{"id":119824,"date":"2026-10-31T00:15:23","date_gmt":"2026-10-30T23:15:23","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=119824"},"modified":"2026-10-30T17:44:28","modified_gmt":"2026-10-30T16:44:28","slug":"podle-studie-provedene-na-bunkach-sarkomu-ma-kurkumin-vyvazeny-profil-v-boji-proti-rakovine","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/10\/31\/podle-studie-provedene-na-bunkach-sarkomu-ma-kurkumin-vyvazeny-profil-v-boji-proti-rakovine\/","title":{"rendered":"Podle studie proveden\u00e9 na bu\u0148k\u00e1ch sarkomu m\u00e1 kurkumin vyv\u00e1\u017een\u00fd profil v boji proti rakovin\u011b"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"has-medium-font-size wp-block-paragraph\"><strong><span dir=\"auto\">P\u0159\u00edb\u011bh v kostce<\/span><\/strong><\/h3>\n<ul>\n<li><span dir=\"auto\">V laboratorn\u00ed studii na L\u00e9ka\u0159sk\u00e9 univerzit\u011b ve Vratislavi bylo zkoum\u00e1no p\u011bt rostlinn\u00fdch l\u00e1tek \u2013 kurkumin, berberin, biochanin A, kukurbitacin E a CAPE \u2013 a porovn\u00e1na jejich schopnost ovliv\u0148ovat rakovinn\u00e9 bu\u0148ky fibrosarkomu ve srovn\u00e1n\u00ed se zdrav\u00fdmi svalov\u00fdmi bu\u0148kami.<\/span><\/li>\n<li><span dir=\"auto\">Tyto slou\u010deniny naru\u0161ily produkci energie mnohem z\u00e1va\u017en\u011bji v rakovinn\u00fdch bu\u0148k\u00e1ch, kde hladiny adenosintrifosf\u00e1tu (ATP) klesly p\u0159ibli\u017en\u011b o 83 % a\u017e 92 %, ve srovn\u00e1n\u00ed s 23 % a\u017e 73 % ve zdrav\u00fdch bu\u0148k\u00e1ch.<\/span><\/li>\n<li><span dir=\"auto\">V\u0161ech p\u011bt l\u00e1tek vedlo k trval\u00e9mu zastaven\u00ed r\u016fstu rakovinn\u00fdch bun\u011bk. Kurkumin v\u0161ak vynikal a vykazoval nejsiln\u011bj\u0161\u00ed \u00fa\u010dinek, kdy\u017e zv\u00fd\u0161il pod\u00edl st\u00e1rnouc\u00edch rakovinn\u00fdch bun\u011bk z p\u0159ibli\u017en\u011b 16,5 % na v\u00edce ne\u017e 75 %.<\/span><\/li>\n<li><span dir=\"auto\">V bezpe\u010dnostn\u00edm screeningu larev voskov\u00e9ho molu byly kurkumin a berberin nejl\u00e9pe sn\u00e1\u0161eny, zat\u00edmco biochanin A se uk\u00e1zal jako nejtoxi\u010dt\u011bj\u0161\u00ed, co\u017e dokazuje, \u017ee siln\u00fd protirakovinn\u00fd \u00fa\u010dinek nen\u00ed z\u00e1rukou bezpe\u010dnosti.<\/span><\/li>\n<li><span dir=\"auto\">Proto\u017ee studie pou\u017eila \u017eivo\u010di\u0161n\u00e9 bun\u011b\u010dn\u00e9 linie a jednoduch\u00fd model bezobratl\u00fdch, v\u011bdci si uv\u011bdomuj\u00ed, \u017ee tyto slou\u010deniny nep\u0159edstavuj\u00ed l\u00e9\u010dbu rakoviny a je t\u0159eba je testovat na pokro\u010dilej\u0161\u00edch modelech.<\/span><\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pravd\u011bpodobn\u011b jste sly\u0161eli, \u017ee kurkuma, \u017elut\u00e9 ko\u0159en\u00ed z jihov\u00fdchodn\u00ed Asie, m\u00e1 \u00fadajn\u011b protirakovinn\u00fd potenci\u00e1l. Onkologick\u00e9 centrum Memorial Sloan Kettering (MSK) dokonce uv\u00e1d\u00ed, \u017ee kurkuma se v tradi\u010dn\u00ed medic\u00edn\u011b pou\u017e\u00edv\u00e1 ji\u017e v\u00edce ne\u017e 5 000 let.1<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Tato pov\u011bst p\u0159itahuje \u0161irokou v\u011bdeckou z\u00e1kladnu ji\u017e v\u00edce ne\u017e dv\u011b desetilet\u00ed2 a nad\u0161en\u00ed pro kurkumu jako \u201ep\u0159\u00edrodn\u00ed\u201c l\u00e9\u010dbu je \u010dasto vn\u00edm\u00e1no jako synonymum pro \u201ebezpe\u010dnou\u201c a \u201e\u00fa\u010dinnou\u201c. Nov\u00fd v\u00fdzkum v\u0161ak nazna\u010duje, \u017ee tyto dv\u011b vlastnosti ne v\u017edy jdou ruku v ruce s n\u011bkter\u00fdmi l\u00e9ky na rostlinn\u00e9 b\u00e1zi.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Nov\u00e1 laboratorn\u00ed studie\u00b3 v\u011bdc\u016f z L\u00e9ka\u0159sk\u00e9 univerzity ve Vratislavi a Vratislavsk\u00e9 univerzity porovnala vedle sebe p\u011bt rostlinn\u00fdch slou\u010denin, v\u010detn\u011b kurkuminu (\u00fa\u010dinn\u00e9 l\u00e1tky v kurkum\u011b) a berberinu, a zkoumala, jak ka\u017ed\u00e1 z nich ovliv\u0148uje rakovinn\u00e9 bu\u0148ky ve srovn\u00e1n\u00ed se zdrav\u00fdmi bu\u0148kami.\u2074<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V\u00fdsledkem je podrobn\u011bj\u0161\u00ed obraz ne\u017e obvykl\u00e9 vypr\u00e1v\u011bn\u00ed o \u201erostlinn\u00fdch l\u00e1tk\u00e1ch, kter\u00e9 bojuj\u00ed proti rakovin\u011b\u201c, kter\u00e9 se opakovan\u011b \u0161\u00ed\u0159\u00ed vir\u00e1ln\u011b. Zat\u00edmco n\u011bkter\u00e9 z l\u00e1tek byly vysoce \u00fa\u010dinn\u00e9 proti n\u00e1dorov\u00fdm bu\u0148k\u00e1m, uk\u00e1zaly se b\u00fdt \u0161kodliv\u00e9 pro cel\u00fd organismus, zat\u00edmco jin\u00e9 kombinovaly v\u00fdznamnou \u00fa\u010dinnost s \u0161etrn\u011bj\u0161\u00edm bezpe\u010dnostn\u00edm profilem.<\/span><\/p>\n<figure class=\"wp-block-embed aligncenter is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n<div class=\"wp-block-embed__wrapper\"><iframe loading=\"lazy\" title=\"Ko\u0159en\u00ed ve va\u0161\u00ed sk\u0159\u00edni p\u0159ekonalo 4 soupe\u0159e | Mercola Cellular Wisdom\" src=\"https:\/\/www.youtube.com\/embed\/Za0aqnriaxw?feature=oembed\" width=\"800\" height=\"450\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\" data-mce-fragment=\"1\"><\/iframe><\/div>\n<\/figure>\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong><span dir=\"auto\">Kurkumin prok\u00e1zal v laboratorn\u00edch testech protirakovinn\u00fd \u00fa\u010dinek a vykazoval sn\u00e1\u0161enliv\u011bj\u0161\u00ed bezpe\u010dnostn\u00ed profil ne\u017e srovnateln\u00e9 l\u00e1tky.<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V\u011bdci cht\u011bli odpov\u011bd\u011bt na n\u00e1sleduj\u00edc\u00ed ot\u00e1zku: Chovaj\u00ed se aktivn\u00ed slo\u017eky rostlinn\u00e9ho p\u016fvodu zn\u00e1m\u00e9 sv\u00fdmi protiz\u00e1n\u011btliv\u00fdmi a protirakovinn\u00fdmi \u00fa\u010dinky stejn\u011b, kdy\u017e jsou testov\u00e1ny vedle sebe? Podle laboratorn\u00ed studie L\u00e9ka\u0159sk\u00e9 univerzity ve Vratislavi, publikovan\u00e9 v \u010dasopise \u201eInternational Journal of Molecular Sciences\u201c, je odpov\u011b\u010f \u201ene\u201c.5<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">T\u00fdm porovnal p\u011bt rostlinn\u00fdch slou\u010denin \u2013 kurkumin (z kurkumy), berberin, biochanin A, kukurbitacin E a kofeinfenethylester (CAPE) \u2013 a zkoumal, jak ka\u017ed\u00e1 z nich ovliv\u0148uje bu\u0148ky fibrosarkomu, co\u017e je typ rakoviny, kter\u00fd vznik\u00e1 v pojivov\u00e9 tk\u00e1ni, ve srovn\u00e1n\u00ed se zdrav\u00fdmi svalov\u00fdmi bu\u0148kami. N\u00e1sleduj\u00edc\u00ed v\u00fdsledky shrnuj\u00ed, co v\u011bdci pozorovali a pro\u010d se zdr\u017eeli ozna\u010den\u00ed jak\u00e9koli z t\u011bchto slou\u010denin za terapii.<\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\">Studie porovn\u00e1vala dv\u011b bun\u011b\u010dn\u00e9 linie hlodavc\u016f<\/span><\/strong><span dir=\"auto\"> : bu\u0148ky WEHI-164, bun\u011b\u010dnou linii fibrosarkomu (rakovina pojivov\u00e9 tk\u00e1n\u011b) z my\u0161\u00ed, a bu\u0148ky L6, norm\u00e1ln\u00ed svalovou prekurzorovou bun\u011b\u010dnou linii (myoblasty) z potkan\u016f. V pr\u016fb\u011bhu experiment\u016f byla sledov\u00e1na \u017eivotaschopnost bun\u011bk, mitochondri\u00e1ln\u00ed funkce, produkce energie, bun\u011b\u010dn\u00e1 degradace, st\u00e1rnut\u00ed bun\u011bk a aktivita gen\u016f souvisej\u00edc\u00edch s NF-\u03baB, a z\u00e1v\u011brem byl proveden test toxicity na cel\u00e9m organismu. P\u011bt rostlinn\u00fdch slou\u010denin bylo testov\u00e1no v r\u016fzn\u00fdch koncentrac\u00edch po dobu 24 a 48 hodin.<\/span><\/li>\n<li><strong><span dir=\"auto\">Samotn\u00e1 \u00fa\u010dinnost nebyla ukazatelem selektivity<\/span><\/strong><span dir=\"auto\"> ; byly vypo\u010d\u00edt\u00e1ny hodnoty IC50 (koncentrace slou\u010deniny pot\u0159ebn\u00e1 ke sn\u00ed\u017een\u00ed \u017eivotaschopnosti bun\u011bk na polovinu), p\u0159i\u010dem\u017e ni\u017e\u0161\u00ed hodnota znamenala vy\u0161\u0161\u00ed \u00fa\u010dinnost. Po 24 hodin\u00e1ch byly kurkumin a CAPE prim\u00e1rn\u011b toxick\u00e9 pro rakovinnou bun\u011b\u010dnou linii, zat\u00edmco biochanin A, berberin a zejm\u00e9na kukurbitacin E vykazovaly relativn\u011b vy\u0161\u0161\u00ed toxicitu pro norm\u00e1ln\u00ed svalov\u00e9 bu\u0148ky. Nap\u0159\u00edklad 24hodinov\u00e1 hodnota IC50 kurkuminu v norm\u00e1ln\u00edch bu\u0148k\u00e1ch byla 29,305 mikromol\u016f oproti 14,049 v rakovinn\u00fdch bu\u0148k\u00e1ch, co\u017e nazna\u010duje, \u017ee k ovlivn\u011bn\u00ed n\u00e1dorov\u00fdch bun\u011bk sta\u010dilo men\u0161\u00ed mno\u017estv\u00ed. Po 48 hodin\u00e1ch se \u00fa\u010dinnost ka\u017ed\u00e9 slou\u010deniny zv\u00fd\u0161ila a rakovinn\u00e9 bu\u0148ky se p\u0159i opo\u017ed\u011bn\u00fdch m\u011b\u0159en\u00edch konzistentn\u011b uk\u00e1zaly jako n\u00e1chyln\u011bj\u0161\u00ed.<\/span><\/li>\n<li><strong><span dir=\"auto\">Oblast\u00ed, kde n\u00e1dorov\u00e9 bu\u0148ky trp\u011bly nejv\u00edce, byl energetick\u00fd metabolismus<\/span><\/strong><span dir=\"auto\"> . T\u00fdm pomoc\u00ed barviva s n\u00e1zvem JC-1 m\u011b\u0159il mitochondri\u00e1ln\u00ed membr\u00e1nov\u00fd potenci\u00e1l, co\u017e je ukazatel toho, jak dob\u0159e si \u201eelektr\u00e1rny\u201c bun\u011bk udr\u017euj\u00ed sv\u016fj elektrick\u00fd n\u00e1boj. V\u0161ech p\u011bt l\u00e9k\u016f tento n\u00e1boj sn\u00ed\u017eilo v norm\u00e1ln\u00edch svalov\u00fdch bu\u0148k\u00e1ch, p\u0159i\u010dem\u017e kukurbitacin E a berberin zp\u016fsobily nejv\u00fdznamn\u011bj\u0161\u00ed poklesy. V\u00fdmluvn\u011bj\u0161\u00ed byl adenosintrifosf\u00e1t (ATP), energetick\u00e1 m\u011bna bun\u011bk. Po 48 hodin\u00e1ch hladiny ATP v rakovinn\u00fdch bu\u0148k\u00e1ch klesly p\u0159ibli\u017en\u011b o 83 % a\u017e 92 %, ve srovn\u00e1n\u00ed s 23 % a\u017e 73 % v norm\u00e1ln\u00edch bu\u0148k\u00e1ch, p\u0159i\u010dem\u017e berberin zp\u016fsobil sn\u00ed\u017een\u00ed o p\u0159ibli\u017en\u011b 92 % v n\u00e1dorov\u00e9 bun\u011b\u010dn\u00e9 linii. Je pozoruhodn\u00e9, \u017ee ztr\u00e1ta membr\u00e1nov\u00e9ho n\u00e1boje a pokles hladin ATP neprob\u00edhaly v\u017edy paraleln\u011b, co\u017e vedlo autory k z\u00e1v\u011bru, \u017ee p\u0159i trval\u00e9m stresu byly rakovinn\u00e9 bu\u0148ky jednodu\u0161e m\u00e9n\u011b schopn\u00e9 obnovit svou energetickou rovnov\u00e1hu.<\/span><\/li>\n<li><strong><span dir=\"auto\">Bun\u011b\u010dn\u00e9 st\u00e1rnut\u00ed bylo v rakovinn\u00fdch bu\u0148k\u00e1ch v\u00fdznamn\u011b zrychleno<\/span><\/strong><span dir=\"auto\"> . Pomoc\u00ed markeru zvan\u00e9ho SA-\u03b2-galaktosid\u00e1za, kter\u00fd identifikuje senescentn\u00ed (trvale se ned\u011bl\u00edc\u00ed) bu\u0148ky, v\u011bdci zjistili z\u00e1kladn\u00ed pozitivitu p\u0159ibli\u017en\u011b 16,5 % u nel\u00e9\u010den\u00fdch rakovinn\u00fdch bun\u011bk. Kurkumin zv\u00fd\u0161il tuto hodnotu na 75,56 % \u2013 nejvy\u0161\u0161\u00ed hodnotu ve skupin\u011b \u2013 n\u00e1sledovan\u00fd berberinem s 69,68 %, CAPE s 68,45 %, kukurbitacinem E s 66,11 % a biochaninem A s 66,02 %. V norm\u00e1ln\u00edch svalov\u00fdch bu\u0148k\u00e1ch bylo zv\u00fd\u0161en\u00ed m\u00edrn\u011bj\u0161\u00ed, co\u017e podporuje vzorec stresov\u00e9 reakce preferen\u010dn\u00ed pro n\u00e1dor.<\/span><\/li>\n<li><strong><span dir=\"auto\">Dv\u011b slou\u010deniny vykazovaly odli\u0161n\u00e9 \u00fa\u010dinky na genetick\u00e9 \u00farovni<\/span><\/strong><span dir=\"auto\"> . V rakovinn\u00fdch bu\u0148k\u00e1ch o\u0161et\u0159en\u00fdch kukurbitacinem E a biochaninem A t\u00fdm m\u011b\u0159il medi\u00e1torovou RNA pro \u010dty\u0159i slo\u017eky NF-\u03baB a tak\u00e9 pro PFKFB3, enzym, kter\u00fd \u0159\u00edd\u00ed glykol\u00fdzu (bun\u011b\u010dn\u00e1 energetick\u00e1 dr\u00e1ha spalov\u00e1n\u00edm cukru). Kukurbitacin E udr\u017eoval tyto geny potla\u010den\u00e9 po del\u0161\u00ed dobu, zat\u00edmco biochanin A se po 48 hodin\u00e1ch op\u011bt zv\u00fd\u0161il a spustil p\u0159ibli\u017en\u011b dev\u00edtin\u00e1sobn\u00fd n\u00e1r\u016fst PFKFB3. Je d\u016fle\u017eit\u00e9 poznamenat, \u017ee auto\u0159i to prezentovali sp\u00ed\u0161e jako pozorov\u00e1n\u00ed ne\u017e jako d\u016fkaz mechanismu \u00fa\u010dinku, proto\u017ee p\u0159\u00edmo nezkoumali \u00fa\u010dinky zv\u00fd\u0161en\u00ed PFKFB3.<\/span><\/li>\n<li><strong><span dir=\"auto\">Bezpe\u010dnostn\u00ed screening u larev byl informativn\u00ed, ale z\u00e1m\u011brn\u011b omezen\u00fd<\/span><\/strong><span dir=\"auto\"> . V modelu Galleria mellonella (larvy voskov\u00e9ho m\u016fry) byl berberin nejl\u00e9pe sn\u00e1\u0161en: p\u0159e\u017eilo 9 z 10 larev a kurkumin zp\u016fsobil pouze n\u00edzkou \u00famrtnost. CAPE a kukurbitacin E sn\u00ed\u017eily m\u00edru p\u0159e\u017eit\u00ed v\u00fdrazn\u011bji a biochanin A sn\u00ed\u017eil m\u00edru p\u0159e\u017eit\u00ed na 2 z 10 ji\u017e 1. den. Berberin a kurkumin se v\u00fdznamn\u011b neli\u0161ily od kontroln\u00edch roztok\u016f, zat\u00edmco CAPE, kukurbitacin E a biochanin A ano. Auto\u0159i zd\u016fraz\u0148uj\u00ed, \u017ee se jednalo pouze o p\u0159edb\u011b\u017en\u00fd screening akutn\u00ed toxicity, a nikoli o demonstraci syst\u00e9mov\u00e9 bezpe\u010dnosti; poukazuj\u00ed tak\u00e9 na to, \u017ee studie porovn\u00e1vala dv\u011b r\u016fzn\u00e9 linie hlodavc\u016f, \u017ee aktivita NF-\u03baB byla odvozena sp\u00ed\u0161e z mRNA ne\u017e z proteinu a \u017ee studie nem\u016f\u017ee nahradit testov\u00e1n\u00ed u savc\u016f.<\/span><\/li>\n<\/ul>\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong><span dir=\"auto\">P\u0159ehled v\u011bdeck\u00fdch poznatk\u016f o \u00fa\u010dinku kurkuminu na r\u016fzn\u00e9 typy rakoviny.<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Abychom pochopili, pro\u010d kurkumin v d\u0159\u00edve prezentovan\u00e9 studii vynikal, je u\u017eite\u010dn\u00e9 zv\u00e1\u017eit jeho \u00fa\u010dinnost v \u0161ir\u0161\u00edm v\u00fdzkumn\u00e9m kontextu. Recenzovan\u00fd \u010dl\u00e1nek publikovan\u00fd v roce 2021 v \u010dasopise \u201eBiomedicines\u201c shrnuje molekul\u00e1rn\u00ed mechanismy p\u0159ipisovan\u00e9 kurkuminu u r\u016fzn\u00fdch druh\u016f rakoviny a prezentuje zji\u0161t\u011bn\u00ed z klinick\u00fdch studi\u00ed na lidech.6<\/span><\/p>\n<ul>\n<li><strong><span dir=\"auto\">Kurkumin interaguje s mnoha sign\u00e1ln\u00edmi drahami<\/span><\/strong><span dir=\"auto\"> \u2013 Tato recenze popisuje, jak kurkumin p\u016fsob\u00ed na imunomodul\u00e1tory, v\u010detn\u011b cytokin\u016f, enzymu COX-2 a reaktivn\u00edch forem kysl\u00edku (ROS), co\u017e jsou nestabiln\u00ed molekuly obsahuj\u00edc\u00ed kysl\u00edk zapojen\u00e9 do z\u00e1n\u011btliv\u00fdch proces\u016f a bun\u011b\u010dn\u00e9 signalizace. Tak\u00e9 se zab\u00fdv\u00e1 zapojen\u00edm kurkuminu do downregulace r\u016fstov\u00fdch faktor\u016f, proteinkin\u00e1z a sign\u00e1ln\u00edch drah, jako jsou NF-\u03baB, JNK a STAT3.<\/span><\/li>\n<li><strong><span dir=\"auto\">Inhibi\u010dn\u00ed \u00fa\u010dinek kurkuminu na NF-\u03baB je opakovan\u011b prokazovateln\u00fd<\/span><\/strong><span dir=\"auto\"> \u2013 NF-\u03baB je transkrip\u010dn\u00ed faktor, kter\u00fd pom\u00e1h\u00e1 kontrolovat expresi protein\u016f spojen\u00fdch jak se z\u00e1n\u011btem, tak s progres\u00ed rakoviny. Podle studie m\u00e1 kurkumin inhibi\u010dn\u00ed \u00fa\u010dinek na sign\u00e1ln\u00ed dr\u00e1hu z\u00e1vislou na NF-\u03baB, kter\u00e1 byla v laboratorn\u00edch modelech spojov\u00e1na s potla\u010den\u00edm r\u016fstu n\u00e1dorov\u00fdch bun\u011bk a indukc\u00ed apopt\u00f3zy, procesu programovan\u00e9 bun\u011b\u010dn\u00e9 smrti. Studie rovn\u011b\u017e zd\u016fraz\u0148uje, \u017ee kurkumin m\u016f\u017ee modulovat r\u016fzn\u00e9 typy imunitn\u00edch bun\u011bk a potla\u010dovat aktivaci inflamasomu NLRP3, sou\u010d\u00e1sti vrozen\u00e9ho imunitn\u00edho syst\u00e9mu, co\u017e vede ke sn\u00ed\u017een\u00e9mu uvol\u0148ov\u00e1n\u00ed z\u00e1n\u011btliv\u00e9 sign\u00e1ln\u00ed molekuly IL-1\u03b2.<\/span><\/li>\n<li><strong><span dir=\"auto\">Tato slou\u010denina byla studov\u00e1na u \u0159ady druh\u016f rakoviny, p\u0159ev\u00e1\u017en\u011b v bun\u011b\u010dn\u00fdch a zv\u00ed\u0159ec\u00edch studi\u00edch<\/span><\/strong><span dir=\"auto\"> . Tato recenze se zab\u00fdv\u00e1 rakovinou plic, prsu, prostaty, mozku, slinivky b\u0159i\u0161n\u00ed, \u017ealudku a krve a popisuje rozmanit\u00e9 \u00fa\u010dinky kurkuminu na r\u016fzn\u00e9 c\u00edlov\u00e9 struktury u ka\u017ed\u00e9ho z t\u011bchto onemocn\u011bn\u00ed. Nap\u0159\u00edklad v bun\u011b\u010dn\u00fdch lini\u00edch rakoviny prsu bylo zji\u0161t\u011bno, \u017ee kurkumin potla\u010duje translokaci NF-\u03baB do j\u00e1dra, zat\u00edmco v bu\u0148k\u00e1ch rakoviny plic p\u016fsob\u00ed na sign\u00e1ln\u00ed dr\u00e1hu Wnt\/\u03b2-katenin. Recenze v\u00fdslovn\u011b uv\u00e1d\u00ed, \u017ee v\u011bt\u0161ina t\u011bchto zji\u0161t\u011bn\u00ed poch\u00e1z\u00ed ze studi\u00ed in vitro nebo na zv\u00ed\u0159atech, a opakovan\u011b prezentuje kurkumin jako zkoumanou slou\u010deninu, nikoli jako zavedenou terapii.<\/span><\/li>\n<li><strong><span dir=\"auto\">Ran\u00e9 studie na lidech ukazuj\u00ed \u00fa\u010dinek, ale st\u00e1le jsou p\u0159edb\u011b\u017en\u00e9<\/span><\/strong><span dir=\"auto\"> . V jedn\u00e9 studii f\u00e1ze 2, kterou v\u011bdci cituj\u00ed, dost\u00e1valo 21 pacient\u016f s pokro\u010dil\u00fdm karcinomem slinivky b\u0159i\u0161n\u00ed peror\u00e1ln\u011b 8 gram\u016f kurkuminu denn\u011b po dobu osmi t\u00fddn\u016f. U dvou pacient\u016f se projevily klinick\u00e9 zn\u00e1mky biologick\u00e9 aktivity: onemocn\u011bn\u00ed jednoho pacienta z\u016fstalo stabiln\u00ed po dobu del\u0161\u00ed ne\u017e 18 m\u011bs\u00edc\u016f, zat\u00edmco u jin\u00e9ho do\u0161lo ke kr\u00e1tkodob\u00e9, ale v\u00fdznamn\u00e9 regresi n\u00e1doru. Studie f\u00e1ze 1 kombinuj\u00edc\u00ed kurkumin s chemoterapeutick\u00fdm l\u00e9kem docetaxelem u pokro\u010dil\u00e9ho karcinomu prsu uvedla, \u017ee u\u017e\u00edv\u00e1n\u00ed 6 gram\u016f kurkuminu denn\u011b vedle standardn\u00ed l\u00e9\u010dby docetaxelem bylo provediteln\u00e9 a obecn\u011b dob\u0159e tolerovan\u00e9. Proto\u017ee se jednalo o studii v ran\u00e9 f\u00e1zi, byla navr\u017eena k posouzen\u00ed bezpe\u010dnosti a d\u00e1vkov\u00e1n\u00ed, nikoli k prok\u00e1z\u00e1n\u00ed \u00fa\u010dinnosti. N\u00e1rodn\u00ed onkologick\u00fd institut (NCI) zast\u00e1v\u00e1 podobn\u011b opatrn\u011b optimistick\u00fd postoj. Ve sv\u00e9 anal\u00fdze zji\u0161t\u011bn\u00ed NCI uv\u00e1d\u00ed, \u017ee v\u00fdsledky ran\u00fdch klinick\u00fdch studi\u00ed kurkuminu v chemoprevenci kolorekt\u00e1ln\u00edho, \u00fastn\u00edho a jatern\u00edho karcinomu \u201ese zdaj\u00ed b\u00fdt slibn\u00e9\u201c. Zd\u016fraz\u0148uje v\u0161ak, \u017ee tyto v\u00fdsledky ran\u00fdch studi\u00ed \u201emus\u00ed b\u00fdt potvrzeny v dostate\u010dn\u011b rozs\u00e1hl\u00fdch studi\u00edch, kter\u00e9 hodnot\u00ed bezpe\u010dnost a \u00fa\u010dinnost m\u011b\u0159en\u00edm zm\u011bn klinick\u00fdch ukazatel\u016f\u201c.\u2077 Stejn\u00e1 studie v\u00fdslovn\u011b uv\u00e1d\u00ed, \u017ee d\u016fkazy \u201ev sou\u010dasn\u00e9 dob\u011b nejsou dostate\u010dn\u00e9 k doporu\u010den\u00ed produkt\u016f obsahuj\u00edc\u00edch kurkumin k l\u00e9\u010db\u011b rakoviny\u201c.<\/span><\/li>\n<li><strong><span dir=\"auto\">Bezpe\u010dnostn\u00ed profil je obecn\u011b p\u0159\u00edzniv\u00fd, a\u010dkoli je t\u0159eba dodr\u017eovat ur\u010dit\u00e1 opat\u0159en\u00ed<\/span><\/strong><span dir=\"auto\"> \u2013 kurkumin byl americk\u00fdm \u00da\u0159adem pro kontrolu potravin a l\u00e9\u010div (FDA) klasifikov\u00e1n jako \u201eobecn\u011b bezpe\u010dn\u00fd\u201c \u2013 tato klasifikace odkazuje na jeho status potravin\u00e1\u0159sk\u00e9 slo\u017eky a nem\u011bla by b\u00fdt interpretov\u00e1na jako schv\u00e1len\u00ed jeho pou\u017eit\u00ed jako l\u00e9ku proti rakovin\u011b. S ohledem na tento rozd\u00edl studie s eskalac\u00ed d\u00e1vky citovan\u00e9 v p\u0159ehledu zjistily, \u017ee denn\u00ed p\u0159\u00edjem a\u017e 12 gram\u016f nezp\u016fsobil ne\u017e\u00e1douc\u00ed \u00fa\u010dinky. V samostatn\u00e9 studii pacient\u016f se solidn\u00edmi n\u00e1dory byl kurkumin pod\u00e1van\u00fd v d\u00e1vce 900 miligram\u016f (mg) denn\u011b po dobu osmi t\u00fddn\u016f tak\u00e9 dob\u0159e sn\u00e1\u0161en. Jedin\u00fdm hl\u00e1\u0161en\u00fdm ne\u017e\u00e1douc\u00edm \u00fa\u010dinkem byly m\u00edrn\u00e9 gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee. P\u0159ehled v\u0161ak uv\u00e1d\u00ed n\u011bkolik omezen\u00ed. Kurkumin m\u00e1 v\u00fdrazn\u00fd \u00fa\u010dinek v\u00e1zaj\u00edc\u00ed \u017eelezo, co\u017e vede k nedostatku \u017eeleza u mlad\u00fdch my\u0161\u00ed. M\u00e1 antikoagula\u010dn\u00ed vlastnosti, kter\u00e9 mohou prodlou\u017eit dobu krv\u00e1cen\u00ed, a m\u016f\u017ee inhibovat ur\u010dit\u00e9 enzymy cytochromu P450, co\u017e znamen\u00e1, \u017ee m\u016f\u017ee interagovat s n\u011bkter\u00fdmi l\u00e9\u010dbami. Klinika Mayo tak\u00e9 doporu\u010duje opatrnost p\u0159i u\u017e\u00edv\u00e1n\u00ed kurkuminu, proto\u017ee m\u016f\u017ee ovlivnit \u00fa\u010dinnost n\u011bkter\u00fdch l\u00e9k\u016f, v\u010detn\u011b n\u011bkter\u00fdch chemoterapeutick\u00fdch l\u00e9k\u016f.\u2078<\/span><\/li>\n<li><strong><span dir=\"auto\">N\u00edzk\u00e1 biologick\u00e1 dostupnost je kl\u00ed\u010dovou p\u0159ek\u00e1\u017ekou<\/span><\/strong><span dir=\"auto\"> \u2013 p\u0159ehled tak\u00e9 zd\u016fraz\u0148uje nev\u00fdhody kurkuminu, v\u010detn\u011b jeho n\u00edzk\u00e9 rozpustnosti ve vod\u011b, \u0161patn\u00e9 absorpce a rychl\u00e9ho metabolismu. V d\u016fsledku toho z\u016fst\u00e1v\u00e1 jeho biologick\u00e1 dostupnost extr\u00e9mn\u011b n\u00edzk\u00e1 i p\u0159i denn\u00edm p\u0159\u00edjmu 12 gram\u016f. V jedn\u00e9 studii byl voln\u00fd kurkumin detekovateln\u00fd v plazm\u011b pouze u 1 z 12 dobrovoln\u00edk\u016f po d\u00e1vce 10 a\u017e 12 gram\u016f. V\u011bdci vyvinuli r\u016fzn\u00e9 formulace \u2013 v\u010detn\u011b micel, nano\u010d\u00e1stic a syst\u00e9m\u016f pro pod\u00e1v\u00e1n\u00ed na b\u00e1zi lipid\u016f \u2013 pro zv\u00fd\u0161en\u00ed absorpce. P\u0159ehled uv\u00e1d\u00ed, \u017ee tyto p\u0159\u00edstupy mohou pomoci zv\u00fd\u0161it plazmatick\u00e9 koncentrace kurkuminu.<\/span><\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Celkov\u011b v\u011bdci dosp\u011bli k vyv\u00e1\u017een\u00e9mu z\u00e1v\u011bru. Kurkumin p\u016fsob\u00ed na n\u011bkolik sign\u00e1ln\u00edch drah zapojen\u00fdch do v\u00fdvoje n\u00e1dor\u016f. Pro p\u0159esn\u011bj\u0161\u00ed ur\u010den\u00ed mechanismu jeho \u00fa\u010dinku u jednotliv\u00fdch typ\u016f rakoviny a pro potvrzen\u00ed jeho bezpe\u010dnosti pro lidsk\u00e9 pou\u017eit\u00ed jsou v\u0161ak zapot\u0159eb\u00ed dal\u0161\u00ed laboratorn\u00ed studie a klinick\u00e9 testy na lidech.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">Tato zji\u0161t\u011bn\u00ed t\u00fdkaj\u00edc\u00ed se kurkuminu v boji proti rakovin\u011b vych\u00e1zej\u00ed z kombinace r\u016fzn\u00fdch typ\u016f studi\u00ed. V\u00fd\u0161e \u200b\u200bpopsan\u00e9 v\u00fdsledky u lid\u00ed poch\u00e1zej\u00ed ze studi\u00ed proveden\u00fdch v klinick\u00fdch podm\u00ednk\u00e1ch a nemus\u00ed b\u00fdt zobecniteln\u00e9 na v\u0161echny jedince. V\u00fdsledky z bun\u011b\u010dn\u00fdch lini\u00ed a studi\u00ed na zv\u00ed\u0159atech \u2013 v\u010detn\u011b studie fibrosarkomu, na kterou se tento \u010dl\u00e1nek zam\u011b\u0159uje \u2013 poch\u00e1zej\u00ed z laboratorn\u00edho nebo zv\u00ed\u0159ec\u00edho v\u00fdzkumu a nemus\u00ed b\u00fdt p\u0159\u00edmo pou\u017eiteln\u00e9 na lidsk\u00e9 zdrav\u00ed.<\/span><\/em><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Praktick\u00e9 zp\u016fsoby, jak podpo\u0159it bun\u011b\u010dnou energii a celkov\u00e9 zdrav\u00ed<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Laboratorn\u00ed v\u00fdsledky pro kurkumin a podobn\u00e9 rostlinn\u00e9 slou\u010deniny jsou p\u0159edb\u011b\u017en\u00e9 a nep\u0159edstavuj\u00ed z\u00e1klad pro jejich pou\u017eit\u00ed jako terapie. Co si v\u0161ak m\u016f\u017eete odn\u00e9st, je zast\u0159e\u0161uj\u00edc\u00ed princip, kter\u00fd se prol\u00edn\u00e1 cel\u00fdm v\u00fdzkumem: va\u0161e bu\u0148ky z\u00e1vis\u00ed na dob\u0159e funguj\u00edc\u00edm energetick\u00e9m metabolismu a \u201ep\u0159\u00edrodn\u00ed\u201c nikdy nenahrazuje pe\u010dliv\u00e9 a informovan\u00e9 rozhodnut\u00ed. N\u00e1sleduj\u00edc\u00ed kroky se zam\u011b\u0159uj\u00ed na podporu tohoto z\u00e1kladu a nahl\u00ed\u017een\u00ed na bylinn\u00e9 dopl\u0148ky s jasn\u00fdm a kritick\u00fdm pohledem:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">1. Dod\u00e1vejte sv\u00fdm bu\u0148k\u00e1m energii jejich preferovan\u00fdm zdrojem<\/span><\/strong><span dir=\"auto\"> \u2013 gluk\u00f3za, nikoli tuk, je ide\u00e1ln\u00edm nosi\u010dem energie, kter\u00fd va\u0161e bu\u0148ky mohou vyu\u017e\u00edt nejefektivn\u011bji. Chronick\u00fd nedostatek sacharid\u016f m\u016f\u017ee podporovat oxida\u010dn\u011b-reduk\u010dn\u00ed stres a sni\u017eovat produkci energie na bun\u011b\u010dn\u00e9 \u00farovni. Jako pr\u016fm\u011brn\u00fd dosp\u011bl\u00fd \u010dlov\u011bk se sna\u017ete p\u0159ij\u00edmat p\u0159ibli\u017en\u011b 250 gram\u016f c\u00edlen\u00fdch sacharid\u016f denn\u011b; v\u00edce, pokud jste velmi fyzicky aktivn\u00ed. Cel\u00e9 ovoce a dob\u0159e uva\u0159en\u00e1 b\u00edl\u00e1 r\u00fd\u017ee jsou dobr\u00fdm v\u00fdchoz\u00edm bodem pro v\u011bt\u0161inu lid\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">2. Sni\u017ete p\u0159\u00edjem kyseliny linolov\u00e9 (LA) a vyh\u00fdbejte se olej\u016fm ze semen<\/span><\/strong><span dir=\"auto\"> \u2013 Pr\u016fmyslov\u011b vyr\u00e1b\u011bn\u00e9 oleje ze semen (naz\u00fdvan\u00e9 tak\u00e9 rostlinn\u00e9 oleje) jsou nejv\u011bt\u0161\u00edm zdrojem LA, omega-6 mastn\u00e9 kyseliny, kter\u00e1 se \u010dasem hromad\u00ed v tk\u00e1n\u00edch a m\u016f\u017ee po\u0161kodit mitochondri\u00e1ln\u00ed funkci. Sna\u017ete se omezit p\u0159\u00edjem LA na m\u00e9n\u011b ne\u017e 5 gram\u016f denn\u011b va\u0159en\u00edm se stabiln\u00edmi nasycen\u00fdmi tuky, jako je hov\u011bz\u00ed l\u016fj, gh\u00ed a m\u00e1slo z krav krmen\u00fdch tr\u00e1vou. Stejn\u011b d\u016fle\u017eit\u00e9 je vyh\u00fdbat se balen\u00fdm potravin\u00e1m a j\u00eddl\u016fm v restaurac\u00edch, kde se \u010dasto skr\u00fdvaj\u00ed oleje ze semen. Tato zm\u011bna c\u00edl\u00ed na jeden z hlavn\u00edch stresor\u016f ovliv\u0148uj\u00edc\u00edch produkci bun\u011b\u010dn\u00e9 energie.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">3. Pou\u017e\u00edvejte kurkumu jako ko\u0159en\u00ed, ne jako l\u00e9k ve vysok\u00fdch d\u00e1vk\u00e1ch<\/span><\/strong><span dir=\"auto\"> \u2013 Podle Jasona Houa, specialisty na integrativn\u00ed medic\u00ednu v MSK, je pou\u017e\u00edv\u00e1n\u00ed kurkumy p\u0159i va\u0159en\u00ed obecn\u011b pova\u017eov\u00e1no za bezpe\u010dn\u00e9 a skv\u011bl\u00fd zp\u016fsob, jak si ji u\u017e\u00edt. Koncentrovan\u00e9 kapsle s kurkuminem jsou v\u0161ak jin\u00fd p\u0159\u00edb\u011bh. Hou zd\u016fraz\u0148uje, \u017ee mohou zp\u016fsobovat interakce s n\u011bkter\u00fdmi l\u00e9ky.\u2079 Kvalita produkt\u016f se tak\u00e9 zna\u010dn\u011b li\u0161\u00ed a vysok\u00e9 d\u00e1vky byly u n\u011bkter\u00fdch lid\u00ed spojov\u00e1ny s probl\u00e9my s j\u00e1try.\u00b9\u2070 Pokud v sou\u010dasn\u00e9 dob\u011b podstupujete l\u00e9\u010dbu rakoviny nebo u\u017e\u00edv\u00e1te l\u00e9ky na p\u0159edpis, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em, ne\u017e za\u010dnete u\u017e\u00edvat kurkumin nebo dopl\u0148ky stravy s kurkuminem.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">4. Optimalizujte hladinu vitaminu D, ide\u00e1ln\u011b m\u00edrn\u00fdm slune\u010dn\u00edm z\u00e1\u0159en\u00edm<\/span><\/strong><span dir=\"auto\"> \u2013 Vitamin D p\u016fsob\u00ed jako d\u016fle\u017eit\u00fd regul\u00e1tor genov\u00e9 aktivity a podporuje bun\u011b\u010dn\u00e9 energetick\u00e9 procesy, na kter\u00fdch je va\u0161e t\u011blo z\u00e1visl\u00e9. M\u00edrn\u00e9 slun\u011bn\u00ed kolem poledne je preferovanou metodou pro budov\u00e1n\u00ed hladiny vitaminu D. Za optim\u00e1ln\u00ed se pova\u017euje rozmez\u00ed p\u0159ibli\u017en\u011b 60 a\u017e 80 nanogram\u016f na mililitr (ng\/ml). Vzhledem k tomu, \u017ee zp\u016fsob, jak tohoto rozmez\u00ed bezpe\u010dn\u011b dos\u00e1hnout, z\u00e1vis\u00ed na va\u0161\u00ed po\u010d\u00e1te\u010dn\u00ed hladin\u011b, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em, zda by pro v\u00e1s bylo prosp\u011b\u0161n\u00e9 m\u011b\u0159en\u00ed hladiny 25(OH)D.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">5. Obnovte funkci st\u0159ev, aby va\u0161e t\u011blo mohlo vyu\u017e\u00edvat celozrnn\u00e9 potraviny<\/span><\/strong><span dir=\"auto\"> \u2013 Mnoho lid\u00ed m\u00e1 naru\u0161en\u00fd st\u0159evn\u00ed mikrobiom a okam\u017eit\u00fd p\u0159echod na potraviny s vysok\u00fdm obsahem vl\u00e1kniny se m\u016f\u017ee obr\u00e1tit proti v\u00e1m v podob\u011b zv\u00fd\u0161en\u00ed hladiny endotoxin\u016f. Pro v\u011bt\u0161inu lid\u00ed je rozumn\u00fdm prvn\u00edm krokem dob\u0159e uva\u0159en\u00e1 b\u00edl\u00e1 r\u00fd\u017ee a cel\u00e9 ovoce. Pokud je va\u0161e st\u0159evn\u00ed funkce naru\u0161ena v\u00e1\u017en\u011bji, postupujte postupn\u011b \u2013 za\u010dn\u011bte s snadn\u011bji straviteln\u00fdmi mo\u017enostmi, jako je ovocn\u00e1 \u0161\u0165\u00e1va s du\u017einou, ne\u017e p\u0159ejdete na cel\u00e9 ovoce a pot\u00e9, jakmile se v\u00e1m zlep\u0161\u00ed tr\u00e1ven\u00ed, p\u0159ejd\u011bte na \u0161krobov\u00e9 zdroje, jako je b\u00edl\u00e1 r\u00fd\u017ee. Pro dal\u0161\u00ed podporu metabolick\u00e9ho zdrav\u00ed to kombinujte s ka\u017edodenn\u00edm cvi\u010den\u00edm, nap\u0159\u00edklad s c\u00edlem asi hodinov\u00e9 ch\u016fze denn\u011b.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">\u010casto kladen\u00e9 ot\u00e1zky o \u00fa\u010dinc\u00edch kurkuminu na rakovinu<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">Ot\u00e1zka: Co odhalila studie z Vratislavi o kurkuminu?<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">A<\/span><\/strong><span dir=\"auto\"> : V\u00fdzkumn\u00edci porovnali p\u011bt rostlinn\u00fdch slou\u010denin a zjistili, \u017ee kurkumin kombinuje siln\u00fd \u00fa\u010dinek proti bu\u0148k\u00e1m fibrosarkomu s indukc\u00ed bun\u011b\u010dn\u00e9 senescence a z\u00e1rove\u0148 vykazuje pom\u011brn\u011b p\u0159\u00edzniv\u00fd bezpe\u010dnostn\u00ed profil. Mezi testovan\u00fdmi slou\u010deninami v\u011bdci popsali kurkumin jako l\u00e1tku s nejvyv\u00e1\u017een\u011bj\u0161\u00edm profilem \u00fa\u010dinnosti. Je t\u0159eba poznamenat, \u017ee se jednalo o laboratorn\u00ed studie s pou\u017eit\u00edm zv\u00ed\u0159ec\u00edch bun\u011b\u010dn\u00fdch lini\u00ed a hmyz\u00edho modelu, nikoli o studii na lidech.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">Ot\u00e1zka: M\u016f\u017ee kurkumin l\u00e9\u010dit rakovinu?<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">A<\/span><\/strong><span dir=\"auto\"> : Ne. V\u00fdzkumn\u00edci v\u00fdslovn\u011b uvedli, \u017ee v\u00fdsledky neznamenaj\u00ed, \u017ee kurkumin, berberin ani \u017e\u00e1dn\u00e1 z dal\u0161\u00edch testovan\u00fdch slou\u010denin mohou b\u00fdt pou\u017eity k l\u00e9\u010db\u011b sarkom\u016f. Studie byla zalo\u017eena na \u017eivo\u010di\u0161n\u00fdch bun\u011b\u010dn\u00fdch lini\u00edch a jednoduch\u00e9m modelu bezobratl\u00fdch. Dal\u0161\u00ed kroky zahrnuj\u00ed testy ve slo\u017eit\u011bj\u0161\u00edch \u017eiv\u00fdch syst\u00e9mech a podrobn\u011bj\u0161\u00ed zkoum\u00e1n\u00ed mechanism\u016f \u00fa\u010dinku, d\u00e1vkov\u00e1n\u00ed a pod\u00e1v\u00e1n\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">Ot\u00e1zka: Pro\u010d studie testovala slou\u010deniny na larv\u00e1ch hmyzu?<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">A<\/span><\/strong><span dir=\"auto\"> : Pro posouzen\u00ed bezpe\u010dnosti nad r\u00e1mec izolovan\u00fdch bun\u011bk pou\u017eil v\u00fdzkumn\u00fd t\u00fdm jako po\u010d\u00e1te\u010dn\u00ed test toxicity larvy m\u016fry voskov\u00e9 (Galleria mellonella). Tento krok prok\u00e1zal, \u017ee siln\u00e1 aktivita sama o sob\u011b proti rakovinn\u00fdm bu\u0148k\u00e1m nen\u00ed dostate\u010dn\u00e1, proto\u017ee berberin a kurkumin byly nejl\u00e9pe sn\u00e1\u0161eny, zat\u00edmco kukurbitacin E a zejm\u00e9na biochanin A zp\u016fsobovaly vy\u0161\u0161\u00ed \u00famrtnost. V\u00fdzkumn\u00edci zd\u016fraznili, \u017ee se jedn\u00e1 o p\u0159edb\u011b\u017enou studii a nikoli o d\u016fkaz syst\u00e9mov\u00e9 bezpe\u010dnosti.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">Ot\u00e1zka: Je u\u017e\u00edv\u00e1n\u00ed dopl\u0148k\u016f stravy s kurkuminem nebo kurkumou bezpe\u010dn\u00e9?<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">A<\/span><\/strong><span dir=\"auto\"> : Kurkuma jako kulin\u00e1\u0159sk\u00e9 ko\u0159en\u00ed je obecn\u011b pova\u017eov\u00e1na za bezpe\u010dnou. Studie s postupn\u00fdm zvy\u0161ov\u00e1n\u00edm d\u00e1vky uk\u00e1zaly, \u017ee denn\u00ed p\u0159\u00edjem a\u017e 12 gram\u016f kurkuminu nezp\u016fsobil \u017e\u00e1dn\u00e9 \u0161kodliv\u00e9 \u00fa\u010dinky. V samostatn\u00e9 studii zp\u016fsobila d\u00e1vka 900 mg u n\u011bkter\u00fdch lid\u00ed m\u00edrn\u00e9 gastrointestin\u00e1ln\u00ed pot\u00ed\u017ee. U koncentrovan\u00fdch produkt\u016f je v\u0161ak t\u0159eba db\u00e1t ur\u010dit\u00fdch opat\u0159en\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Po u\u017e\u00edv\u00e1n\u00ed produkt\u016f ozna\u010den\u00fdch jako obsahuj\u00edc\u00ed kurkumin byly hl\u00e1\u0161eny p\u0159\u00edpady z\u00e1va\u017en\u00e9ho po\u0161kozen\u00ed jater. Kurkumin m\u016f\u017ee tak\u00e9 interagovat s n\u011bkter\u00fdmi l\u00e9ky, v\u010detn\u011b n\u011bkter\u00fdch chemoterapeutick\u00fdch l\u00e9k\u016f. P\u0159ed u\u017e\u00edv\u00e1n\u00edm jak\u00e9hokoli dopl\u0148ku stravy se pora\u010fte se sv\u00fdm l\u00e9ka\u0159em, zejm\u00e9na pokud v sou\u010dasn\u00e9 dob\u011b podstupujete l\u00e9\u010dbu.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">Ot\u00e1zka: Pro\u010d je kurkumin pova\u017eov\u00e1n za obt\u00ed\u017en\u011b vst\u0159ebateln\u00fd pro t\u011blo?<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">A<\/span><\/strong><span dir=\"auto\"> : Kurkumin je \u0161patn\u011b rozpustn\u00fd ve vod\u011b, vst\u0159eb\u00e1v\u00e1 se pouze omezen\u011b a rychle se metabolizuje. Jeho biologick\u00e1 dostupnost proto z\u016fst\u00e1v\u00e1 i p\u0159i vysok\u00fdch peror\u00e1ln\u00edch d\u00e1vk\u00e1ch velmi n\u00edzk\u00e1. Podle studi\u00ed se v\u011bt\u0161ina slou\u010deniny detekovateln\u00e9 v krvi skl\u00e1d\u00e1 z konjugovan\u00e9 formy, kter\u00e1 se jev\u00ed jako m\u00e9n\u011b biologicky aktivn\u00ed. D\u00e1le se obecn\u011b p\u0159edpokl\u00e1d\u00e1, \u017ee koncentrace pot\u0159ebn\u00e9 pro biologick\u00fd \u00fa\u010dinek jsou v\u00fdrazn\u011b vy\u0161\u0161\u00ed ne\u017e skute\u010dn\u011b pozorovan\u00e9 hodnoty. Speci\u00e1ln\u00ed formulace mohou zv\u00fd\u0161it koncentraci kurkuminu v plazm\u011b, ale \u010dasto st\u00e1le nedosahuj\u00ed koncentrac\u00ed dostate\u010dn\u00fdch pro terapeutick\u00fd \u00fa\u010dinek.<\/span><\/p>\n<p><strong><em><span dir=\"auto\">Anal\u00fdza Dr. Josepha Mercoly<\/span><\/em><\/strong><\/p>\n<h4 class=\"wp-block-paragraph\"><span dir=\"auto\">Zdroje:<\/span><\/h4>\n<ul>\n<li><span dir=\"auto\">1, 9, 10. Pam\u011btn\u00ed onkologick\u00e9 centrum Sloan Kettering, 13. dubna 2026<\/span><\/li>\n<li><span dir=\"auto\">2, 7. N\u00e1rodn\u00ed onkologick\u00fd institut, Kurkumin a rakovina<\/span><\/li>\n<li><span dir=\"auto\">3, 5. Mezin\u00e1rodn\u00ed \u010dasopis molekul\u00e1rn\u00edch v\u011bd (Int. J. Mol. Sci.), 2026, 27(11), 5025<\/span><\/li>\n<li><span dir=\"auto\">4. News-Medical.net, 22. \u010dervence 2026<\/span><\/li>\n<li><span dir=\"auto\">6. Biomedic\u00edna, 26. srpna 2021, 9(9), 1086<\/span><\/li>\n<li><span dir=\"auto\">8. Klinika Mayo, 28. srpna 2026<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/articles.mercola.com\/sites\/articles\/archive\/2026\/10\/22\/curcumin-anticancer-effects-study.aspx\" target=\"_blank\" rel=\"nofollow noopener\"><span dir=\"auto\">Zdroj<\/span><\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>P\u0159\u00edb\u011bh v kostce V laboratorn\u00ed studii na L\u00e9ka\u0159sk\u00e9 univerzit\u011b ve Vratislavi bylo zkoum\u00e1no p\u011bt rostlinn\u00fdch&#8230;<\/p>\n","protected":false},"author":2,"featured_media":70493,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1042,4776,11951,938,1366,839],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/119824"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=119824"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/119824\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/70493"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=119824"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=119824"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=119824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}