{"id":119881,"date":"2026-11-01T00:18:57","date_gmt":"2026-10-31T23:18:57","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=119881"},"modified":"2026-10-31T12:58:00","modified_gmt":"2026-10-31T11:58:00","slug":"sest-let-dat-mrna-nova-studie-wiley-identifikuje-dosud-vyznamne-bezpecnostni-mezery","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/11\/01\/sest-let-dat-mrna-nova-studie-wiley-identifikuje-dosud-vyznamne-bezpecnostni-mezery\/","title":{"rendered":"\u0160est let dat mRNA: Nov\u00e1 studie Wiley identifikuje dosud v\u00fdznamn\u00e9 bezpe\u010dnostn\u00ed mezery"},"content":{"rendered":"
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P\u0159ehled literatury publikovan\u00fd v <\/a><\/span>\u010dasopise Journal of Toxicology<\/span><\/em> 15. \u0159\u00edjna 2026 shrnuje v\u011bdeck\u00e9 poznatky o technologii modifikovan\u00e9 mRNA od za\u010d\u00e1tku \u00e9ry COVIDu. Auto\u0159i zkoumaj\u00ed v\u00fdzkum trvaj\u00edc\u00ed p\u0159ibli\u017en\u011b \u0161est let \u2013 od prvn\u00edch preklinick\u00fdch studi\u00ed v roce 2020 a\u017e po publikace z roku 2026 \u2013 a identifikuj\u00ed \u0159adu nevy\u0159e\u0161en\u00fdch bezpe\u010dnostn\u00edch ot\u00e1zek. Zam\u011b\u0159uj\u00ed se na biodistribuci, lipidov\u00e9 nano\u010d\u00e1stice, trv\u00e1n\u00ed a m\u00edsto produkce hrot\u016f, myokarditidu, neurologick\u00e9 a reproduk\u010dn\u00ed ud\u00e1losti, zbytky DNA a potenci\u00e1ln\u00ed dlouhodob\u00e9 biologick\u00e9 d\u016fsledky. Zvl\u00e1\u0161t\u011b pozoruhodn\u00e9 je zahrnut\u00ed Helmuta Sterze, jednoho ze 16 autor\u016f, kter\u00fd p\u0159ed n\u011bmeck\u00fdm Bundestagem potvrdil, \u017ee d\u0159\u00edve byl hlavn\u00edm toxikologem spole\u010dnosti Pfizer Europe a byl zodpov\u011bdn\u00fd za testov\u00e1n\u00ed na zv\u00ed\u0159atech v souvislosti s bezpe\u010dnost\u00ed l\u00e9\u010div.<\/span><\/strong><\/p>\n

Pr\u00e1ce s n\u00e1zvem \u201eToxikologick\u00e9 zranitelnosti a vznikaj\u00edc\u00ed bezpe\u010dnostn\u00ed sign\u00e1ly v technologii modifikovan\u00fdch mRNA vakc\u00edn: Narativn\u00ed p\u0159ehled zku\u0161enost\u00ed s COVID-19\u201c<\/strong> byla publikov\u00e1na jako p\u0159ehled s otev\u0159en\u00fdm p\u0159\u00edstupem <\/span>.<\/span><\/a><\/p>\n

Nejedn\u00e1 se o novou klinickou studii s vlastn\u00edmi pacienty autor\u016f, ale sp\u00ed\u0161e o <\/span>narativn\u00ed liter\u00e1rn\u00ed p\u0159ehled<\/span><\/strong> . Auto\u0159i vyhledali v datab\u00e1z\u00edch PubMed a Google Scholar publikace o hodnocen\u00ed rizik, toxicit\u011b, ne\u017e\u00e1douc\u00edch \u00fa\u010dinc\u00edch, vakc\u00edn\u00e1ch proti COVID-19 a po\u0161kozen\u00ed zdrav\u00ed zp\u016fsoben\u00fdch vakc\u00ednou a sledovali dal\u0161\u00ed literaturu prost\u0159ednictv\u00edm dop\u0159edn\u00fdch a zp\u011btn\u00fdch citac\u00ed. Samotn\u00ed auto\u0159i neshroma\u017e\u010fovali \u017e\u00e1dn\u00e1 nov\u00e1 data.<\/span><\/p>\n

Hodnocen\u00e1 literatura sah\u00e1 od studi\u00ed ran\u00e9ho v\u00fdvoje a schvalov\u00e1n\u00ed z roku 2020 a\u017e po studie z roku 2026. Tato pr\u00e1ce tak shrnuje p\u0159ibli\u017en\u011b \u0161est let v\u011bdeck\u00e9ho v\u00fdzkumu technologie COVID mRNA. Auto\u0159i sami tak\u00e9 odkazuj\u00ed na p\u011bt let zku\u0161enost\u00ed od jej\u00edho rozs\u00e1hl\u00e9ho zaveden\u00ed na za\u010d\u00e1tku roku 2021.<\/span><\/p>\n

Mezi autory je i b\u00fdval\u00fd hlavn\u00ed toxikolog spole\u010dnosti Pfizer Helmut Sterz<\/span><\/h2>\n

Zvl\u00e1\u0161tn\u00ed pozornost si zaslou\u017e\u00ed slo\u017een\u00ed autorsk\u00e9 skupiny.<\/span><\/p>\n

Mezi 16 autory je i <\/span>Dr. Helmut Sterz<\/span><\/strong> , kter\u00e9ho Wiley uv\u00e1d\u00ed jako nez\u00e1visl\u00e9ho v\u00fdzkumn\u00edka. Jeho p\u0159edchoz\u00ed pozice ve spole\u010dnosti Pfizer byla v\u00fdslovn\u011b potvrzena v b\u0159eznu 2026 p\u0159ed vy\u0161et\u0159ovac\u00ed komis\u00ed n\u011bmeck\u00e9ho Spolkov\u00e9ho sn\u011bmu.<\/span><\/p>\n

V odpov\u011bdi na ot\u00e1zku:<\/span><\/p>\n

\u201ePracoval jste jako hlavn\u00ed toxikolog pro Pfizer Europe. Je to tak?\u201c<\/span><\/em><\/p>\n

Sterz odpov\u011bd\u011bl:<\/span><\/p>\n

„Ano, to je spr\u00e1vn\u011b.“<\/span><\/em><\/p>\n

Pot\u00e9 vysv\u011btlil, \u017ee tam byl zodpov\u011bdn\u00fd za pokusy na zv\u00ed\u0159atech, kter\u00e9 slou\u017eily k bezpe\u010dnosti l\u00e9\u010div. <\/span>N\u011bmeck\u00fd Bundestag<\/span><\/a><\/p>\n

Sterz na stejn\u00e9m sly\u0161en\u00ed rovn\u011b\u017e uvedl, \u017ee karcinogenn\u00ed riziko p\u0159\u00edpravku Comiraty nebylo p\u0159ed jeho schv\u00e1len\u00edm zkoum\u00e1no. Jako d\u016fvod uvedl nedostatek \u010dasu a vysv\u011btlil, \u017ee pova\u017euje za znepokojiv\u00e9, \u017ee nebyly provedeny \u017e\u00e1dn\u00e9 alternativn\u00ed studie.<\/span><\/p>\n

\u010c\u00e1st sou\u010dasn\u00e9 kritiky toxikologick\u00e9ho hodnocen\u00ed technologie mRNA tedy poch\u00e1z\u00ed od v\u011bdce, kter\u00fd s\u00e1m zast\u00e1val vedouc\u00ed pozici v oblasti bezpe\u010dnosti l\u00e9\u010div ve spole\u010dnosti Pfizer.<\/span><\/p>\n

Auto\u0159i: Rychl\u00e9 zaveden\u00ed zanechalo toxikologick\u00e9 ot\u00e1zky nezodpov\u011bzen\u00e9<\/span><\/h2>\n

\u00dast\u0159edn\u00ed tez\u00ed studie je, \u017ee mimo\u0159\u00e1dn\u011b rychl\u00e9 zaveden\u00ed technologie modifikovan\u00e9 mRNA b\u011bhem pandemie nemuselo poskytnout dostatek \u010dasu k pln\u00e9mu prozkoum\u00e1n\u00ed ur\u010dit\u00fdch toxikologick\u00fdch rizik.<\/span><\/p>\n

Auto\u0159i p\u00ed\u0161\u00ed, \u017ee p\u011bt let po zaveden\u00ed se nahromadilo st\u00e1le v\u00edce dat, kter\u00e1 je t\u0159eba podrobn\u011bji prozkoumat, zejm\u00e9na pokud jde o <\/span>biodistribuci, ne\u017e\u00e1douc\u00ed \u00fa\u010dinky mimo c\u00edlovou tk\u00e1\u0148 a p\u0159etrv\u00e1vaj\u00edc\u00ed vedlej\u0161\u00ed \u00fa\u010dinky .<\/span><\/strong><\/p>\n

Odkazuj\u00ed tak\u00e9 na nez\u00e1visl\u00e9 anal\u00fdzy dat z f\u00e1ze III a zpr\u00e1vy o farmakovigilanci, kter\u00e9 podle jejich n\u00e1zoru vyvol\u00e1vaj\u00ed dal\u0161\u00ed ot\u00e1zky ohledn\u011b pom\u011bru p\u0159\u00ednos\u016f a rizik a mo\u017en\u00fdch dlouhodob\u00fdch biologick\u00fdch \u00fa\u010dink\u016f.<\/span><\/p>\n

Co jsme v\u011bd\u011bli v roce 2020 \u2013 a co ne?<\/span><\/h2>\n

P\u0159ehled explicitn\u011b porovn\u00e1v\u00e1 to, co bylo zn\u00e1mo v dob\u011b schv\u00e1len\u00ed mimo\u0159\u00e1dn\u00fdch ud\u00e1lost\u00ed v letech 2020\/2021, s t\u00edm, co bylo dosud nedostate\u010dn\u011b charakterizov\u00e1no.<\/span><\/p>\n

Podle zpr\u00e1vy mezi zn\u00e1m\u00fdmi informacemi byly \u00fadaje o kr\u00e1tkodob\u00e9 bezpe\u010dnosti z klinick\u00fdch studi\u00ed a schopnost vakc\u00edn vyvolat imunitn\u00ed odpov\u011b\u010f.<\/span><\/p>\n

Auto\u0159i v\u0161ak uv\u00e1d\u011bj\u00ed n\u011bkolik aspekt\u016f, kter\u00e9 v t\u00e9 dob\u011b nebyly dostate\u010dn\u011b objasn\u011bny, v\u010detn\u011b dlouhodob\u00e9 bezpe\u010dnosti platformy, \u00fa\u010dink\u016f opakovan\u00fdch posilova\u010d\u016f, \u00fapln\u00e9 distribuce lipidov\u00fdch nano\u010d\u00e1stic v t\u011ble a r\u016fzn\u00fdch biologick\u00fdch d\u016fsledk\u016f pou\u017eit\u00e9 modifikovan\u00e9 RNA. <\/span>Knihovna<\/span><\/a><\/p>\n

Jeden z bod\u016f jejich kritiky se t\u00fdk\u00e1 \u010dasov\u00e9 osy v\u00fdvoje BNT162b2. Podle nich experimenty na zv\u00ed\u0159atech za\u010daly v b\u0159eznu 2020, zat\u00edmco studie na lidech za\u010daly ji\u017e na konci dubna 2020. Dal\u0161\u00ed preklinick\u00e1 studie s pozd\u011bj\u0161\u00edmi variantami vakc\u00edny n\u00e1sledovaly a\u017e pot\u00e9.<\/span><\/p>\n

Studijn\u00ed produkt a s\u00e9riov\u011b vyr\u00e1b\u011bn\u00fd produkt nebyly zcela identick\u00e9<\/span><\/h2>\n

Pr\u00e1ce se zam\u011b\u0159uje na zm\u011bny mezi v\u00fdrobn\u00edm procesem pro kl\u00ed\u010dov\u00e9 klinick\u00e9 studie a n\u00e1slednou hromadnou v\u00fdrobou.<\/span><\/p>\n

Auto\u0159i rozli\u0161uj\u00ed mezi <\/span>Procesem 1 (P1)<\/span><\/strong> a <\/span>Procesem 2 (P2)<\/span><\/strong> .<\/span><\/p>\n

P1 byl pou\u017eit ve v\u011bt\u0161in\u011b kl\u00ed\u010dov\u00fdch klinick\u00fdch studi\u00ed. P2 byl n\u00e1sledn\u011b zaveden do velkov\u00fdroby.<\/span><\/p>\n

Podle p\u0159ehledu zm\u011bny zahrnovaly modifikace plazmidov\u00fdch templ\u00e1t\u016f, velikosti produkce, krok\u016f purifikace, lipidov\u00fdch slo\u017eek a dal\u0161\u00edch v\u00fdrobn\u00edch parametr\u016f. Auto\u0159i tvrd\u00ed, \u017ee takov\u00e9 zm\u011bny mohou ovlivnit integritu RNA, profily ne\u010distot a fyzik\u00e1ln\u00ed vlastnosti lipidov\u00fdch nano\u010d\u00e1stic.<\/span><\/p>\n

Jejich z\u00e1v\u011brem je zn\u00e1m\u00fd farmaceutick\u00fd princip:<\/span><\/p>\n

\u201eProces je produkt\u201c \u2013 v\u00fdrobn\u00ed proces je sou\u010d\u00e1st\u00ed produktu.<\/span><\/strong><\/p>\n

Auto\u0159i kritizuj\u00ed skute\u010dnost, \u017ee p\u0159ed zah\u00e1jen\u00edm \u0161irok\u00e9ho pou\u017e\u00edv\u00e1n\u00ed nebyly k dispozici komplexn\u00ed srovn\u00e1vac\u00ed \u00fadaje o toxikologick\u00e9 ekvivalenci.<\/span><\/p>\n

Myokarditida: Rizikov\u00fd profil se po zaveden\u00ed zm\u011bnil<\/span><\/h2>\n

Tato recenze se rozs\u00e1hle zab\u00fdv\u00e1 myokarditidou a perikarditidou.<\/span><\/p>\n

Auto\u0159i poukazuj\u00ed na to, \u017ee tyto ud\u00e1losti byly zpo\u010d\u00e1tku klasifikov\u00e1ny jako velmi vz\u00e1cn\u00e9. Pozd\u011bji se v\u0161ak objevil odli\u0161n\u011bj\u0161\u00ed rizikov\u00fd profil, zejm\u00e9na u mlad\u0161\u00edch mu\u017e\u016f.<\/span><\/p>\n

Mimo jin\u00e9 cituj\u00ed rozs\u00e1hlou severskou kohortovou studii, kter\u00e1 zjistila, \u017ee u 16 a\u017e 24let\u00fdch bylo riziko myokarditidy nebo perikarditidy vy\u0161\u0161\u00ed po o\u010dkov\u00e1n\u00ed p\u0159\u00edpravkem Pfizer ne\u017e po infekci COVID-19.<\/span><\/p>\n

Thajsk\u00e1 studie mlad\u00fdch lid\u00ed ve v\u011bku 13 a\u017e 18 let uv\u00e1d\u011bla subklinickou myoperikarditidu u 3,5 procenta studovan\u00fdch chlapc\u016f po druh\u00e9 d\u00e1vce vakc\u00edny Pfizer; podle studie se posti\u017een\u00ed zotavili do dvou t\u00fddn\u016f.<\/span><\/p>\n

P\u0159ehled rovn\u011b\u017e zd\u016fraz\u0148uje, \u017ee u n\u011bkter\u00fdch pacient\u016f s klinicky diagnostikovanou myokarditidou byly dlouhodob\u00e9 p\u0159\u00edznaky zdokumentov\u00e1ny i po normalizaci laboratorn\u00edch hodnot.<\/span><\/p>\n

Zbytky DNA a sekvence SV40<\/span><\/h2>\n

Jedna z nejkontroverzn\u011bj\u0161\u00edch \u010d\u00e1st\u00ed se t\u00fdk\u00e1 zbytkov\u00e9 DNA z v\u00fdrobn\u00edho procesu.<\/span><\/p>\n

Pr\u016fmyslov\u00e1 produkce mRNA vyu\u017e\u00edv\u00e1 bakteri\u00e1ln\u00ed plazmidy jako templ\u00e1ty DNA. Auto\u0159i cituj\u00ed n\u011bkolik studi\u00ed, ve kter\u00fdch byla v \u0161ar\u017e\u00edch vakc\u00edn nalezena zbytkov\u00e1 DNA.<\/span><\/p>\n

N\u011bkter\u00e9 z t\u011bchto studi\u00ed tak\u00e9 detekovaly promotorov\u00e9\/enhancerov\u00e9 sekvence SV40<\/span><\/strong> v ur\u010dit\u00fdch \u0161ar\u017e\u00edch Pfizeru a hl\u00e1sily hodnoty nad regula\u010dn\u00edmi limity.<\/span><\/p>\n

Auto\u0159i diskutuj\u00ed o v\u00fdsledn\u00fdch teoretick\u00fdch rizic\u00edch absorpce takov\u00e9 DNA do bun\u011bk a o mo\u017en\u00e9 genomov\u00e9 integraci.<\/span><\/p>\n

Sami v\u0161ak jasn\u011b uv\u00e1d\u011bj\u00ed, \u017ee tato ot\u00e1zka <\/span>nebyla definitivn\u011b vy\u0159e\u0161ena<\/span><\/strong> . Jedin\u00fd p\u0159\u00edpad, kter\u00fd cituj\u00ed a kter\u00fd m\u00e1 nazna\u010dovat mo\u017enou integraci sekvenc\u00ed souvisej\u00edc\u00edch s vakc\u00ednou, mus\u00ed b\u00fdt explicitn\u011b potvrzen nez\u00e1visl\u00fdm zdrojem. P\u0159ehled tak\u00e9 popisuje rozsah a v\u00fdznam zji\u0161t\u011bn\u00ed souvisej\u00edc\u00edch s SV40 jako v\u011bdecky kontroverzn\u00ed.<\/span><\/p>\n

Tato studie nedokazuje, \u017ee vakc\u00edny proti COVID-19 mRNA obecn\u011b integruj\u00ed DNA do lidsk\u00e9ho genomu. Sp\u00ed\u0161e vol\u00e1 po dal\u0161\u00edm toxikologick\u00e9m zkoum\u00e1n\u00ed t\u00e9to mo\u017enosti.<\/span><\/strong><\/p>\n

Podle autor\u016f z\u016fst\u00e1v\u00e1 jeden\u00e1ct ot\u00e1zek nezodpov\u011bzen\u00fdch<\/span><\/h2>\n

Na konci sv\u00e9 anal\u00fdzy auto\u0159i jmenuj\u00ed jeden\u00e1ct oblast\u00ed, kter\u00e9 st\u00e1le pova\u017euj\u00ed za nedostate\u010dn\u011b objasn\u011bn\u00e9.<\/span><\/p>\n

Pat\u0159\u00ed mezi n\u011b zm\u011bny v bun\u011b\u010dn\u00e9m metabolismu a imunitn\u00edch funkc\u00edch, mo\u017en\u00e9 vychyt\u00e1v\u00e1n\u00ed \u010d\u00e1stic ne\u017e\u00e1douc\u00edmi bu\u0148kami, mno\u017estv\u00ed a trv\u00e1n\u00ed produkce hrot\u016f, z\u00e1n\u011btliv\u00e9 \u00fa\u010dinky lipidov\u00fdch nano\u010d\u00e1stic a ot\u00e1zky t\u00fdkaj\u00edc\u00ed se vylu\u010dov\u00e1n\u00ed a distribuce modRNA a spike proteinu.<\/span><\/p>\n

Krom\u011b toho zmi\u0148uj\u00ed mo\u017en\u00e9 souvislosti s rakovinou, zpr\u00e1vy o mo\u017en\u00e9 genomov\u00e9 integraci, reproduk\u010dn\u00ed rizika, mo\u017enou specifickou srde\u010dn\u00ed toxicitu a nevysv\u011btliteln\u00e9 dlouhodob\u00e9 d\u016fsledky posunu sm\u011brem k protil\u00e1tk\u00e1m IgG4 pozorovan\u00fdm po opakovan\u00fdch posilovac\u00edch d\u00e1vk\u00e1ch.<\/span><\/p>\n

Toto jsou explicitn\u011b <\/span>otev\u0159en\u00e9 ot\u00e1zky a potenci\u00e1ln\u00ed rizika<\/span><\/strong> , nikoli d\u016fkaz, \u017ee v\u0161echna zm\u00edn\u011bn\u00e1 onemocn\u011bn\u00ed jsou zp\u016fsobena vakc\u00ednami.<\/span><\/p>\n

Srdce, nervov\u00fd syst\u00e9m, koagulace a reprodukce<\/span><\/h2>\n

Ve sv\u00e9m z\u00e1v\u011bru auto\u0159i p\u00ed\u0161\u00ed, \u017ee po schv\u00e1len\u00ed jsou st\u00e1le \u010dast\u011bji zkoum\u00e1ny bezpe\u010dnostn\u00ed zpr\u00e1vy z r\u016fzn\u00fdch org\u00e1nov\u00fdch syst\u00e9m\u016f.<\/span><\/p>\n

Konkr\u00e9tn\u011b jsou zm\u00edn\u011bny kardiovaskul\u00e1rn\u00ed, neurologick\u00e9, trombotick\u00e9 a reproduk\u010dn\u00ed p\u0159\u00edhody.<\/span><\/p>\n

Podle jejich interpretace byly n\u011bkter\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky, kter\u00e9 byly p\u016fvodn\u011b pops\u00e1ny jako \u201evelmi vz\u00e1cn\u00e9\u201c, v pozd\u011bj\u0161\u00edch studi\u00edch pozorov\u00e1ny s vy\u0161\u0161\u00ed frekvenc\u00ed, ne\u017e se p\u016fvodn\u011b o\u010dek\u00e1valo.<\/span><\/p>\n

Z\u00e1rove\u0148 p\u0159ehled poukazuje na z\u00e1sadn\u00ed probl\u00e9m s dostupn\u00fdmi daty: mnoho zji\u0161t\u011bn\u00ed poch\u00e1z\u00ed z retrospektivn\u00edch studi\u00ed, pasivn\u00edch syst\u00e9m\u016f hl\u00e1\u0161en\u00ed a kr\u00e1tkodob\u00fdch pozorov\u00e1n\u00ed.<\/span><\/p>\n

Takov\u00e1 data mohou odhalit sign\u00e1ly, ale neumo\u017e\u0148uj\u00ed automaticky jasn\u00fd d\u016fkaz kauzality.<\/span><\/p>\n

Farmakovigilance mohla n\u011bkter\u00e9 z ud\u00e1lost\u00ed p\u0159ehl\u00e9dnout<\/span><\/h2>\n

Monitorov\u00e1n\u00ed po schv\u00e1len\u00ed je tak\u00e9 vn\u00edm\u00e1no kriticky.<\/span><\/p>\n

Auto\u0159i poukazuj\u00ed na zn\u00e1m\u00e9 slabiny pasivn\u00edch syst\u00e9m\u016f hl\u00e1\u0161en\u00ed: nedostate\u010dn\u00e9 hl\u00e1\u0161en\u00ed, ne\u00fapln\u00e1 data a prom\u011bnliv\u00e1 kvalita hl\u00e1\u0161en\u00ed. Skute\u010dnou \u010detnost ur\u010dit\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f proto m\u016f\u017ee b\u00fdt obt\u00ed\u017en\u011bj\u0161\u00ed ur\u010dit, ne\u017e se \u010dasto p\u0159edpokl\u00e1d\u00e1. Auto\u0159i volaj\u00ed po robustn\u011bj\u0161\u00edch syst\u00e9mech aktivn\u00edho monitorov\u00e1n\u00ed a dlouhodob\u00e9m sledov\u00e1n\u00ed.<\/span><\/p>\n

Auto\u0159i kritizuj\u00ed ran\u00e9 zvl\u00e1d\u00e1n\u00ed v\u011bdeck\u00e9 nejistoty<\/span><\/h2>\n

Krom\u011b toxikologie se studie zab\u00fdv\u00e1 tak\u00e9 v\u011bdeck\u00fdm zvl\u00e1d\u00e1n\u00edm nejistoty b\u011bhem pandemie.<\/span><\/p>\n

Auto\u0159i tvrd\u00ed, \u017ee rozhodnut\u00ed u\u010din\u011bn\u00e1 pod siln\u00fdm \u010dasov\u00fdm tlakem mohla upevnit ran\u00e1 hodnocen\u00ed je\u0161t\u011b p\u0159edt\u00edm, ne\u017e byly k dispozici dostate\u010dn\u00e9 \u00fadaje.<\/span><\/p>\n

Obzvl\u00e1\u0161t\u011b kritizuj\u00ed p\u0159ed\u010dasn\u00e9 odm\u00edt\u00e1n\u00ed odli\u0161n\u00fdch v\u011bdeck\u00fdch hodnocen\u00ed jako \u201edezinformac\u00ed\u201c. Tvrd\u00ed, \u017ee to m\u016f\u017ee br\u00e1nit debat\u011b, replikaci a oprav\u011b chyb \u2013 proces\u016fm, kter\u00e9 jsou podle nich nezbytn\u00e9, zejm\u00e9na v toxikologii a ve\u0159ejn\u00e9m zdrav\u00ed.<\/span><\/p>\n

\u0160est let v\u00fdzkumu \u2013 ale st\u00e1le bez definitivn\u00ed odpov\u011bdi<\/span><\/h2>\n

V\u00fdznam nov\u00e9ho d\u00edla spo\u010d\u00edv\u00e1 p\u0159edev\u0161\u00edm v jeho rozsahu.<\/span><\/p>\n

Sna\u017e\u00ed se shrnout v\u00fdvoj znalost\u00ed o modifikovan\u00e9 platform\u011b mRNA <\/span>od po\u010d\u00e1te\u010dn\u00edch v\u00fdvojov\u00fdch prac\u00ed v roce 2020 p\u0159es celosv\u011btov\u00e9 zaveden\u00ed v roce 2021 a\u017e po v\u011bdeck\u00e9 publikace od roku 2026<\/span><\/strong> .<\/span><\/p>\n

To zahrnuje p\u0159ibli\u017en\u011b \u0161est let v\u00fdzkumu a zku\u0161enost\u00ed s technologi\u00ed, kter\u00e1 se z omezen\u00fdch klinick\u00fdch studi\u00ed dostala k miliard\u00e1m podan\u00fdch d\u00e1vek za mimo\u0159\u00e1dn\u011b kr\u00e1tkou dobu.<\/span><\/p>\n

Auto\u0159i nedoch\u00e1zej\u00ed k z\u00e1v\u011bru, \u017ee ka\u017ed\u00e9 diskutovan\u00e9 nebezpe\u010d\u00ed ji\u017e bylo prok\u00e1z\u00e1no. Rozli\u0161uj\u00ed mezi zdokumentovan\u00fdmi vedlej\u0161\u00edmi \u00fa\u010dinky, bezpe\u010dnostn\u00edmi sign\u00e1ly, mechanistick\u00fdmi hypot\u00e9zami a riziky, kter\u00e1 z\u016fst\u00e1vaj\u00ed nejasn\u00e1.<\/span><\/p>\n

Jejich \u00fast\u0159edn\u00edm po\u017eadavkem je proto: <\/span>dlouhodob\u00fd prospektivn\u00ed v\u00fdzkum, lep\u0161\u00ed monitorov\u00e1n\u00ed bezpe\u010dnosti, nez\u00e1visl\u00e1 reprodukovatelnost toxikologick\u00fdch studi\u00ed a v\u00fdrazn\u011b v\u011bt\u0161\u00ed transparentnost v budouc\u00edch aplikac\u00edch technologie mRNA.<\/span><\/strong><\/p>\n

Zapojen\u00ed b\u00fdval\u00e9ho hlavn\u00edho toxikologa spole\u010dnosti Pfizer Helmuta Sterze dod\u00e1v\u00e1 tomuto po\u017eadavku dal\u0161\u00ed v\u00e1hu. Sterz ji\u017e p\u0159ed n\u011bmeck\u00fdm Bundestagem potvrdil, \u017ee je ve spole\u010dnosti Pfizer zodpov\u011bdn\u00fd za testov\u00e1n\u00ed bezpe\u010dnosti l\u00e9\u010div na zv\u00ed\u0159atech \u2013 a z\u00e1rove\u0148 kritizoval skute\u010dnost, \u017ee pod \u010dasov\u00fdm tlakem pandemie nebyly kl\u00ed\u010dov\u00e9 bezpe\u010dnostn\u00ed ot\u00e1zky v Comirnaty pro\u0161et\u0159eny v rozsahu, kter\u00fd pova\u017eoval za nezbytn\u00fd.<\/span><\/p>\n

Tato nov\u00e1 liter\u00e1rn\u00ed re\u0161er\u0161e nep\u0159edstavuje konec v\u011bdeck\u00e9 debaty. Sp\u00ed\u0161e dokumentuje, \u017ee podle n\u00e1zoru autor\u016f z\u016fst\u00e1vaj\u00ed i \u0161est let po zah\u00e1jen\u00ed v\u00fdvoje a p\u011bt let po celosv\u011btov\u00e9m zaveden\u00ed z\u00e1kladn\u00ed toxikologick\u00e9 ot\u00e1zky nezodpov\u011bzeny.<\/span><\/strong><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

P\u0159ehled literatury publikovan\u00fd v \u010dasopise Journal of Toxicology 15. \u0159\u00edjna 2026 shrnuje v\u011bdeck\u00e9 poznatky o…<\/p>\n","protected":false},"author":2,"featured_media":88578,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,694,213,315,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/119881"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=119881"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/119881\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/88578"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=119881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=119881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=119881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}