{"id":13583,"date":"2022-08-15T01:09:07","date_gmt":"2022-08-14T23:09:07","guid":{"rendered":"http:\/\/www.infokuryr.cz\/n\/?p=13583"},"modified":"2022-08-14T16:09:23","modified_gmt":"2022-08-14T14:09:23","slug":"vakcina-novavax-obsahuje-1-mcg-hmyzich-hadatek-a-bakulovirovych-proteinu-a-cast-jejich-dna-ktere-se-vam-vstriknou-s-kazdou-davkou","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2022\/08\/15\/vakcina-novavax-obsahuje-1-mcg-hmyzich-hadatek-a-bakulovirovych-proteinu-a-cast-jejich-dna-ktere-se-vam-vstriknou-s-kazdou-davkou\/","title":{"rendered":"Vakc\u00edna Novavax obsahuje 1 mcg hmyz\u00edch (h\u00e1\u010f\u00e1tek) a bakulovirov\u00fdch protein\u016f a \u010d\u00e1st jejich DNA, kter\u00e9 se v\u00e1m vst\u0159\u00edknou s ka\u017edou d\u00e1vkou"},"content":{"rendered":"
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A to je\u0161t\u011b p\u0159edt\u00edm, ne\u017e vezmeme v \u00favahu nov\u00fd adjuvans Matrix-M<\/strong><\/span><\/p>\n

Na sch\u016fzce Poradn\u00edho v\u00fdboru CDC pro imuniza\u010dn\u00ed praktiky, o kter\u00e9 jsem se \u017eiv\u011b informoval minul\u00fd t\u00fdden\u00a0<\/span>,<\/span><\/a>\u00a0bylo odhaleno, \u017ee vakc\u00edna Novavax byla uvedena na trh, proto\u017ee mohla b\u00fdt prod\u00e1v\u00e1na jako \u201etradi\u010dn\u00ed\u201c vakc\u00edna, proto\u017ee nebyla vyrobena z mRNA.\u00a0Novavax m\u011bl b\u00fdt zam\u011b\u0159en na neo\u010dkovan\u00e9, i kdy\u017e se odhadovalo, \u017ee vakc\u00ednu dostane pouze 10 procent neo\u010dkovan\u00fdch.<\/span><\/p>\n

Jako marketingov\u00e1 v\u00fdhoda byla propagov\u00e1na skute\u010dnost, \u017ee p\u0159i v\u00fdvoji nebyly pou\u017eity \u017e\u00e1dn\u00e9 fet\u00e1ln\u00ed bu\u0148ky.\u00a0D\u00edky \u010dten\u00e1\u0159i se v\u0161ak uk\u00e1zalo, \u017ee k testov\u00e1n\u00ed vakc\u00edny byla pou\u017eita lidsk\u00e1 fet\u00e1ln\u00ed bun\u011b\u010dn\u00e1 linie \u2014 (HEK) 293F \u2014 jak je podrobn\u011b pops\u00e1no v \u010dl\u00e1nku\u00a0v\u00a0<\/span>Science\u00a0<\/span><\/em>.<\/span><\/a><\/p>\n

NIC na t\u00e9to vakc\u00edn\u011b nen\u00ed tradi\u010dn\u00ed!<\/span><\/h1>\n

Za prv\u00e9, spole\u010dnost Novavax nevlastn\u00ed vlastn\u00ed v\u00fdrobn\u00ed za\u0159\u00edzen\u00ed, tak\u017ee vakc\u00edna distribuovan\u00e1 ve Spojen\u00fdch st\u00e1tech\u00a0<\/span>je vyr\u00e1b\u011bna<\/span><\/a>\u00a0v Serum Institute of India .<\/span><\/p>\n

Za druh\u00e9, adjuvans Matrix-M (nespecifick\u00fd, siln\u00fd imunostimulant) nebyl nikdy pou\u017eit.\u00a0Z\u00edsk\u00e1v\u00e1 se ze stromu Quillaja Saponaria (strom z m\u00fddlov\u00e9 k\u016fry).\u00a0Existuje dal\u0161\u00ed adjuvans pou\u017e\u00edvan\u00fd pouze ve vysoce reaktogenn\u00ed americk\u00e9 vakc\u00edn\u011b, Shingrix, co\u017e je extrakt z tohoto stromu.\u00a0Toto adjuvans GSK, naz\u00fdvan\u00e9 ASO1B, obsahuje QS-21, extrakt z vakc\u00edny Shingrix.<\/span><\/p>\n

Probl\u00e9m je v tom, \u017ee nev\u00edme, kter\u00e9 extrakty ze stromu jsou v Matrix-M.\u00a0Tyto informace jsou chr\u00e1n\u011bny autorsk\u00fdm pr\u00e1vem!\u00a0Adjuvans Matrix-M pou\u017e\u00edv\u00e1 dv\u011b bl\u00ed\u017ee nespecifikovan\u00e9 \u201efrakce\u201c ze stromu Quillaja saponaria a neexistuj\u00ed \u017e\u00e1dn\u00e9 \u00fadaje o jeho bezpe\u010dnosti.\u00a0Matrix-M nezahrnuje QS-21, i kdy\u017e spole\u010dnost n\u011bkdy nazna\u010duje, \u017ee to d\u011bl\u00e1, aby odvr\u00e1tila pozornost od jeho novinky.\u00a0Spole\u010dn\u011b s fosfolipidy a cholesterolem tvo\u0159\u00ed tyto dv\u011b frakce 40 nanometrov\u00e9 \u010d\u00e1stice Matrix M.<\/span><\/p>\n

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\"obr\u00e1zek\"<\/figure>\n<\/div>\n

Zat\u00edmco extrakty ze strom\u016f jsou siln\u00fdmi imunostimulanty, v\u0161echny tyto l\u00e1tky tak\u00e9 vykazuj\u00ed v\u00fdznamnou\u00a0<\/span>toxicitu<\/span><\/a>\u00a0.<\/span><\/p>\n

Za t\u0159et\u00ed, krom\u011b 5 mcg spike proteinu v ka\u017ed\u00e9 d\u00e1vce obdr\u017e\u00edte 1 mcg zbytkov\u00e9ho mno\u017estv\u00ed bakuloviru a bun\u011b\u010dn\u00fdch protein\u016f Sf9 (\u2264 0,96 mcg) a bakuloviru a bun\u011b\u010dnou (z h\u00e1\u010f\u00e1tka) DNA (\u2264 0,00016 mcg), podle na\u00a0<\/span>FDA<\/span><\/a>\u00a0.<\/span><\/p>\n

Tak\u017ee krom\u011b 5 mcg spike proteinu v ka\u017ed\u00e9 ze dvou d\u00e1vek z\u00edsk\u00e1v\u00e1te dal\u0161\u00edch 20 procent proteinu z hmyzu a bakulovir\u016f.<\/span><\/p>\n

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\"obr\u00e1zek\"<\/figure>\n<\/div>\n

Podzimn\u00ed Armyworm<\/span><\/h1>\n

Jin\u00fdmi slovy:<\/span><\/p>\n

Vakc\u00edna Novavax nen\u00ed dostate\u010dn\u011b purifikov\u00e1na.\u00a0A nikdo v\u00e1m ne\u0159ekne, jak v\u00e1s ovlivn\u00ed hmyz\u00ed a virov\u00e1 kontaminace proteiny a DNA.\u00a0Ka\u017ed\u00fd, kdo v\u00e1m tvrd\u00ed, \u017ee vakc\u00edna Novavax je konven\u010dn\u00ed proteinov\u00e1 vakc\u00edna, je dareb\u00e1k.<\/em><\/strong><\/p>\n

Tato vakc\u00edna je dal\u0161\u00ed \u201en\u00e1vnadou\u201c, kter\u00e1 se uv\u00e1d\u00ed na trh pouze proto, aby nal\u00e1kala neo\u010dkovan\u00e9 lidi, proto\u017ee nen\u00ed vyrobena z mRNA.\u00a0Ale st\u00e1le v\u00e1m d\u00e1v\u00e1 velkou d\u00e1vku Spike Venom.<\/span><\/p>\n

V USA existuje pouze jedna dal\u0161\u00ed vakc\u00edna, kter\u00e1 k produkci virov\u00fdch protein\u016f vyu\u017e\u00edv\u00e1 platformu bakulovir\u016f arm\u00e1dn\u00edch \u010derv\u016f.\u00a0Je to jedna z asi tuctu dostupn\u00fdch vakc\u00edn proti ch\u0159ipce a nese zna\u010dku Flublok.\u00a0Obsahuje tak\u00e9 DNA \u010derv\u016f a vir\u016f a\u00a0<\/span>proteiny<\/span><\/a>\u00a0, viz polo\u017eka 11 na\u00a0<\/span>\u0161t\u00edtku<\/span><\/a>\u00a0.<\/span><\/p>\n

Za \u010dtvrt\u00e9, regula\u010dn\u00ed org\u00e1ny p\u0159izn\u00e1vaj\u00ed, \u017ee nemaj\u00ed pon\u011bt\u00ed, zda vakc\u00edna funguje a jak je nebezpe\u010dn\u00e1;\u00a0viz n\u00ed\u017ee sn\u00edmek obrazovky, kter\u00fd jsem po\u0159\u00eddil ze zased\u00e1n\u00ed poradn\u00edho v\u00fdboru ACIP o\u00a0<\/span>Novavaxu<\/span><\/a>\u00a0.<\/span><\/p>\n

Odhaluje, \u017ee regula\u010dn\u00ed org\u00e1ny nev\u011bd\u00ed, jakou rychlost z\u00e1n\u011btu srde\u010dn\u00edho svalu Novavax zp\u016fsobuje, ani zda je \u00fa\u010dinn\u00fd proti sou\u010dasn\u00fdm variant\u00e1m.<\/span><\/p>\n

Ale p\u0159esto cht\u011bj\u00ed, abyste se nechali o\u010dkovat.\u00a0Viz posledn\u00ed \u0159\u00e1dek:<\/span><\/p>\n

\u201eBude d\u016fle\u017eit\u00e9 zjistit, jestli vakc\u00edna funguje nebo je bezpe\u010dn\u00e1, jakmile bude schv\u00e1lena.\u201c Pen\u00edze va\u0161ich da\u0148ov\u00fdch poplatn\u00edk\u016f v pr\u00e1ci.\u00a0Ale vakc\u00edna je „zdarma“<\/span><\/em>\u00a0.<\/span><\/p>\n

Nech\u00e1te se zase zm\u00e1st?<\/span><\/p>\n

\"obr\u00e1zek\"<\/figure>\n
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ZDROJ<\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

A to je\u0161t\u011b p\u0159edt\u00edm, ne\u017e vezmeme v \u00favahu nov\u00fd adjuvans Matrix-M Na sch\u016fzce Poradn\u00edho v\u00fdboru…<\/p>\n","protected":false},"author":2,"featured_media":3283,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[895,2902,46],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/13583"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=13583"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/13583\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/3283"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=13583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=13583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=13583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}