogram neboli zpr\u00e1vu o nej\u010dast\u011bj\u0161\u00edch infekc\u00edch a o tom, kter\u00e1 antibiotika jsou \u00fa\u010dinn\u00e1 (organismus je vn\u00edmav\u00fd) nebo ne\u00fa\u010dinn\u00e1 (organismus je odoln\u00fd).<\/span><\/p>\n

V pandemii SARS-CoV-2 byly tyto principy aplikov\u00e1ny na pou\u017eit\u00ed monoklon\u00e1ln\u00edch protil\u00e1tek a tento proces vysv\u011btluje, pro\u010d byly r\u016fzn\u00e9 produkty EUA (nap\u0159. bamlanivimab) sta\u017eeny z trhu, kdy\u017e se zjistilo, \u017ee ji\u017e nebyly \u00fa\u010dinn\u00e9 a se mohly pod\u00edlet na neutralizaci SARS -CoV-2 .<\/span><\/p>\n

Cel\u00fd tento my\u0161lenkov\u00fd proces byl u vakc\u00edn proti COVID-19 uvr\u017een do zmatku.\u00a0Kl\u00ed\u010dov\u00fdm antigenem pro vakc\u00edny od spole\u010dnost\u00ed Pfizer, Moderna, Janssen, AstraZeneca a Novavax byl 18 m\u011bs\u00edc\u016f spike protein z kmene Wuhan Institute of Virology.<\/span><\/p>\n

B\u011bhem n\u011bkolika m\u011bs\u00edc\u016f se objevily d\u016fkazy, \u017ee SARS-CoV-2 m\u00edrn\u011b zmutoval, aby se vyhnul \u0159ad\u011b protil\u00e1tek produkovan\u00fdch vakc\u00ednami, co\u017e by se vztahovalo na z\u00e1va\u017en\u00e1 invazivn\u00ed onemocn\u011bn\u00ed (IgG a IgM).<\/span><\/p>\n

Vzhledem k tomu, \u017ee nikdy nebylo prok\u00e1z\u00e1no, \u017ee vakc\u00edny COVID-19 neutralizuj\u00ed SARS-CoV-2 v nosohltanu, jedin\u00fd teoretick\u00fd p\u0159\u00ednos by byl u syst\u00e9mov\u00e9ho onemocn\u011bn\u00ed.<\/span><\/p>\n

Nyn\u00ed se uk\u00e1zalo, \u017ee p\u0159\u00edroda m\u00e1 nad v\u00fdrobci vakc\u00edn navrch, proto\u017ee SARS-CoV-2 m\u00e1 mnohem v\u011bt\u0161\u00ed p\u0159izp\u016fsobivost.<\/span><\/p>\n

Proto\u017ee replikace umo\u017e\u0148uje zm\u011bny v genetick\u00e9m k\u00f3du, kter\u00e9 umo\u017e\u0148uj\u00ed nep\u0159etr\u017eit\u00e9 p\u0159e\u017eit\u00ed, SARS-CoV-2 m\u00e1 knihovnu p\u0159ibli\u017en\u011b 28 000 mutac\u00ed, z nich\u017e p\u0159ibli\u017en\u011b 4,5 000 je v dom\u00e9n\u011b spike proteinu nebo \u0161pi\u010dky kop\u00ed le\u017e.<\/span><\/p>\n

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zdroj<\/span><\/a><\/figcaption><\/figure>\n<\/div>\n

Pomoc\u00ed podrobn\u00fdch technik modelov\u00e1n\u00ed mutac\u00ed p\u0159evl\u00e1daj\u00edc\u00edch v nejv\u00edce proo\u010dkovan\u00fdch zem\u00edch Rui Wang a jeho kolegov\u00e9 uk\u00e1zali, \u017ee hromadn\u00e9 o\u010dkov\u00e1n\u00ed ve skute\u010dnosti selh\u00e1v\u00e1 a zvy\u0161uje odolnost viru v\u016f\u010di omezen\u00e9 knihovn\u011b protil\u00e1tek, kterou by vakc\u00edny mohly vytvo\u0159it.<\/span><\/p>\n

Wangova anal\u00fdza nazna\u010duje, \u017ee budouc\u00ed v\u00fdvoj vakc\u00edny proti SARS-CoV-2 je beznad\u011bjn\u00fd.\u00a0Virus je prost\u011b p\u0159\u00edli\u0161 agiln\u00ed a dok\u00e1\u017ee manipulovat s \u201evazbou volnou energi\u00ed\u201c mezi RBD a jeho lidsk\u00fdm c\u00edlem, receptorem ACE2.<\/span><\/p>\n

To znamen\u00e1, \u017ee \u010d\u00edm v\u00edce o\u010dkov\u00e1n\u00ed bude provedeno, t\u00edm v\u011bt\u0161\u00ed bude po\u010det mutovan\u00fdch skvrn a t\u00edm d\u00e9le se bude virus \u0161\u00ed\u0159it a prodlu\u017eovat pandemii.<\/span><\/p>\n

D\u016fle\u017eit\u00fdm krokem k ukon\u010den\u00ed pandemie je proto ukon\u010den\u00ed hromadn\u00e9ho o\u010dkov\u00e1n\u00ed.\u00a0Virus se nezastav\u00ed, dokud to lidstvo neud\u011bl\u00e1.<\/span><\/p>\n<\/div>\n<\/div>\n

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ZDROJ<\/a><\/span><\/h3>\n<\/div>\n<\/div>\n

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V\u00fdzkum publikovan\u00fd v \u010dasopise ACS Infectious Diseases ukazuje, \u017ee hromadn\u00e9 o\u010dkov\u00e1n\u00ed proti COVID-19 selh\u00e1v\u00e1, proto\u017ee…<\/p>\n","protected":false},"author":2,"featured_media":6066,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[593,213,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/19259"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=19259"}],"version-history":[{"count":1,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/19259\/revisions"}],"predecessor-version":[{"id":19260,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/19259\/revisions\/19260"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/6066"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=19259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=19259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=19259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}